LOCUS       NM_201630               3468 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens leucine rich repeat neuronal 2 (LRRN2), transcript
            variant 2, mRNA.
ACCESSION   NM_201630
VERSION     NM_201630.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3468)
  AUTHORS   Tomiyama,T., Yamamoto,T., Takahama,S., Toshima,T., Itoh,S.,
            Harada,N., Shimokawa,M., Okuzaki,D., Mori,M. and Yoshizumi,T.
  TITLE     Up-regulated LRRN2 expression as a marker for graft quality in
            living donor liver transplantation
  JOURNAL   Hepatol Commun 6 (10), 2836-2849 (2022)
   PUBMED   35894759
  REMARK    GeneRIF: Up-regulated LRRN2 expression as a marker for graft
            quality in living donor liver transplantation.
REFERENCE   2  (bases 1 to 3468)
  AUTHORS   Rong,H., Li,Y., Hu,S., Gao,L., Yi,T., Xie,Y., Cai,P., Li,J.,
            Dai,X., Ye,M. and Liao,Q.
  TITLE     Prognostic signatures and potential pathogenesis of eRNAs-related
            genes in colon adenocarcinoma
  JOURNAL   Mol Carcinog 61 (1), 59-72 (2022)
   PUBMED   34622496
  REMARK    GeneRIF: Prognostic signatures and potential pathogenesis of
            eRNAs-related genes in colon adenocarcinoma.
REFERENCE   3  (bases 1 to 3468)
  AUTHORS   Sheikh,A., Takatori,A., Hossain,M.S., Hasan,M.K., Tagawa,M.,
            Nagase,H. and Nakagawara,A.
  TITLE     Unfavorable neuroblastoma prognostic factor NLRR2 inhibits cell
            differentiation by transcriptional induction through JNK pathway
  JOURNAL   Cancer Sci 107 (9), 1223-1232 (2016)
   PUBMED   27357360
  REMARK    GeneRIF: NLRR2 must be an inducible gene regulated by the JNK
            pathway to enhance cell survival and inhibit NB cell
            differentiation.
REFERENCE   4  (bases 1 to 3468)
  AUTHORS   Rietveld,C.A., Esko,T., Davies,G., Pers,T.H., Turley,P.,
            Benyamin,B., Chabris,C.F., Emilsson,V., Johnson,A.D., Lee,J.J., de
            Leeuw,C., Marioni,R.E., Medland,S.E., Miller,M.B., Rostapshova,O.,
            van der Lee,S.J., Vinkhuyzen,A.A., Amin,N., Conley,D.,
            Derringer,J., van Duijn,C.M., Fehrmann,R., Franke,L., Glaeser,E.L.,
            Hansell,N.K., Hayward,C., Iacono,W.G., Ibrahim-Verbaas,C.,
            Jaddoe,V., Karjalainen,J., Laibson,D., Lichtenstein,P.,
            Liewald,D.C., Magnusson,P.K., Martin,N.G., McGue,M., McMahon,G.,
            Pedersen,N.L., Pinker,S., Porteous,D.J., Posthuma,D.,
            Rivadeneira,F., Smith,B.H., Starr,J.M., Tiemeier,H., Timpson,N.J.,
            Trzaskowski,M., Uitterlinden,A.G., Verhulst,F.C., Ward,M.E.,
            Wright,M.J., Davey Smith,G., Deary,I.J., Johannesson,M., Plomin,R.,
            Visscher,P.M., Benjamin,D.J., Cesarini,D. and Koellinger,P.D.
