LOCUS       NM_001080460            2033 bp    mRNA    linear   PRI 17-FEB-2024
DEFINITION  Homo sapiens leucine rich repeats and IQ motif containing 4
            (LRRIQ4), mRNA.
ACCESSION   NM_001080460 XM_005247421 XM_293529
VERSION     NM_001080460.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2033)
  AUTHORS   Kobe,B. and Kajava,A.V.
  TITLE     The leucine-rich repeat as a protein recognition motif
  JOURNAL   Curr Opin Struct Biol 11 (6), 725-732 (2001)
   PUBMED   11751054
  REMARK    Review article
REFERENCE   2  (bases 1 to 2033)
  AUTHORS   Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
            Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
            Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
            Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
            Offenbacher,J., Danzig,J. and Ducar,M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat Biotechnol 19 (5), 440-445 (2001)
   PUBMED   11329013
REFERENCE   3  (bases 1 to 2033)
  AUTHORS   Hocking,A.M., Shinomura,T. and McQuillan,D.J.
  TITLE     Leucine-rich repeat glycoproteins of the extracellular matrix
  JOURNAL   Matrix Biol 17 (1), 1-19 (1998)
   PUBMED   9628249
  REMARK    Review article
REFERENCE   4  (bases 1 to 2033)
  AUTHORS   Rhoads,A.R. and Friedberg,F.
  TITLE     Sequence motifs for calmodulin recognition
  JOURNAL   FASEB J 11 (5), 331-340 (1997)
   PUBMED   9141499
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC078795.19.
            
            On or before Mar 18, 2021 this sequence version replaced
            XM_005247421.3, NM_001080460.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968968,
                              SAMEA2148874 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000340806.7/ ENSP00000342188.6
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-177               AC078795.19        87506-87682         c
            178-1228            AC078795.19        77611-78661         c
            1229-1402           AC078795.19        71620-71793         c
            1403-1541           AC078795.19        69922-70060         c
            1542-1738           AC078795.19        67369-67565         c
            1739-2033           AC078795.19        62779-63073         c
FEATURES             Location/Qualifiers
     source          1..2033
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q26.2"
     gene            1..2033
                     /gene="LRRIQ4"
                     /gene_synonym="LRRC64"
                     /note="leucine rich repeats and IQ motif containing 4"
                     /db_xref="GeneID:344657"
                     /db_xref="HGNC:HGNC:34298"
     exon            1..177
                     /gene="LRRIQ4"
                     /gene_synonym="LRRC64"
                     /inference="alignment:Splign:2.1.0"
     exon            178..1228
                     /gene="LRRIQ4"
                     /gene_synonym="LRRC64"
                     /inference="alignment:Splign:2.1.0"
     CDS             209..1891
                     /gene="LRRIQ4"
                     /gene_synonym="LRRC64"
                     /note="leucine rich repeat containing 64"
                     /codon_start=1
                     /product="leucine-rich repeat and IQ domain-containing
                     protein 4"
                     /protein_id="NP_001073929.1"
                     /db_xref="CCDS:CCDS46951.1"
                     /db_xref="GeneID:344657"
                     /db_xref="HGNC:HGNC:34298"
                     /translation="MSKDIKSVEHSPKIHQRNDPQHVNDRTFFIDASNQSLTAIPLEI
                     FTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCPALGLLSSLESLDLS
                     YNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLGLTGNHLKCLPKE
                     IVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIGHLTGLQKFYM
                     ASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKVPRLI
                     CRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGLD
                     DNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGFKLTYVPE
