LOCUS       NM_001137550            4092 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens LRR binding FLII interacting protein 1 (LRRFIP1),
            transcript variant 1, mRNA.
ACCESSION   NM_001137550
VERSION     NM_001137550.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4092)
  AUTHORS   Ma,W., Bao,Z., Qian,Z., Zhang,K., Fan,W., Xu,J., Ren,C., Zhang,Y.
            and Jiang,T.
  TITLE     LRRFIP1, an epigenetically regulated gene, is a prognostic
            biomarker and predicts malignant phenotypes of glioma
  JOURNAL   CNS Neurosci Ther 28 (6), 873-883 (2022)
   PUBMED   35338570
  REMARK    GeneRIF: LRRFIP1, an epigenetically regulated gene, is a prognostic
            biomarker and predicts malignant phenotypes of glioma.
REFERENCE   2  (bases 1 to 4092)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 4092)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 4092)
  AUTHORS   Takimoto,M.
  TITLE     Multidisciplinary Roles of LRRFIP1/GCF2 in Human Biological Systems
            and Diseases
  JOURNAL   Cells 8 (2), 108 (2019)
   PUBMED   30709060
  REMARK    GeneRIF: LRRFIP1/GCF2 is a bioregulator in multidisciplinary
            systems of the human body and its dysregulation can cause diverse
            human diseases.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4092)
  AUTHORS   Kopecki,Z., Stevens,N.E., Yang,G.N., Melville,E. and Cowin,A.J.
  TITLE     Recombinant Leucine-Rich Repeat Flightless-Interacting Protein-1
            Improves Healing of Acute Wounds through Its Effects on
            Proliferation Inflammation and Collagen Deposition
  JOURNAL   Int J Mol Sci 19 (7), 2014 (2018)
   PUBMED   29996558
  REMARK    GeneRIF: Results show that LRRFIP-1 is mainly produced by
            keratinocytes in the unwounded skin but is upregulated in both
            keratinocytes and fibroblasts in response to wounding, suggesting a
            role in the wound repair process.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4092)
  AUTHORS   Khachigian,L.M., Santiago,F.S., Rafty,L.A., Chan,O.L.,
            Delbridge,G.J., Bobik,A., Collins,T. and Johnson,A.C.
  TITLE     GC factor 2 represses platelet-derived growth factor A-chain gene
            transcription and is itself induced by arterial injury
  JOURNAL   Circ Res 84 (11), 1258-1267 (1999)
   PUBMED   10364563
REFERENCE   7  (bases 1 to 4092)
  AUTHORS   Fong,K.S. and de Couet,H.G.
  TITLE     Novel proteins interacting with the leucine-rich repeat domain of
            human flightless-I identified by the yeast two-hybrid system
  JOURNAL   Genomics 58 (2), 146-157 (1999)
   PUBMED   10366446
REFERENCE   8  (bases 1 to 4092)
  AUTHORS   Reed,A.L., Yamazaki,H., Kaufman,J.D., Rubinstein,Y., Murphy,B. and
            Johnson,A.C.
  TITLE     Molecular cloning and characterization of a transcription regulator
            with homology to GC-binding factor
  JOURNAL   J Biol Chem 273 (34), 21594-21602 (1998)
   PUBMED   9705290
REFERENCE   9  (bases 1 to 4092)
  AUTHORS   Wilson,S.A., Brown,E.C., Kingsman,A.J. and Kingsman,S.M.
  TITLE     TRIP: a novel double stranded RNA binding protein which interacts
            with the leucine rich repeat of flightless I
  JOURNAL   Nucleic Acids Res 26 (15), 3460-3467 (1998)
   PUBMED   9671805
REFERENCE   10 (bases 1 to 4092)
  AUTHORS   Liu,Y.T. and Yin,H.L.
  TITLE     Identification of the binding partners for flightless I, A novel
            protein bridging the leucine-rich repeat and the gelsolin
            superfamilies
  JOURNAL   J Biol Chem 273 (14), 7920-7927 (1998)
   PUBMED   9525888
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG699031.1, AF115510.1, AC012076.5 and AA975133.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001137550.1.
            
            Transcript Variant: This variant (1) differs in the 5' and 3' UTRs,
            and has multiple coding region differences, compared to variant 3.
