LOCUS       NM_198578               9239 bp    mRNA    linear   PRI 05-DEC-2024
DEFINITION  Homo sapiens leucine rich repeat kinase 2 (LRRK2), mRNA.
ACCESSION   NM_198578 XM_058513 XM_930820 XM_930832 XM_936405 XM_942804
VERSION     NM_198578.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9239)
  AUTHORS   Keeney,M.T., Rocha,E.M., Hoffman,E.K., Farmer,K., Di Maio,R.,
            Weir,J., Wagner,W.G., Hu,X., Clark,C.L., Castro,S.L., Scheirer,A.,
            Fazzari,M., De Miranda,B.R., Pintchovski,S.A., Shrader,W.D.,
            Pagano,P.J., Hastings,T.G. and Greenamyre,J.T.
  TITLE     LRRK2 regulates production of reactive oxygen species in cell and
            animal models of Parkinson's disease
  JOURNAL   Sci Transl Med 16 (767), eadl3438 (2024)
   PUBMED   39356746
  REMARK    GeneRIF: LRRK2 regulates production of reactive oxygen species in
            cell and animal models of Parkinson's disease.
REFERENCE   2  (bases 1 to 9239)
  AUTHORS   Tezuka,T., Ishiguro,M., Taniguchi,D., Osogaguchi,E.,
            Shiba-Fukushima,K., Ogata,J., Ishii,R., Ikeda,A., Li,Y.,
            Yoshino,H., Matsui,T., Kaida,K., Funayama,M., Nishioka,K.,
            Kumazawa,F., Matsubara,T., Tsuda,H., Saito,Y., Murayama,S., Imai,Y.
            and Hattori,N.
  TITLE     Clinical characteristics and pathophysiological properties of newly
            discovered LRRK2 variants associated with Parkinson's disease
  JOURNAL   Neurobiol Dis 199, 106571 (2024)
   PUBMED   38901781
  REMARK    GeneRIF: Clinical characteristics and pathophysiological properties
            of newly discovered LRRK2 variants associated with Parkinson's
            disease.
REFERENCE   3  (bases 1 to 9239)
  AUTHORS   Guenther,D.T., Follett,J., Amouri,R., Sassi,S.B., Hentati,F. and
            Farrer,M.J.
  TITLE     The Evolution of Genetic Variability at the LRRK2 Locus
  JOURNAL   Genes (Basel) 15 (7), 878 (2024)
   PUBMED   39062657
  REMARK    GeneRIF: The Evolution of Genetic Variability at the LRRK2 Locus.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9239)
  AUTHORS   Hop,P.J., Lai,D., Keagle,P.J., Baron,D.M., Kenna,B.J., Kooyman,M.,
            Shankaracharya, Halter,C., Straniero,L., Asselta,R., Bonvegna,S.,
            Soto-Beasley,A.I., Wszolek,Z.K., Uitti,R.J., Isaias,I.U.,
            Pezzoli,G., Ticozzi,N., Ross,O.A., Veldink,J.H., Foroud,T.M.,
            Kenna,K.P. and Landers,J.E.
  CONSRTM   Project MinE ALS Sequencing Consortium
  TITLE     Systematic rare variant analyses identify RAB32 as a susceptibility
            gene for familial Parkinson's disease
  JOURNAL   Nat Genet 56 (7), 1371-1376 (2024)
   PUBMED   38858457
REFERENCE   5  (bases 1 to 9239)
  AUTHORS   Paisan-Ruiz,C., Jain,S., Evans,E.W., Gilks,W.P., Simon,J., van der
            Brug,M., Lopez de Munain,A., Aparicio,S., Gil,A.M., Khan,N.,
            Johnson,J., Martinez,J.R., Nicholl,D., Marti Carrera,I., Pena,A.S.,
            de Silva,R., Lees,A., Marti-Masso,J.F., Perez-Tur,J., Wood,N.W. and
            Singleton,A.B.
  TITLE     Cloning of the gene containing mutations that cause PARK8-linked
            Parkinson's disease
  JOURNAL   Neuron 44 (4), 595-600 (2004)
   PUBMED   15541308
  REMARK    GeneRIF: missense mutations segregating with PARK8-linked
            Parkinson's disease
REFERENCE   6  (bases 1 to 9239)
  AUTHORS   Zimprich,A., Muller-Myhsok,B., Farrer,M., Leitner,P., Sharma,M.,
            Hulihan,M., Lockhart,P., Strongosky,A., Kachergus,J., Calne,D.B.,
            Stoessl,J., Uitti,R.J., Pfeiffer,R.F., Trenkwalder,C., Homann,N.,
            Ott,E., Wenzel,K., Asmus,F., Hardy,J., Wszolek,Z. and Gasser,T.
  TITLE     The PARK8 locus in autosomal dominant parkinsonism: confirmation of
            linkage and further delineation of the disease-containing interval
  JOURNAL   Am J Hum Genet 74 (1), 11-19 (2004)
   PUBMED   14691730
  REMARK    GeneRIF: PARK8 locus is responsible for the disease in a subset of
            families of white ancestry with autosomal dominant parkinsonism
            Erratum:[Am J Hum Genet. 2004 Sep;75(3):534]
REFERENCE   7  (bases 1 to 9239)
  AUTHORS   Chen,J., Sun,M., Lee,S., Zhou,G., Rowley,J.D. and Wang,S.M.