  TITLE     Common genetic variants associated with cognitive performance
            identified using the proxy-phenotype method
  JOURNAL   Proc Natl Acad Sci U S A 111 (38), 13790-13794 (2014)
   PUBMED   25201988
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2015 Jan 27;112(4):E380. doi:
            10.1073/pnas.1424631112.. PMID: 25572966]
REFERENCE   5  (bases 1 to 3468)
  AUTHORS   Rietveld,C.A., Medland,S.E., Derringer,J., Yang,J., Esko,T.,
            Martin,N.W., Westra,H.J., Shakhbazov,K., Abdellaoui,A., Agrawal,A.,
            Albrecht,E., Alizadeh,B.Z., Amin,N., Barnard,J., Baumeister,S.E.,
            Benke,K.S., Bielak,L.F., Boatman,J.A., Boyle,P.A., Davies,G., de
            Leeuw,C., Eklund,N., Evans,D.S., Ferhmann,R., Fischer,K.,
            Gieger,C., Gjessing,H.K., Hagg,S., Harris,J.R., Hayward,C.,
            Holzapfel,C., Ibrahim-Verbaas,C.A., Ingelsson,E., Jacobsson,B.,
            Joshi,P.K., Jugessur,A., Kaakinen,M., Kanoni,S., Karjalainen,J.,
            Kolcic,I., Kristiansson,K., Kutalik,Z., Lahti,J., Lee,S.H., Lin,P.,
            Lind,P.A., Liu,Y., Lohman,K., Loitfelder,M., McMahon,G.,
            Vidal,P.M., Meirelles,O., Milani,L., Myhre,R., Nuotio,M.L.,
            Oldmeadow,C.J., Petrovic,K.E., Peyrot,W.J., Polasek,O., Quaye,L.,
            Reinmaa,E., Rice,J.P., Rizzi,T.S., Schmidt,H., Schmidt,R.,
            Smith,A.V., Smith,J.A., Tanaka,T., Terracciano,A., van der
            Loos,M.J., Vitart,V., Volzke,H., Wellmann,J., Yu,L., Zhao,W.,
            Allik,J., Attia,J.R., Bandinelli,S., Bastardot,F., Beauchamp,J.,
            Bennett,D.A., Berger,K., Bierut,L.J., Boomsma,D.I., Bultmann,U.,
            Campbell,H., Chabris,C.F., Cherkas,L., Chung,M.K., Cucca,F., de
            Andrade,M., De Jager,P.L., De Neve,J.E., Deary,I.J.,
            Dedoussis,G.V., Deloukas,P., Dimitriou,M., Eiriksdottir,G.,
            Elderson,M.F., Eriksson,J.G., Evans,D.M., Faul,J.D., Ferrucci,L.,
            Garcia,M.E., Gronberg,H., Guethnason,V., Hall,P., Harris,J.M.,
            Harris,T.B., Hastie,N.D., Heath,A.C., Hernandez,D.G., Hoffmann,W.,
            Hofman,A., Holle,R., Holliday,E.G., Hottenga,J.J., Iacono,W.G.,
            Illig,T., Jarvelin,M.R., Kahonen,M., Kaprio,J., Kirkpatrick,R.M.,
            Kowgier,M., Latvala,A., Launer,L.J., Lawlor,D.A., Lehtimaki,T.,
            Li,J., Lichtenstein,P., Lichtner,P., Liewald,D.C., Madden,P.A.,
            Magnusson,P.K., Makinen,T.E., Masala,M., McGue,M., Metspalu,A.,
            Mielck,A., Miller,M.B., Montgomery,G.W., Mukherjee,S., Nyholt,D.R.,
            Oostra,B.A., Palmer,L.J., Palotie,A., Penninx,B.W., Perola,M.,
            Peyser,P.A., Preisig,M., Raikkonen,K., Raitakari,O.T., Realo,A.,
            Ring,S.M., Ripatti,S., Rivadeneira,F., Rudan,I., Rustichini,A.,
            Salomaa,V., Sarin,A.P., Schlessinger,D., Scott,R.J., Snieder,H., St
            Pourcain,B., Starr,J.M., Sul,J.H., Surakka,I., Svento,R.,
            Teumer,A., Tiemeier,H., van Rooij,F.J., Van Wagoner,D.R.,
            Vartiainen,E., Viikari,J., Vollenweider,P., Vonk,J.M., Waeber,G.,
            Weir,D.R., Wichmann,H.E., Widen,E., Willemsen,G., Wilson,J.F.,
            Wright,A.F., Conley,D., Davey-Smith,G., Franke,L., Groenen,P.J.,
            Hofman,A., Johannesson,M., Kardia,S.L., Krueger,R.F., Laibson,D.,
            Martin,N.G., Meyer,M.N., Posthuma,D., Thurik,A.R., Timpson,N.J.,
            Uitterlinden,A.G., van Duijn,C.M., Visscher,P.M., Benjamin,D.J.,
            Cesarini,D. and Koellinger,P.D.