            The resulting isoform (1) has a longer and distinct N-terminus,
            three additional internal segments and a shorter and distinct
            C-terminus, compared to isoform 3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF115510.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2151741, SAMEA2159607
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000308482.14/ ENSP00000310109.9
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-125               BG699031.1         17-141
            126-1936            AF115510.1         1-1811
            1937-4004           AC012076.5         101209-103276
            4005-4092           AA975133.1         12-99               c
FEATURES             Location/Qualifiers
     source          1..4092
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q37.3"
     gene            1..4092
                     /gene="LRRFIP1"
                     /gene_synonym="FLAP-1; FLAP1; FLIIAP1; GCF-2; GCF2;
                     HUFI-1; TRIP"
                     /note="LRR binding FLII interacting protein 1"
                     /db_xref="GeneID:9208"
                     /db_xref="HGNC:HGNC:6702"
                     /db_xref="MIM:603256"
     exon            1..154
                     /gene="LRRFIP1"
                     /gene_synonym="FLAP-1; FLAP1; FLIIAP1; GCF-2; GCF2;
                     HUFI-1; TRIP"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..1981
                     /gene="LRRFIP1"
                     /gene_synonym="FLAP-1; FLAP1; FLIIAP1; GCF-2; GCF2;
                     HUFI-1; TRIP"
                     /note="isoform 1 is encoded by transcript variant 1;
                     GC-binding factor 2; leucine-rich repeat
                     flightless-interacting protein 1; TAR RNA-interacting
                     protein; LRR FLII-interacting protein 1; NEDD8-conjugating
                     enzyme; leucine rich repeat (in FLII) interacting protein
                     1"
                     /codon_start=1
                     /product="leucine-rich repeat flightless-interacting
                     protein 1 isoform 1"
                     /protein_id="NP_001131022.1"
                     /db_xref="CCDS:CCDS46551.1"
                     /db_xref="GeneID:9208"
                     /db_xref="HGNC:HGNC:6702"
                     /db_xref="MIM:603256"
                     /translation="MDMGTQGSGRKRLPNRERLTAEDDALNQIAREAEARLAAKRAAR
                     AEAREIRMKELERQQKEIYQVQKKYYGLDTKWGDIEQWMEDSERYSRRSRRNTSASDE
                     DERMSVGSRGSLRSQPDLEYGGPYAWTNGYDGELYGSQSLNRRSGRPSCLYSAARPSG
                     SYRASVLDEGSFGGTRRGSTSGSRAPSEYSGHLNSSSRASSRASSARASPVVEERPEK
                     DFTEKGSRNMPGLSAATLASLGGTSSRRGSGDTSISIDTEASIREIKELNELKDQIQD
                     VEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDTLKDMLLELEEQL
                     AESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREEMLEEIRQLQQKQASSIRE
                     ISDLQETIEWKDKKIGALERQKEFFDSVRSERDDLREEVVMLKEELKKHGIILNSEIA
                     TNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLDIRLKKLVDERECLLEQIKKLK
                     GQLEERQKIGKLDNLRSEDDVLENGTDMHVMDLQRDANRQISDLKFKLAKSEQEITAL
                     EQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQRELRSALDKTEELEVSNGHLVK
                     RLEKMKANRSALLSQQ"
     exon            155..241
                     /gene="LRRFIP1"
                     /gene_synonym="FLAP-1; FLAP1; FLIIAP1; GCF-2; GCF2;
                     HUFI-1; TRIP"
                     /inference="alignment:Splign:2.1.0"
     exon            242..259
                     /gene="LRRFIP1"
                     /gene_synonym="FLAP-1; FLAP1; FLIIAP1; GCF-2; GCF2;
                     HUFI-1; TRIP"
