LOCUS       NM_001079910            5414 bp    mRNA    linear   PRI 08-DEC-2024
DEFINITION  Homo sapiens leucine rich repeats and IQ motif containing 1
            (LRRIQ1), mRNA.
ACCESSION   NM_001079910 XM_001126298
VERSION     NM_001079910.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5414)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AU122206.2, DB447399.2, AB058704.1, AC079631.16, DN831755.1,
            CA502842.1, BU677204.1 and BU608190.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001079910.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: HM005424.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2144333
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000393217.7/ ENSP00000376910.2
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-166               AU122206.2         32-197
            167-547             DB447399.2         207-587
            548-974             AB058704.1         142-568
            975-975             AC079631.16        5196-5196
            976-2814            AB058704.1         570-2408
            2815-2815           AC079631.16        22454-22454
            2816-3638           AB058704.1         2410-3232
            3639-4406           DN831755.1         40-807
            4407-4695           CA502842.1         364-652
            4696-5186           BU677204.1         7-497               c
            5187-5414           BU608190.1         17-244              c
FEATURES             Location/Qualifiers
     source          1..5414
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q21.31"
     gene            1..5414
                     /gene="LRRIQ1"
                     /note="leucine rich repeats and IQ motif containing 1"
                     /db_xref="GeneID:84125"
                     /db_xref="HGNC:HGNC:25708"
                     /db_xref="MIM:620922"
     exon            1..57
                     /gene="LRRIQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            58..213
                     /gene="LRRIQ1"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..5250
                     /gene="LRRIQ1"
                     /note="leucine-rich repeat and IQ domain-containing
                     protein 1; testicular tissue protein Li 111"
                     /codon_start=1
                     /product="leucine-rich repeat- and IQ domain-containing
                     protein 1"
                     /protein_id="NP_001073379.1"
                     /db_xref="CCDS:CCDS41816.1"
                     /db_xref="GeneID:84125"
                     /db_xref="HGNC:HGNC:25708"
                     /db_xref="MIM:620922"
                     /translation="MDDDDAKLKAEIEAELDKLSISSLEKEDIESDAKSETQSDDSDT
                     DSVELPESVLHCINIIKNRSKAVEELILQDLEDTDILSCSYGAVSNNHMHLRTGLSTE
                     YEESSEQLIKILSEIEKEEFMRSKTDCATPDFVPEPSPHDLPMDEHVLPDDADINFGY
                     CEVEEKCRQSFEAWQEKQKELEDKEKQTLKAQRDREEKQFQEEEEKRHCWMKQFKVEK
                     KKLENIQKQEQDKMNDELYKEEKIWKEKFKQHEEYIRNLHLQMEEERTRFKDQQEKEK
                     NSLLKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEKEAKIRQKEEE
                     NRKRLEEEQRIKEERKKQKEEERKRREKEYEEKKNIVKQEREQLISKEKIILREDASQ
                     QLIISSALKKSGYNNKHLSLEDISNDKGDIAKNLVDENSKKQEDVLLWLVEESNMKEN
                     VDRQTILKESIQVKLKESISSQTILADFKMEEKNENLAKKRCSEELVKQERKYENTDN
                     KTELGNSDLKGNLKEQFPLQELKSDAQKEEKIMKHVINENTGQKTQIILGHNQEISEV
                     KTNEEQKIIKDNQQKKIQKVEKEEIQEQNGLLYKDKDTLVISVKQRSLSLTSENSKDV
                     RENVILQEKEIYSKSKEIEENPKDNAWNSGIVIFNTTDTMINIEGKRNDQDYVLGRHA
                     PCEGLSNYNAESSMVSKEVNSLKSEIRNISEKCHENAPEPDSMTCCVSESTLLYSIEE
