LOCUS       NM_024652              15674 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens leucine rich repeat kinase 1 (LRRK1), mRNA.
ACCESSION   NM_024652 XM_928328 XM_932785
VERSION     NM_024652.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 15674)
  AUTHORS   Metcalfe,R.D., Martinez Fiesco,J.A., Bonet-Ponce,L., Kluss,J.H.,
            Cookson,M.R. and Zhang,P.
  TITLE     Structure and regulation of full-length human leucine-rich repeat
            kinase 1
  JOURNAL   Nat Commun 14 (1), 4797 (2023)
   PUBMED   37558661
  REMARK    GeneRIF: Structure and regulation of full-length human leucine-rich
            repeat kinase 1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 15674)
  AUTHORS   Malik,A.U., Karapetsas,A., Nirujogi,R.S., Chatterjee,D.,
            Phung,T.K., Wightman,M., Gourlay,R., Morrice,N., Mathea,S.,
            Knapp,S. and Alessi,D.R.
  TITLE     PKC isoforms activate LRRK1 kinase by phosphorylating conserved
            residues (Ser1064, Ser1074 and Thr1075) within the CORB GTPase
            domain
  JOURNAL   Biochem J 479 (18), 1941-1965 (2022)
   PUBMED   36040231
  REMARK    GeneRIF: PKC isoforms activate LRRK1 kinase by phosphorylating
            conserved residues (Ser1064, Ser1074 and Thr1075) within the CORB
            GTPase domain.
REFERENCE   3  (bases 1 to 15674)
  AUTHORS   Chorin,O., Chowers,G., Agbariah,R., Karklinsky,S., Barel,O.,
            Bar-Joseph,I., Reznik-Wolf,H., Shamash,J., Pode-Shakked,B.,
            Jacobson,J.M., Huna-Baron,R., Redler,Y., Tirosh,I., Vivante,A. and
            Raas-Rothschild,A.
  TITLE     Broadening the phenotype of LRRK1 mutations - Features of malignant
            osteopetrosis and optic nerve atrophy with intrafamilial variable
            expressivity
  JOURNAL   Eur J Med Genet 65 (1), 104383 (2022)
   PUBMED   34798323
  REMARK    GeneRIF: Broadening the phenotype of LRRK1 mutations - Features of
            malignant osteopetrosis and optic nerve atrophy with intrafamilial
            variable expressivity.
REFERENCE   4  (bases 1 to 15674)
  AUTHORS   Malik,A.U., Karapetsas,A., Nirujogi,R.S., Mathea,S., Chatterjee,D.,
            Pal,P., Lis,P., Taylor,M., Purlyte,E., Gourlay,R., Dorward,M.,
            Weidlich,S., Toth,R., Polinski,N.K., Knapp,S., Tonelli,F. and
            Alessi,D.R.
  TITLE     Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct
            Rab proteins and are regulated by diverse mechanisms
  JOURNAL   Biochem J 478 (3), 553-578 (2021)
   PUBMED   33459343
  REMARK    GeneRIF: Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate
            distinct Rab proteins and are regulated by diverse mechanisms.
REFERENCE   5  (bases 1 to 15674)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 15674)
  AUTHORS   Iida,A., Xing,W., Docx,M.K., Nakashima,T., Wang,Z., Kimizuka,M.,
            Van Hul,W., Rating,D., Spranger,J., Ohashi,H., Miyake,N.,
            Matsumoto,N., Mohan,S., Nishimura,G., Mortier,G. and Ikegawa,S.
  TITLE     Identification of biallelic LRRK1 mutations in osteosclerotic
            metaphyseal dysplasia and evidence for locus heterogeneity
  JOURNAL   J Med Genet 53 (8), 568-574 (2016)
   PUBMED   27055475
  REMARK    GeneRIF: LRRK1 plays a critical role in the regulation of bone mass
            in humans.
REFERENCE   7  (bases 1 to 15674)
  AUTHORS   Taylor,J.P., Hulihan,M.M., Kachergus,J.M., Melrose,H.L.,
            Lincoln,S.J., Hinkle,K.M., Stone,J.T., Ross,O.A., Hauser,R.,
            Aasly,J., Gasser,T., Payami,H., Wszolek,Z.K. and Farrer,M.J.
  TITLE     Leucine-rich repeat kinase 1: a paralog of LRRK2 and a candidate
            gene for Parkinson's disease
  JOURNAL   Neurogenetics 8 (2), 95-102 (2007)
   PUBMED   17225181
  REMARK    GeneRIF: Comparison of evolutionary interspecies sequences of LRRK1
            and LRRK2 suggests they diverged from a common founder gene
            implicated in Parkinson disease.
REFERENCE   8  (bases 1 to 15674)
  AUTHORS   Korr,D., Toschi,L., Donner,P., Pohlenz,H.D., Kreft,B. and Weiss,B.
  TITLE     LRRK1 protein kinase activity is stimulated upon binding of GTP to
            its Roc domain
  JOURNAL   Cell Signal 18 (6), 910-920 (2006)
   PUBMED   16243488
  REMARK    GeneRIF: We report the molecular characterization of human LRRK1
            and show for the first time that LRRK1 is a functional protein
            kinase and a GDP/GTP-binding protein. We propose a model in which
            LRRK1 cycles between a GTP-bound active and a GDP-bound inactive
            state
            GeneRIF: LRRK1 binds GTP and GDP via its Roc domain and
            autophosphorylation activity is selectively triggered by GTP.
            Kinase activity was decreased following introduction of mutations
            homologous to those of LRRK2 that have been associated with
            Parkinson's disease.
REFERENCE   9  (bases 1 to 15674)
  AUTHORS   Zody,M.C., Garber,M., Sharpe,T., Young,S.K., Rowen,L., O'Neill,K.,
            Whittaker,C.A., Kamal,M., Chang,J.L., Cuomo,C.A., Dewar,K.,
            FitzGerald,M.G., Kodira,C.D., Madan,A., Qin,S., Yang,X., Abbasi,N.,
            Abouelleil,A., Arachchi,H.M., Baradarani,L., Birditt,B., Bloom,S.,
            Bloom,T., Borowsky,M.L., Burke,J., Butler,J., Cook,A.,
            DeArellano,K., DeCaprio,D., Dorris,L. 3rd, Dors,M., Eichler,E.E.,
            Engels,R., Fahey,J., Fleetwood,P., Friedman,C., Gearin,G.,
            Hall,J.L., Hensley,G., Johnson,E., Jones,C., Kamat,A., Kaur,A.,
            Locke,D.P., Madan,A., Munson,G., Jaffe,D.B., Lui,A., Macdonald,P.,
            Mauceli,E., Naylor,J.W., Nesbitt,R., Nicol,R., O'Leary,S.B.,
            Ratcliffe,A., Rounsley,S., She,X., Sneddon,K.M., Stewart,S.,
            Sougnez,C., Stone,S.M., Topham,K., Vincent,D., Wang,S.,
            Zimmer,A.R., Birren,B.W., Hood,L., Lander,E.S. and Nusbaum,C.
