LOCUS       NM_203422               2212 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens LRRN4 C-terminal like (LRRN4CL), mRNA.
ACCESSION   NM_203422 XM_938275
VERSION     NM_203422.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2212)
  AUTHORS   van der Weyden,L., Harle,V., Turner,G., Offord,V., Iyer,V.,
            Droop,A., Swiatkowska,A., Rabbie,R., Campbell,A.D., Sansom,O.J.,
            Pardo,M., Choudhary,J.S., Ferreira,I., Tullett,M., Arends,M.J.,
            Speak,A.O. and Adams,D.J.
  TITLE     CRISPR activation screen in mice identifies novel membrane proteins
            enhancing pulmonary metastatic colonisation
  JOURNAL   Commun Biol 4 (1), 395 (2021)
   PUBMED   33758365
  REMARK    GeneRIF: CRISPR activation screen in mice identifies novel membrane
            proteins enhancing pulmonary metastatic colonisation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2212)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL834319.1 and AP001458.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_203422.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK291334.1, AL834319.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2149398 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000317449.5/ ENSP00000325808.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1321              AL834319.1         199-1519
            1322-2138           AP001458.6         93747-94563         c
            2139-2212           AL834319.1         2337-2410
FEATURES             Location/Qualifiers
     source          1..2212
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.3"
     gene            1..2212
                     /gene="LRRN4CL"
                     /note="LRRN4 C-terminal like"
                     /db_xref="GeneID:221091"
                     /db_xref="HGNC:HGNC:33724"
     exon            1..104
                     /gene="LRRN4CL"
                     /inference="alignment:Splign:2.1.0"
     exon            105..2212
                     /gene="LRRN4CL"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..826
                     /gene="LRRN4CL"
                     /note="LRRN4 C-terminal-like protein"
                     /codon_start=1
                     /product="LRRN4 C-terminal-like protein precursor"
                     /protein_id="NP_981967.1"
                     /db_xref="CCDS:CCDS8030.1"
                     /db_xref="GeneID:221091"
                     /db_xref="HGNC:HGNC:33724"
                     /translation="MLGSPCLLWLLAVTFLVPRAQPLAPQDFEEEEADETETAWPPLP
                     AVPCDYDHCRHLQVPCKELQRVGPAACLCPGLSSPAQPPDPPRMGEVRIAAEEGRAVV
                     HWCAPFSPVLHYWLLLWDGSEAAQKGPPLNATVRRAELKGLKPGGIYVVCVVAANEAG
                     ASRVPQAGGEGLEGADIPAFGPCSRLAVPPNPRTLVHAAVGVGTALALLSCAALVWHF
                     CLRDRWGCPRRAAARAAGAL"
     regulatory      2191..2196
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRN4CL"
                     /note="hexamer: ATTAAA"
     polyA_site      2212
                     /gene="LRRN4CL"
                     /note="major polyA site"
ORIGIN      
        1 gaagatacaa cctgacagca cagcctgaga tcttggggat ccctcagcct aacacccaca
       61 gacgtcagct ggtggattcc cgctgcatca aggcctaccc actgtctcca tgctgggctc
      121 tccctgcctt ctgtggctcc tggccgtgac cttcttggtt cccagagctc agcccttggc
      181 ccctcaagac tttgaagaag aggaggcaga tgagactgag acggcgtggc cgcctttgcc
      241 ggctgtcccc tgcgactacg accactgccg acacctgcag gtgccctgca aggagctaca
      301 gagggtcggg ccggcggcct gcctgtgccc aggactctcc agccccgccc agccgcccga
      361 cccgccgcgc atgggagaag tgcgcattgc ggccgaagag ggccgcgcag tggtccactg
      421 gtgtgccccc ttctccccgg tcctccacta ctggctgctg ctttgggacg gcagcgaggc
      481 tgcgcagaag gggcccccgc tgaacgctac ggtccgcaga gccgaactga aggggctgaa
      541 gccagggggc atttatgtcg tttgcgtagt ggccgctaac gaggccgggg caagccgcgt
      601 gccccaggct ggaggagagg gcctcgaggg ggccgacatc cctgccttcg ggccttgcag
      661 ccgccttgcg gtgccgccca acccccgcac tctggtccac gcggccgtcg gggtgggcac
      721 ggccctggcc ctgctaagct gtgccgccct ggtgtggcac ttctgcctgc gcgatcgctg
      781 gggctgcccg cgccgagccg ccgcccgagc cgcaggggcg ctctgaaagg ggcctggggg
      841 catctcgggc acagacagcc ccacctgggg cgctcagcct ggcccccggg aaagaggaaa
      901 acccgctgcc tccagggagg gctggacggc gagctgggag ccagccccag gctccagggc
      961 cacggcggag tcatggttct caggactgag cgcttgttta ggtccggtac ttggcgcttt
     1021 gtttcctggc tgaggtctgg gaaggaatag aaaggggccc ccaatttttt tttaagcggc
     1081 cagataataa ataatgtaac ctttgcggtt taagaggata aaatggagga tattattatg
     1141 tgggtattta tatgaccttt gtaaccattt aaaaatgtaa aaacgacctg acttagtaat
     1201 gcgaacctat agtagcagct actccagagg ctgaaatggg aggatctctt gagcccagga
     1261 gttggagtcc agtccagcca gggcaacaca gccagacgcc cttgtttttt attttgtttt
     1321 gttttggttt tttgtttttt gaggagtttc cctctgtcac acaagctgga gggcaatggc
     1381 gccatctcag ctcactgcaa cgtccacctc ctgggttcaa gcgattctcc tgcctcagca
     1441 tcctaattag ttgggattac aggcgcccac caccatgccc ggctaatttt tgtgtttttt
     1501 tagtagagac ggggtttcac catgttgtca ggctggtctc aaactcctga cctcaggtac
     1561 tccacccgcc ttggtctctc aaagtgctgg gattacaggc ataagccact gtgcccaggc
     1621 agaccccctt ctttaaagat gtaaaacccg gccgggcgcg gtggctcacg cctgtaatcc
     1681 cagcactttg ggaggctgag gcgggcagat cacgaagtca ggagatcgag accatcctgg
     1741 ctaacacggt gaaaccccgt ctctactaaa aatacaaaaa ttagccgggc atggtggtgg
     1801 gtacctgtag tcccagctac tccggaggct gaggcaggag aatggcgtga acccgggagg
     1861 cggatcttgc agtgagcgga gattgcacca ctgcactcca gcctgggtga cagagcaaga
     1921 ctccctctca aaagaaaaag aaaaaagatg taaaaaccat tcttagtttg tgggccttac
     1981 aaatcaggcc actggcccat tgcttgtagt tagttgatcc atgtcatgca ccctaaaaat
     2041 ggctctgtca ctgtgagtgg cttcagtagg attttgagaa taagtttata ttcttgctag
     2101 gtaaaacaaa acaaaaacga cagtaatacc aaggaatctc cccccccttt taccctccat
     2161 ttgtgtttat tgcatatcca ctataacaac attaaaggac ctttaaaagg aa
//