                     RRLAWIKSFKPWLEIFKQNQQKKIVRRKRPVKCPANMTPALDKLEILRCGPWDTLQQV
                     TTVTFQDLPGCVLSTLAECTNLQFLSLRRCGLTSLHSLSNCKKLKYIDAQENHIEAIE
                     CENLENLCVVLLNKNQLTSLHGLDGCTNIQCLELSYNKITRIGYSFFLEEKLVDNAGF
                     CHHLGTSTSYLSLAQVWIPTGLCWSWIPITSLTKNSDCNFLISHLYWNCGLESLKNLQ
                     QLILDHNQLINTKGLCDTPTIVYLDCSHNHLTDVEGVENCGLLQILKLQGNYLSELPS
                     LENLVLLRELHLDDNSISTVEAFSSYWLPLLQNITISQNSLTKIVPLFHFVSLEKLDV
                     SHNCLSDLKSAIKWFDACYSLHELSLTGNPLLQETNWRDSLLKVLPALRILNGNILNS
                     NSESRTEEHNQLGSAGFLALCQSQIREFNLLIENYITGKGDVFTLDTAENLCHYFKKL
                     MILSTEYRHAHERGDVTITKKDESEAQKNHLAPTNSDSTLQNGVFYSCAREGEPDSPD
                     IPEKWMDSVSSHSPLSKSATCENMEGRHQEILVCQKREDSKASSIPTIRIPFKEVVMT
                     NSLLRNHQNIEPSEKIMAAVVIQSYWRGYLMRRQTHFSTRLHTAATEGLPNSSIKNQT
                     ILKKGKRENIVNIRKQREKAAILIQAVWKGFILRKKLTTALEAIKNEESDEEYREIDL
                     EDFIFDEAALEEEWLALDSTRFPSQTLLLSNQLHWPKIPGNLKWDDTSFNLPSNPAQA
                     WLCNDKENLSSSEHTQFNSRSENKTSSWTPESKTSRKSLLKSEKEKKISEEWGFKDIS
                     TAQQMLKRAQKMKSKKLKKKIDSTVRLALFKNNENKVSLPKSPKMVQPRRDGYFEGIE
                     EDPIHKDTTANEKLERNREYTYQWLHTQVGVHETTSSRNMKCNHFLPELDPDVLNGGR
                     VQLVARLVSREDTDLDLFSMTNGSALSVNREKKNQAHRHSAGSSSKLWFPSKLI"
     exon            214..325
                     /gene="LRRIQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            326..417
                     /gene="LRRIQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            418..535
                     /gene="LRRIQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            536..759
                     /gene="LRRIQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            760..834
                     /gene="LRRIQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            835..2472
                     /gene="LRRIQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            2473..2625
                     /gene="LRRIQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            2626..2776
                     /gene="LRRIQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            2777..2968
                     /gene="LRRIQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            2969..3162
                     /gene="LRRIQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            3163..3290
                     /gene="LRRIQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            3291..3364
                     /gene="LRRIQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            3365..3458
                     /gene="LRRIQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            3459..3638
                     /gene="LRRIQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            3639..4088
                     /gene="LRRIQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            4089..4290
                     /gene="LRRIQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            4291..4410
                     /gene="LRRIQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            4411..4500
                     /gene="LRRIQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            4501..4622
                     /gene="LRRIQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            4623..4718
                     /gene="LRRIQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            4719..4801
                     /gene="LRRIQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            4802..4903
                     /gene="LRRIQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            4904..5036