  TITLE     Identifying novel transcripts and novel genes in the human genome
            by using novel SAGE tags
  JOURNAL   Proc Natl Acad Sci U S A 99 (19), 12257-12262 (2002)
   PUBMED   12213963
REFERENCE   8  (bases 1 to 9239)
  AUTHORS   Funayama,M., Hasegawa,K., Kowa,H., Saito,M., Tsuji,S. and Obata,F.
  TITLE     A new locus for Parkinson's disease (PARK8) maps to chromosome
            12p11.2-q13.1
  JOURNAL   Ann Neurol 51 (3), 296-301 (2002)
   PUBMED   11891824
  REMARK    GeneRIF: A new locus for Parkinson's disease (PARK8) maps to
            chromosome 12p11.2-q13.1
REFERENCE   9  (bases 1 to 9239)
  AUTHORS   Cook Shukla,L., Schulze,J., Farlow,J., Pankratz,N.D., Wojcieszek,J.
            and Foroud,T.
  TITLE     Parkinson Disease Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301402
REFERENCE   10 (bases 1 to 9239)
  AUTHORS   Saunders-Pullman,R., Raymond,D. and Elango,S.
  TITLE     LRRK2 Parkinson Disease
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301387
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC079630.18, AC084290.15 and
            AC107023.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 24, 2018 this sequence version replaced NM_198578.3.
            
            Summary: This gene is a member of the leucine-rich repeat kinase
            family and encodes a protein with an ankryin repeat region, a
            leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like
            motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40
            domain. The protein is present largely in the cytoplasm but also
            associates with the mitochondrial outer membrane. Mutations in this
            gene have been associated with Parkinson disease-8. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.76959.1,
                                           SRR1803616.135112.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000298910.12/ ENSP00000298910.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-286               AC079630.18        144095-144380
            287-372             AC079630.18        144653-144738
            373-482             AC079630.18        151372-151481
            483-571             AC079630.18        154724-154812
            572-706             AC079630.18        157067-157201
            707-841             AC079630.18        159581-159715
            842-973             AC079630.18        162648-162779
            974-1093            AC079630.18        168924-169043
            1094-1236           AC079630.18        170330-170472
            1237-1316           AC079630.18        170563-170642
            1317-1423           AC079630.18        172008-172114
            1424-1553           AC079630.18        176346-176475
            1554-1678           AC084290.15        1491-1615
            1679-1791           AC084290.15        5800-5912
            1792-1936           AC084290.15        16594-16738
            1937-2076           AC084290.15        16865-17004
            2077-2205           AC084290.15        19899-20027
            2206-2376           AC084290.15        20102-20272
            2377-2635           AC084290.15        25886-26144
            2636-2824           AC084290.15        29362-29550
            2825-2943           AC084290.15        35556-35674
            2944-3013           AC084290.15        36856-36925
            3014-3231           AC084290.15        37438-37655
            3232-3482           AC084290.15        40254-40504
            3483-3631           AC084290.15        41120-41268
            3632-3725           AC084290.15        44800-44893
            3726-3912           AC084290.15        45959-46145
            3913-4094           AC084290.15        47796-47977
            4095-4324           AC084290.15        50478-50707
            4325-4452           AC084290.15        51117-51244
            4453-4671           AC084290.15        52442-52660
            4672-4873           AC107023.4         2904-3105
            4874-4962           AC107023.4         4144-4232
            4963-5150           AC107023.4         8920-9107
            5151-5305           AC107023.4         9966-10120
            5306-5452           AC107023.4         10967-11113
            5453-5644           AC107023.4         11251-11442
            5645-5791           AC107023.4         12092-12238
            5792-5892           AC107023.4         17292-17392
            5893-6083           AC107023.4         23899-24089
            6084-6244           AC107023.4         29226-29386
            6245-6415           AC107023.4         35685-35855