                     /inference="alignment:Splign:2.1.0"
     exon            260..307
                     /gene="LRRFIP1"
                     /gene_synonym="FLAP-1; FLAP1; FLIIAP1; GCF-2; GCF2;
                     HUFI-1; TRIP"
                     /inference="alignment:Splign:2.1.0"
     exon            308..352
                     /gene="LRRFIP1"
                     /gene_synonym="FLAP-1; FLAP1; FLIIAP1; GCF-2; GCF2;
                     HUFI-1; TRIP"
                     /inference="alignment:Splign:2.1.0"
     exon            353..403
                     /gene="LRRFIP1"
                     /gene_synonym="FLAP-1; FLAP1; FLIIAP1; GCF-2; GCF2;
                     HUFI-1; TRIP"
                     /inference="alignment:Splign:2.1.0"
     exon            404..442
                     /gene="LRRFIP1"
                     /gene_synonym="FLAP-1; FLAP1; FLIIAP1; GCF-2; GCF2;
                     HUFI-1; TRIP"
                     /inference="alignment:Splign:2.1.0"
     exon            443..502
                     /gene="LRRFIP1"
                     /gene_synonym="FLAP-1; FLAP1; FLIIAP1; GCF-2; GCF2;
                     HUFI-1; TRIP"
                     /inference="alignment:Splign:2.1.0"
     exon            503..547
                     /gene="LRRFIP1"
                     /gene_synonym="FLAP-1; FLAP1; FLIIAP1; GCF-2; GCF2;
                     HUFI-1; TRIP"
                     /inference="alignment:Splign:2.1.0"
     exon            548..613
                     /gene="LRRFIP1"
                     /gene_synonym="FLAP-1; FLAP1; FLIIAP1; GCF-2; GCF2;
                     HUFI-1; TRIP"
                     /inference="alignment:Splign:2.1.0"
     exon            614..691
                     /gene="LRRFIP1"
                     /gene_synonym="FLAP-1; FLAP1; FLIIAP1; GCF-2; GCF2;
                     HUFI-1; TRIP"
                     /inference="alignment:Splign:2.1.0"
     exon            692..727
                     /gene="LRRFIP1"
                     /gene_synonym="FLAP-1; FLAP1; FLIIAP1; GCF-2; GCF2;
                     HUFI-1; TRIP"
                     /inference="alignment:Splign:2.1.0"
     exon            728..853
                     /gene="LRRFIP1"
                     /gene_synonym="FLAP-1; FLAP1; FLIIAP1; GCF-2; GCF2;
                     HUFI-1; TRIP"
                     /inference="alignment:Splign:2.1.0"
     exon            854..925
                     /gene="LRRFIP1"
                     /gene_synonym="FLAP-1; FLAP1; FLIIAP1; GCF-2; GCF2;
                     HUFI-1; TRIP"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1096
                     /gene="LRRFIP1"
                     /gene_synonym="FLAP-1; FLAP1; FLIIAP1; GCF-2; GCF2;
                     HUFI-1; TRIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1189
                     /gene="LRRFIP1"
                     /gene_synonym="FLAP-1; FLAP1; FLIIAP1; GCF-2; GCF2;
                     HUFI-1; TRIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1282
                     /gene="LRRFIP1"
                     /gene_synonym="FLAP-1; FLAP1; FLIIAP1; GCF-2; GCF2;
                     HUFI-1; TRIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1375
                     /gene="LRRFIP1"
                     /gene_synonym="FLAP-1; FLAP1; FLIIAP1; GCF-2; GCF2;
                     HUFI-1; TRIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1517
                     /gene="LRRFIP1"
                     /gene_synonym="FLAP-1; FLAP1; FLIIAP1; GCF-2; GCF2;
                     HUFI-1; TRIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..1567
                     /gene="LRRFIP1"
                     /gene_synonym="FLAP-1; FLAP1; FLIIAP1; GCF-2; GCF2;
                     HUFI-1; TRIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..1685
