LOCUS       NM_020873               5960 bp    mRNA    linear   PRI 01-JUL-2024
DEFINITION  Homo sapiens leucine rich repeat neuronal 1 (LRRN1), transcript
            variant 3, mRNA.
ACCESSION   NM_020873
VERSION     NM_020873.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5960)
  AUTHORS   Antikainen,A.A., Haukka,J.K., Kumar,A., Syreeni,A.,
            Hagg-Holmberg,S., Ylinen,A., Kilpelainen,E., Kytola,A., Palotie,A.,
            Putaala,J., Thorn,L.M., Harjutsalo,V., Groop,P.H. and Sandholm,N.
  CONSRTM   FinnDiane Study Group
  TITLE     Whole-genome sequencing identifies variants in ANK1, LRRN1, HAS1,
            and other genes and regulatory regions for stroke in type 1
            diabetes
  JOURNAL   Sci Rep 14 (1), 13453 (2024)
   PUBMED   38862513
  REMARK    GeneRIF: Whole-genome sequencing identifies variants in ANK1,
            LRRN1, HAS1, and other genes and regulatory regions for stroke in
            type 1 diabetes.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5960)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 5960)
  AUTHORS   Liu,B., Zhang,Y., Fan,Y., Wang,S., Li,Z., Deng,M., Li,C., Wang,J.,
            Ma,R., Wang,X., Wang,Y., Xu,L., Hou,K., Che,X., Liu,Y. and Qu,X.
  TITLE     Leucine-rich repeat neuronal protein-1 suppresses apoptosis of
            gastric cancer cells through regulation of Fas/FasL
  JOURNAL   Cancer Sci 110 (7), 2145-2155 (2019)
   PUBMED   31087525
  REMARK    GeneRIF: Study found that LRRN1 is upregulated in gastric cancer
            (GC) tissue samples and its expression is closely related to poor
            prognosis. Knocking down LRRN1 expression promoted GC cell
            apoptosis, and activated the Fas/FasL pathway.
REFERENCE   4  (bases 1 to 5960)
  AUTHORS   Liao,C.H., Wang,Y.H., Chang,W.W., Yang,B.C., Wu,T.J., Liu,W.L.,
            Yu,A.L. and Yu,J.
  TITLE     Leucine-Rich Repeat Neuronal Protein 1 Regulates Differentiation of
            Embryonic Stem Cells by Post-Translational Modifications of
            Pluripotency Factors
  JOURNAL   Stem Cells 36 (10), 1514-1524 (2018)
   PUBMED   29893054
  REMARK    GeneRIF: Authors found that LRRN1 contributes to pluripotency of
            hESC by preventing translocation of OCT4, NANOG, and SOX2 from
            nucleus to cytoplasm, thereby lessening their post-translational
            modification and degradation.
REFERENCE   5  (bases 1 to 5960)
  AUTHORS   Satoh,S., Takatori,A., Ogura,A., Kohashi,K., Souzaki,R.,
            Kinoshita,Y., Taguchi,T., Hossain,M.S., Ohira,M., Nakamura,Y. and
            Nakagawara,A.
  TITLE     Neuronal leucine-rich repeat 1 negatively regulates anaplastic
            lymphoma kinase in neuroblastoma
  JOURNAL   Sci Rep 6, 32682 (2016)
   PUBMED   27604320
  REMARK    GeneRIF: NLRR1 appears to be an extracellular negative regulator of
            ALK signalling in neuroblastoma and neuronal development.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5960)
  AUTHORS   Sousa,I., Clark,T.G., Holt,R., Pagnamenta,A.T., Mulder,E.J.,
            Minderaa,R.B., Bailey,A.J., Battaglia,A., Klauck,S.M., Poustka,F.
            and Monaco,A.P.
  CONSRTM   International Molecular Genetic Study of Autism Consortium (IMGSAC)
  TITLE     Polymorphisms in leucine-rich repeat genes are associated with
            autism spectrum disorder susceptibility in populations of European
            ancestry
  JOURNAL   Mol Autism 1 (1), 7 (2010)
   PUBMED   20678249
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 5960)
  AUTHORS   Hossain,M.S., Ozaki,T., Wang,H., Nakagawa,A., Takenobu,H.,
            Ohira,M., Kamijo,T. and Nakagawara,A.
  TITLE     N-MYC promotes cell proliferation through a direct transactivation
            of neuronal leucine-rich repeat protein-1 (NLRR1) gene in
            neuroblastoma
  JOURNAL   Oncogene 27 (46), 6075-6082 (2008)
   PUBMED   18591937
  REMARK    GeneRIF: N-MYC promotes cell proliferation through a direct
            transactivation of neuronal leucine-rich repeat protein-1 (NLRR1)
            gene in neuroblastoma.