  TITLE     Analysis of the DNA sequence and duplication history of human
            chromosome 15
  JOURNAL   Nature 440 (7084), 671-675 (2006)
   PUBMED   16572171
REFERENCE   10 (bases 1 to 15674)
  AUTHORS   Bosgraaf,L. and Van Haastert,P.J.
  TITLE     Roc, a Ras/GTPase domain in complex proteins
  JOURNAL   Biochim Biophys Acta 1643 (1-3), 5-10 (2003)
   PUBMED   14654223
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AW592808.1, BC171802.1,
            AC090907.14, DQ013130.1, AK131075.1, AK058028.1, BQ187037.1 and
            AC019254.12.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 24, 2018 this sequence version replaced NM_024652.5.
            
            Summary: This gene encodes a multi-domain protein that is a
            leucine-rich repeat kinase and a GDP/GTP binding protein. The
            encoded protein is thought to play a role in the regulation of bone
            mass. Mice lacking a similar gene showed severe osteopetrosis,
            increased bone mineralization and decreased bone resorption.
            [provided by RefSeq, Jan 2017].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1965299,
                              SAMEA1966682 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000388948.8/ ENSP00000373600.3
            RefSeq Select criteria    :: based on single protein-coding
                                         transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-187               AW592808.1         143-329
            188-2274            BC171802.1         1-2087
            2275-2275           AC090907.14        80939-80939
            2276-2703           DQ013130.1         2056-2483
            2704-4749           BC171802.1         2520-4565
            4750-4750           AC090907.14        116346-116346
            4751-4863           BC171802.1         4567-4679
            4864-6360           AK131075.1         1939-3435
            6361-7520           AK058028.1         3051-4210
            7521-7529           BQ187037.1         506-514
            7530-7569           AC090907.14        128464-128503
            7570-15674          AC019254.12        19581-27685
FEATURES             Location/Qualifiers
     source          1..15674
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q26.3"
     gene            1..15674
                     /gene="LRRK1"
                     /gene_synonym="OSMD; RIPK6; Roco1"
                     /note="leucine rich repeat kinase 1"
                     /db_xref="GeneID:79705"
                     /db_xref="HGNC:HGNC:18608"
                     /db_xref="MIM:610986"
     exon            1..95
                     /gene="LRRK1"
                     /gene_synonym="OSMD; RIPK6; Roco1"
                     /inference="alignment:Splign:2.1.0"
     exon            96..314
                     /gene="LRRK1"
                     /gene_synonym="OSMD; RIPK6; Roco1"
                     /inference="alignment:Splign:2.1.0"
     CDS             218..6265
                     /gene="LRRK1"
                     /gene_synonym="OSMD; RIPK6; Roco1"
                     /EC_number="2.7.11.1"
                     /codon_start=1
                     /product="leucine-rich repeat serine/threonine-protein
                     kinase 1"
                     /protein_id="NP_078928.3"
                     /db_xref="CCDS:CCDS42086.1"
                     /db_xref="GeneID:79705"
                     /db_xref="HGNC:HGNC:18608"
                     /db_xref="MIM:610986"
                     /translation="MAGMSQRPPSMYWCVGPEESAVCPERAMETLNGAGDTGGKPSTR
                     GGDPAARSRRTEGIRAAYRRGDRGGARDLLEEACDQCASQLEKGQLLSIPAAYGDLEM
                     VRYLLSKRLVELPTEPTDDNPAVVAAYFGHTAVVQELLESLPGPCSPQRLLNWMLALA
                     CQRGHLGVVKLLVLTHGADPESYAVRKNEFPVIVRLPLYAAIKSGNEDIAIFLLRHGA
                     YFCSYILLDSPDPSKHLLRKYFIEASPLPSSYPGKTALRVKWSHLRLPWVDLDWLIDI
                     SCQITELDLSANCLATLPSVIPWGLINLRKLNLSDNHLGELPGVQSSDEIICSRLLEI
                     DISSNKLSHLPPGFLHLSKLQKLTASKNCLEKLFEEENATNWIGLRKLQELDISDNKL
                     TELPALFLHSFKSLNSLNVSRNNLKVFPDPWACPLKCCKASRNALECLPDKMAVFWKN
                     HLKDVDFSENALKEVPLGLFQLDALMFLRLQGNQLAALPPQEKWTCRQLKTLDLSRNQ
                     LGKNEDGLKTKRIAFFTTRGRQRSGTEAASVLEFPAFLSESLEVLCLNDNHLDTVPPS
                     VCLLKSLSELYLGNNPGLRELPPELGQLGNLWQLDTEDLTISNVPAEIQKEGPKAMLS
                     YLRAQLRKAEKCKLMKMIIVGPPRQGKSTLLEILQTGRAPQVVHGEATIRTTKWELQR
                     PAGSRAKVESVEFNVWDIGGPASMATVNQCFFTDKALYVVVWNLALGEEAVANLQFWL
                     LNIEAKAPNAVVLVVGTHLDLIEAKFRVERIATLRAYVLALCRSPSGSRATGFPDITF