                     /gene="LRRFIP1"
                     /gene_synonym="FLAP-1; FLAP1; FLIIAP1; GCF-2; GCF2;
                     HUFI-1; TRIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..1765
                     /gene="LRRFIP1"
                     /gene_synonym="FLAP-1; FLAP1; FLIIAP1; GCF-2; GCF2;
                     HUFI-1; TRIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1766..1870
                     /gene="LRRFIP1"
                     /gene_synonym="FLAP-1; FLAP1; FLIIAP1; GCF-2; GCF2;
                     HUFI-1; TRIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1871..4092
                     /gene="LRRFIP1"
                     /gene_synonym="FLAP-1; FLAP1; FLIIAP1; GCF-2; GCF2;
                     HUFI-1; TRIP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2737..2742
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRFIP1"
                     /gene_synonym="FLAP-1; FLAP1; FLIIAP1; GCF-2; GCF2;
                     HUFI-1; TRIP"
                     /note="hexamer: ATTAAA"
     polyA_site      2737
                     /gene="LRRFIP1"
                     /gene_synonym="FLAP-1; FLAP1; FLIIAP1; GCF-2; GCF2;
                     HUFI-1; TRIP"
                     /note="major polyA site"
     polyA_site      2764
                     /gene="LRRFIP1"
                     /gene_synonym="FLAP-1; FLAP1; FLIIAP1; GCF-2; GCF2;
                     HUFI-1; TRIP"
                     /note="major polyA site"
     regulatory      2989..2994
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRFIP1"
                     /gene_synonym="FLAP-1; FLAP1; FLIIAP1; GCF-2; GCF2;
                     HUFI-1; TRIP"
                     /note="hexamer: AGTAAA"
     polyA_site      3014
                     /gene="LRRFIP1"
                     /gene_synonym="FLAP-1; FLAP1; FLIIAP1; GCF-2; GCF2;
                     HUFI-1; TRIP"
     regulatory      4068..4073
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRFIP1"
                     /gene_synonym="FLAP-1; FLAP1; FLIIAP1; GCF-2; GCF2;
                     HUFI-1; TRIP"
                     /note="hexamer: AATAAA"
     polyA_site      4092
                     /gene="LRRFIP1"
                     /gene_synonym="FLAP-1; FLAP1; FLIIAP1; GCF-2; GCF2;
                     HUFI-1; TRIP"
ORIGIN      
        1 ggggcggcgc gagcggctgg agcaacgggc cccgcggcag ctgcgggcga cgcggtcgat
       61 ggacatgggc acccagggat cggggcgcaa gcggctcccc aaccgggagc ggctcacggc
      121 ggaggacgac gcgctcaacc agatcgcgcg ggaggcggaa gcccggctcg ctgcaaaacg
      181 ggcggcccgc gcggaggctc gcgagatccg catgaaggag ctggagcggc agcagaagga
      241 gatctatcag gtccaaaaga aatattatgg gctggataca aaatggggtg acatcgagca
      301 gtggatggaa gacagtgagc gctactctcg tagatccaga agaaacacat cggcttctga
      361 tgaagacgag cgcatgtcag tgggtagtcg tggaagcctg aggtcgcagc ctgacttgga
      421 gtatgggggt ccttacgcct ggacaaatgg ttatgatgga gaattgtatg gatcacagtc
      481 cctgaataga agatctggca ggccctcctg tctgtacagc gctgcccggc cttcggggag
      541 ttaccgggcg tctgtgttgg atgaaggcag cttcggtggg acccgacggg gcagcacctc
      601 cggctcccgt gctccctcgg agtacagcgg ccacctcaac tccagctccc gcgcctcctc
      661 cagggccagc tcggcccggg ccagccctgt ggtagaagag agaccagaaa aagattttac
      721 tgagaagggg tctcgtaaca tgccgggcct gtctgcagcc acgctggcct ctctgggtgg
      781 gacttcctct cggagaggca gcggagacac ctccatctcc atcgacaccg aggcatccat
      841 cagggaaatc aaggaactca atgagttaaa ggaccagatt caggatgtag aaggcaaata
      901 catgcaggga ttgaaagaga tgaaggactc tctagcagaa gttgaagaga aatataagaa
      961 ggctatggtt tccaatgctc agctagacaa tgaaaagaca aacttcatgt accaggttga
     1021 taccctaaaa gatatgttgc tggagcttga agaacagctg gctgaatcta ggcggcagta
     1081 cgaagagaaa aacaaagaat ttgaaaggga aaaacacgcc cacagtatac tgcaatttca
