LOCUS       NM_152611               2935 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens leucine rich repeat neuronal 4 (LRRN4), mRNA.
ACCESSION   NM_152611
VERSION     NM_152611.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2935)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2935)
  AUTHORS   Kanamori-Katayama,M., Kaiho,A., Ishizu,Y., Okamura-Oho,Y., Hino,O.,
            Abe,M., Kishimoto,T., Sekihara,H., Nakamura,Y., Suzuki,H.,
            Forrest,A.R. and Hayashizaki,Y.
  TITLE     LRRN4 and UPK3B are markers of primary mesothelial cells
  JOURNAL   PLoS One 6 (10), e25391 (2011)
   PUBMED   21984916
  REMARK    GeneRIF: LRRN4 was only detected in primary mesothelial cells, but
            MSLN and UPK3B were also detected in other cell types.
REFERENCE   3  (bases 1 to 2935)
  AUTHORS   Stolk,L., Zhai,G., van Meurs,J.B., Verbiest,M.M., Visser,J.A.,
            Estrada,K., Rivadeneira,F., Williams,F.M., Cherkas,L., Deloukas,P.,
            Soranzo,N., de Keyzer,J.J., Pop,V.J., Lips,P., Lebrun,C.E., van der
            Schouw,Y.T., Grobbee,D.E., Witteman,J., Hofman,A., Pols,H.A.,
            Laven,J.S., Spector,T.D. and Uitterlinden,A.G.
  TITLE     Loci at chromosomes 13, 19 and 20 influence age at natural
            menopause
  JOURNAL   Nat Genet 41 (6), 645-647 (2009)
   PUBMED   19448619
REFERENCE   4  (bases 1 to 2935)
  AUTHORS   Bando,T., Sekine,K., Kobayashi,S., Watabe,A.M., Rump,A., Tanaka,M.,
            Suda,Y., Kato,S., Morikawa,Y., Manabe,T. and Miyajima,A.
  TITLE     Neuronal leucine-rich repeat protein 4 functions in
            hippocampus-dependent long-lasting memory
  JOURNAL   Mol Cell Biol 25 (10), 4166-4175 (2005)
   PUBMED   15870286
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP252017.1, AK290123.1, BC027720.2 and AA464555.1.
            
            On May 17, 2019 this sequence version replaced NM_152611.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC027720.2, AK290123.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1970526,
                                           SAMEA2142363 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000378858.5/ ENSP00000368135.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 BP252017.1         21-24
            5-67                BP252017.1         26-88
            68-2555             AK290123.1         1-2488
            2556-2702           BC027720.2         2526-2672
            2703-2935           AA464555.1         28-260              c
FEATURES             Location/Qualifiers
     source          1..2935
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p12.3"
     gene            1..2935
                     /gene="LRRN4"
                     /gene_synonym="C20orf75; dJ1056H1.1; NLRR-4; NLRR4"
                     /note="leucine rich repeat neuronal 4"
                     /db_xref="GeneID:164312"
                     /db_xref="HGNC:HGNC:16208"
                     /db_xref="MIM:619706"
     exon            1..231
                     /gene="LRRN4"
                     /gene_synonym="C20orf75; dJ1056H1.1; NLRR-4; NLRR4"
                     /inference="alignment:Splign:2.1.0"