  CONSRTM   LifeLines Cohort Study
  TITLE     GWAS of 126,559 individuals identifies genetic variants associated
            with educational attainment
  JOURNAL   Science 340 (6139), 1467-1471 (2013)
   PUBMED   23722424
REFERENCE   6  (bases 1 to 3468)
  AUTHORS   Garcia-Closas,M., Couch,F.J., Lindstrom,S., Michailidou,K.,
            Schmidt,M.K., Brook,M.N., Orr,N., Rhie,S.K., Riboli,E.,
            Feigelson,H.S., Le Marchand,L., Buring,J.E., Eccles,D., Miron,P.,
            Fasching,P.A., Brauch,H., Chang-Claude,J., Carpenter,J.,
            Godwin,A.K., Nevanlinna,H., Giles,G.G., Cox,A., Hopper,J.L.,
            Bolla,M.K., Wang,Q., Dennis,J., Dicks,E., Howat,W.J., Schoof,N.,
            Bojesen,S.E., Lambrechts,D., Broeks,A., Andrulis,I.L., Guenel,P.,
            Burwinkel,B., Sawyer,E.J., Hollestelle,A., Fletcher,O.,
            Winqvist,R., Brenner,H., Mannermaa,A., Hamann,U., Meindl,A.,
            Lindblom,A., Zheng,W., Devillee,P., Goldberg,M.S., Lubinski,J.,
            Kristensen,V., Swerdlow,A., Anton-Culver,H., Dork,T., Muir,K.,
            Matsuo,K., Wu,A.H., Radice,P., Teo,S.H., Shu,X.O., Blot,W.,
            Kang,D., Hartman,M., Sangrajrang,S., Shen,C.Y., Southey,M.C.,
            Park,D.J., Hammet,F., Stone,J., Veer,L.J., Rutgers,E.J.,
            Lophatananon,A., Stewart-Brown,S., Siriwanarangsan,P., Peto,J.,
            Schrauder,M.G., Ekici,A.B., Beckmann,M.W., Dos Santos Silva,I.,
            Johnson,N., Warren,H., Tomlinson,I., Kerin,M.J., Miller,N.,
            Marme,F., Schneeweiss,A., Sohn,C., Truong,T., Laurent-Puig,P.,
            Kerbrat,P., Nordestgaard,B.G., Nielsen,S.F., Flyger,H., Milne,R.L.,
            Perez,J.I., Menendez,P., Muller,H., Arndt,V., Stegmaier,C.,
            Lichtner,P., Lochmann,M., Justenhoven,C., Ko,Y.D., Muranen,T.A.,
            Aittomaki,K., Blomqvist,C., Greco,D., Heikkinen,T., Ito,H.,
            Iwata,H., Yatabe,Y., Antonenkova,N.N., Margolin,S., Kataja,V.,
            Kosma,V.M., Hartikainen,J.M., Balleine,R., Tseng,C.C., Berg,D.V.,
            Stram,D.O., Neven,P., Dieudonne,A.S., Leunen,K., Rudolph,A.,
            Nickels,S., Flesch-Janys,D., Peterlongo,P., Peissel,B., Bernard,L.,