     1141 gtttgctgaa gtcaaggagg ccctgaagca aagagaggaa atgctcgagg aaatccgaca
     1201 gctacagcag aaacaggcga gttctatcag ggagatttct gatcttcagg aaacaataga
     1261 gtggaaagac aaaaagatag gggcattaga gaggcagaaa gagttctttg attccgtaag
     1321 gagtgaacgg gatgatctta gagaagaagt agtcatgctg aaagaggaat taaagaaaca
     1381 tggaataatc ctaaattcag aaatagctac caatggagag acttccgaca ccctcaataa
     1441 tgttggatac caaggtccta ccaagatgac aaaagaagag ttaaatgccc tcaagtcgac
     1501 aggggatggg accctagata ttaggttgaa aaagctggtt gatgaacggg aatgcttatt
     1561 ggaacagatt aagaaactca aagggcagct ggaggagaga cagaagattg gcaaactaga
     1621 caatcttcga tctgaagatg atgtcttgga aaacgggaca gacatgcatg taatggacct
     1681 acaaagggat gccaacagac agatcagcga cctcaaattt aaacttgcaa aatctgagca
     1741 agagataact gcattagaac aaaatgtaat aaggttagag agtcaagtat cacgttacaa
     1801 atcagcggct gaaaatgcag aaaaaataga agatgaactt aaggcagaaa aacggaaact
     1861 ccaaagagag ctccgctctg cattggataa aacagaagag ctcgaggtga gcaacggcca
     1921 cttagtgaag cgtctggaaa aaatgaaagc aaatcggagt gcactcttgt cccagcagta
     1981 aattccagct ctgatcaggc aactggttgg tgactggaga gcattgtttc ataggctttt
     2041 ctctgtccta tctgggagcg ctgcttcttc ccctgccttc cgagagacga agaccgtggc
     2101 gagcttggcg cttaggggct cccgtgccat ggctcacccc agggagcccc agcagccacc
     2161 aggtgcctct gtctgcagac ccctggcccg ggctggcgcc gacgctcaga acctgcaggt
     2221 acttcataag cacacagggg cctcgaggga gctctgtgtc tgaccgcaca gcagcctctg
     2281 aatgccgctg gaagtgatga tcaaagtaaa gattcagttg ggacttgagt tttttttttt
     2341 tttcatgtgt cttgctgaag attaagggga aatgttacag tgttgggact tcctttcatg
     2401 gcagaatcta caatttgagc gacttcagta gtatctctta gtctacgctt ttcatacaca
     2461 aaacactgtg gaaccacaag ccattaccaa gcaaaactct ttcactggaa acaagggggc
     2521 agtctagaag taaaagtgac cttaagaaga ctctttacag gcaacaaatg aagcttttct
     2581 aagggatttt tgcatcagtt cagtcataag aatacttttt tccagggtaa ttaggcaata
     2641 gcttcactga aaatgacagc ttttcattgc attatttaat ccttatattt ggaattgaag
     2701 tcgttaactt cttttaaaga atgtactatt agaaaaatta aaaatgaaat gttgagagac
     2761 ttcagcaatg tggttctaat ttttttccac tgagaaagaa gatctttaat ttcatattaa
     2821 tggttctgta tattttgggt catcttttta ttttttaaga atatcaagtc aattcatttt
     2881 tctttcccta tttaaaaaaa aaggtgtttt cacagaatga gtgcacttaa aaagtgaagt
     2941 gaaggaggag gtaacagtag agacgatggc aatatcatca aggacaaaag taaaaacgtt
     3001 tagctacctg ctgattttta gtgactgttc atatatgttg tatttcaagt atggctggtg
     3061 aagccagtca gcttttcggg acgttagcaa gtggaaactg agtcagtatc atccaaaacc
     3121 atatctagtc ttaacacatg gagaatgctg gagtgagggt tgtgagttca gggtatataa
     3181 tcaagaaaac actcccagca taatgctagg ggtcaccagt gtccatcccc cagaactgta
     3241 tggatctagg atatacacag ctgcgttgca ttaagaaaga gatgaaatct ctattaaaat
     3301 acacaagatt tttgtatctc cttgtgcaga ggatatttgc cactgcccat tgggaagcag
     3361 acaagttata gggggctggg ggccaacact ggcaagtagg aaaccacggg tcggacaggt
     3421 gagcaaaatg tgctggcagg tgggcaccac tgggagaccc acactgcaca cccgggcacc
     3481 gtatgaacag gaaagaggaa ggaagctgga cgaagcccct cagggaccct gtgctgacca
     3541 tgctgggccc accggcaaaa gggagatatt cagttccttg tctcatcctt aaggtttctt
     3601 ccacaacatc tgaatacaag catgtttaac tgggaaaatg tctatgtcat gcgtgaataa
     3661 caccagcagc aaacactcac acatcacgca gacacggccg gcagcatgct gacgctttta
     3721 ggtatttttc actcatgcaa ttttcacata ttttcactca tttcatttgc acggaaattc
     3781 tatgaggtag atgctgttat caaatccaca ttacagatga gggacccagg gtccaggaag
     3841 gtgaactggc agaagtctcc cagctggtag aacagggctg caaggcatcg attcccaggt
     3901 gtctcacagc cctgagaaga tggcgttttc cctatcagtg gctctgagga agtcaagcct
     3961 tcagtctcta cctctcccac caattctttt ggaaacagca aaccaatgtt acacacactt
     4021 cctaatccag aggaagctag aacacgattt ttaaatttat ttagtaaaat aaaacttttt
     4081 ttgcagatgt aa
//
