LOCUS       NP_065924                716 aa            linear   PRI 01-JUL-2024
DEFINITION  leucine-rich repeat neuronal protein 1 precursor [Homo sapiens].
ACCESSION   NP_065924
VERSION     NP_065924.3
DBSOURCE    REFSEQ: accession NM_020873.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 716)
  AUTHORS   Antikainen,A.A., Haukka,J.K., Kumar,A., Syreeni,A.,
            Hagg-Holmberg,S., Ylinen,A., Kilpelainen,E., Kytola,A., Palotie,A.,
            Putaala,J., Thorn,L.M., Harjutsalo,V., Groop,P.H. and Sandholm,N.
  CONSRTM   FinnDiane Study Group
  TITLE     Whole-genome sequencing identifies variants in ANK1, LRRN1, HAS1,
            and other genes and regulatory regions for stroke in type 1
            diabetes
  JOURNAL   Sci Rep 14 (1), 13453 (2024)
   PUBMED   38862513
  REMARK    GeneRIF: Whole-genome sequencing identifies variants in ANK1,
            LRRN1, HAS1, and other genes and regulatory regions for stroke in
            type 1 diabetes.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 716)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (residues 1 to 716)
  AUTHORS   Liu,B., Zhang,Y., Fan,Y., Wang,S., Li,Z., Deng,M., Li,C., Wang,J.,
            Ma,R., Wang,X., Wang,Y., Xu,L., Hou,K., Che,X., Liu,Y. and Qu,X.
  TITLE     Leucine-rich repeat neuronal protein-1 suppresses apoptosis of
            gastric cancer cells through regulation of Fas/FasL
  JOURNAL   Cancer Sci 110 (7), 2145-2155 (2019)
   PUBMED   31087525
  REMARK    GeneRIF: Study found that LRRN1 is upregulated in gastric cancer
            (GC) tissue samples and its expression is closely related to poor
            prognosis. Knocking down LRRN1 expression promoted GC cell
            apoptosis, and activated the Fas/FasL pathway.
REFERENCE   4  (residues 1 to 716)
  AUTHORS   Liao,C.H., Wang,Y.H., Chang,W.W., Yang,B.C., Wu,T.J., Liu,W.L.,
            Yu,A.L. and Yu,J.
  TITLE     Leucine-Rich Repeat Neuronal Protein 1 Regulates Differentiation of
            Embryonic Stem Cells by Post-Translational Modifications of
            Pluripotency Factors
  JOURNAL   Stem Cells 36 (10), 1514-1524 (2018)
   PUBMED   29893054
  REMARK    GeneRIF: Authors found that LRRN1 contributes to pluripotency of
            hESC by preventing translocation of OCT4, NANOG, and SOX2 from
            nucleus to cytoplasm, thereby lessening their post-translational
            modification and degradation.
REFERENCE   5  (residues 1 to 716)
  AUTHORS   Satoh,S., Takatori,A., Ogura,A., Kohashi,K., Souzaki,R.,
            Kinoshita,Y., Taguchi,T., Hossain,M.S., Ohira,M., Nakamura,Y. and
            Nakagawara,A.
  TITLE     Neuronal leucine-rich repeat 1 negatively regulates anaplastic
            lymphoma kinase in neuroblastoma
  JOURNAL   Sci Rep 6, 32682 (2016)
   PUBMED   27604320
  REMARK    GeneRIF: NLRR1 appears to be an extracellular negative regulator of
            ALK signalling in neuroblastoma and neuronal development.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 716)
  AUTHORS   Sousa,I., Clark,T.G., Holt,R., Pagnamenta,A.T., Mulder,E.J.,
            Minderaa,R.B., Bailey,A.J., Battaglia,A., Klauck,S.M., Poustka,F.
            and Monaco,A.P.
  CONSRTM   International Molecular Genetic Study of Autism Consortium (IMGSAC)
  TITLE     Polymorphisms in leucine-rich repeat genes are associated with
            autism spectrum disorder susceptibility in populations of European
            ancestry
  JOURNAL   Mol Autism 1 (1), 7 (2010)
   PUBMED   20678249
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   7  (residues 1 to 716)
  AUTHORS   Hossain,M.S., Ozaki,T., Wang,H., Nakagawa,A., Takenobu,H.,
            Ohira,M., Kamijo,T. and Nakagawara,A.
  TITLE     N-MYC promotes cell proliferation through a direct transactivation
            of neuronal leucine-rich repeat protein-1 (NLRR1) gene in
            neuroblastoma
  JOURNAL   Oncogene 27 (46), 6075-6082 (2008)
   PUBMED   18591937
  REMARK    GeneRIF: N-MYC promotes cell proliferation through a direct
            transactivation of neuronal leucine-rich repeat protein-1 (NLRR1)
            gene in neuroblastoma.
REFERENCE   8  (residues 1 to 716)
  AUTHORS   Zhang,Z. and Henzel,W.J.
  TITLE     Signal peptide prediction based on analysis of experimentally
            verified cleavage sites
  JOURNAL   Protein Sci 13 (10), 2819-2824 (2004)
   PUBMED   15340161
REFERENCE   9  (residues 1 to 716)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   10 (residues 1 to 716)
  AUTHORS   Ohira,M., Morohashi,A., Nakamura,Y., Isogai,E., Furuya,K.,
            Hamano,S., Machida,T., Aoyama,M., Fukumura,M., Miyazaki,K.,
            Suzuki,Y., Sugano,S., Hirato,J. and Nakagawara,A.