REFERENCE   8  (bases 1 to 5960)
  AUTHORS   Zhang,Z. and Henzel,W.J.
  TITLE     Signal peptide prediction based on analysis of experimentally
            verified cleavage sites
  JOURNAL   Protein Sci 13 (10), 2819-2824 (2004)
   PUBMED   15340161
REFERENCE   9  (bases 1 to 5960)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   10 (bases 1 to 5960)
  AUTHORS   Ohira,M., Morohashi,A., Nakamura,Y., Isogai,E., Furuya,K.,
            Hamano,S., Machida,T., Aoyama,M., Fukumura,M., Miyazaki,K.,
            Suzuki,Y., Sugano,S., Hirato,J. and Nakagawara,A.
  TITLE     Neuroblastoma oligo-capping cDNA project: toward the understanding
            of the genesis and biology of neuroblastoma
  JOURNAL   Cancer Lett 197 (1-2), 63-68 (2003)
   PUBMED   12880961
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA736067.1, AC023484.5, AK291717.1, BC034947.2, BU685265.1,
            AU154359.1, CX867219.1 and BC012463.1.
            
            On May 17, 2019 this sequence version replaced NM_020873.6.
            
            Transcript Variant: Variants 1, 2 and 3 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.151344.1,
                                           SRR1660809.78102.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000319331.4/ ENSP00000314901.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-105               DA736067.1         1-105
            106-106             AC023484.5         129349-129349
            107-316             DA736067.1         107-316
            317-317             AC023484.5         129560-129560
            318-416             DA736067.1         318-416
            417-621             AK291717.1         1-205
            622-2512            AC023484.5         174309-176199
            2513-3112           AK291717.1         2097-2696
            3113-3521           BC034947.2         2676-3084
            3522-3523           AC023484.5         177209-177210
            3524-3663           BC034947.2         3085-3224
            3664-3664           AC023484.5         177351-177351
            3665-3743           BC034947.2         3226-3304
            3744-4150           BU685265.1         17-423              c
            4151-4340           AU154359.1         3-192               c
            4341-4675           AC023484.5         178028-178362
            4676-5353           CX867219.1         160-837
            5354-5603           BC012463.1         292-541
            5604-5872           AC023484.5         179291-179559
            5873-5960           BC012463.1         811-898
FEATURES             Location/Qualifiers
     source          1..5960
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p26.2"
     gene            1..5960
                     /gene="LRRN1"
                     /gene_synonym="FIGLER3; NLRR-1; NLRR1"
                     /note="leucine rich repeat neuronal 1"
                     /db_xref="GeneID:57633"
                     /db_xref="HGNC:HGNC:20980"
                     /db_xref="MIM:619623"
     exon            1..489
                     /gene="LRRN1"
                     /gene_synonym="FIGLER3; NLRR-1; NLRR1"
                     /inference="alignment:Splign:2.1.0"
     exon            490..5960
                     /gene="LRRN1"
                     /gene_synonym="FIGLER3; NLRR-1; NLRR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             768..2918
                     /gene="LRRN1"
