LOCUS       NM_001105659            2854 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens leucine rich repeats and IQ motif containing 3
            (LRRIQ3), transcript variant 1, mRNA.
ACCESSION   NM_001105659
VERSION     NM_001105659.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2854)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   2  (bases 1 to 2854)
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium
  TITLE     Biological insights from 108 schizophrenia-associated genetic loci
  JOURNAL   Nature 511 (7510), 421-427 (2014)
   PUBMED   25056061
REFERENCE   3  (bases 1 to 2854)
  AUTHORS   Yu,B., Zheng,Y., Alexander,D., Manolio,T.A., Alonso,A.,
            Nettleton,J.A. and Boerwinkle,E.
  TITLE     Genome-wide association study of a heart failure related
            metabolomic profile among African Americans in the Atherosclerosis
            Risk in Communities (ARIC) study
  JOURNAL   Genet Epidemiol 37 (8), 840-845 (2013)
   PUBMED   23934736
REFERENCE   4  (bases 1 to 2854)
  AUTHORS   Yu,B., Barbalic,M., Brautbar,A., Nambi,V., Hoogeveen,R.C., Tang,W.,
            Mosley,T.H., Rotter,J.I., deFilippi,C.R., O'Donnell,C.J.,
            Kathiresan,S., Rice,K., Heckbert,S.R., Ballantyne,C.M., Psaty,B.M.
            and Boerwinkle,E.
  CONSRTM   CARDIoGRAM Consortium
  TITLE     Association of genome-wide variation with highly sensitive cardiac
            troponin-T levels in European Americans and Blacks: a meta-analysis
            from atherosclerosis risk in communities and cardiovascular health
            studies
  JOURNAL   Circ Cardiovasc Genet 6 (1), 82-88 (2013)
   PUBMED   23247143
REFERENCE   5  (bases 1 to 2854)
  AUTHORS   Curtis,D., Vine,A.E., McQuillin,A., Bass,N.J., Pereira,A.,
            Kandaswamy,R., Lawrence,J., Anjorin,A., Choudhury,K., Datta,S.R.,
            Puri,V., Krasucki,R., Pimm,J., Thirumalai,S., Quested,D. and
            Gurling,H.M.
  TITLE     Case-case genome-wide association analysis shows markers
            differentially associated with schizophrenia and bipolar disorder
            and implicates calcium channel genes
  JOURNAL   Psychiatr Genet 21 (1), 1-4 (2011)
   PUBMED   21057379
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC098692.3 and AL359205.15.
            
            On Nov 23, 2018 this sequence version replaced NM_001105659.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA1968968, SAMEA2148093
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000354431.9/ ENSP00000346414.4
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-181               AC098692.3         33608-33788         c
            182-430             AC098692.3         19048-19296         c
            431-754             AC098692.3         18150-18473         c
            755-888             AL359205.15        156450-156583       c
            889-1048            AL359205.15        110111-110270       c
            1049-1178           AL359205.15        75378-75507         c
            1179-1899           AL359205.15        41930-42650         c
            1900-2854           AL359205.15        26732-27686         c
FEATURES             Location/Qualifiers
     source          1..2854
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p31.1"
     gene            1..2854
                     /gene="LRRIQ3"
                     /gene_synonym="LRRC44"
                     /note="leucine rich repeats and IQ motif containing 3"
                     /db_xref="GeneID:127255"
                     /db_xref="HGNC:HGNC:28318"
                     /db_xref="MIM:617957"