            Olson,J.E., Wang,X., Stevens,K., Severi,G., Baglietto,L.,
            McLean,C., Coetzee,G.A., Feng,Y., Henderson,B.E., Schumacher,F.,
            Bogdanova,N.V., Labreche,F., Dumont,M., Yip,C.H., Taib,N.A.,
            Cheng,C.Y., Shrubsole,M., Long,J., Pylkas,K., Jukkola-Vuorinen,A.,
            Kauppila,S., Knight,J.A., Glendon,G., Mulligan,A.M.,
            Tollenaar,R.A., Seynaeve,C.M., Kriege,M., Hooning,M.J., van den
            Ouweland,A.M., van Deurzen,C.H., Lu,W., Gao,Y.T., Cai,H.,
            Balasubramanian,S.P., Cross,S.S., Reed,M.W., Signorello,L., Cai,Q.,
            Shah,M., Miao,H., Chan,C.W., Chia,K.S., Jakubowska,A., Jaworska,K.,
            Durda,K., Hsiung,C.N., Wu,P.E., Yu,J.C., Ashworth,A., Jones,M.,
            Tessier,D.C., Gonzalez-Neira,A., Pita,G., Alonso,M.R., Vincent,D.,
            Bacot,F., Ambrosone,C.B., Bandera,E.V., John,E.M., Chen,G.K.,
            Hu,J.J., Rodriguez-Gil,J.L., Bernstein,L., Press,M.F.,
            Ziegler,R.G., Millikan,R.M., Deming-Halverson,S.L., Nyante,S.,
            Ingles,S.A., Waisfisz,Q., Tsimiklis,H., Makalic,E., Schmidt,D.,
            Bui,M., Gibson,L., Muller-Myhsok,B., Schmutzler,R.K., Hein,R.,
            Dahmen,N., Beckmann,L., Aaltonen,K., Czene,K., Irwanto,A., Liu,J.,
            Turnbull,C., Rahman,N., Meijers-Heijboer,H., Uitterlinden,A.G.,
            Rivadeneira,F., Olswold,C., Slager,S., Pilarski,R., Ademuyiwa,F.,
            Konstantopoulou,I., Martin,N.G., Montgomery,G.W., Slamon,D.J.,
            Rauh,C., Lux,M.P., Jud,S.M., Bruning,T., Weaver,J., Sharma,P.,
            Pathak,H., Tapper,W., Gerty,S., Durcan,L., Trichopoulos,D.,
            Tumino,R., Peeters,P.H., Kaaks,R., Campa,D., Canzian,F.,
            Weiderpass,E., Johansson,M., Khaw,K.T., Travis,R.,
            Clavel-Chapelon,F., Kolonel,L.N., Chen,C., Beck,A., Hankinson,S.E.,
            Berg,C.D., Hoover,R.N., Lissowska,J., Figueroa,J.D., Chasman,D.I.,
            Gaudet,M.M., Diver,W.R., Willett,W.C., Hunter,D.J., Simard,J.,
            Benitez,J., Dunning,A.M., Sherman,M.E., Chenevix-Trench,G.,
            Chanock,S.J., Hall,P., Pharoah,P.D., Vachon,C., Easton,D.F.,
            Haiman,C.A. and Kraft,P.