                     KHLHEISCKSLEGQEGLRQLIFHVTCSMKDVGSTIGCQRLAGRLIPRSYLSLQEAVLA
                     EQQRRSRDDDVQYLTDRQLEQLVEQTPDNDIKDYEDLQSAISFLIETGTLLHFPDTSH
                     GLRNLYFLDPIWLSECLQRIFNIKGSRSVAKNGVIRAEDLRMLLVGTGFTQQTEEQYF
                     QFLAKFEIALPVANDSYLLPHLLPSKPGLDTHGMRHPTANTIQRVFKMSFVPVGFWQR
                     FIARMLISLAEMDLQLFENKKNTKSRNRKVTIYSFTGNQRNRCSTFRVKRNQTIYWQE
                     GLLVTFDGGYLSVESSDVNWKKKKSGGMKIVCQSEVRDFSAMAFITDHVNSLIDQWFP
                     ALTATESDGTPLMEQYVPCPVCETAWAQHTDPSEKSEDVQYFDMEDCVLTAIERDFIS
                     CPRHPDLPVPLQELVPELFMTDFPARLFLENSKLEHSEDEGSVLGQGGSGTVIYRARY
                     QGQPVAVKRFHIKKFKNFANVPADTMLRHLRATDAMKNFSEFRQEASMLHALQHPCIV
                     ALIGISIHPLCFALELAPLSSLNTVLSENARDSSFIPLGHMLTQKIAYQIASGLAYLH
                     KKNIIFCDLKSDNILVWSLDVKEHINIKLSDYGISRQSFHEGALGVEGTPGYQAPEIR
                     PRIVYDEKVDMFSYGMVLYELLSGQRPALGHHQLQIAKKLSKGIRPVLGQPEEVQFRR
                     LQALMMECWDTKPEKRPLALSVVSQMKDPTFATFMYELCCGKQTAFFSSQGQEYTVVF
                     WDGKEESRNYTVVNTEKGLMEVQRMCCPGMKVSCQLQVQRSLWTATEDQKIYIYTLKG
                     MCPLNTPQQALDTPAVVTCFLAVPVIKKNSYLVLAGLADGLVAVFPVVRGTPKDSCSY
                     LCSHTANRSKFSIADEDARQNPYPVKAMEVVNSGSEVWYSNGPGLLVIDCASLEICRR
                     LEPYMAPSMVTSVVCSSEGRGEEVVWCLDDKANSLVMYHSTTYQLCARYFCGVPSPLR
                     DMFPVRPLDTEPPAASHTANPKVPEGDSIADVSIMYSEELGTQILIHQESLTDYCSMS
                     SYSSSPPRQAARSPSSLPSSPASSSSVPFSTDCEDSDMLHTPGAASDRSEHDLTPMDG
                     ETFSQHLQAVKILAVRDLIWVPRRGGDVIVIGLEKDSGAQRGRVIAVLKARELTPHGV
                     LVDAAVVAKDTVVCTFENENTEWCLAVWRGWGAREFDIFYQSYEELGRLEACTRKRR"
     exon            315..478
                     /gene="LRRK1"
                     /gene_synonym="OSMD; RIPK6; Roco1"
                     /inference="alignment:Splign:2.1.0"
     exon            479..650
                     /gene="LRRK1"
                     /gene_synonym="OSMD; RIPK6; Roco1"
                     /inference="alignment:Splign:2.1.0"
     exon            651..830
                     /gene="LRRK1"
                     /gene_synonym="OSMD; RIPK6; Roco1"
                     /inference="alignment:Splign:2.1.0"
     exon            831..979
                     /gene="LRRK1"
                     /gene_synonym="OSMD; RIPK6; Roco1"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1206
                     /gene="LRRK1"
                     /gene_synonym="OSMD; RIPK6; Roco1"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1334
                     /gene="LRRK1"
                     /gene_synonym="OSMD; RIPK6; Roco1"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1498
                     /gene="LRRK1"
                     /gene_synonym="OSMD; RIPK6; Roco1"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1636
                     /gene="LRRK1"
                     /gene_synonym="OSMD; RIPK6; Roco1"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..1749
                     /gene="LRRK1"
                     /gene_synonym="OSMD; RIPK6; Roco1"
                     /inference="alignment:Splign:2.1.0"
     exon            1750..1826
                     /gene="LRRK1"
                     /gene_synonym="OSMD; RIPK6; Roco1"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..1956
                     /gene="LRRK1"
                     /gene_synonym="OSMD; RIPK6; Roco1"
                     /inference="alignment:Splign:2.1.0"
     exon            1957..2069
                     /gene="LRRK1"
                     /gene_synonym="OSMD; RIPK6; Roco1"
                     /inference="alignment:Splign:2.1.0"
     exon            2070..2284
                     /gene="LRRK1"
                     /gene_synonym="OSMD; RIPK6; Roco1"
                     /inference="alignment:Splign:2.1.0"
     exon            2285..2449
                     /gene="LRRK1"
                     /gene_synonym="OSMD; RIPK6; Roco1"
                     /inference="alignment:Splign:2.1.0"
     exon            2450..2622
                     /gene="LRRK1"
                     /gene_synonym="OSMD; RIPK6; Roco1"
                     /inference="alignment:Splign:2.1.0"
     exon            2623..2743
                     /gene="LRRK1"
                     /gene_synonym="OSMD; RIPK6; Roco1"
                     /inference="alignment:Splign:2.1.0"
     exon            2744..2903
                     /gene="LRRK1"
                     /gene_synonym="OSMD; RIPK6; Roco1"
                     /inference="alignment:Splign:2.1.0"
     exon            2904..3180
                     /gene="LRRK1"
                     /gene_synonym="OSMD; RIPK6; Roco1"
                     /inference="alignment:Splign:2.1.0"