     exon            1..181
                     /gene="LRRIQ3"
                     /gene_synonym="LRRC44"
                     /inference="alignment:Splign:2.1.0"
     CDS             182..2056
                     /gene="LRRIQ3"
                     /gene_synonym="LRRC44"
                     /note="isoform 1 is encoded by transcript variant 1;
                     leucine rich repeat containing 44; leucine-rich repeat and
                     IQ domain-containing protein 3; leucine-rich
                     repeat-containing protein 44"
                     /codon_start=1
                     /product="leucine-rich repeat and IQ domain-containing
                     protein 3 isoform 1"
                     /protein_id="NP_001099129.1"
                     /db_xref="CCDS:CCDS41350.1"
                     /db_xref="GeneID:127255"
                     /db_xref="HGNC:HGNC:28318"
                     /db_xref="MIM:617957"
                     /translation="MFHGTVTEELTSHEEWSHYNENIREGQKDFVFVKFNGLHLKSME
                     NLQSCISLRVCIFSNNFITDIHPLQSCIKLIKLDLHGNQIKSLPNTKFWNGLKNLKLL
                     YLHDNGFAKLKNICVLSACPTLIALTMFDCPVSLKKGYRHVLVNSIWPLKALDHHVIS
                     DEEIIQNWHLPERFKACNHRLFFNFCPALRKGTTYEEEINNIKHITSKINAILAHNSP
                     VLIVQRWIRGFLVRKNLSPVFFHKKKQQEKIIRGYEAKWIYITKGYEDKLLKDLFFKP
                     ETNIKGKLAYWKHNIYYPVDLKNSSEHRKHVSSILCELKPKDLGMKSKTSRHLIQKGQ
                     ESEDEIVDEKLDTSFRISVFKLPIYTSGSLKNNAVLREKKQHFFPAYPQPIYTTHPKP
                     IIKKDIRLERSMKEFFAPQRAGMKLRTFSDIDKYYTEQKKQEYHKEKVRVVAMAQVAR
                     ERVRVAVNEHLNQKKYATQKLIEENKETIQNSLRQVWQNRFNYLEKARERKALFLKEK
                     SQKASERLLVQNLNNERTLLTRGLLKIDRLEKNEAVLKEKSLIVKQKLKAEKYRKNLL
                     KEMKKVRSQEIYKRHCEEKFVMDMIAFEKACERLQDAKTKVAIVKTNLDFKVPNGLIK
                     "
     exon            182..430
                     /gene="LRRIQ3"
                     /gene_synonym="LRRC44"
                     /inference="alignment:Splign:2.1.0"
     exon            431..754
                     /gene="LRRIQ3"
                     /gene_synonym="LRRC44"
                     /inference="alignment:Splign:2.1.0"
     exon            755..888
                     /gene="LRRIQ3"
                     /gene_synonym="LRRC44"
                     /inference="alignment:Splign:2.1.0"
     exon            889..1048
                     /gene="LRRIQ3"
                     /gene_synonym="LRRC44"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1178
                     /gene="LRRIQ3"
                     /gene_synonym="LRRC44"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1899
                     /gene="LRRIQ3"
                     /gene_synonym="LRRC44"
                     /inference="alignment:Splign:2.1.0"
     exon            1900..2854
                     /gene="LRRIQ3"
                     /gene_synonym="LRRC44"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2607..2612
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRIQ3"
                     /gene_synonym="LRRC44"
                     /note="hexamer: ATTAAA"
     polyA_site      2628
                     /gene="LRRIQ3"
                     /gene_synonym="LRRC44"
                     /note="major polyA site"
     regulatory      2828..2833
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRIQ3"
                     /gene_synonym="LRRC44"
                     /note="hexamer: AATAAA"
     polyA_site      2854
                     /gene="LRRIQ3"
                     /gene_synonym="LRRC44"
ORIGIN      