  CONSRTM   Gene ENvironmental Interaction and breast CAncer (GENICA) Network;
            kConFab Investigators; Familial Breast Cancer Study (FBCS);
            Australian Breast Cancer Tissue Bank (ABCTB) Investigators
  TITLE     Genome-wide association studies identify four ER negative-specific
            breast cancer risk loci
  JOURNAL   Nat Genet 45 (4), 392-398 (2013)
   PUBMED   23535733
REFERENCE   7  (bases 1 to 3468)
  AUTHORS   Eeles,R.A., Olama,A.A., Benlloch,S., Saunders,E.J.,
            Leongamornlert,D.A., Tymrakiewicz,M., Ghoussaini,M., Luccarini,C.,
            Dennis,J., Jugurnauth-Little,S., Dadaev,T., Neal,D.E., Hamdy,F.C.,
            Donovan,J.L., Muir,K., Giles,G.G., Severi,G., Wiklund,F.,
            Gronberg,H., Haiman,C.A., Schumacher,F., Henderson,B.E., Le
            Marchand,L., Lindstrom,S., Kraft,P., Hunter,D.J., Gapstur,S.,
            Chanock,S.J., Berndt,S.I., Albanes,D., Andriole,G., Schleutker,J.,
            Weischer,M., Canzian,F., Riboli,E., Key,T.J., Travis,R.C.,
            Campa,D., Ingles,S.A., John,E.M., Hayes,R.B., Pharoah,P.D.,
            Pashayan,N., Khaw,K.T., Stanford,J.L., Ostrander,E.A.,
            Signorello,L.B., Thibodeau,S.N., Schaid,D., Maier,C., Vogel,W.,
            Kibel,A.S., Cybulski,C., Lubinski,J., Cannon-Albright,L.,
            Brenner,H., Park,J.Y., Kaneva,R., Batra,J., Spurdle,A.B.,
            Clements,J.A., Teixeira,M.R., Dicks,E., Lee,A., Dunning,A.M.,
            Baynes,C., Conroy,D., Maranian,M.J., Ahmed,S., Govindasami,K.,
            Guy,M., Wilkinson,R.A., Sawyer,E.J., Morgan,A., Dearnaley,D.P.,
            Horwich,A., Huddart,R.A., Khoo,V.S., Parker,C.C., Van As,N.J.,
            Woodhouse,C.J., Thompson,A., Dudderidge,T., Ogden,C., Cooper,C.S.,
            Lophatananon,A., Cox,A., Southey,M.C., Hopper,J.L., English,D.R.,
            Aly,M., Adolfsson,J., Xu,J., Zheng,S.L., Yeager,M., Kaaks,R.,
            Diver,W.R., Gaudet,M.M., Stern,M.C., Corral,R., Joshi,A.D.,
            Shahabi,A., Wahlfors,T., Tammela,T.L., Auvinen,A., Virtamo,J.,
            Klarskov,P., Nordestgaard,B.G., Roder,M.A., Nielsen,S.F.,
            Bojesen,S.E., Siddiq,A., Fitzgerald,L.M., Kolb,S., Kwon,E.M.,
            Karyadi,D.M., Blot,W.J., Zheng,W., Cai,Q., McDonnell,S.K.,
            Rinckleb,A.E., Drake,B., Colditz,G., Wokolorczyk,D.,
            Stephenson,R.A., Teerlink,C., Muller,H., Rothenbacher,D.,
            Sellers,T.A., Lin,H.Y., Slavov,C., Mitev,V., Lose,F.,
            Srinivasan,S., Maia,S., Paulo,P., Lange,E., Cooney,K.A.,
            Antoniou,A.C., Vincent,D., Bacot,F., Tessier,D.C., Kote-Jarai,Z.
            and Easton,D.F.
  CONSRTM   COGS-Cancer Research UK GWAS-ELLIPSE (part of GAME-ON) Initiative;
            Australian Prostate Cancer Bioresource; UK Genetic Prostate Cancer
            Study Collaborators/British Association of Urological Surgeons'
            Section of Oncology; UK ProtecT (Prostate testing for cancer and
            Treatment) Study Collaborators; PRACTICAL (Prostate Cancer
            Association Group to Investigate Cancer-Associated Alterations in
            the Genome) Consortium
  TITLE     Identification of 23 new prostate cancer susceptibility loci using
            the iCOGS custom genotyping array
  JOURNAL   Nat Genet 45 (4), 385-391 (2013)
   PUBMED   23535732
REFERENCE   8  (bases 1 to 3468)
  AUTHORS   Almeida,A., Zhu,X.X., Vogt,N., Tyagi,R., Muleris,M.,
            Dutrillaux,A.M., Dutrillaux,B., Ross,D., Malfoy,B. and Hanash,S.