     exon            3181..3352
                     /gene="LRRK1"
                     /gene_synonym="OSMD; RIPK6; Roco1"
                     /inference="alignment:Splign:2.1.0"
     exon            3353..3516
                     /gene="LRRK1"
                     /gene_synonym="OSMD; RIPK6; Roco1"
                     /inference="alignment:Splign:2.1.0"
     exon            3517..3656
                     /gene="LRRK1"
                     /gene_synonym="OSMD; RIPK6; Roco1"
                     /inference="alignment:Splign:2.1.0"
     exon            3657..3906
                     /gene="LRRK1"
                     /gene_synonym="OSMD; RIPK6; Roco1"
                     /inference="alignment:Splign:2.1.0"
     exon            3907..4073
                     /gene="LRRK1"
                     /gene_synonym="OSMD; RIPK6; Roco1"
                     /inference="alignment:Splign:2.1.0"
     exon            4074..4271
                     /gene="LRRK1"
                     /gene_synonym="OSMD; RIPK6; Roco1"
                     /inference="alignment:Splign:2.1.0"
     exon            4272..4549
                     /gene="LRRK1"
                     /gene_synonym="OSMD; RIPK6; Roco1"
                     /inference="alignment:Splign:2.1.0"
     exon            4550..4744
                     /gene="LRRK1"
                     /gene_synonym="OSMD; RIPK6; Roco1"
                     /inference="alignment:Splign:2.1.0"
     exon            4745..4896
                     /gene="LRRK1"
                     /gene_synonym="OSMD; RIPK6; Roco1"
                     /inference="alignment:Splign:2.1.0"
     exon            4897..5014
                     /gene="LRRK1"
                     /gene_synonym="OSMD; RIPK6; Roco1"
                     /inference="alignment:Splign:2.1.0"
     exon            5015..5131
                     /gene="LRRK1"
                     /gene_synonym="OSMD; RIPK6; Roco1"
                     /inference="alignment:Splign:2.1.0"
     exon            5132..5985
                     /gene="LRRK1"
                     /gene_synonym="OSMD; RIPK6; Roco1"
                     /inference="alignment:Splign:2.1.0"
     exon            5986..6087
                     /gene="LRRK1"
                     /gene_synonym="OSMD; RIPK6; Roco1"
                     /inference="alignment:Splign:2.1.0"
     exon            6088..15674
                     /gene="LRRK1"
                     /gene_synonym="OSMD; RIPK6; Roco1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7504..7509
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRK1"
                     /gene_synonym="OSMD; RIPK6; Roco1"
                     /note="hexamer: AATAAA"
     polyA_site      7525
                     /gene="LRRK1"
                     /gene_synonym="OSMD; RIPK6; Roco1"
                     /note="major polyA site"
     regulatory      10281..10286
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRK1"
                     /gene_synonym="OSMD; RIPK6; Roco1"
                     /note="hexamer: AATAAA"
     polyA_site      10307
                     /gene="LRRK1"
                     /gene_synonym="OSMD; RIPK6; Roco1"
     regulatory      15648..15653
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRK1"
                     /gene_synonym="OSMD; RIPK6; Roco1"
                     /note="hexamer: AATAAA"
     polyA_site      15674
                     /gene="LRRK1"
                     /gene_synonym="OSMD; RIPK6; Roco1"
ORIGIN      
        1 agacggcggt gggacggcca ggccccggcc ccgccagtgt gtccgcccgg ccccgcgtcc
       61 cggagcgccc gcacccggcc ccgccgccgc ctcagagcaa gaaagctttc tgctcagcca
      121 tggctacgag tccacgcctt aatgcacccc acagccagcg gcagtggcag tgacaacagc
      181 gggacctgcc tttgaagatc ggctgctgca agggttgatg gctggcatgt cgcaaagacc
      241 ccccagcatg tactggtgtg tggggccgga ggagtcagct gtgtgtccag aacgtgccat
      301 ggagacgctt aacggtgccg gggacacggg cggcaagccg tccacgcggg gcggtgaccc
      361 tgcagcgcgg tcccgcagga cggaaggcat ccgcgccgcg tacaggcggg gagaccgcgg
      421 cggcgcccgg gacctgctgg aggaggcctg cgaccagtgc gcgtcccagc tggaaaaggg
      481 ccagcttctg agcatcccgg cagcctatgg ggatctggag atggtccgct acctactcag
      541 caagagactg gtggagctgc ccaccgagcc cacggatgac aacccagccg tggtggcagc
      601 gtattttgga cacacggcag ttgtgcagga attgcttgag tccttaccag gtccctgcag
      661 tccccagcgg cttctgaact ggatgctggc cttggcttgc cagcgagggc acctgggggt
      721 tgtgaagctc ctggtcctga cgcacggggc tgacccggag agctacgctg tcaggaagaa
      781 tgagttccct gtcatcgtgc gcttgcccct gtatgcggcc atcaagtcag ggaatgaaga
      841 cattgcaata ttcctgcttc ggcatggggc ctatttctgt tcctacatct tgctggatag