  TITLE     Neuroblastoma oligo-capping cDNA project: toward the understanding
            of the genesis and biology of neuroblastoma
  JOURNAL   Cancer Lett 197 (1-2), 63-68 (2003)
   PUBMED   12880961
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA736067.1, AC023484.5, AK291717.1, BC034947.2, BU685265.1,
            AU154359.1, CX867219.1 and BC012463.1.
            
            On Jul 25, 2007 this sequence version replaced NP_065924.2.
            
            Transcript Variant: Variants 1, 2 and 3 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.151344.1,
                                           SRR1660809.78102.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000319331.4/ ENSP00000314901.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..716
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p26.2"
     Protein         1..716
                     /product="leucine-rich repeat neuronal protein 1
                     precursor"
                     /note="fibronectin type III, immunoglobulin and leucine
                     rich repeat domains 3; leucine-rich repeat neuronal
                     protein 1; neuronal leucine-rich repeat protein 1"
                     /calculated_mol_wt=78049
     sig_peptide     1..25
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2686
     mat_peptide     26..716
                     /product="Leucine-rich repeat neuronal protein 1.
                     /id=PRO_0000014847"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6UXK5.1)"
                     /calculated_mol_wt=78049
     Region          32..75
                     /region_name="LRRNT"
                     /note="Leucine rich repeat N-terminal domain; smart00013"
                     /db_xref="CDD:214470"
     Region          54..73
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          73..95
                     /region_name="LRR 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6UXK5.1)"
     Region          74..96
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          <89..355
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          96..117
                     /region_name="LRR 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6UXK5.1)"
     Site            96
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6UXK5.1)"
     Region          97..120
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Site            117
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6UXK5.1)"
     Region          120..141
                     /region_name="LRR 3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6UXK5.1)"
     Region          121..144
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          144..165
                     /region_name="LRR 4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6UXK5.1)"
     Region          145..168
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          168..189
                     /region_name="LRR 5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6UXK5.1)"
     Region          169..192
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          192..213
                     /region_name="LRR 6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6UXK5.1)"
     Region          193..216
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          216..237
                     /region_name="LRR 7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6UXK5.1)"
     Region          217..240
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          240..261
                     /region_name="LRR 8"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6UXK5.1)"
     Region          241..264
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          264..285
                     /region_name="LRR 9"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6UXK5.1)"
     Region          265..288
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          289..313
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          313..335
                     /region_name="LRR 10"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6UXK5.1)"
     Region          314..335
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          338..359
                     /region_name="LRR 11"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6UXK5.1)"
     Region          339..362
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          363..375
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275378"
     Region          371..419
                     /region_name="LRRCT"
                     /note="Leucine rich repeat C-terminal domain; smart00082"
                     /db_xref="CDD:214507"
     Site            385
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6UXK5.1)"
     Region          429..516
                     /region_name="I-set"
                     /note="Immunoglobulin I-set domain; pfam07679"
                     /db_xref="CDD:400151"
     Region          443..447
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409562"
     Region          456..460
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409562"
     Region          483..486
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409562"
     Region          496..501
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409562"
     Region          509..512
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409562"
     Site            517
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6UXK5.1)"
     Region          531..600
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; smart00060"
                     /db_xref="CDD:214495"
     Site            order(604..605,607..608)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     Site            632..652
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6UXK5.1)"
     Region          691..716
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6UXK5.1)"
     CDS             1..716
                     /gene="LRRN1"
                     /gene_synonym="FIGLER3; NLRR-1; NLRR1"
                     /coded_by="NM_020873.7:768..2918"
                     /db_xref="CCDS:CCDS33685.1"
                     /db_xref="GeneID:57633"
                     /db_xref="HGNC:HGNC:20980"
                     /db_xref="MIM:619623"
ORIGIN      
        1 marmsfviaa cqlvlgllmt sltessiqns ecpqlcvcei rpwftpqsty reattvdcnd
       61 lrltripsnl ssdtqvlllq snniaktvde lqqlfnltel dfsqnnftni kevglanltq
      121 lttlhleenq itemtdyclq dlsnlqelyi nhnqistisa hafaglknll rlhlnsnklk
      181 vidsrwfdst pnleilmige npvigildmn fkplanlrsl vlagmyltdi pgnalvglds
      241 leslsfydnk lvkvpqlalq kvpnlkfldl nknpihkiqe gdfknmlrlk elginnmgel
      301 vsvdryaldn lpeltkleat nnpklsyihr lafrsvpale slmlnnnaln aiyqktvesl
      361 pnlreisihs nplrcdcvih winsnktnir fmeplsmfca mppeykghqv kevliqdsse
      421 qclpmishds fpnrlnvdig ttvfldcram aepepeiywv tpignkitve tlsdkyklss
      481 egtleisniq iedsgrytcv aqnvqgadtr vatikvngtl ldgtqvlkiy vkqteshsil
      541 vswkvnsnvm tsnlkwssat mkidnphity tarvpvdvhe ynlthlqpst dyevcltvsn
      601 ihqqtqkscv nvttknaafa vdisdqetst alaavmgsmf avislasiav yfakrfkrkn
      661 yhhslkkymq ktssiplnel ypplinlweg dsekdkdgsa dtkptqvdts rsyymw
//
