LOCUS       NM_001161528            2839 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens leucine rich repeats and death domain containing 1
            (LRRD1), transcript variant 1, mRNA.
ACCESSION   NM_001161528 XM_001717179 XM_001723422 XM_001723440 XM_001723454
            XM_001723463 XM_001724142 XM_001724160 XM_002344370
VERSION     NM_001161528.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2839)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC000120.1.
            
            On Jul 1, 2020 this sequence version replaced NM_001161528.1.
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1968968, SAMEA2142586
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000458448.6/ ENSP00000405987.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-136               AC000120.1         70644-70779         c
            137-2127            AC000120.1         54923-56913         c
            2128-2326           AC000120.1         50642-50840         c
            2327-2488           AC000120.1         42171-42332         c
            2489-2606           AC000120.1         37720-37837         c
            2607-2839           AC000120.1         36479-36711         c
FEATURES             Location/Qualifiers
     source          1..2839
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q21.2"
     gene            1..2839
                     /gene="LRRD1"
                     /note="leucine rich repeats and death domain containing 1"
                     /db_xref="GeneID:401387"
                     /db_xref="HGNC:HGNC:34300"
     exon            1..136
                     /gene="LRRD1"
                     /inference="alignment:Splign:2.1.0"
     exon            137..2127
                     /gene="LRRD1"
                     /inference="alignment:Splign:2.1.0"
     CDS             211..2793
                     /gene="LRRD1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     leucine-rich repeat and death domain-containing protein
                     LOC401387; leucine-rich repeat and death domain-containing
                     protein 1"
                     /codon_start=1
                     /product="leucine-rich repeat and death domain-containing
                     protein 1 isoform 1"
                     /protein_id="NP_001155000.1"
                     /db_xref="CCDS:CCDS55124.1"
                     /db_xref="GeneID:401387"
                     /db_xref="HGNC:HGNC:34300"
                     /translation="MSEKEGMSEVLEDTISQFRKESRSQSMKEPGFIKETSNLINEAS
                     DYLEGKSSNQIYETHPRQNTLESTSSSGRKSKRNEEQKKNLQFSETSTRTGTSQSLSS
                     LTGRTAEYQALVNFLSHETVGEVSPQVSEENQKQLGLGADNFTVNLEAKGLQEFPKDI
                     LKIKYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLSSLPSEIQLLHNLRILNV
                     SHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSLGKNKLRHIPDTL
                     PSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELKNLETLLMD
                     HNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKIS
                     CCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSG
                     NIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISF
                     SKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCN
                     KFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQL
                     QSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNLVSLHAY
                     NNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPPVEIC
                     KGKQLYTIARYLQRADERDEKILEKIFKIVANNITETNFEFLCQKLNLANSETDMPTK
                     STVSLSERAHQALVIWKTQSNKLSLTAAALRDQLIRALTMIGAYEIMDKITALNLFTR
                     AIKF"
     exon            2128..2326
                     /gene="LRRD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2327..2488
                     /gene="LRRD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2489..2606