            6416-6516           AC107023.4         37341-37441
            6517-6711           AC107023.4         40471-40665
            6712-6905           AC107023.4         43231-43424
            6906-6978           AC107023.4         45047-45119
            6979-7163           AC107023.4         48192-48376
            7164-7316           AC107023.4         52334-52486
            7317-7525           AC107023.4         53774-53982
            7526-7597           AC107023.4         55938-56009
            7598-9239           AC107023.4         56576-58217
FEATURES             Location/Qualifiers
     source          1..9239
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q12"
     gene            1..9239
                     /gene="LRRK2"
                     /gene_synonym="AURA17; DARDARIN; PARK8; RIPK7; ROCO2"
                     /note="leucine rich repeat kinase 2"
                     /db_xref="GeneID:120892"
                     /db_xref="HGNC:HGNC:18618"
                     /db_xref="MIM:609007"
     exon            1..286
                     /gene="LRRK2"
                     /gene_synonym="AURA17; DARDARIN; PARK8; RIPK7; ROCO2"
                     /inference="alignment:Splign:2.1.0"
     CDS             136..7719
                     /gene="LRRK2"
                     /gene_synonym="AURA17; DARDARIN; PARK8; RIPK7; ROCO2"
                     /EC_number="2.7.11.1"
                     /note="augmented in rheumatoid arthritis 17"
                     /codon_start=1
                     /product="leucine-rich repeat serine/threonine-protein
                     kinase 2"
                     /protein_id="NP_940980.4"
                     /db_xref="CCDS:CCDS31774.1"
                     /db_xref="GeneID:120892"
                     /db_xref="HGNC:HGNC:18618"
                     /db_xref="MIM:609007"
                     /translation="MASGSCQGCEEDEETLKKLIVRLNNVQEGKQIETLVQILEDLLV
                     FTYSERASKLFQGKNIHVPLLIVLDSYMRVASVQQVGWSLLCKLIEVCPGTMQSLMGP
                     QDVGNDWEVLGVHQLILKMLTVHNASVNLSVIGLKTLDLLLTSGKITLLILDEESDIF
                     MLIFDAMHSFPANDEVQKLGCKALHVLFERVSEEQLTEFVENKDYMILLSALTNFKDE
                     EEIVLHVLHCLHSLAIPCNNVEVLMSGNVRCYNIVVEAMKAFPMSERIQEVSCCLLHR
                     LTLGNFFNILVLNEVHEFVVKAVQQYPENAALQISALSCLALLTETIFLNQDLEEKNE
                     NQENDDEGEEDKLFWLEACYKALTWHRKNKHVQEAACWALNNLLMYQNSLHEKIGDED
                     GHFPAHREVMLSMLMHSSSKEVFQASANALSTLLEQNVNFRKILLSKGIHLNVLELMQ
                     KHIHSPEVAESGCKMLNHLFEGSNTSLDIMAAVVPKILTVMKRHETSLPVQLEALRAI
                     LHFIVPGMPEESREDTEFHHKLNMVKKQCFKNDIHKLVLAALNRFIGNPGIQKCGLKV
                     ISSIVHFPDALEMLSLEGAMDSVLHTLQMYPDDQEIQCLGLSLIGYLITKKNVFIGTG
                     HLLAKILVSSLYRFKDVAEIQTKGFQTILAILKLSASFSKLLVHHSFDLVIFHQMSSN
                     IMEQKDQQFLNLCCKCFAKVAMDDYLKNVMLERACDQNNSIMVECLLLLGADANQAKE
                     GSSLICQVCEKESSPKLVELLLNSGSREQDVRKALTISIGKGDSQIISLLLRRLALDV
                     ANNSICLGGFCIGKVEPSWLGPLFPDKTSNLRKQTNIASTLARMVIRYQMKSAVEEGT
                     ASGSDGNFSEDVLSKFDEWTFIPDSSMDSVFAQSDDLDSEGSEGSFLVKKKSNSISVG
                     EFYRDAVLQRCSPNLQRHSNSLGPIFDHEDLLKRKRKILSSDDSLRSSKLQSHMRHSD
                     SISSLASEREYITSLDLSANELRDIDALSQKCCISVHLEHLEKLELHQNALTSFPQQL
                     CETLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQF
                     NLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLRLKELKILNLSKNHISSLSE
                     NFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMS
                     SNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPP
                     EIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHIGCKAKDIIR
                     FLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLMKTKKSDLGMQSATVGIDVKDWPI
                     QIRDKRKRDLVLNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLF
                     NIKARASSSPVILVGTHLDVSDEKQRKACMSKITKELLNKRGFPAIRDYHFVNATEES
                     DALAKLRKTIINESLNFKIRDQLVVGQLIPDCYVELEKIILSERKNVPIEFPVIDRKR
                     LLQLVRENQLQLDENELPHAVHFLNESGVLLHFQDPALQLSDLYFVEPKWLCKIMAQI
                     LTVKVEGCPKHPKGIISRRDVEKFLSKKRKFPKNYMSQYFKLLEKFQIALPIGEEYLL
                     VPSSLSDHRPVIELPHCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPYMLSGRERA
                     LRPNRMYWRQGIYLNWSPEAYCLVGSEVLDNHPESFLKITVPSCRKGCILLGQVVDHI
                     DSLMEEWFPGLLEIDICGEGETLLKKWALYSFNDGEEHQKILLDDLMKKAEEGDLLVN
                     PDQPRLTIPISQIAPDLILADLPRNIMLNNDELEFEQAPEFLLGDGSFGSVYRAAYEG