  TITLE     GAC1, a new member of the leucine-rich repeat superfamily on
            chromosome band 1q32.1, is amplified and overexpressed in malignant
            gliomas
  JOURNAL   Oncogene 16 (23), 2997-3002 (1998)
   PUBMED   9662332
REFERENCE   9  (bases 1 to 3468)
  AUTHORS   Adams,M.D., Soares,M.B., Kerlavage,A.R., Fields,C. and Venter,J.C.
  TITLE     Rapid cDNA sequencing (expressed sequence tags) from a
            directionally cloned human infant brain cDNA library
  JOURNAL   Nat Genet 4 (4), 373-380 (1993)
   PUBMED   8401585
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL161793.9, BC034047.1,
            AF030435.1 and AL512306.16.
            
            On Nov 23, 2018 this sequence version replaced NM_201630.1.
            
            Summary: The protein encoded by this gene belongs to the
            leucine-rich repeat superfamily. This gene was found to be
            amplified and overexpressed in malignant gliomas. The encoded
            protein has homology with other proteins that function as
            cell-adhesion molecules or as signal transduction receptors and is
            a candidate for the target gene in the 1q32.1 amplicon in malignant
            gliomas. Two alternatively spliced transcript variants encoding the
            same protein have been described for this gene. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 encode the same isoform.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC034047.1, SRR1803613.251943.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367177.4/ ENSP00000356145.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-269               AL161793.9         40365-40633         c
            270-1708            BC034047.1         1-1439
            1709-2065           AF030435.1         1452-1808
            2066-2120           BC034047.1         1797-1851
            2121-2525           AF030435.1         1864-2268
            2526-2670           BC034047.1         2257-2401
            2671-2960           AF030435.1         2414-2703
            2961-3465           BC034047.1         2692-3196
            3466-3468           AL512306.16        29934-29936
FEATURES             Location/Qualifiers
     source          1..3468
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..3468
                     /gene="LRRN2"
                     /gene_synonym="FIGLER7; GAC1; LRANK1; LRRN5"
                     /note="leucine rich repeat neuronal 2"
                     /db_xref="GeneID:10446"
                     /db_xref="HGNC:HGNC:16914"
                     /db_xref="MIM:605492"
     exon            1..419
                     /gene="LRRN2"
                     /gene_synonym="FIGLER7; GAC1; LRANK1; LRRN5"
                     /inference="alignment:Splign:2.1.0"
     exon            420..3468
                     /gene="LRRN2"
                     /gene_synonym="FIGLER7; GAC1; LRANK1; LRRN5"
                     /inference="alignment:Splign:2.1.0"
     CDS             646..2787
                     /gene="LRRN2"
                     /gene_synonym="FIGLER7; GAC1; LRANK1; LRRN5"
                     /note="leucine rich repeat neuronal 5; fibronectin type
                     III, immunoglobulin and leucine rich repeat domain 7;