                     /gene="LRRD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2607..2839
                     /gene="LRRD1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2807..2812
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRD1"
                     /note="hexamer: AATAAA"
     polyA_site      2839
                     /gene="LRRD1"
                     /note="major polyA site"
ORIGIN      
        1 gggaaagagg agccacggcc cggagaggcg tcagtgctgg gctgcgcctg cggaggtcct
       61 cgcaattgct ggactcaacc gcgcgcgccc cctaccggtc ctgcgaagga gccgcagccg
      121 ccgcgggagg ccacagattc aaaggaaaaa acatgaaaat taaaatcaag ttacaatttt
      181 gtattggcat aaaacatatc agcaaataag atgtctgaaa aggagggtat gtcagaagtg
      241 ctagaggata ctattagtca atttaggaaa gaatctagat cacagtcaat gaaggagcct
      301 ggctttatta aagaaacatc aaatttgata aacgaagctt ctgattacct ggaagggaaa
      361 tcttctaacc agatttatga aacacatcct agacagaata cattagagtc aacatcttcc
      421 tctggaagga agtctaagag aaatgaagaa caaaagaaaa atcttcaatt ttctgaaaca
      481 agcactagaa caggaacttc acagagttta tcatcactaa ctgggaggac tgcagaatat
      541 caggctttgg ttaacttcct atctcatgaa acagtaggag aagttagtcc acaagtctct
      601 gaagaaaatc agaaacaact tggcctaggg gcagataact ttacagttaa ccttgaggcc
      661 aagggtttac aggaatttcc taaggacatt ttaaaaatca aatatgtaaa atatctatat
      721 ttagacaaga atcaaatcaa aacatttcaa ggggcagact caggtgatct gttaggactt
      781 gaaattctat ccctgcaaga aaatggatta tcatcacttc catctgaaat tcagttactt
      841 cataatttaa ggatattaaa tgtcagtcat aaccacatat cacatatacc taaagaaata
      901 tctcagcttg ggaatatcag acaactcttt ttttataaca attacattga aaattttcct
      961 tctgacttag aatgtcttgg aaacttggaa attttaagtt tgggtaaaaa taagttaaga
     1021 catataccag atactctgcc tagtttaaaa accttgaggg ttctcaattt ggaatataat
     1081 cagttaacaa catttcctaa agctctctgc ttccttccaa agttaatttc actagacctt
     1141 actggaaacc taataagcag tttgccaaaa gaaattagag agcttaaaaa tttagaaaca
     1201 cttttaatgg atcacaataa gcttaccttt ctggctgtag aaatttttca gttactcaaa
     1261 ataaaagaac tccaactggc cgacaataaa ttggaagtta tttcacacaa aattgagaat
     1321 ttcagggaac ttaggattct tatacttgat aaaaatttat tgaaaaatat accagagaaa
     1381 atatcttgct gtgcaatgtt ggaatgcctt agtcttagtg ataataaatt aacagaactc
     1441 cctaagtaca tccataagct taacaattta agaaaactcc atgtaaacag aaataatatg
     1501 gtaaaaataa ctgactgtat ctcacatctt aataacatat gcagtctaga attttcagga
     1561 aacataatca cagatgttcc cattgaaata aaaaactgcc aaaaaataat taaaattgaa
     1621 ttgagttata acaaaataat gtattttcca ttgggactgt gtgctttaga ttctctttat
     1681 tatttgagtg ttaatggaaa ttatatttca gaaatacctg tggatatatc tttcagtaaa
     1741 caactgcttc atttagaatt gagtgaaaac aaactcctca tattttctga gcacttttgt
     1801 tctcttatta atcttaaata cctggatctt ggtaaaaacc aaataaagaa aattccagca
     1861 tcaatttcta atatgatatc actccacgta cttattttat gctgtaataa atttgaaact
     1921 ttccctagag aattgtgtac tttagaaaat ttgcaagtac ttgatctttc ggaaaaccaa
     1981 ttacagaaaa tctcttcaga catctgtaat ttaaaaggaa tccagaaatt aaacttctca
     2041 agcaatcaat ttatacattt tcctattgaa ctgtgccaac ttcaatcact ggaacagctg
     2101 aatataagtc agataaaagg gagaaagcta acaagacttc caggagagct atctaatatg
     2161 actcaactta aagaacttga tatctcaaat aatgcaatca gagagattcc aagaaatata
     2221 ggagaattga gaaatttggt tagtttacat gcatacaata atcaaataag ttatcttcca
     2281 ccatctttgc tatctttaaa tgatctgcag caactaaacc tgagtggaaa taatctgaca
     2341 gctctaccta gtgctatcta caatattttt tcactgaagg agataaattt tgatgacaac
     2401 cctttgctga gacctccagt ggaaatctgt aaaggaaaac agttgtatac tattgcacgc
     2461 tatctacaga gggcagatga aagagatgag aaaattttag agaagatatt caagatagtt
     2521 gccaacaaca tcactgaaac caattttgaa tttttatgtc aaaaactaaa cctggcaaac
     2581 tcagaaactg atatgcctac aaagagcact gtttcattaa gtgagagagc ccaccaagca
     2641 cttgttatat ggaaaacaca aagtaacaag ttatcactaa ctgctgctgc tttaagagat
     2701 caactaattc gagcactaac tatgatagga gcatatgaaa ttatggacaa aataacagct
     2761 ttaaatcttt ttacgcgtgc aattaaattc taaccagtgg atcaataata aaaactgaaa
     2821 acttttgatg cacttataa
//