                     EEVAVKIFNKHTSLRLLRQELVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRL
                     LQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIA
                     DYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLLYDILTTGGRIV
                     EGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQVFDIL
                     NSAELVCLTRRILLPKNVIVECMVATHHNSRNASIWLGCGHTDRGQLSFLDLNTEGYT
                     SEEVADSRILCLALVHLPVEKESWIVSGTQSGTLLVINTEDGKKRHTLEKMTDSVTCL
                     YCNSFSKQSKQKNFLLVGTADGKLAIFEDKTVKLKGAAPLKILNIGNVSTPLMCLSES
                     TNSTERNVMWGGCGTKIFSFSNDFTIQKLIETRTSQLFSYAAFSDSNIITVVVDTALY
                     IAKQNSPVVEVWDKKTEKLCGLIDCVHFLREVMVKENKESKHKMSYSGRVKTLCLQKN
                     TALWIGTGGGHILLLDLSTRRLIRVIYNFCNSVRVMMTAQLGSLKNVMLVLGYNRKNT
                     EGTQKQKEIQSCLTVWDINLPHEVQNLEKHIEVRKELAEKMRRTSVE"
     exon            287..372
                     /gene="LRRK2"
                     /gene_synonym="AURA17; DARDARIN; PARK8; RIPK7; ROCO2"
                     /inference="alignment:Splign:2.1.0"
     exon            373..482
                     /gene="LRRK2"
                     /gene_synonym="AURA17; DARDARIN; PARK8; RIPK7; ROCO2"
                     /inference="alignment:Splign:2.1.0"
     exon            483..571
                     /gene="LRRK2"
                     /gene_synonym="AURA17; DARDARIN; PARK8; RIPK7; ROCO2"
                     /inference="alignment:Splign:2.1.0"
     exon            572..706
                     /gene="LRRK2"
                     /gene_synonym="AURA17; DARDARIN; PARK8; RIPK7; ROCO2"
                     /inference="alignment:Splign:2.1.0"
     exon            707..841
                     /gene="LRRK2"
                     /gene_synonym="AURA17; DARDARIN; PARK8; RIPK7; ROCO2"
                     /inference="alignment:Splign:2.1.0"
     exon            842..973
                     /gene="LRRK2"
                     /gene_synonym="AURA17; DARDARIN; PARK8; RIPK7; ROCO2"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1093
                     /gene="LRRK2"
                     /gene_synonym="AURA17; DARDARIN; PARK8; RIPK7; ROCO2"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1236
                     /gene="LRRK2"
                     /gene_synonym="AURA17; DARDARIN; PARK8; RIPK7; ROCO2"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1316
                     /gene="LRRK2"
                     /gene_synonym="AURA17; DARDARIN; PARK8; RIPK7; ROCO2"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1423
                     /gene="LRRK2"
                     /gene_synonym="AURA17; DARDARIN; PARK8; RIPK7; ROCO2"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1553
                     /gene="LRRK2"
                     /gene_synonym="AURA17; DARDARIN; PARK8; RIPK7; ROCO2"
                     /inference="alignment:Splign:2.1.0"
     exon            1554..1678
                     /gene="LRRK2"
                     /gene_synonym="AURA17; DARDARIN; PARK8; RIPK7; ROCO2"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..1791
                     /gene="LRRK2"
                     /gene_synonym="AURA17; DARDARIN; PARK8; RIPK7; ROCO2"
                     /inference="alignment:Splign:2.1.0"
     exon            1792..1936
                     /gene="LRRK2"
                     /gene_synonym="AURA17; DARDARIN; PARK8; RIPK7; ROCO2"
                     /inference="alignment:Splign:2.1.0"
     exon            1937..2076
                     /gene="LRRK2"
                     /gene_synonym="AURA17; DARDARIN; PARK8; RIPK7; ROCO2"
                     /inference="alignment:Splign:2.1.0"
     exon            2077..2205
                     /gene="LRRK2"
                     /gene_synonym="AURA17; DARDARIN; PARK8; RIPK7; ROCO2"
                     /inference="alignment:Splign:2.1.0"
     exon            2206..2376
                     /gene="LRRK2"
                     /gene_synonym="AURA17; DARDARIN; PARK8; RIPK7; ROCO2"
                     /inference="alignment:Splign:2.1.0"
     exon            2377..2635
                     /gene="LRRK2"
                     /gene_synonym="AURA17; DARDARIN; PARK8; RIPK7; ROCO2"
                     /inference="alignment:Splign:2.1.0"
     exon            2636..2824
                     /gene="LRRK2"
                     /gene_synonym="AURA17; DARDARIN; PARK8; RIPK7; ROCO2"
                     /inference="alignment:Splign:2.1.0"
     exon            2825..2943
                     /gene="LRRK2"
                     /gene_synonym="AURA17; DARDARIN; PARK8; RIPK7; ROCO2"