                     leucine rich and ankyrin repeats 1; leucine-rich repeat
                     neuronal protein 2; leucine-rich repeat neuronal protein
                     5; glioma amplified on chromosome 1 protein"
                     /codon_start=1
                     /product="leucine-rich repeat neuronal protein 2
                     precursor"
                     /protein_id="NP_963924.1"
                     /db_xref="CCDS:CCDS1448.1"
                     /db_xref="GeneID:10446"
                     /db_xref="HGNC:HGNC:16914"
                     /db_xref="MIM:605492"
                     /translation="MRLLVAPLLLAWVAGATAAVPVVPWHVPCPPQCACQIRPWYTPR
                     SSYREATTVDCNDLFLTAVPPALPAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQ
                     NSFSDARDCDFHALPQLLSLHLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRA
                     FSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSL
                     VLAGMNLREISDYALEGLQSLESLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRV
                     GPGDFANMLHLKELGLNNMEELVSIDKFALVNLPELTKLDITNNPRLSFIHPRAFHHL
                     PQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNPIRCDCVIRWANATGTRVRFIEP
                     QSTLCAEPPDLQRLPVREVPFREMTDHCLPLISPRSFPPSLQVASGESMVLHCRALAE
                     PEPEIYWVTPAGLRLTPAHAGRRYRVYPEGTLELRRVTAEEAGLYTCVAQNLVGADTK
                     TVSVVVGRALLQPGRDEGQGLELRVQETHPYHILLSWVTPPNTVSTNLTWSSASSLRG
                     QGATALARLPRGTHSYNITRLLQATEYWACLQVAFADAHTQLACVWARTKEATSCHRA
                     LGDRPGLIAILALAVLLLAAGLAAHLGTGQPRKGVGGRRPLPPAWAFWGWSAPSVRVV
                     SAPLVLPWNPGRKLPRSSEGETLLPPLSQNS"
     regulatory      3435..3440
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRN2"
                     /gene_synonym="FIGLER7; GAC1; LRANK1; LRRN5"
                     /note="hexamer: AATAAT"
     polyA_site      3468
                     /gene="LRRN2"
                     /gene_synonym="FIGLER7; GAC1; LRANK1; LRRN5"
                     /note="major polyA site"
ORIGIN      
        1 aggttgggag agcggcggag aagcgagtga ggagggcgag cgcgaagccg ggaagagggg
       61 cgcgcgtgga gggggtgccg ggcgccgcga gggcctgctc cgggcacctg cgaacgcgcg
      121 gcgctctcaa ggagcgcctg gctctcgccc gccagcctcc ggccgcgacg cgcccagggc
      181 gcggagaggg ggtggggacg gattgggatt ctgccatcgc cctcaccggc tgggccctgg
      241 agccgctccc aggataactc cacgttgggg agggcgcccg ccgagcctcc ccggcctgtg
      301 cagacggcgc gcgcggcggg agggcgcgga ccagcgtccc cagcccggcc ccgggcggaa
      361 ggcgagcgga gcgcggccgc gcgggcagca gacggcagac ggtgcccggc gcccacgggg
      421 gctgcccctg atggggcctg gcaatgactg agcaggccca gccccagagg acaaggaaga
      481 gaaggcatat tgaggagggc aagaagtgac gcccggtgta gaatgactgc cctgggaggg
      541 tggttccttg ggccctggca gggttgctga cccttaccct gcaaaacaca aagagcagga
      601 ctccagactc ttcttgtgaa tggtcccctg ccctgcagct ccaccatgag gcttctcgtg
      661 gccccactct tgctagcttg ggtggctggt gccactgccg ctgtgcccgt ggtaccctgg
      721 catgttccct gcccccctca gtgtgcctgc cagatccggc cctggtatac gccccgctcg
      781 tcctaccgcg aggctaccac tgtggactgc aatgacctat tcctgacggc agtccccccg
      841 gcactccccg caggcacaca gaccctgctc ctgcagagca acagcattgt ccgtgtggac