        1 aaccacgccc ccggagcgcc ttggctggcg cccggaaaac catgatgtgg agaacttgga
       61 tgttgtcttg tttctctagc aacggtctca ggagcagatg gccgcccagc gatttgtctg
      121 actgtgttgg ggctgggcca cttgtctcca actcataagg gcttgcagcc cagttgaccc
      181 gatgtttcat ggaacagtca cagaagagct aaccagtcat gaagaatgga gtcactataa
      241 tgaaaacata agagaaggtc aaaaagattt tgtttttgtg aagttcaatg gccttcattt
      301 aaagtctatg gaaaatttgc agtcttgcat ctctcttaga gtatgcatct tctcaaacaa
      361 ttttattaca gatattcatc cacttcaaag ttgtataaaa ttaatcaaac ttgatctcca
      421 tggaaatcag ataaagagtc taccaaatac caaattttgg aatggattga agaacctaaa
      481 actactctat cttcatgaca atgggtttgc aaagttaaag aatatatgtg tattatctgc
      541 ctgtccaacc ctcattgccc tcactatgtt tgattgtcca gtaagcctta aaaaaggata
      601 tagacatgtt cttgttaaca gtatatggcc tctcaaagcg ctggatcatc atgtgatttc
      661 tgatgaagaa ataattcaga actggcatct tcctgaaaga ttcaaagcat gtaaccatcg
      721 acttttcttt aatttctgcc cagctttgag aaagggaaca acctatgaag aggaaattaa
      781 taatattaaa catattactt caaaaattaa tgcaattctg gctcataatt caccagtttt
      841 gattgttcaa agatggatac gtggtttctt agttagaaaa aatttgagcc ctgtgttttt
      901 ccacaaaaaa aaacagcagg aaaaaattat tagaggatat gaagcaaaat ggatttacat
      961 aaccaaaggg tatgaagata agctccttaa ggatctcttt ttcaaacctg aaactaatat
     1021 aaaaggaaag cttgcatatt ggaaacataa tatatattat cctgttgatt taaaaaattc
     1081 cagtgaacac agaaaacatg tgtcatctat tttatgtgaa ttaaaaccaa aagatctagg
     1141 catgaaatca aaaacatcaa gacatctcat tcaaaaaggt caggagtctg aagatgaaat
     1201 tgtggatgaa aaattggata ccagttttag gatatcagtt ttcaaactac ccatatacac
     1261 ttcaggttca ttgaagaata atgcagtatt gagagagaaa aaacaacatt tttttcctgc
     1321 atatcctcag ccaatctata ctactcatcc aaagccaatc attaaaaaag acatacgatt
     1381 ggagcggagt atgaaagagt tttttgcacc acaaagagct ggtatgaaac tccgaacatt
     1441 tagtgatatt gacaaatatt acacagaaca aaagaagcag gaataccata aagaaaaagt
     1501 aagagttgta gccatggcac aagttgctcg agaaagagtt agagtagctg ttaatgaaca
     1561 tttgaatcag aaaaaatatg ctacacaaaa actaattgaa gaaaataaag agacaattca
     1621 gaacagttta cgacaagttt ggcaaaacag attcaactac cttgaaaaag ctagagagag
     1681 aaaagctctg tttctaaaag aaaaatccca aaaggcttca gagcgtttat tagttcaaaa
     1741 cttaaataat gagcgcactc ttttgaccag aggactactt aaaattgaca gactggagaa
     1801 gaatgaggct gtcctaaaag agaaaagcct gattgttaag caaaaactaa aagcagaaaa
     1861 atatagaaag aatttactta aagaaatgaa aaaagttaga tctcaagaaa tatataaaag
     1921 acattgtgaa gaaaaatttg ttatggatat gattgccttt gaaaaagcct gtgaaagact
     1981 tcaagatgct aaaacaaaag tagcaattgt gaaaacaaat ttagacttta aagttcccaa
     2041 tggactgata aaatgaatca atgccagatc acatcctatg atcatcttaa attatagtca
     2101 ttatttttag ttgaaggaat ttgaaataat actctaaagc aagaaatact ctacatcaca
     2161 agatggattt atatataagt cttctaaaaa tataaagatt agttaaaatg tttctcttat
     2221 tggtcataat ttaacttaaa gttgacttag cacctctgaa aaatttctta gatcagatgc
     2281 ctaaggaaca attaaactga tttaatgtat tgcagacaat gttgcaatga cattgctgat
     2341 attctgtttc atattctttc taaatatagc aattcataag ctaatttagg tttttctgga
     2401 aaccttagaa tagtaatttc tactccaact gctgactttt attaagacac tgtgtacgtt
     2461 gatgactttt attacctgct tttatatatt tcctgcttat tttgttaaaa caatttctga
     2521 atttattttt taaagtatgg tttcaatatt ttgtcagtga tatatgctgt tataaaaatt
     2581 cagaaaatat gaactatgaa aagtaaatta aacattctta tcaccttcct tgaagactgt
     2641 aagatttttg tatatttact tttgatgggt ttgccctgtt tggtatacat gtgaagacag
     2701 ggaaaagaca gaggagagaa gcaagagaca acccatataa ttatatattg gaatcataaa
     2761 atatacagaa atggtatata ttaaccataa gtctgtttaa tacataccaa tggtagaaaa
     2821 tttgaaaaat aaactgttaa aaaagacaga aaaa
//