                     /inference="alignment:Splign:2.1.0"
     exon            2944..3013
                     /gene="LRRK2"
                     /gene_synonym="AURA17; DARDARIN; PARK8; RIPK7; ROCO2"
                     /inference="alignment:Splign:2.1.0"
     exon            3014..3231
                     /gene="LRRK2"
                     /gene_synonym="AURA17; DARDARIN; PARK8; RIPK7; ROCO2"
                     /inference="alignment:Splign:2.1.0"
     exon            3232..3482
                     /gene="LRRK2"
                     /gene_synonym="AURA17; DARDARIN; PARK8; RIPK7; ROCO2"
                     /inference="alignment:Splign:2.1.0"
     exon            3483..3631
                     /gene="LRRK2"
                     /gene_synonym="AURA17; DARDARIN; PARK8; RIPK7; ROCO2"
                     /inference="alignment:Splign:2.1.0"
     exon            3632..3725
                     /gene="LRRK2"
                     /gene_synonym="AURA17; DARDARIN; PARK8; RIPK7; ROCO2"
                     /inference="alignment:Splign:2.1.0"
     exon            3726..3912
                     /gene="LRRK2"
                     /gene_synonym="AURA17; DARDARIN; PARK8; RIPK7; ROCO2"
                     /inference="alignment:Splign:2.1.0"
     exon            3913..4094
                     /gene="LRRK2"
                     /gene_synonym="AURA17; DARDARIN; PARK8; RIPK7; ROCO2"
                     /inference="alignment:Splign:2.1.0"
     exon            4095..4324
                     /gene="LRRK2"
                     /gene_synonym="AURA17; DARDARIN; PARK8; RIPK7; ROCO2"
                     /inference="alignment:Splign:2.1.0"
     exon            4325..4452
                     /gene="LRRK2"
                     /gene_synonym="AURA17; DARDARIN; PARK8; RIPK7; ROCO2"
                     /inference="alignment:Splign:2.1.0"
     exon            4453..4671
                     /gene="LRRK2"
                     /gene_synonym="AURA17; DARDARIN; PARK8; RIPK7; ROCO2"
                     /inference="alignment:Splign:2.1.0"
     exon            4672..4873
                     /gene="LRRK2"
                     /gene_synonym="AURA17; DARDARIN; PARK8; RIPK7; ROCO2"
                     /inference="alignment:Splign:2.1.0"
     exon            4874..4962
                     /gene="LRRK2"
                     /gene_synonym="AURA17; DARDARIN; PARK8; RIPK7; ROCO2"
                     /inference="alignment:Splign:2.1.0"
     exon            4963..5150
                     /gene="LRRK2"
                     /gene_synonym="AURA17; DARDARIN; PARK8; RIPK7; ROCO2"
                     /inference="alignment:Splign:2.1.0"
     exon            5151..5305
                     /gene="LRRK2"
                     /gene_synonym="AURA17; DARDARIN; PARK8; RIPK7; ROCO2"
                     /inference="alignment:Splign:2.1.0"
     exon            5306..5452
                     /gene="LRRK2"
                     /gene_synonym="AURA17; DARDARIN; PARK8; RIPK7; ROCO2"
                     /inference="alignment:Splign:2.1.0"
     exon            5453..5644
                     /gene="LRRK2"
                     /gene_synonym="AURA17; DARDARIN; PARK8; RIPK7; ROCO2"
                     /inference="alignment:Splign:2.1.0"
     exon            5645..5791
                     /gene="LRRK2"
                     /gene_synonym="AURA17; DARDARIN; PARK8; RIPK7; ROCO2"
                     /inference="alignment:Splign:2.1.0"
     exon            5792..5892
                     /gene="LRRK2"
                     /gene_synonym="AURA17; DARDARIN; PARK8; RIPK7; ROCO2"
                     /inference="alignment:Splign:2.1.0"
     exon            5893..6083
                     /gene="LRRK2"
                     /gene_synonym="AURA17; DARDARIN; PARK8; RIPK7; ROCO2"
                     /inference="alignment:Splign:2.1.0"
     exon            6084..6244
                     /gene="LRRK2"
                     /gene_synonym="AURA17; DARDARIN; PARK8; RIPK7; ROCO2"
                     /inference="alignment:Splign:2.1.0"
     exon            6245..6415
                     /gene="LRRK2"
                     /gene_synonym="AURA17; DARDARIN; PARK8; RIPK7; ROCO2"
                     /inference="alignment:Splign:2.1.0"
     exon            6416..6516
                     /gene="LRRK2"
                     /gene_synonym="AURA17; DARDARIN; PARK8; RIPK7; ROCO2"
                     /inference="alignment:Splign:2.1.0"
     exon            6517..6711
                     /gene="LRRK2"
                     /gene_synonym="AURA17; DARDARIN; PARK8; RIPK7; ROCO2"
                     /inference="alignment:Splign:2.1.0"