                     /gene_synonym="FIGLER3; NLRR-1; NLRR1"
                     /note="fibronectin type III, immunoglobulin and leucine
                     rich repeat domains 3; leucine-rich repeat neuronal
                     protein 1; neuronal leucine-rich repeat protein 1"
                     /codon_start=1
                     /product="leucine-rich repeat neuronal protein 1
                     precursor"
                     /protein_id="NP_065924.3"
                     /db_xref="CCDS:CCDS33685.1"
                     /db_xref="GeneID:57633"
                     /db_xref="HGNC:HGNC:20980"
                     /db_xref="MIM:619623"
                     /translation="MARMSFVIAACQLVLGLLMTSLTESSIQNSECPQLCVCEIRPWF
                     TPQSTYREATTVDCNDLRLTRIPSNLSSDTQVLLLQSNNIAKTVDELQQLFNLTELDF
                     SQNNFTNIKEVGLANLTQLTTLHLEENQITEMTDYCLQDLSNLQELYINHNQISTISA
                     HAFAGLKNLLRLHLNSNKLKVIDSRWFDSTPNLEILMIGENPVIGILDMNFKPLANLR
                     SLVLAGMYLTDIPGNALVGLDSLESLSFYDNKLVKVPQLALQKVPNLKFLDLNKNPIH
                     KIQEGDFKNMLRLKELGINNMGELVSVDRYALDNLPELTKLEATNNPKLSYIHRLAFR
                     SVPALESLMLNNNALNAIYQKTVESLPNLREISIHSNPLRCDCVIHWINSNKTNIRFM
                     EPLSMFCAMPPEYKGHQVKEVLIQDSSEQCLPMISHDSFPNRLNVDIGTTVFLDCRAM
                     AEPEPEIYWVTPIGNKITVETLSDKYKLSSEGTLEISNIQIEDSGRYTCVAQNVQGAD
                     TRVATIKVNGTLLDGTQVLKIYVKQTESHSILVSWKVNSNVMTSNLKWSSATMKIDNP
                     HITYTARVPVDVHEYNLTHLQPSTDYEVCLTVSNIHQQTQKSCVNVTTKNAAFAVDIS
                     DQETSTALAAVMGSMFAVISLASIAVYFAKRFKRKNYHHSLKKYMQKTSSIPLNELYP
                     PLINLWEGDSEKDKDGSADTKPTQVDTSRSYYMW"
     regulatory      3716..3721
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRN1"
                     /gene_synonym="FIGLER3; NLRR-1; NLRR1"
                     /note="hexamer: AATAAA"
     polyA_site      3746
                     /gene="LRRN1"
                     /gene_synonym="FIGLER3; NLRR-1; NLRR1"
                     /note="major polyA site"
     regulatory      3808..3813
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRN1"
                     /gene_synonym="FIGLER3; NLRR-1; NLRR1"
                     /note="hexamer: CATAAA"
     polyA_site      3831
                     /gene="LRRN1"
                     /gene_synonym="FIGLER3; NLRR-1; NLRR1"
                     /note="major polyA site"
     regulatory      4322..4327
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRN1"
                     /gene_synonym="FIGLER3; NLRR-1; NLRR1"
                     /note="hexamer: AGTAAA"
     polyA_site      4346
                     /gene="LRRN1"
                     /gene_synonym="FIGLER3; NLRR-1; NLRR1"
     polyA_site      5960
                     /gene="LRRN1"
                     /gene_synonym="FIGLER3; NLRR-1; NLRR1"
ORIGIN      
        1 gagcacaaag cggggcgcac cgcgggcgcc ggcaacgagc cggtgaacga ggcgaggccc
       61 gtgcgcccgc ggctgcaagc gcccgcctgg cggggagagg ggccgacggc gtcagcccgg
      121 gcggcggcat ccctaggcgc ctggggcgcc ttcctccgga cctggccgct cgctgccccg
      181 ccctctgcac cccacttctc cgaccctcct tcccagtcct gcctccccct gccctggcct
      241 ctgagagccg actgagccca gccccgtgca gcagcggttg cctgtgtcgc cgcctagtct
      301 ccggtcttgg tgctctcccg ggggtgcccc aaggagccag tgcgcgctgc gggctgggaa
      361 ggaggcgccg ctcagctagt cctcctcctc ctcctcgtct ttctcctcct cctgctgctg
      421 ctgccgccgc cgccgccgtg ggtgccgggt ccgcgcgcac cccaacaccc ccaccagctg