     exon            232..891
                     /gene="LRRN4"
                     /gene_synonym="C20orf75; dJ1056H1.1; NLRR-4; NLRR4"
                     /inference="alignment:Splign:2.1.0"
     CDS             237..2459
                     /gene="LRRN4"
                     /gene_synonym="C20orf75; dJ1056H1.1; NLRR-4; NLRR4"
                     /note="neuronal leucine-rich repeat protein 4;
                     leucine-rich repeat neuronal protein 4"
                     /codon_start=1
                     /product="leucine-rich repeat neuronal protein 4
                     precursor"
                     /protein_id="NP_689824.2"
                     /db_xref="CCDS:CCDS13097.1"
                     /db_xref="GeneID:164312"
                     /db_xref="HGNC:HGNC:16208"
                     /db_xref="MIM:619706"
                     /translation="MRQTLPLLLLTVLRPSWADPPQEKVPLFRVTQQGPWGSSGSNAT
                     DSPCEGLPAADATALTLANRNLERLPGCLPRTLRSLDASHNLLRALSTSELGHLEQLQ
                     VLTLRHNRIAALRWGPGGPAGLHTLDLSYNQLAALPPCTGPALSSLRALALAGNPLRA
                     LQPRAFACFPALQLLNLSCTALGRGAQGGIAEAAFAGEDGAPLVTLEVLDLSGTFLER
                     VESGWIRDLPKLTSLYLRKMPRLTTLEGDIFKMTPNLQQLDCQDSPALASVATHIFQD
                     TPHLQVLLFQNCNLSSFPPWTLDSSQVLSINLFGNPLTCSCDLSWLLTDAKRTVLSRA
                     ADTMCAPAAGSSGPFSASLSLSQLPGVCQSDQSTTLGASHPPCFNRSTYAQGTTVAPS
                     AAPATRPAGDQQSVSKAPNVGSRTIAAWPHSDAREGTAPSTTNSVAGHSNSSVFPRAA
                     STTRTQHRGEHAPELVLEPDISAASTPLASKLLGPFPTSWDRSISSPQPGQRTHATPQ
                     APNPSLSEGEIPVLLLDDYSEEEEGRKEEVGTPHQDVPCDYHPCKHLQTPCAELQRRW
                     RCRCPGLSGEDTIPDPPRLQGVTETTDTSALVHWCAPNSVVHGYQIRYSAEGWAGNQS
                     VVGVIYATARQHPLYGLSPGTTYRVCVLAANRAGLSQPRSSGWRSPCAAFTTKPSFAL
                     LLSGLCAASGLLLASTVVLSACLCRRGQTLGLQRCDTHLVAYKNPAFDDYPLGLQTVS
                     "
     exon            892..1096
                     /gene="LRRN4"
                     /gene_synonym="C20orf75; dJ1056H1.1; NLRR-4; NLRR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1234
                     /gene="LRRN4"
                     /gene_synonym="C20orf75; dJ1056H1.1; NLRR-4; NLRR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..2935
                     /gene="LRRN4"
                     /gene_synonym="C20orf75; dJ1056H1.1; NLRR-4; NLRR4"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2703
                     /gene="LRRN4"
                     /gene_synonym="C20orf75; dJ1056H1.1; NLRR-4; NLRR4"
                     /note="major polyA site"
ORIGIN      
        1 aaagacaaca gcgtcttgat gggaaaggag gagcaatggg aaagactgga gtatctcagt
       61 ccctctcagt ggatgggggt tgtgggagag aggcagctgg gagacaggcc tccctctgga
      121 gttcatagct gagttgctgt ccaaatcagt ggtccctaga atctataaaa caaagctgag
      181 aacttcagag gtgcatccag agaagccaca ctccaaaagg accacttcca gacgccatgc
      241 ggcaaaccct accgctgctg ctgctgacgg tgctgcgccc cagctgggca gaccctcccc
      301 aggagaaggt cccgctcttc cgggtcactc agcagggccc ctgggggagc agtggcagca
      361 acgccaccga ctcgccctgc gaggggctgc ccgccgcgga tgcgacggcc ttgaccctgg