     exon            6712..6905
                     /gene="LRRK2"
                     /gene_synonym="AURA17; DARDARIN; PARK8; RIPK7; ROCO2"
                     /inference="alignment:Splign:2.1.0"
     exon            6906..6978
                     /gene="LRRK2"
                     /gene_synonym="AURA17; DARDARIN; PARK8; RIPK7; ROCO2"
                     /inference="alignment:Splign:2.1.0"
     exon            6979..7163
                     /gene="LRRK2"
                     /gene_synonym="AURA17; DARDARIN; PARK8; RIPK7; ROCO2"
                     /inference="alignment:Splign:2.1.0"
     exon            7164..7316
                     /gene="LRRK2"
                     /gene_synonym="AURA17; DARDARIN; PARK8; RIPK7; ROCO2"
                     /inference="alignment:Splign:2.1.0"
     exon            7317..7525
                     /gene="LRRK2"
                     /gene_synonym="AURA17; DARDARIN; PARK8; RIPK7; ROCO2"
                     /inference="alignment:Splign:2.1.0"
     exon            7526..7597
                     /gene="LRRK2"
                     /gene_synonym="AURA17; DARDARIN; PARK8; RIPK7; ROCO2"
                     /inference="alignment:Splign:2.1.0"
     exon            7598..9239
                     /gene="LRRK2"
                     /gene_synonym="AURA17; DARDARIN; PARK8; RIPK7; ROCO2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8232..8237
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRK2"
                     /gene_synonym="AURA17; DARDARIN; PARK8; RIPK7; ROCO2"
                     /note="hexamer: AATAAA"
     polyA_site      8257
                     /gene="LRRK2"
                     /gene_synonym="AURA17; DARDARIN; PARK8; RIPK7; ROCO2"
                     /note="major polyA site"
     regulatory      9214..9219
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRK2"
                     /gene_synonym="AURA17; DARDARIN; PARK8; RIPK7; ROCO2"
                     /note="hexamer: AATAAA"
     polyA_site      9239
                     /gene="LRRK2"
                     /gene_synonym="AURA17; DARDARIN; PARK8; RIPK7; ROCO2"
                     /note="major polyA site"
ORIGIN      
        1 ggggcccgcg gggagcgctg gctgcgggcg gtgagctgag ctcgcccccg gggagctgtg
       61 gccggcgccc ctgccggttc cctgagcagc ggacgttcat gctgggaggg cggcgggttg
      121 gaagcaggtg ccaccatggc tagtggcagc tgtcaggggt gcgaagagga cgaggaaact
      181 ctgaagaagt tgatagtcag gctgaacaat gtccaggaag gaaaacagat agaaacgctg
      241 gtccaaatcc tggaggatct gctggtgttc acgtactccg agcgcgcctc caagttattt
      301 caaggcaaaa atatccatgt gcctctgttg atcgtcttgg actcctatat gagagtcgcg
      361 agtgtgcagc aggtgggttg gtcacttctg tgcaaattaa tagaagtctg tccaggtaca
      421 atgcaaagct taatgggacc ccaggatgtt ggaaatgatt gggaagtcct tggtgttcac
      481 caattgattc ttaaaatgct aacagttcat aatgccagtg taaacttgtc agtgattgga
      541 ctgaagacct tagatctcct cctaacttca ggtaaaatca ccttgctgat attggatgaa
      601 gaaagtgata ttttcatgtt aatttttgat gccatgcact catttccagc caatgatgaa
      661 gtccagaaac ttggatgcaa agctttacat gtgctgtttg agagagtctc agaggagcaa
      721 ctgactgaat ttgttgagaa caaagattat atgatattgt taagtgcgtt aacaaatttt
      781 aaagatgaag aggaaattgt gcttcatgtg ctgcattgtt tacattccct agcgattcct
      841 tgcaataatg tggaagtcct catgagtggc aatgtcaggt gttataatat tgtggtggaa
      901 gctatgaaag cattccctat gagtgaaaga attcaagaag tgagttgctg tttgctccat
      961 aggcttacat taggtaattt tttcaatatc ctggtattaa acgaagtcca tgagtttgtg
     1021 gtgaaagctg tgcagcagta cccagagaat gcagcattgc agatctcagc gctcagctgt
     1081 ttggccctcc tcactgagac tattttctta aatcaagatt tagaggaaaa gaatgagaat
     1141 caagagaatg atgatgaggg ggaagaagat aaattgtttt ggctggaagc ctgttacaaa
     1201 gcattaacgt ggcatagaaa gaacaagcac gtgcaggagg ccgcatgctg ggcactaaat
     1261 aatctcctta tgtaccaaaa cagtttacat gagaagattg gagatgaaga tggccatttc
     1321 ccagctcata gggaagtgat gctctccatg ctgatgcatt cttcatcaaa ggaagttttc
     1381 caggcatctg cgaatgcatt gtcaactctc ttagaacaaa atgttaattt cagaaaaata
     1441 ctgttatcaa aaggaataca cctgaatgtt ttggagttaa tgcagaagca tatacattct
     1501 cctgaagtgg ctgaaagtgg ctgtaaaatg ctaaatcatc tttttgaagg aagcaacact
     1561 tccctggata taatggcagc agtggtcccc aaaatactaa cagttatgaa acgtcatgag
     1621 acatcattac cagtgcagct ggaggcgctt cgagctattt tacattttat agtgcctggc
     1681 atgccagaag aatccaggga ggatacagaa tttcatcata agctaaatat ggttaaaaaa
     1741 cagtgtttca agaatgatat tcacaaactg gtcctagcag ctttgaacag gttcattgga
     1801 aatcctggga ttcagaaatg tggattaaaa gtaatttctt ctattgtaca ttttcctgat
     1861 gcattagaga tgttatccct ggaaggtgct atggattcag tgcttcacac actgcagatg