      901 tcctgacccc agcaaacatc tgctgagaaa gtacttcatt gaagccagtc ccttgcccag
      961 cagttatccg ggaaaaacag ctctccgtgt gaaatggtcc catctcagac tgccctgggt
     1021 agacctagac tggctcatag acatctcctg ccagatcacg gagctcgacc tttctgccaa
     1081 ctgcctggcg accctcccct cggttatccc ctggggcctc atcaatctcc ggaagctgaa
     1141 cctctccgac aaccacctgg gggagctgcc tggcgtgcag tcatcggacg aaatcatctg
     1201 ttccaggcta cttgaaattg acatttccag caacaagttg tcccacctcc ctcctggatt
     1261 cttgcacctc tcaaaacttc aaaaactgac agcttcaaaa aattgtttag aaaaattgtt
     1321 cgaagaagaa aatgccacta actggatagg tttacggaag ctacaggaac ttgatatatc
     1381 tgacaataaa ttgacagaac tccctgccct gttccttcac tctttcaagt ccctcaattc
     1441 tctgaatgtc tccagaaaca acctgaaggt gtttccagat ccctgggcct gccctttgaa
     1501 atgttgtaaa gcttccagaa atgccctgga atgtctgcca gacaaaatgg ctgtcttttg
     1561 gaaaaatcac ctgaaggatg tggatttctc agaaaacgca ctcaaagaag ttcccctggg
     1621 acttttccag cttgatgccc tcatgttctt gaggttacag gggaaccagc tggcggcact
     1681 tccacctcaa gagaagtgga cctgcaggca gctcaaaacc ctggatctct ccagaaacca
     1741 acttggcaaa aatgaagatg gactgaaaac gaagcgtatt gcctttttca ccaccagagg
     1801 tcgccagcgc tccgggactg aggcagcaag tgtgctggaa tttccggcct tcctaagtga
     1861 gtctttggaa gtcctttgcc tgaacgacaa ccacctcgac acagtccctc cctcggtttg
     1921 cctactgaag agcttatcag agctctactt gggaaacaac cctggcctcc gggagctccc
     1981 tcctgagctg gggcagctgg gcaacctctg gcagctggac actgaagacc tgaccatcag
     2041 caatgtgcct gcagaaatcc aaaaagaagg ccccaaagca atgctgtctt acctgcgtgc
     2101 tcagctgcgg aaagcggaaa agtgcaagct gatgaagatg atcatcgtgg gtcccccgcg
     2161 ccagggcaag tccaccctcc tggagatctt acagacgggg agggcccccc aggtggtgca
     2221 tggagaggcc accatcagga ccaccaagtg ggagctccag aggccggctg gctcgagagc
     2281 caaggttgag tccgtggagt tcaacgtctg ggacatcggg ggaccggcca gcatggccac
     2341 tgtcaaccag tgcttcttca cggacaaggc cctgtacgtg gtggtctgga acctggcgct
     2401 gggggaggag gccgtggcca acctccagtt ctggctgctc aacatcgagg ccaaggcccc
     2461 aaacgccgtg gtgctggtgg tcgggacgca cctggattta attgaagcca agttccgtgt
     2521 ggaaaggatt gcaacgctgc gtgcctatgt gctggcactc tgccgctccc cctccggctc
     2581 cagggccaca ggcttcccag acatcacctt caaacactta catgagattt cctgcaagag
     2641 cctggaaggt caggaagggc tgcgacagct gattttccac gtcacgtgca gcatgaagga
     2701 cgtgggcagc accatcggct gccagcgact ggcagggcgg ctgatcccca ggagctacct
     2761 gagcctgcag gaggccgtgc tggcagagca gcagcgccgc agccgggacg acgacgtgca
     2821 gtacctgacg gacaggcagc tggagcagct ggtggagcag acgcccgaca acgacatcaa
     2881 ggactacgag gacctgcagt cagccatcag cttcctcata gaaaccggca ccctgctcca
     2941 tttcccggac accagccacg gcctgaggaa cctctacttc ctcgacccta tttggctctc
     3001 cgaatgtctg cagaggatct ttaatattaa gggctctcgg tcagtggcca agaatggggt
     3061 gatcagagca gaagacctca ggatgctgct ggtggggact ggcttcacgc agcagacgga
     3121 agagcagtac ttccagttcc tggccaagtt tgagatcgcc ctgcccgtcg ccaatgacag
     3181 ctacctcctg ccccatctcc ttccatctaa acctggcctg gacacccacg gtatgcggca
     3241 ccccacagcc aacaccattc agagggtatt taagatgagc ttcgttcccg ttggcttctg
     3301 gcaaaggttt atagcacgga tgctgatcag cctggcggag atggacctgc agctttttga
     3361 aaacaagaag aatactaaaa gcaggaacag gaaagtcacc atttacagtt ttacaggaaa
     3421 ccagagaaat cgctgtagca cattcagagt gaaaagaaat cagaccatct attggcagga
     3481 agggctcctg gtcacttttg atgggggcta cctcagtgtg gaatcttccg acgtgaactg
     3541 gaaaaagaag aaaagcggag gaatgaaaat tgtttgccaa tcagaagtga gggacttctc
     3601 agccatggct ttcatcacgg accacgtcaa ttccttgatt gatcagtggt ttcccgccct
     3661 gacagccaca gagagcgacg ggacgccact catggagcag tacgtgccct gcccggtctg
     3721 cgagacagcc tgggcccagc acacggaccc cagtgagaaa tcagaggatg tgcagtactt
     3781 cgacatggaa gactgtgtcc tgacggccat cgagcgggac ttcatctcct gccccagaca
     3841 cccggacctc cccgtgccgc tgcaggagct ggtccctgaa ctgttcatga ccgacttccc
     3901 ggccaggctc ttcctggaga acagcaagct ggagcacagc gaggacgagg gcagcgtcct
     3961 gggccagggc ggcagtggca ccgtcatcta ccgggcccgg taccagggcc agcctgtggc
     4021 cgtcaagcgc ttccacatca aaaaattcaa gaactttgct aacgtaccgg cagacaccat
     4081 gctgaggcac ctgcgggcca ccgatgccat gaagaacttc tccgagttcc ggcaggaggc
     4141 cagcatgctg cacgcgctgc agcacccctg catcgtggcg ctcatcggca tcagcatcca
     4201 cccgctctgc ttcgccctgg agctcgcgcc gctcagcagc ctcaacaccg tgctgtccga
     4261 gaacgccaga gattcttcct ttatacccct gggacacatg ctcacccaaa aaatagccta
     4321 ccagatcgcc tcgggcctgg cctacctgca caagaaaaac atcatcttct gtgacctgaa
     4381 gtcggacaac attctggtgt ggtcccttga cgtcaaggag cacatcaaca tcaagctatc
     4441 tgactacggg atttcgaggc agtcattcca tgagggcgcc ctaggcgtgg agggcactcc
     4501 tggctaccag gccccagaga tcaggcctcg cattgtatat gatgagaagg tagatatgtt
     4561 ctcctatgga atggtgctct acgagttgct gtcaggacag cgccctgcac tgggccacca