      421 cgaaccgcaa cctggagcgc ctgcccggct gcctaccgcg cacactgcgc agcctcgacg
      481 ccagccacaa cctgctgcgc gccctgagca cttccgagct cggccacctg gagcagctgc
      541 aggtgctgac cctgcgccac aaccgcatcg ccgcgctgcg ctggggcccg ggtgggccgg
      601 cggggctgca caccctggac ctcagctaca accagctggc cgctctgccg ccgtgcaccg
      661 ggcccgcgct gagcagcctc cgcgccctgg cgctcgccgg gaatccgctg cgggcgctgc
      721 agccccgggc cttcgcctgc ttccccgcgc tgcagctcct caacctctcc tgcaccgcgc
      781 tgggtcgcgg agcccagggg ggcatcgccg aggcggcgtt cgctggagag gatggcgcgc
      841 ccctggtcac gctcgaagtc ctggatctca gcggcacgtt ccttgaacgg gttgagtcag
      901 ggtggatcag agacctgccg aagctcacat ccctctacct gaggaagatg cctcggctga
      961 cgaccctgga gggggacatt ttcaagatga cccccaacct gcagcagctg gactgtcagg
     1021 actccccagc acttgcttct gtcgccacac acatctttca agatactcca catctacagg
     1081 tccttctgtt ccagaactgc aacttgagtt ccttccctcc ttggaccctg gattcctccc
     1141 aggtcctatc gatcaacctc tttggcaacc ccctcacttg cagttgtgac ttgtcttggc
     1201 tcctcacgga tgcaaagaga actgtcctaa gcagggcagc agacactatg tgcgcgccag
     1261 ctgcgggatc cagcggcccc ttctcagcct ccctgtcact ctcccagctg cccggagtgt
     1321 gccagtccga ccaaagcacc actctcgggg cttcacaccc accttgcttc aaccgctcca
     1381 cctacgcaca gggtaccacc gtcgcgccca gcgcagcccc cgccacccgg cctgcgggag
     1441 accagcagag tgtctccaag gcccctaacg tgggctctcg cacgatagct gcatggccgc
     1501 acagcgatgc acgggagggg actgccccct ccacgaccaa ctctgtagca ggtcacagca
     1561 actccagcgt tttccccagg gctgccagca ccaccaggac ccagcaccga ggagaacatg
     1621 cccccgagct tgtccttgag cctgatatct cagctgcctc caccccactg gccagcaagc
     1681 tcctgggccc cttccctacc tcgtgggacc gcagcataag ctcgcctcag cccggccaga
     1741 ggacacacgc cacaccccaa gcccccaacc cgagtctttc cgagggcgag attccagtct
     1801 tgctgctgga cgactacagt gaggaggagg aagggaggaa ggaggaggtg ggaacgcctc
     1861 accaggacgt cccctgtgat taccatccct gcaagcacct gcagaccccg tgcgcggagc
     1921 tgcagaggcg gtggcggtgc cggtgccccg gcctcagcgg ggaagacacc atcccagacc
     1981 cgcccaggct gcagggggtg acggagacca cggacacgtc ggcgctggtc cactggtgtg
     2041 cccccaactc ggtagtgcat gggtaccaga tccgctactc tgcggagggc tgggcgggga
     2101 accagtcggt ggtgggggtc atctacgcca cggcccggca gcaccctctg tacgggctgt
     2161 cgccgggcac cacctaccgc gtgtgcgtgc tggcggccaa cagggcgggc ttgagccagc
     2221 cacggtcttc gggctggagg agcccgtgcg ccgccttcac caccaagccc agcttcgcgc
     2281 tcctgctctc tgggctgtgc gccgccagcg gcctgttgct cgccagcacc gtggtgctgt
     2341 ccgcatgtct ctgcaggcgg ggccagacgc tgggcctgca gcgctgcgac acgcacctgg
     2401 tggcctacaa aaacccggcc tttgatgatt acccgctggg gctccagacc gtcagttagc
     2461 ccagcttctg ggataacgcg tctcatcgaa ctggatctga gcgcaaaaag gaagacacag
     2521 acggtcaaaa acgaccccat ccgctcctag ggtttctaat tcccgtgaag ccagaatgcc
     2581 ttgagcacac atggaacttg ccacactgag tgtctgggtc caaggaactg ctgccctccc
     2641 ttccttctac ttaactctgt tcccagaaac ctgatggtca atgccagatc gctccccact
     2701 gccgccaggc cttcttgtgt gttgttggtt catttgcggt tttcagcagt cagtgcctct
     2761 ctatccagta gaatagtgta tggacgtagg aagggatgaa acagagaagt tgcataaccc
     2821 agcctctttg atcatgttag aaatcacatc ctcaggtctt tccagcggaa gctccttcat
     2881 ggtcaagctc taagacacaa cgagctctgt tattcaagaa atcaattcca gtgga
//