                     HIRKLQSLKELYIENNHLEYLPVSLGSMPNLEVLDCRHNLLKQLPDAICQAQALKELR
                     LEDNLLTHLPENLDSLVNLKVLTLMDNPMEEPPKEVCAEGNEAIWKYLKENRNRNIMA
                     TKIQAWWRGTMVQRGFGKFGELLKPQKKGKTSPKDKKGKKDVKGKPGKGKKK"
     exon            1229..1402
                     /gene="LRRIQ4"
                     /gene_synonym="LRRC64"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..1541
                     /gene="LRRIQ4"
                     /gene_synonym="LRRC64"
                     /inference="alignment:Splign:2.1.0"
     exon            1542..1738
                     /gene="LRRIQ4"
                     /gene_synonym="LRRC64"
                     /inference="alignment:Splign:2.1.0"
     exon            1739..2033
                     /gene="LRRIQ4"
                     /gene_synonym="LRRC64"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1971..1976
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRIQ4"
                     /gene_synonym="LRRC64"
                     /note="hexamer: ATTAAA"
     polyA_site      1994
                     /gene="LRRIQ4"
                     /gene_synonym="LRRC64"
                     /note="major polyA site"
     regulatory      2007..2012
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRIQ4"
                     /gene_synonym="LRRC64"
                     /note="hexamer: AATAAA"
     polyA_site      2033
                     /gene="LRRIQ4"
                     /gene_synonym="LRRC64"
                     /note="major polyA site"
ORIGIN      
        1 gaagaagcag agtagcatca gcacatgata aaggcgttgg gctttgggag cataaagggt
       61 tttgtgctcc caaagggcgg ggccaccagg gagggcttcc tgaaggaggt gacatctgga
      121 tggtccgaag gaggctgcca gaggacagaa tgcttggtgc gttctgggca tgcgcagatt
      181 ttgaatattt gagcttttct tcacaataat gtcaaaagac ataaaatcag tagaacattc
      241 acctaaaatt catcagagaa atgatccaca gcacgtcaat gatagaacat ttttcattga
      301 tgcctctaat cagagcttga ctgccattcc tttggagatc ttcacattca cagaattaga
      361 agaagtgcat ttggagaata accagattga agaaattccc caggagattc agcgtttaaa
      421 gaacatcagg gtcctctacc tggataagaa caacctgagg agcctgtgcc cggcgctggg
      481 gctgctgagc agcctggaga gcctggacct gagctacaac cccatcttct cctcctccct
      541 tgtcgttgtc agcttcctcc acgccctgcg cgagctccgg ctctaccaga ccgacctgaa
      601 ggaaattccc gtcgtcatct ttaaaaacct ccaccatctc gagctgctcg gactgaccgg
      661 aaaccacctg aaatgtctgc ccaaggaaat agtgaaccag accaagctga gggagatcta
      721 cctgaagcga aaccagtttg aagttttccc ccaggagctc tgtgttctct acaccctgga
      781 aatcattgac ctggacgaga acaaaatagg tgccatccca gaagagatcg gacacctgac
      841 ggggctgcag aagttctata tggcttctaa caaccttccc gttctgcccg cgtccttgtg
      901 ccagtgtagc caactgtcgg tgctcgattt atcccacaac ctcctccact ccatcccgaa
      961 gagcttcgcc gagctcagga agatgacgga aatcgggctg agcgggaacc gcctggagaa
     1021 ggtgccacgc ctcatttgca ggtggacctc gctgcacctg ctctacctgg gaaacaccgg
     1081 cctgcacagg ctgcggggct ccttcaggtg cctggtcaac ttgcgcttcc tggacctaag
     1141 ccagaaccat ctgcaccact gcccgctgca gatctgtgca ctgaagaacc ttgaagtcct
     1201 gggactggat gacaataaaa taggacagtt accttcagaa ttgggctcac tttcaaaact
     1261 gaagatactt ggactaacag gaaatgagtt cctttccttt ccggaggaag tcctttcttt
     1321 agcgtcttta gagaaattat acattgggca agaccaggga ttcaaactta cctatgtgcc
     1381 agaacacatt aggaaactgc agagtctcaa agagctatat atagagaaca atcatctgga
     1441 gtacctgccc gtatccttgg ggtcaatgcc taacctagaa gttcttgatt gccggcacaa
     1501 tttgcttaag caacttccag atgccatttg ccaagcacaa gctttgaaag aattacggct
     1561 ggaggacaac ttgctcaccc atcttccaga gaatttggat tccctagtga atcttaaggt
     1621 tctgacactg atggacaatc ccatggaaga acccccaaaa gaagtgtgtg ctgaaggcaa
     1681 tgaggccata tggaaatacc tcaaggaaaa cagaaacagg aatataatgg caacaaagat
     1741 tcaggcatgg tggcgtggaa caatggtaca gagaggattt gggaaattcg gtgaactact
     1801 aaaaccacaa aagaaaggaa agacctctcc aaaagataag aaaggaaaga aggatgtaaa
     1861 aggaaaacca ggaaagggaa aaaagaaata atcctgtaaa ttgataaatt ggggtaatgg
     1921 accttgatag attaagaaga caaaatatct aggaattaga tgcctactac attaaaatta
     1981 ttcataaaat tacacttatg tgtaaaaata aatgattctt acttttactg aaa
//