                     /gene="LRRIQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            5037..5097
                     /gene="LRRIQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            5098..5414
                     /gene="LRRIQ1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5393..5398
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRIQ1"
                     /note="hexamer: ATTAAA"
     polyA_site      5414
                     /gene="LRRIQ1"
                     /note="major polyA site"
ORIGIN      
        1 gtgtagcggc tatgggcgct gtcttacaac aaagccaagg aatctcgctg ctgagggttc
       61 tgtgctttat tatgaagaat aatggacgat gatgatgcaa agctcaaagc agaaatagaa
      121 gctgaattgg ataaactcag catttcctcc ttggaaaaag aagacattga gagtgatgca
      181 aaatcagaaa cccagagtga tgatagtgat acagattcag ttgaattacc agaatcagtt
      241 cttcactgta ttaacatcat aaagaacagg agtaaagctg ttgaagagct cattcttcag
      301 gacctggaag atactgatat tttaagctgt agttatggag cagtttctaa taatcatatg
      361 catttaagaa caggactatc aactgaatat gaagaaagtt cagagcaatt aattaagata
      421 ttatctgaaa tagaaaaaga agaatttatg agaagtaaaa ccgattgtgc cactcctgat
      481 tttgttcctg agcctagtcc tcatgacttg cctatggatg aacatgtttt accagatgat
      541 gctgatataa attttggata ctgtgaagtg gaagaaaaat gtagacagtc ttttgaggct
      601 tggcaagaga aacagaagga attagaagat aaagagaaac aaactctcaa agctcagagg
      661 gatagagaag aaaaacaatt tcaagaagaa gaagaaaagc gacattgctg gatgaaacaa
      721 tttaaagttg aaaagaagaa attagagaac attcagaagc aagaacagga caagatgaat
      781 gatgaactct ataaagaaga gaaaatttgg aaagagaaat ttaaacagca tgaggagtat
      841 attagaaact tgcatttaca aatggaagaa gaaagaacaa gatttaaaga ccaacaagaa
      901 aaagaaaaaa attctttgtt aaaacagcag aataatgcag ctgttaaaat tcaagctaaa
      961 tataaagcat ttgttgccta tcaaaaatat ggcccaatta ttaaagagca aattgaaagt
     1021 aagaaaagga aagcacaaga gtggaaggaa aaggaagcaa aaatacgaca aaaggaggaa
     1081 gaaaatcgaa aaagattaga ggaggaacaa aggataaaag aagagagaaa aaagcaaaag
     1141 gaagaggaaa ggaaaaggag agaaaaagaa tatgaagaaa aaaagaatat tgtgaaacag
     1201 gaaagagagc aactaataag caaggaaaaa ataatattaa gagaagatgc aagccaacag
     1261 ctaataataa gtagtgcatt aaagaagagc ggatataata acaaacattt aagtcttgaa
     1321 gatatttcaa atgataaggg tgatatagcc aaaaatctag tggatgaaaa ttcaaagaag
     1381 caggaagatg ttctcctttg gctagttgag gaatcaaata tgaaagaaaa tgtagataga
     1441 cagactatat taaaagaatc aatacaagta aagttaaaag aatctatatc aagccaaaca
     1501 attctggcag attttaaaat ggaagaaaaa aatgaaaacc tagcaaaaaa acgatgttca
     1561 gaagaattgg tcaagcaaga aagaaaatat gaaaatacag ataacaaaac tgaattggga
     1621 aactctgatc taaaaggaaa tctgaaagaa cagtttccat tgcaagaatt aaagtctgat
     1681 gcacaaaaag aagaaaaaat catgaaacat gtcataaatg agaatacagg acaaaaaacc
     1741 cagataatat taggacataa ccaagaaatc agtgaggtga aaaccaatga agagcagaaa
     1801 ataatcaaag ataatcagca gaaaaagata caaaaagtag aaaaagaaga gatacaagaa
     1861 cagaatggat tattatataa agataaggat actttagtta tttcagtgaa acaaagatca
     1921 ctctcactaa catcagaaaa ttccaaagat gtaagagaaa acgtaatatt acaagaaaaa
     1981 gaaatttatt caaaatccaa agaaattgag gagaacccaa aagacaatgc ttggaatagt
     2041 ggcattgtga tttttaacac aactgatacc atgataaata tagaaggcaa aagaaatgac
     2101 caagattatg tgttaggtag acatgctcct tgtgagggct tgagtaacta taatgcagaa
     2161 agctccatgg tatctaaaga agtcaactct cttaaatctg agattagaaa tatttcagaa
     2221 aaatgccatg aaaatgcacc tgaacctgat agcatgacct gctgtgtatc agagtcaacc
     2281 cttctatatt ctattgaaga aaggagacta gcctggataa aatcatttaa accttggctt
     2341 gaaattttca agcaaaatca acaaaagaaa attgttagaa gaaagagacc tgtgaaatgc
     2401 ccagccaaca tgacacccgc tttggataaa ctggaaattc ttcgatgtgg cccttgggat