     4621 ccagctccag attgccaaga agctgtccaa gggcatccgc ccggttctgg ggcagccgga
     4681 ggaagtgcag ttccggcgac tgcaggcgct catgatggag tgctgggaca ctaagccaga
     4741 gaagcgaccg ctggccctgt cggtggtgag ccagatgaag gacccgactt ttgccacctt
     4801 catgtatgaa ctgtgctgtg ggaagcagac agccttcttc tcatcccagg gccaggagta
     4861 caccgtggtg ttttgggatg gaaaagagga gtccaggaac tacacggtgg tgaacacaga
     4921 gaagggcctc atggaggtgc agaggatgtg ctgccctggg atgaaggtga gctgccagct
     4981 ccaggtccag agatccctgt ggacagccac cgaggaccag aaaatctaca tctacaccct
     5041 caagggcatg tgccccttaa acacacccca acaggccttg gatactccag ctgtcgtcac
     5101 ctgcttcttg gccgtgcctg ttattaaaaa gaattcctac ctggtcttag cgggcctcgc
     5161 cgatgggctt gtggctgtgt ttcccgtggt gcggggcacc ccaaaggaca gctgctccta
     5221 cctgtgctca cacacagcca acaggtccaa gttcagcatc gcggatgaag acgcacggca
     5281 gaacccctac ccagtgaagg ccatggaggt ggtcaacagc ggctctgagg tctggtacag
     5341 caatgggccg ggcctccttg tcatcgactg tgcctccctg gagatctgca ggcggctgga
     5401 gccctacatg gccccctcca tggttacgtc agtcgtgtgc agctctgagg gcagagggga
     5461 ggaggtcgtc tggtgcctgg atgacaaggc caactccttg gtgatgtacc actccaccac
     5521 ctaccagctg tgtgcccggt acttctgcgg ggtccccagc cccctcaggg acatgtttcc
     5581 cgtgcggccc ttggacacgg aacccccggc agccagccac acggccaacc caaaggtgcc
     5641 tgagggggac tccatcgcgg acgtgagcat catgtacagt gaggagctgg gcacgcagat
     5701 cctgatccac caggaatcac tcactgacta ctgctccatg tcctcctact cctcatcccc
     5761 accccgccag gctgccaggt ccccctcaag cctccccagc tccccagcaa gttcttccag
     5821 tgtgcctttc tccaccgact gcgaggactc agacatgcta catacgcccg gtgctgcctc
     5881 cgacaggtct gagcatgacc tgacccccat ggacggggag accttcagcc agcacctgca
     5941 ggccgtgaag atcctcgccg tcagagacct catttgggtc cccaggcgcg gtggagatgt
     6001 tatcgtcatt ggcctggaga aggattctgg cgcccagcgg ggccgagtca ttgccgtctt
     6061 aaaagcccga gagctgactc cgcatggggt gctggtggat gctgccgtgg tggcaaagga
     6121 cactgttgtg tgcacctttg aaaatgaaaa cacagagtgg tgcctggccg tctggagggg
     6181 ctggggcgcc agggagttcg acattttcta ccagtcctac gaggagctgg gccggctgga
     6241 ggcttgcact cgcaagagaa ggtaattcct gtggaatgac tgtcacacat cagagctggc
     6301 tggcccgggg ctgcagcctg acccctctgc catcggcctc tagttctcca aggacctaga
     6361 agacagatgg agttctcccc tgaactcctt gctgctaaga agtgctgaga agttactcgc
     6421 ctggcggtgg ctccagggtt ctctggttct ctggagcaga gttctctgaa taccccatcc
     6481 cccaactgct gattttacag ccccagggaa gacagtggta tcaggctggg agcggcctcc
     6541 tctggcctcc cccatcagtt tgcaggagca ggggtgcagg atcctgttct gagctgggtc
     6601 aaacaaagca gggccgggcc ttcctgccat ccccaggtct cagatggaat tacactagag
     6661 gccctccgct gggaagcact tgaggtaggg caggaggggg gctgtgaccc ctgccctttc
     6721 cccgccagag acctcaggct ctcagcacat tccacaggct cctgagtccc cgaggcctgg
     6781 gccagcttgg gcaagccaag atcagatgtc tctgtgttcg ggaaggtctc cgtgtgggaa
     6841 agcccttggg ggatcccggg tgaggagtgt tgccccatcc agagaatgaa tgagttcctt
     6901 taagtgccac cgccagcaag cccagaggca cacagtccga gtgcacccgc ttagccttta
     6961 cattcctctc caccgacaaa aggaagggga aactcaatca gcaggacttc agaaagggcc
     7021 ttgtgtttat agctttgtca agtaaatttg gacgcagctg gagcacaggc cctgtttgtt
     7081 tgcacataat aatcttgttt atcactttaa aaaattcagt aatatctcag cagtcaggct
     7141 tctggttgtg aaatcacatt gtatgggatt tataccaaat tatgtatttg ctaaacattc
     7201 actgcacacg tgtacagcgg agtacgaaaa ggaacgttgt ccacagggga tttatggata
     7261 caacagcaaa cattttataa actatgcaca tgcattacac acatgcacac acatatgcac
     7321 acacatgtgc aaacatagcc acttttttgt caagagttac cctttggggc tccttaaacc
     7381 agaatgggag tttgaaagag agatcatact ccagctgaag tttgttgacc cttttctaaa
     7441 attaaaaaga tcaaatttag tatttgctgg atatgcaggg agatgagact cttttaatct
     7501 caaaataaac agattctttc aagaacgaag ctgtggcctc tgtcttttga gcgcttatga
     7561 ccacagcacg ggctcagtcc ctcccagacc cactcgctgt ctggggataa tgggcagccc
     7621 ctccttgccc actgtgccaa catgcaggtg gcccctgagc agcttccatg ggtggagacg
     7681 ctgctctgtc agtcacaggc ttggaaaaag cgagtccccc cactcttttt tttttttttt
     7741 tttttttttt taccaacctg ggcaccaagt cccagggggc tgagggtctg tgcttcctgt
     7801 ctacctccct gccattctct caccctcatc ccacagcagg gtctcaggag tcccactctc
     7861 cctctcctct cattccagtg ccccacaact gcccagttaa cccccagatg caagccagat
     7921 tccatctgcc ccaggcccca agcttttgct ttggcatcac gcgaggccag gctgctttgc
     7981 aggcaccaaa attcaccctc tcctactcct ggaaaagccc agccccaggc ctcacagagc
     8041 caggggaggg gatctcatca catcacagtt agaaatcata caggcctaaa gtcccagcta
     8101 cccaggagcc aaggcaggag gaacccttga gcctgggagt tggaggttac agtgagctat
     8161 gatcacacca gctttctagc ctgggtgaca gagcaagacc caactcttaa aaaaaaaaaa
     8221 aaaatacagg aaatgactaa tgaacttgac tccatgaaat tgaaacttac gtggaaaatt