      901 cagagtgagc tgggctacct ggccaatctc acagagctgg acctgtccca gaacagcttt
      961 tcggatgccc gagactgtga tttccatgcc ctgccccagc tgctgagcct gcacctagag
     1021 gagaaccagc tgacccggct ggaggaccac agctttgcag ggctggccag cctacaggaa
     1081 ctctatctca accacaacca gctctaccgc atcgccccca gggccttttc tggcctcagc
     1141 aacttgctgc ggctgcacct caactccaac ctcctgaggg ccattgacag ccgctggttt
     1201 gaaatgctgc ccaacttgga gatactcatg attggcggca acaaggtaga tgccatcctg
     1261 gacatgaact tccggcccct ggccaacctg cgtagcctgg tgctagcagg catgaacctg
     1321 cgggagatct ccgactatgc cctggagggg ctgcaaagcc tggagagcct ctccttctat
     1381 gacaaccagc tggcccgggt gcccaggcgg gcactggaac aggtgcccgg gctcaagttc
     1441 ctagacctca acaagaaccc gctccagcgg gtagggccgg gggactttgc caacatgctg
     1501 caccttaagg agctgggact gaacaacatg gaggagctgg tctccatcga caagtttgcc
     1561 ctggtgaacc tccccgagct gaccaagctg gacatcacca ataacccacg gctgtccttc
     1621 atccaccccc gcgccttcca ccacctgccc cagatggaga ccctcatgct caacaacaac
     1681 gctctcagtg ccttgcacca gcagacggtg gagtccctgc ccaacctgca ggaggtaggt
     1741 ctccacggca accccatccg ctgtgactgt gtcatccgct gggccaatgc cacgggcacc
     1801 cgtgtccgct tcatcgagcc gcaatccacc ctgtgtgcgg agcctccgga cctccagcgc
     1861 ctcccggtcc gtgaggtgcc cttccgggag atgacggacc actgtttgcc cctcatctcc
     1921 ccacgaagct tccccccaag cctccaggta gccagtggag agagcatggt gctgcattgc
     1981 cgggcactgg ccgaacccga acccgagatc tactgggtca ctccagctgg gcttcgactg
     2041 acacctgccc atgcaggcag gaggtaccgg gtgtaccccg aggggaccct ggagctgcgg
     2101 agggtgacag cagaagaggc agggctatac acctgtgtgg cccagaacct ggtgggggct
     2161 gacactaaga cggttagtgt ggttgtgggc cgtgctctcc tccagccagg cagggacgaa
     2221 ggacaggggc tggagctccg ggtgcaggag acccacccct atcacatcct gctatcttgg
     2281 gtcaccccac ccaacacagt gtccaccaac ctcacctggt ccagtgcctc ctccctccgg
     2341 ggccaggggg ccacagctct ggcccgcctg cctcggggaa cccacagcta caacattacc
     2401 cgcctccttc aggccacgga gtactgggcc tgcctgcaag tggcctttgc tgatgcccac
     2461 acccagttgg cttgtgtatg ggccaggacc aaagaggcca cttcttgcca cagagcctta
     2521 ggggaccgtc ctgggctcat tgccatcctg gctctcgctg tccttctcct ggcagctggg
     2581 ctagcggccc accttggcac aggccaaccc aggaagggtg tgggtgggag gcggcctctc
     2641 cctccagcct gggctttctg gggctggagt gccccttctg tccgggttgt gtctgctccc
     2701 ctcgtcctgc cctggaatcc agggaggaag ctgcccagat cctcagaagg ggagacactg
     2761 ttgccaccat tgtctcaaaa ttcttgaagc tcagcctgtt ctcagcagta gagaaatcac
     2821 taggactact ttttaccaaa agagaagcag tctgggccag atgccctgcc aggaaaggga
     2881 catggaccca cgtgcttgag gcctggcagc tgggccaaga cagatggggc tttgtggccc
     2941 tgggggtgct tctgcagcct cgaaaaagtt gcccttacct cctagggtca cctctgctgc
     3001 cattctgagg aacatctcca aggaacagga gggactttgg ctagagcctc ctgcctcccc
     3061 atcttctctc tgcccagagg ctcctgggcc tggcttggct gtcccctacc tgtgtccccg
     3121 ggctgcaccc cttcctcttc tctttctctg tacagtctca gttgcttgct cttgtgcctc
     3181 ctgggcaagg gctgaaggag gccactccat ctcacctcgg ggggctgccc tcaatgtggg
     3241 agtgacccca gccagatctg aaggacattt gggagaggga tgcccaggaa cgcctcatct
     3301 cagcagcctg ggctcggcat tccgaagctg actttctata ggcaattttg tacctttgtg
     3361 gagaaatgtg tcacctcccc caacccgatt cactcttttc tcctgttttg taaaaaataa
     3421 aaataaataa taacaataat acgggggaaa ggaacgaaag gaaaataa
//