     2461 actttacagc aggttacaac agttacattt caagatttgc caggctgtgt tctctccaca
     2521 ctggcagagt gtacaaatct tcagtttcta tcccttcgac gctgtggatt aacttctttg
     2581 cacagcctga gtaattgtaa aaaacttaag tacattgatg cacaggaaaa ccatattgag
     2641 gctattgagt gtgaaaattt ggaaaatctc tgtgttgttc ttcttaataa aaatcaactg
     2701 acttctcttc atggtttgga tggctgtact aatattcagt gtcttgaact ttcatataat
     2761 aaaattactc gaattggata ttccttcttt ctggaagaaa aacttgttga caatgcaggg
     2821 ttctgccatc acttgggcac ctccacttct tacttatccc tggcacaagt ctggattcca
     2881 actggattat gttggtcctg gatacctatt acctcactta caaaaaattc agattgtaat
     2941 ttccttatct cccacttata ctggaattgt ggtttagaat ctttgaaaaa tcttcaacaa
     3001 ctaattttgg accacaatca gttaattaat acaaaaggtc tttgtgatac acctaccatt
     3061 gtatacctag attgctccca taatcatctt actgatgtag agggcgttga aaattgtgga
     3121 ttgctccaaa tattgaagtt acagggaaat tatctgagtg agcttccatc cttggagaat
     3181 cttgttttac taagagaatt gcacttggat gataacagca tttcaactgt ggaagcattt
     3241 tcttcatact ggctgccttt actacaaaat attactatct ctcaaaacag cttgactaaa
     3301 atcgtaccac tttttcattt tgtttcattg gaaaagctag atgtcagcca caattgtctt
     3361 tctgatctta aaagtgccat aaaatggttt gatgcatgct attctctcca tgaattgtct
     3421 cttactggaa acccacttct tcaagaaaca aactggaggg attctctact taaagtgttg
     3481 cctgctctga gaatcctcaa tggcaatata ctaaactcta attcagaaag ccgcactgaa
     3541 gaacacaatc aactgggatc agcaggtttc ctggcacttt gtcagtctca gattcgagaa
     3601 ttcaacttgc taattgaaaa ttatataact ggaaaaggag atgtatttac cttggatact
     3661 gcagaaaatc tctgtcatta ttttaagaaa ttgatgatac ttagtactga ataccgacat
     3721 gcacacgaac gaggggatgt aactatcacc aagaaagatg aatcagaagc ccagaaaaat
     3781 catttggccc ctacaaacag tgacagcact ctgcaaaatg gagtcttcta ctcttgtgca
     3841 cgtgaaggtg agccagactc accagatatt cctgagaaat ggatggactc tgtctccagc
     3901 cactccccat taagcaaatc cgccacatgt gaaaatatgg aaggaagaca tcaggaaata
     3961 ttagtatgtc agaagagaga agacagcaag gcaagcagta ttcccaccat aagaatccca
     4021 tttaaggaag tagtaatgac aaattctttg ctgaggaatc accaaaatat tgagcctagt
     4081 gaaaaaatta tggcagctgt ggtaatccag tcatactggc gtggttacct catgcgcaga
     4141 cagactcatt tctccacaag gctacatact gctgcaacag aaggcctgcc aaattcttcc
     4201 atcaagaatc agactatttt aaagaaagga aaaagagaaa atattgtgaa tatccgaaaa
     4261 cagagggaga aggctgctat tcttattcag gcagtttgga agggctttat tttgcgaaag
     4321 aaactgacaa cagctctaga ggctattaag aatgaagaat ccgatgaaga atacagagaa
     4381 atagatttag aggattttat atttgatgaa gctgccttag aagaagaatg gctagcatta
     4441 gattccaccc gcttcccttc acaaacactg cttctttcaa accagctgca ttggccaaag
     4501 attcctggaa acttaaaatg ggatgatact tcatttaatt taccaagtaa tccagctcaa
     4561 gcatggttat gtaatgacaa agaaaatttg tcttcttcag aacacacaca atttaatagc
     4621 agatcagaaa ataaaacttc ttcctggaca cctgaatcaa agaccagtag aaagagtttg
     4681 ctaaaatctg aaaaagaaaa aaaaatttca gaagaatggg gctttaagga tatttctact
     4741 gctcagcaaa tgttgaagag ggcacagaaa atgaaatcga agaaactaaa gaaaaaaata
     4801 gattccactg tgcgtctagc cttattcaaa aacaatgaaa ataaagtgtc tcttccaaaa
     4861 tcaccaaaga tggtacagcc cagaagagat ggttactttg aaggtataga agaagaccct
     4921 atccacaaag ataccactgc aaatgaaaaa ttagaacgga atagagaata tacataccaa
     4981 tggcttcaca cacaggttgg ggttcatgaa acgactagtt ccagaaatat gaaatgcaat
     5041 cactttttgc ctgagttaga tccagatgta cttaatggtg gaagagttca gcttgtggca
     5101 agacttgtaa gcagagaaga cacggattta gacctttttt ccatgaccaa tggaagtgct
     5161 ttgtctgtga acagagaaaa aaaaaatcag gcacacagac actcagcagg atcttcaagt
     5221 aagttgtggt ttccttcaaa attaatttag aaatcacaaa cgaattgatg gaacctaatg
     5281 ccaacaagca ttctttttca gatagggggt aggatgccag caacctgaac tgcccaaaaa
     5341 tgtgtattta aattttttct ttctttaaat atcctctttt gatataaaca aaattaaatt
     5401 atttctaaaa ttaa
//