     1921 tatccagatg accaagaaat tcagtgtctg ggtttaagtc ttataggata cttgattaca
     1981 aagaagaatg tgttcatagg aactggacat ctgctggcaa aaattctggt ttccagctta
     2041 taccgattta aggatgttgc tgaaatacag actaaaggat ttcagacaat cttagcaatc
     2101 ctcaaattgt cagcatcttt ttctaagctg ctggtgcatc attcatttga cttagtaata
     2161 ttccatcaaa tgtcttccaa tatcatggaa caaaaggatc aacagtttct aaacctctgt
     2221 tgcaagtgtt ttgcaaaagt agctatggat gattacttaa aaaatgtgat gctagagaga
     2281 gcgtgtgatc agaataacag catcatggtt gaatgcttgc ttctattggg agcagatgcc
     2341 aatcaagcaa aggagggatc ttctttaatt tgtcaggtat gtgagaaaga gagcagtccc
     2401 aaattggtgg aactcttact gaatagtgga tctcgtgaac aagatgtacg aaaagcgttg
     2461 acgataagca ttgggaaagg tgacagccag atcatcagct tgctcttaag gaggctggcc
     2521 ctggatgtgg ccaacaatag catttgcctt ggaggatttt gtataggaaa agttgaacct
     2581 tcttggcttg gtcctttatt tccagataag acttctaatt taaggaaaca aacaaatata
     2641 gcatctacac tagcaagaat ggtgatcaga tatcagatga aaagtgctgt ggaagaagga
     2701 acagcctcag gcagcgatgg aaatttttct gaagatgtgc tgtctaaatt tgatgaatgg
     2761 acctttattc ctgactcttc tatggacagt gtgtttgctc aaagtgatga cctggatagt
     2821 gaaggaagtg aaggctcatt tcttgtgaaa aagaaatcta attcaattag tgtaggagaa
     2881 ttttaccgag atgccgtatt acagcgttgc tcaccaaatt tgcaaagaca ttccaattcc
     2941 ttggggccca tttttgatca tgaagattta ctgaagcgaa aaagaaaaat attatcttca
     3001 gatgattcac tcaggtcatc aaaacttcaa tcccatatga ggcattcaga cagcatttct
     3061 tctctggctt ctgagagaga atatattaca tcactagacc tttcagcaaa tgaactaaga
     3121 gatattgatg ccctaagcca gaaatgctgt ataagtgttc atttggagca tcttgaaaag
     3181 ctggagcttc accagaatgc actcacgagc tttccacaac agctatgtga aactctgaag
     3241 agtttgacac atttggactt gcacagtaat aaatttacat catttccttc ttatttgttg
     3301 aaaatgagtt gtattgctaa tcttgatgtc tctcgaaatg acattggacc ctcagtggtt
     3361 ttagatccta cagtgaaatg tccaactctg aaacagttta acctgtcata taaccagctg
     3421 tcttttgtac ctgagaacct cactgatgtg gtagagaaac tggagcagct cattttagaa
     3481 ggaaataaaa tatcagggat atgctccccc ttgagactga aggaactgaa gattttaaac
     3541 cttagtaaga accacatttc atccctatca gagaactttc ttgaggcttg tcctaaagtg
     3601 gagagtttca gtgccagaat gaattttctt gctgctatgc ctttcttgcc tccttctatg
     3661 acaatcctaa aattatctca gaacaaattt tcctgtattc cagaagcaat tttaaatctt
     3721 ccacacttgc ggtctttaga tatgagcagc aatgatattc agtacctacc aggtcccgca
     3781 cactggaaat ctttgaactt aagggaactc ttatttagcc ataatcagat cagcatcttg
     3841 gacttgagtg aaaaagcata tttatggtct agagtagaga aactgcatct ttctcacaat
     3901 aaactgaaag agattcctcc tgagattggc tgtcttgaaa atctgacatc tctggatgtc
     3961 agttacaact tggaactaag atcctttccc aatgaaatgg ggaaattaag caaaatatgg
     4021 gatcttcctt tggatgaact gcatcttaac tttgatttta aacatatagg atgtaaagcc
     4081 aaagacatca taaggtttct tcaacagcga ttaaaaaagg ctgtgcctta taaccgaatg
     4141 aaacttatga ttgtgggaaa tactgggagt ggtaaaacca ccttattgca gcaattaatg
     4201 aaaaccaaga aatcagatct tggaatgcaa agtgccacag ttggcataga tgtgaaagac
     4261 tggcctatcc aaataagaga caaaagaaag agagatctcg tcctaaatgt gtgggatttt
     4321 gcaggtcgtg aggaattcta tagtactcat ccccatttta tgacgcagcg agcattgtac
     4381 cttgctgtct atgacctcag caagggacag gctgaagttg atgccatgaa gccttggctc
     4441 ttcaatataa aggctcgcgc ttcttcttcc cctgtgattc tcgttggcac acatttggat
     4501 gtttctgatg agaagcaacg caaagcctgc atgagtaaaa tcaccaagga actcctgaat
     4561 aagcgagggt tccctgccat acgagattac cactttgtga atgccaccga ggaatctgat
     4621 gctttggcaa aacttcggaa aaccatcata aacgagagcc ttaatttcaa gatccgagat
     4681 cagcttgttg ttggacagct gattccagac tgctatgtag aacttgaaaa aatcatttta
     4741 tcggagcgta aaaatgtgcc aattgaattt cccgtaattg accggaaacg attattacaa
     4801 ctagtgagag aaaatcagct gcagttagat gaaaatgagc ttcctcacgc agttcacttt
     4861 ctaaatgaat caggagtcct tcttcatttt caagacccag cactgcagtt aagtgacttg
     4921 tactttgtgg aacccaagtg gctttgtaaa atcatggcac agattttgac agtgaaagtg
     4981 gaaggttgtc caaaacaccc taagggcatt atttcgcgta gagatgtgga aaaatttctt
     5041 tcaaaaaaaa ggaaatttcc aaagaactac atgtcacagt attttaagct cctagaaaaa
     5101 ttccagattg ctttgccaat aggagaagaa tatttgctgg ttccaagcag tttgtctgac
     5161 cacaggcctg tgatagagct tccccattgt gagaactctg aaattatcat ccgactatat
     5221 gaaatgcctt attttccaat gggattttgg tcaagattaa tcaatcgatt acttgagatt
     5281 tcaccttaca tgctttcagg gagagaacga gcacttcgcc caaacagaat gtattggcga
     5341 caaggcattt acttaaattg gtctcctgaa gcttattgtc tggtaggatc tgaagtctta
     5401 gacaatcatc cagagagttt cttaaaaatt acagttcctt cttgtagaaa aggctgtatt
     5461 cttttgggcc aagttgtgga ccacattgat tctctcatgg aagaatggtt tcctgggttg
     5521 ctggagattg atatttgtgg tgaaggagaa actctgttga agaaatgggc attatatagt