      481 ggcctcgggg cacatctcca gacttcaatt tggctgaaat aattcatgcc acggacctgt
      541 gcacatgcct ggaattgaga gacacagtta aaagactcca agttgctttc tgccttttga
      601 aaactcctga aaaccatccc tttggactct ggaattctac acagctcaac caagactttg
      661 cttgaatgtt tacattttct gctcgctgtc ctacatatca caatatagtg ttcacgtttt
      721 gttaaaactt tggggtgtca ggagttgagc ttgctcagca agccagcatg gctaggatga
      781 gctttgttat agcagcttgc caattggtgc tgggcctact aatgacttca ttaaccgagt
      841 cttccataca gaatagtgag tgtccacaac tttgcgtatg tgaaattcgt ccctggttta
      901 ccccacagtc aacttacaga gaagccacca ctgttgattg caatgacctc cgcttaacaa
      961 ggattcccag taacctctct agtgacacac aagtgcttct cttacagagc aataacatcg
     1021 caaagactgt ggatgagctg cagcagcttt tcaacttgac tgaactagat ttctcccaaa
     1081 acaactttac taacattaag gaggtcgggc tggcaaacct aacccagctc acaacgctgc
     1141 atttggagga aaatcagatt accgagatga ctgattactg tctacaagac ctcagcaacc
     1201 ttcaagaact ctacatcaac cacaaccaaa ttagcactat ttctgctcat gcttttgcag
     1261 gcttaaaaaa tctattaagg ctccacctga actccaacaa attgaaagtt attgatagtc
     1321 gctggtttga ttctacaccc aacctggaaa ttctcatgat cggagaaaac cctgtgattg
     1381 gaattctgga tatgaacttc aaacccctcg caaatttgag aagcttagtt ttggcaggaa
     1441 tgtatctcac tgatattcct ggaaatgctt tggtgggtct ggatagcctt gagagcctgt
     1501 ctttttatga taacaaactg gttaaagtcc ctcaacttgc cctgcaaaaa gttccaaatt
     1561 tgaaattctt agacctcaac aaaaacccca ttcacaaaat ccaagaaggg gacttcaaaa
     1621 atatgcttcg gttaaaagaa ctgggaatca acaatatggg cgagctcgtt tctgtcgacc
     1681 gctatgccct ggataacttg cctgaactca caaagctgga agccaccaat aaccctaaac
     1741 tctcttacat ccaccgcttg gctttccgaa gtgtccctgc tctggaaagc ttgatgctga
     1801 acaacaatgc cttgaatgcc atttaccaaa agacagtcga atccctcccc aatctgcgtg
     1861 agatcagtat ccatagcaat cccctcaggt gtgactgtgt gatccactgg attaactcca
     1921 acaaaaccaa catccgcttc atggagcccc tgtccatgtt ctgtgccatg ccgcccgaat
     1981 ataaagggca ccaggtgaag gaagttttaa tccaggattc gagtgaacag tgcctcccaa
     2041 tgatatctca cgacagcttc ccaaatcgtt taaacgtgga tatcggcacg acggttttcc
     2101 tagactgtcg agccatggct gagccagaac ctgaaattta ctgggtcact cccattggaa
     2161 ataagataac tgtggaaacc ctttcagata aatacaagct aagtagcgaa ggtaccttgg
     2221 aaatatctaa catacaaatt gaagactcag gaagatacac atgtgttgcc cagaatgtcc
     2281 aaggggcaga cactcgggtg gcaacaatta aggttaatgg gacccttctg gatggtaccc
     2341 aggtgctaaa aatatacgtc aagcagacag aatcccattc catcttagtg tcctggaaag
     2401 ttaattccaa tgtcatgacg tcaaacttaa aatggtcgtc tgccaccatg aagattgata
     2461 accctcacat aacatatact gccagggtcc cagtcgatgt ccatgaatac aacctaacgc
     2521 atctgcagcc ttccacagat tatgaagtgt gtctcacagt gtccaatatt catcagcaga
     2581 ctcaaaagtc atgcgtaaat gtcacaacca aaaatgccgc cttcgcagtg gacatctctg
     2641 atcaagaaac cagtacagcc cttgctgcag taatggggtc tatgtttgcc gtcattagcc
     2701 ttgcgtccat tgctgtgtac tttgccaaaa gatttaagag aaaaaactac caccactcat
     2761 taaaaaagta tatgcaaaaa acctcttcaa tcccactaaa tgagctgtac ccaccactca
     2821 ttaacctctg ggaaggtgac agcgagaaag acaaagatgg ttctgcagac accaagccaa
     2881 cccaggtcga cacatccaga agctattaca tgtggtaact cagaggatat tttgcttctg
     2941 gtagtaagga gcacaaagac gtttttgctt tattctgcaa aagtgaacaa gttgaagact
     3001 tttgtatttt tgactttgct agtttgtggc agagtggaga ggacgggtgg atatttcaaa
     3061 tttttttagt atagcgtatc gcaagggttt gacacggctg ccagcgactc taggcttcca
     3121 gtctgtgttt ggtttttatt cttatcatta ttatgattgt tattatatta ttattttatt
     3181 ttagttgttg tgctaaactc aataatgctg ttctaactac agtgctcaat aaaatgatta