     8281 agtccaaagc ctaaaagact agcaactgag aaaaaaaaac attgcaacac aaatgagaga
     8341 caaagacctc acttatcttc attacagaga gttcgtaatg tcaataagaa acagaaaacc
     8401 ggaaaggcaa acaggttaag ggcatgggca gcaattgaat tacaaagaaa cagacagacc
     8461 cttaaacatc aatgcttgac ctcacccaac agcagggaaa cagtctccac aacagtaaaa
     8521 tgttgctggg atgggcccag cattcagcat ggtccctgca actttggcct ctgcccagtg
     8581 acctctggcg ggtgtagaag agctcatgct tcagtgaggg ggtggggggc accctgagga
     8641 ccctgtcaac atcagctgga ccacaggcat ctcagataga tgtcacttac caccctcatg
     8701 ttggcagagg gtggtaacca gccagcatct ccttcttaaa cacctactaa gtgtcaggca
     8761 ctgtgaccgg agacacagtc aagaatctct gtgttttttt tgttttgttt tgtttttgtt
     8821 ttttgagacg gagtctcgct ctgttgccca ggctggagtg caatggcgcg atctcagctc
     8881 actgccacct ccgcctccca ggttcaagca attctcctgc ctcagcctcc cgagtagctg
     8941 cgattacagg cgtgcaccac aatgcctgga taatttttgt attttcagta gaaacggggt
     9001 ttcaccatgt tggccaggat ggtcttgaac tcctgagctc aggtgatccg cccgcctcat
     9061 cctcccaaag tgctgggatt acaggtgtga gctacctgcg ctggccgaat ctctgctttt
     9121 aggagctcac tcctcatagg tagagttgac aataagcaca caaacaagtg agatagcagg
     9181 gcagccggac cacccagttg ggcaattcgt ggcttggcct aggaacgtta catttgactg
     9241 aggctggcga ggcctgcagc ctgcaccagg aggtacaatg tgagactgag gaatgggaag
     9301 aaggcattcc atggagctct gagggcactg ggtgcaaggg ccttgcacat gcaaagaccc
     9361 tgttgtgggt tcaagccact gtgtgggagg gacaggagag cctggcgtgg ctgcggcctt
     9421 gaaggagggg actgtgcaca cagaattgca agtgggggtc tccgcggaag ctcctggcag
     9481 ttttaagcag gattattaga tgattcagtc aactttacaa ctcactttgc tgaatggagg
     9541 gtggattaac gagggggtag ttggaggcta ccccttggag ggcattctgg acttatctac
     9601 caaaatttca aatgcacata ccctctgacc cagcagttcc acttaagtat ttggtcctga
     9661 aatcttggta aaagtgccca aagatacaga acaaggatgt tcactatagc atctcttaga
     9721 atatggcccc aaacaggaag caaccccaac ctctatcatg agggaggtca taaaattcct
     9781 gcacatgcaa cagtgccatc ctctgcagcc tgtcaaagag gcaggcagca ctaactgctg
     9841 gactggaatg ttctccaaga tataataaat gcatttgttt gaaagcagct tgcagcacag
     9901 tgcgtcaggc ctctgagccc aagccaagcc atcgcatccc ctgtgacttg cacgtatatg
     9961 cctagatggc ctgaagtaac tgaagaatca caaaagaagt gaatatgccc tgccccgcct
    10021 taactgatga cattccacca caaaagaagt gaaaaaggcc ggtccttgac ttaactgatg
    10081 acattatctt atgaaattcc ttctcctggc tcatcctggc tcaaaaagct cccccactga
    10141 gcacgttgcc acccccactc ctgcccgcca gagaacaaac cccctttttc ctttacctac
    10201 ccaaatctta taaaacggcc tcacgcctat ctcccttcac tgactccctt ttcggactca
    10261 gcccacctgc gcccaggtga aataaacagc cttgttgctc acacaaagcc tgtttggtgg
    10321 tctcttcaca tggacgtgca ttaaatttgg tgccgtaact ggcgcggggg gagggggggg
    10381 ggaacctccc ttgggagatc aatcccctgt cctcctgctc tttggtccat gagaaagatc
    10441 cacctacaac ctcaagtcct cagaccaacc agcccaagaa acatctcacc aatttcaaat
    10501 ccagtaagca gcctcttttt actctcttct ccaacctccc tcactatccc tcaacctctt
    10561 tctcctttca atcttggcgc cacacttcaa tttctccctt ctcttaactt caattccttt
    10621 cattttctgg tagagataaa ggagacacgt tttatccgtg gacccaaaac tccagcgccg
    10681 gtcacggact gggaaggcag ccttcccttg gtgtttaatc attgcaggga cacctctctg
    10741 attattcacc caggtttcag aggtgtcaga ccacgcaggg acgcctgcct tggtccttca
    10801 cccttagcgg caagtcccgc ttttctgggg aatgggcaag gaccccaacc ccttctctcc
    10861 gtgtctctac cccttctccg cctttctggg gggcaagaaa cccccaaccc cttctccttc
    10921 accctgagcg gcaagtcccg cttttctaga ggaggagcaa gtactccaac ctcatatctc
    10981 tgcgccccaa tcccttattt ctgtgcccca acctcttatc tctgtgcccc aatcccttat
    11041 ttccatgccc ccacctctta tatctctgca ccttgatccc ttatttccac atcccgacct
    11101 cgtatctctg caccccgacc cctttcccac ttttctggag agtaagaacc cctgaaccgc
    11161 ttctctccgt gtctctactc tcccttttct ttaaacttgc ctccttcact gtaggcaacc
    11221 ttccactctc cattcctcct tcttctccct tagcctatgt tctcaaaaac ttaaaacctc
    11281 ttcaactcac acctgaccta aaacctaaat gccttatttt cttctgcaat gccgcttgac
    11341 cccaatacaa actcaacagt agttccaaat agccggaaaa cagcactttc aatttttcca
    11401 tcctgcaaga tctaaataat tcttgtcgta aaatgggcaa atggtctgag gtgcctgacg
    11461 tccaggcgtt cttttacaca tcagtccctc cctagtctct gttcccagtg caactcatcc
    11521 caaatcttcc ttctttccct cccgcctgtc tcctcagtcc caaccccaag catcgctgag
    11581 tctttctaat cttttctata gacccatctg acctctcccc tcctccccag gctgctcctt
    11641 gccaggccga gctaggtccc aattcttcct cagcctccgc tcctccacca tataatcttt
    11701 ttatcacctc ccctcctcac acccggtccg gcttacagtt tccttccgtg actagccctc
    11761 ccctacctgc ccagcaattt tctcttaaaa aggtggctgg agctaaaggc atagtcaagg
    11821 ttaatgctcc tttttcttta tcccaaatca gatagcgttt aggctctttt tcatcaaata
    11881 taaaaaccca gcccagttca tgcctcgttt ggcagcaacc ctgagacact ttacggccct
    11941 agaccctaaa agcccaaaag gccgtcttat tctcaatata tattttatca cccaatctgc