     5581 tttaatgatg gtgaagaaca tcaaaaaatc ttacttgatg acttgatgaa gaaagcagag
     5641 gaaggagatc tcttagtaaa tccagatcaa ccaaggctca ccattccaat atctcagatt
     5701 gcccctgact tgattttggc tgacctgcct agaaatatta tgttgaataa tgatgagttg
     5761 gaatttgaac aagctccaga gtttctccta ggtgatggca gttttggatc agtttaccga
     5821 gcagcctatg aaggagaaga agtggctgtg aagattttta ataaacatac atcactcagg
     5881 ctgttaagac aagagcttgt ggtgctttgc cacctccacc accccagttt gatatctttg
     5941 ctggcagctg ggattcgtcc ccggatgttg gtgatggagt tagcctccaa gggttccttg
     6001 gatcgcctgc ttcagcagga caaagccagc ctcactagaa ccctacagca caggattgca
     6061 ctccacgtag ctgatggttt gagatacctc cactcagcca tgattatata ccgagacctg
     6121 aaaccccaca atgtgctgct tttcacactg tatcccaatg ctgccatcat tgcaaagatt
     6181 gctgactacg gcattgctca gtactgctgt agaatgggga taaaaacatc agagggcaca
     6241 ccagggtttc gtgcacctga agttgccaga ggaaatgtca tttataacca acaggctgat
     6301 gtttattcat ttggtttact actctatgac attttgacaa ctggaggtag aatagtagag
     6361 ggtttgaagt ttccaaatga gtttgatgaa ttagaaatac aaggaaaatt acctgatcca
     6421 gttaaagaat atggttgtgc cccatggcct atggttgaga aattaattaa acagtgtttg
     6481 aaagaaaatc ctcaagaaag gcctacttct gcccaggtct ttgacatttt gaattcagct
     6541 gaattagtct gtctgacgag acgcatttta ttacctaaaa acgtaattgt tgaatgcatg
     6601 gttgctacac atcacaacag caggaatgca agcatttggc tgggctgtgg gcacaccgac
     6661 agaggacagc tctcatttct tgacttaaat actgaaggat acacttctga ggaagttgct
     6721 gatagtagaa tattgtgctt agccttggtg catcttcctg ttgaaaagga aagctggatt
     6781 gtgtctggga cacagtctgg tactctcctg gtcatcaata ccgaagatgg gaaaaagaga
     6841 cataccctag aaaagatgac tgattctgtc acttgtttgt attgcaattc cttttccaag
     6901 caaagcaaac aaaaaaattt tcttttggtt ggaaccgctg atggcaagtt agcaattttt
     6961 gaagataaga ctgttaagct taaaggagct gctcctttga agatactaaa tataggaaat
     7021 gtcagtactc cattgatgtg tttgagtgaa tccacaaatt caacggaaag aaatgtaatg
     7081 tggggaggat gtggcacaaa gattttctcc ttttctaatg atttcaccat tcagaaactc
     7141 attgagacaa gaacaagcca actgttttct tatgcagctt tcagtgattc caacatcata
     7201 acagtggtgg tagacactgc tctctatatt gctaagcaaa atagccctgt tgtggaagtg
     7261 tgggataaga aaactgaaaa actctgtgga ctaatagact gcgtgcactt tttaagggag
     7321 gtaatggtaa aagaaaacaa ggaatcaaaa cacaaaatgt cttattctgg gagagtgaaa
     7381 accctctgcc ttcagaagaa cactgctctt tggataggaa ctggaggagg ccatatttta
     7441 ctcctggatc tttcaactcg tcgacttata cgtgtaattt acaacttttg taattcggtc
     7501 agagtcatga tgacagcaca gctaggaagc cttaaaaatg tcatgctggt attgggctac
     7561 aaccggaaaa atactgaagg tacacaaaag cagaaagaga tacaatcttg cttgaccgtt
     7621 tgggacatca atcttccaca tgaagtgcaa aatttagaaa aacacattga agtgagaaaa
     7681 gaattagctg aaaaaatgag acgaacatct gttgagtaag agagaaatag gaattgtctt
     7741 tggataggaa aattattctc tcctcttgta aatatttatt ttaaaaatgt tcacatggaa
     7801 agggtactca cattttttga aatagctcgt gtgtatgaag gaatgttatt atttttaatt
     7861 taaatatatg taaaaatact taccagtaaa tgtgtatttt aaagaactat ttaaaacaca
     7921 atgttatatt tcttataaat accagttact ttcgttcatt aattaatgaa aataaatctg
     7981 tgaagtacct aatttaagta ctcatactaa aatttataag gccgataatt ttttgttttc
     8041 ttgtctgtaa tggaggtaaa ctttatttta aattctgtgc ttaagacagg actattgctt
     8101 gtcgattttt ctagaaatct gcacggtata atgaaaatat taagacagtt tcccatgtaa
     8161 tgtattcctt cttagattgc atcgaaatgc actatcatat atgcttgtaa atattcaaat
     8221 gaatttgcac taataaagtc ctttgttggt atgtgaattc tctttgttgc tgttgcaaac
     8281 agtgcatctt acacaacttc actcaattca aaagaaaact ccattaaaag tactaatgaa
     8341 aaaacatgac atactgtcaa agtcctcata tctaggaaag acacagaaac tctctttgtc
     8401 acagaaactc tctgtgtctt tcctagacat aatagagttg tttttcaact ctatgtttga
     8461 atgtggatac cctgaatttt gtataattag tgtaaataca gtgttcagtc cttcaagtga
     8521 tatttttatt tttttattca taccactagc tacttgtttt ctaatctgct tcattctaat
     8581 gcttatattc atcttttccc taaatttgtg atgctgcaga tcctacatca ttcagataga
     8641 aacctttttt tttttcagaa ttatagaatt ccacagctcc taccaagacc atgaggataa
     8701 atatctaaca cttttcagtt gctgaaggag aaaggagctt tagttatgat ggataaaaat
     8761 atctgccacc ctaggcttcc aaattatact taaattgttt acatagctta ccacaatagg
     8821 agtatcaggg ccaaatacct atgtaataat ttgaggtcat ttctgcttta ggaaaagtac
     8881 tttcggtaaa ttctttggcc ctgaccagta ttcattattt cagataattc cctgtgatag
     8941 gacaactagt acatttaata ttctcagaac ttatggcatt ttactatgtg aaaactttaa
     9001 atttatttat attaagggta atcaaattct taaagatgaa agattttctg tattttaaag
     9061 gaagctatgc tttaacttgt tatgtaatta acaaaaaaat catatataat agagctcttt
     9121 gttccagtgt tatctctttc attgttactt tgtatttgca atttttttta ccaaagacaa
     9181 attaaaaaaa tgaataccat atttaaatgg aataataaag gttttttaaa aactttaaa
//