     3241 atgacaggat ggggttcccc tgtgctttta ccagtagcat gaccccttct gaagccatcc
     3301 gtagaaagta ctttgtcctc caaaaagcta acatacggtt ttgaagcagc attgaaactt
     3361 ttgtagcaat ctggtctata gacttttaac tcaagaagct aaggctagac ttgttacctt
     3421 cgttgaatga tgttagttga ctgtactgta atgttgtatc aactgaattg aatgtttgcc
     3481 tttaaacaat gaattttctt tttctttcct tttttttttt tttgttgtaa tagttaaaga
     3541 ggcttagaac aagctaacag gcaatagaaa tatgtatatc agatttttta atgtaacaaa
     3601 ctacatgtta attgttatct tattcttttt atctttagta gacactttta aaagaaaaga
     3661 caagtttgtt gtgtttaact caccaacacg tggtgtataa tgaagacaga actataataa
     3721 attagttttg ttctgatttt ttagaacact tgcaataatg tatcatttat agttcttgct
     3781 agttgcagtg gtaatatttt tcacatccat aaaaacaact accaaaataa atcagctgta
     3841 gcatgttgct ttttaaagct aggccctaaa aggttttaat tctttttcta agggaagaaa
     3901 tgtctatttt aattaagata ttttaatgaa caggatttct gtattttaaa tagtactgac
     3961 tagcacctaa tgggcagtgg gagggtggtt catatgaaga aaaaaaggtg tattgttgta
     4021 tcccatgcat aaataaaggt aaatatatat atacaccaat atattcatat atactcacac
     4081 acatcccaac ctgtcacaca caatgcgtgt gtatatatat atgaatatat tggatatgtc
     4141 atttctgtaa gagttttgtt aaaacctgat tttcttttgt agtatccaca ttcttcatca
     4201 aagtacaaaa acgtctgtgg agtgtcacaa actgtatgac atgttatttc tttttaacag
     4261 ttgtctatat gcttagaccc gtgttagtct ctatatctgt gtggcaatat ctgctgagac
     4321 aagtaaatga ttaatagaaa acaaaacaac ttccgtacag ttcaaacttt tcatccaaat
     4381 atatatagac agttttggag aattgtttca agattataga ggaaacatgt aacatttaga
     4441 gcagatggaa ctaggtttag gtagaaggcc agttccacaa agggcagagg gagggatggg
     4501 atttaatagg taaagaagaa cccatttgaa aataaaggtt gtttcaaaag gcagctgccg
     4561 ccaggcacac agcattccat cagacaggtg ccagacaagc aaaagcaagg aagttggcag
     4621 aaagaaagtc caggtgatgt aggttgaggt atttctttct ttggcagtat cttgcttttg
     4681 tgaatcactt tattaaaaaa aatcactttc ttcccattct taaggggttt tggcaaacag
     4741 aatttcagat cttgaaacaa atgagctgca acagaaaaat aagtacctga gctcgaggta
     4801 tcccttccca aagccttcac ttattggtga gaaaaacctg ggcccaggga gggcttgcag
     4861 cttacccagt tcggactcct gccagttcag cgctctgcac tccattgatt gttctaggcc
     4921 cggcagcctg ttaggttcct gtgcagggcc cctcttttgc agttctgaat aacctctagt
     4981 gcccctgctt caaaaatgca gtacatcctc aagttcccat ttactcagga tacattttag
     5041 cacagggcag atcagacggt gtctctactg ttagtattgc aaagtatgta tgggaaacac
     5101 agagaattgg agctgcgttg aatgcaaact tgaggtgttt cccttgagga attcttgtct
     5161 tcaaacgtct gcagagtaat ggaccatgtt acaactttcc tgttcatctg tgaaccatga
     5221 aaatggatgg cactgatgca ttagaccctc agcagcctgc aattgcaaat ctgcgaggtt
     5281 tcattcggcc cataaagcaa acatttgaac ttacacagaa tgagcactta aatacgggtg
     5341 caataaatga agggaaaaac ctcagccgtt tctccattct gaagatatag caagcaccgg
     5401 gaaatctaag atttttcatc aacaatatct tctgccagcc cagtttgggg ggaaaaaccc
     5461 cttttacatt tttcttcagt aaagtactgg aacttacttt tccctgtctg tgctaatgag
     5521 ctgattttca gctgatagaa aacaaaatga tagagtactt ttttccttgg ccaagtattt
     5581 tctcatttgt atttaatttc ataaattaga cagccagtga aattagacct caaactaggt
     5641 cctgatggat aatgaatgtt atgtcacctt taacagtgaa gtggttatta taggtcactt
     5701 tctaatttca tattttccct tttgctttct gctgccttca gggtatatag tgtatctcta
     5761 acctgatttt tcaaggttat ttttggagca gtttcttaaa acaggcattc cctaacttgc
     5821 tcatttaatt aatgaaaaat tgaactgatg ccatggatat aaaaacaaat gtaatgtttg
     5881 attgtcagtg tttctgattt ggcaaaaagg aatcatctct atttttttgc aaacaatatc
     5941 aaagtgcata ttttctctca
//