    12001 tccctacatt aaataaaact ccaaaaatta aattccggcc ctcaaacccc acaacaggat
    12061 ttaattaacc ttgccttcaa ggtgtacaat aatagaaaaa agttgcaatt ccttgcctcc
    12121 actgtgagac aaaccccagc cacatctcca gcacacaaga acttccaaac acctgaactg
    12181 cagcggccag gcattcctcc agaacctcct cccccaggag cttgctacaa gtgccagaaa
    12241 tctggccacc aggccaagga atgcctgcag cccaggattc ctcctaagcc gtgtcccatc
    12301 tgtgcgggac cccactggaa atcggactgt ccaactcacc tggcagccac tcccagagcc
    12361 cctggaactc cggcccaagg ctctctgact gactccttcc cagatcttct tggcttagcg
    12421 gctgaagact gacactgccc gatcacctcg gaagccccct agaccatcac ggacgccgag
    12481 ctgccagtaa ctctcacagt ggaaggtaaa cccgtcccct tcttaatcaa tacggaggct
    12541 acccactcca cattaccttc ttttcaaggg cctgtttccc ttacctccat aactgttgtg
    12601 cgtattgaca gccaggcttc taaacctctt aaaactcccc aactctggtg ccaacttaga
    12661 caatactctt ttaagcactc cttttagtta tccccagctg cccagttccc ttattaggct
    12721 gagacacttt aactaaatta tctgcttccc tgactattcc tgggctacag ccacacctca
    12781 ttactgccct tcttcccaat ccaaagcctc ctttgtgtcc tcctcttgta tcccccgacc
    12841 ttaacccata agtataagat acctctactc cctccttggt gaccgatcat gcacccctta
    12901 ccatctcatc gaaacctaat cacccttacc ccgctcaaca ccaatatccc atcccacagc
    12961 atgctttgaa aagactaaag cctgttatca ctctcctgct acagcatggc cttttaaagc
    13021 ctataaactc tccttacaat tcccccattt cacttgtcct aaaaccagac aagccttaca
    13081 agttagttca ggatctgtgc cttatcaacc acattgtttt gcctatccac cccatggtgt
    13141 caaacccata tactctccta tcctcaatac ctcactccat aatccattat tgtgttctgg
    13201 atctcaaaca tgctttcttt actattcctt tgcacccttc atcccagcct ctcttcactt
    13261 tcacttggac tgaccctgac acccatcagg ctcagcaaat tacctgggct gtactgcccc
    13321 aaagcttcac agacagcccc cattacatca gtcaagccca aattttttcc ctatctgtta
    13381 cctatctcag cataattctc ataaagacac acgtgctctc cctgccgatc atgtccgatt
    13441 aatctcccaa accccaaccc cttctacaaa acaagaactc ctttccttcc taggcatggt
    13501 tagtgcagtc agaattctta cacaagagcc aggaccgcac cctgtagacc ttctgtccaa
    13561 acaacttgac cttactgttt tagcctagcc ctcatgtctc tgtgcagcgg ctgctgccac
    13621 cctaatactt ttagaggccc tcaaaatcac aaactatgct caactcactc tctacagtta
    13681 tcataacttc caaaatctat tttcttcctc atacctgaca tatatacttt ctgctccccg
    13741 gctccttcag ctgtactcac tctttattga gtctcccaca attaccattt ttcctggcac
    13801 cgacttcaat ccagcctccc acattattcc tgataccaca cctgaccccc atgactgcat
    13861 ctctctgatc cacctgacgt tcaccccatt tccccacatt tccttcttcc ctgcttctca
    13921 ccctgatcac acttggttta tggatggcag ttccaccagg cctaatggcc acacaccagc
    13981 aaaggcaggc tgtgctatag tacaagccgc tagcccgcct cttagaacct ctcatttcct
    14041 ttccatcgtg gaaatctatc ctcaaggaaa taacttctca gtgttccatc tgctattcta
    14101 ctgctcctca gggattattc aggccccctc ccttccctac acatcaagct cagggatttg
    14161 cctccaccca ggactggcaa attgacttta ctcaacatgc cccgagtcag ataactaaaa
    14221 tacctcttat tctaggtaga cactttcact ggataggtag aggcctttcc tacagggtct
    14281 gagaaggcca ccatggtcat ttcttccctt ctgtcaaaca taattcctcg gtttggcctt
    14341 cccacctcta tactgtctga taacagacca gcctttatta gtcaaatcag ccaagcgttt
    14401 tttcaggctc ttagtattca gtgaaacctt tatatccctt acagtcctca gccttcagga
    14461 aaggtagaac ggactaatga tcttttaaaa acacacctca ccaagctcag ccaccaactt
    14521 aaaaaagact ggacaatact tttaccactt tcccttctca gaattcaggc ctgtccttgg
    14581 aatgctacaa ggtacagccc atttgagctc ctgtatagac gctccttttt attaggcccc
    14641 agtctcattc cagacaccag accaacttgg actgtgcccc aaaaaacttg tcatccctac
    14701 tatcttctgt ctagtcgtac tcctattcac cattctcaac tactcatacg tgccctgctc
    14761 ttgtttacac tgccagttta cactgtttct ccaagccatc acagctgata tctcctggtg
    14821 ctatccccaa accgccactc tgaactctta aatacataat ctttgctggc aggactatgc
    14881 tgaacctcct ttggcactct ctaatcagat gtcctgagtc atctcaattc ttagaccttt
    14941 tatacctgtt tttctccttt acttattccg tttagttttt caattcatac aaaaccgtat
    15001 ccaggtcatc accaataatt ctaaatgacg aatgtttctt ctaacaaccg cacaatatca
    15061 ccccttacca caagacctcc cttcagctta atctctccca ctctaggttc ccacgccgcc
    15121 ccgaatcccg ctcgaagcag ccctgagaaa catcgcccat tctctctctc cacaccgccc
    15181 cccaaaaatt ttcgctgccc caacacttcg acactatttt gttttatttt tcttattaat
    15241 ataagaaggc aggaatgtca ggcctctgag cccaagctaa gccatcgcat cccctgtgac
    15301 ctgcacgcat atataagccc agatggcctg aagtaactga agaatcacaa aagaagtgaa
    15361 tatgccctgc cccaccttaa ctgatgacat tccaccacaa aagaagtgta aatggctggt
    15421 tcttgcctta agtgatgaca ttaccttgtg aaagtccttt tcctggctca tcctggctca
    15481 aaaagcaccc ccactgagca ccttgccgcc cccactcctg cccgccagag aacaaacccc
    15541 ctttgactgt aattttcctt tacctaccca aatcctataa aacggcccca cccccatctc
    15601 cctgcactga ctctcttttc ggactcagcc cgcctgcacc caggtgaaat aaacagcttt
    15661 attgctcaca caaa
//
