LOCUS       NM_033402               3726 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens leucine rich repeat and coiled-coil centrosomal
            protein 1 (LRRCC1), transcript variant 1, mRNA.
ACCESSION   NM_033402
VERSION     NM_033402.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3726)
  AUTHORS   Gaudin,N., Martin Gil,P., Boumendjel,M., Ershov,D.,
            Pioche-Durieu,C., Bouix,M., Delobelle,Q., Maniscalco,L.,
            Phan,T.B.N., Heyer,V., Reina-San-Martin,B. and Azimzadeh,J.
  TITLE     Evolutionary conservation of centriole rotational asymmetry in the
            human centrosome
  JOURNAL   Elife 11, e72382 (2022)
   PUBMED   35319462
  REMARK    GeneRIF: Evolutionary conservation of centriole rotational
            asymmetry in the human centrosome.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3726)
  AUTHORS   Prosser,S.L. and Pelletier,L.
  TITLE     Mitotic spindle assembly in animal cells: a fine balancing act
  JOURNAL   Nat Rev Mol Cell Biol 18 (3), 187-201 (2017)
   PUBMED   28174430
  REMARK    Review article
REFERENCE   3  (bases 1 to 3726)
  AUTHORS   Vertii,A., Hehnly,H. and Doxsey,S.
  TITLE     The Centrosome, a Multitalented Renaissance Organelle
  JOURNAL   Cold Spring Harb Perspect Biol 8 (12), a025049 (2016)
   PUBMED   27908937
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3726)
  AUTHORS   Jakobsen,L., Vanselow,K., Skogs,M., Toyoda,Y., Lundberg,E.,
            Poser,I., Falkenby,L.G., Bennetzen,M., Westendorf,J., Nigg,E.A.,
            Uhlen,M., Hyman,A.A. and Andersen,J.S.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
REFERENCE   5  (bases 1 to 3726)
  AUTHORS   Muto,Y., Yoshioka,T., Kimura,M., Matsunami,M., Saya,H. and Okano,Y.
  TITLE     An evolutionarily conserved leucine-rich repeat protein CLERC is a
            centrosomal protein required for spindle pole integrity
  JOURNAL   Cell Cycle 7 (17), 2738-2748 (2008)
   PUBMED   18728398
  REMARK    GeneRIF: These data indicate that the major function of CLERC
            during mitosis is to maintain the structural integrity of
            centrosomes, thereby contributing to spindle bipolarity.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB458600.1, BR000818.1,
            BC030701.2 and AA000990.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_033402.4.
            
            Summary: This gene encodes a centrosomal protein that maintains the
            structural integrity of the centrosome and plays a key role in
            mitotic spindle formation. The encoded protein contains an
            N-terminal leucine-rich repeat domain and a C-terminal coiled-coil
            domain. It associates with the centrosome throughout the cell cycle
            and accumulates on the mitotic centrosome. [provided by RefSeq, Mar
            2017].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK302648.1, BC030701.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000360375.8/ ENSP00000353538.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                DB458600.1         62-119
            59-3157             BR000818.1         1-3099
            3158-3722           BC030701.2         3181-3745
            3723-3726           AA000990.1         4-7                 c
FEATURES             Location/Qualifiers
     source          1..3726
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q21.2"
     gene            1..3726
                     /gene="LRRCC1"
                     /gene_synonym="CLERC; CLERK; SAP2; VFL1"
                     /note="leucine rich repeat and coiled-coil centrosomal
                     protein 1"
                     /db_xref="GeneID:85444"
                     /db_xref="HGNC:HGNC:29373"
                     /db_xref="MIM:617791"
     exon            1..162
                     /gene="LRRCC1"
                     /gene_synonym="CLERC; CLERK; SAP2; VFL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..3157
                     /gene="LRRCC1"
                     /gene_synonym="CLERC; CLERK; SAP2; VFL1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     sodium channel associated protein 2; centrosomal
                     leucine-rich repeat and coiled-coil domain-containing
                     protein; variable number of flagella 1 homolog;
                     leucine-rich repeat and coiled-coil domain-containing
                     protein 1"
                     /codon_start=1
                     /product="leucine-rich repeat and coiled-coil
                     domain-containing protein 1 isoform 1"
                     /protein_id="NP_208325.3"
                     /db_xref="CCDS:CCDS43750.1"
                     /db_xref="GeneID:85444"
                     /db_xref="HGNC:HGNC:29373"
                     /db_xref="MIM:617791"
                     /translation="MEAAAAVVAAEAEVENEDGDSSCGDVCFMDKGLQSISELSLDST
                     LHAVNLHCNNISKIEAIDHIWNLQHLDLSSNQISRIEGLNTLTKLCTLNLSCNLITKV
                     EGLEELINLTRLNVSYNHIDDLSGLIPLHGIKHKLRYIDLHSNRIDSIHHLLQCMVGL
                     HFLTNLILEKDGDDNPVCRLPGYRAVILQTLPQLRILDCKNIFGEPVNLTEINSSQLQ
                     CLEGLLDNLVSSDSPLNISEDEIIDRMPVITAPIDELVPLEQFASTPSDAVLTSFMSV
                     CQSSEPEKNNHENDLQNEIKLQKLDDQILQLLNETSNSIDNVLEKDPRPKRDTDITSE
                     SDYGNRKECNRKVPRRSKIPYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYLKELYVSS
                     SLANCPMLQESEKPKTEIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKLMDY
                     IDELHKHANEKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELM
                     KAKDQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTS
                     LHREREQAQQLHQLLALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKE
                     YQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKDGFENVATELAKSKHALIWAQRKE
                     NESSSLIKDLTCMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQKSIQIEL
                     LKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQIESLSREN
                     ECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEKITEIEKCTQE
                     QLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDKGELL
                     CHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMDDAFKRQVDAIVEAHQ
                     AEIAQLANEKQKCIDSANLKVHQIEKEMRELLEETCKNKKTMEAKIKQLAFALNEIQQ
                     DM"
     exon            163..368
                     /gene="LRRCC1"
                     /gene_synonym="CLERC; CLERK; SAP2; VFL1"
                     /inference="alignment:Splign:2.1.0"
     exon            369..434
                     /gene="LRRCC1"
                     /gene_synonym="CLERC; CLERK; SAP2; VFL1"
                     /inference="alignment:Splign:2.1.0"
     exon            435..602
                     /gene="LRRCC1"
                     /gene_synonym="CLERC; CLERK; SAP2; VFL1"
                     /inference="alignment:Splign:2.1.0"
     exon            603..778
                     /gene="LRRCC1"
                     /gene_synonym="CLERC; CLERK; SAP2; VFL1"
                     /inference="alignment:Splign:2.1.0"
     exon            779..988
                     /gene="LRRCC1"
                     /gene_synonym="CLERC; CLERK; SAP2; VFL1"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1182
                     /gene="LRRCC1"
                     /gene_synonym="CLERC; CLERK; SAP2; VFL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1330
                     /gene="LRRCC1"
                     /gene_synonym="CLERC; CLERK; SAP2; VFL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1479
                     /gene="LRRCC1"
                     /gene_synonym="CLERC; CLERK; SAP2; VFL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..1684
                     /gene="LRRCC1"
                     /gene_synonym="CLERC; CLERK; SAP2; VFL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1685..1824
                     /gene="LRRCC1"
                     /gene_synonym="CLERC; CLERK; SAP2; VFL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1825..2026
                     /gene="LRRCC1"
                     /gene_synonym="CLERC; CLERK; SAP2; VFL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2027..2212
                     /gene="LRRCC1"
                     /gene_synonym="CLERC; CLERK; SAP2; VFL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2213..2387
                     /gene="LRRCC1"
                     /gene_synonym="CLERC; CLERK; SAP2; VFL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2388..2551
                     /gene="LRRCC1"
                     /gene_synonym="CLERC; CLERK; SAP2; VFL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2552..2760
                     /gene="LRRCC1"
                     /gene_synonym="CLERC; CLERK; SAP2; VFL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2761..2898
                     /gene="LRRCC1"
                     /gene_synonym="CLERC; CLERK; SAP2; VFL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2899..3034
                     /gene="LRRCC1"
                     /gene_synonym="CLERC; CLERK; SAP2; VFL1"
                     /inference="alignment:Splign:2.1.0"
     exon            3035..3726
                     /gene="LRRCC1"
                     /gene_synonym="CLERC; CLERK; SAP2; VFL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3698..3703
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRCC1"
                     /gene_synonym="CLERC; CLERK; SAP2; VFL1"
                     /note="hexamer: ATTAAA"
     regulatory      3705..3710
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRCC1"
                     /gene_synonym="CLERC; CLERK; SAP2; VFL1"
                     /note="hexamer: ATTACA"
     polyA_site      3722
                     /gene="LRRCC1"
                     /gene_synonym="CLERC; CLERK; SAP2; VFL1"
     polyA_site      3726
                     /gene="LRRCC1"
                     /gene_synonym="CLERC; CLERK; SAP2; VFL1"
                     /note="major polyA site"
ORIGIN      
        1 aagctcacgg acccctcgct gggtgccggt taagaccccg ctccccgtcg ccagtgctat
       61 ggaggcggcg gcggcggtgg tggcggcaga ggcggaagtg gaaaacgaag acggcgacag
      121 cagctgcggg gatgtatgct tcatggacaa aggcttgcag agcatatcag aattatcttt
      181 agattcaact cttcatgccg tcaatcttca ttgcaataac atctccaaga tcgaagccat
      241 tgatcatatt tggaatttac aacatctaga tctgtcatct aatcaaataa gtagaattga
      301 aggactaaac acactgacaa aactgtgcac attaaatttg tcctgcaatt tgattacaaa
      361 agtagaagga cttgaagaac taattaatct gactagacta aatgtatctt ataaccacat
      421 agatgatctt agtggattga ttccccttca tggaattaag cataaactta gatatattga
      481 tctacatagt aatcgtatag atagtatcca tcacttactt cagtgtatgg taggattgca
      541 cttcctgacc aatcttattt tggagaaaga tggagacgat aatcctgtct gtcgactgcc
      601 agggtacaga gcagttattc tccagacttt gccacagctt agaatcctag attgcaagaa
      661 catatttggt gaaccagtaa atttgacaga aataaattca tcacagctgc agtgcctaga
      721 aggtcttttg gataatttag tttcttctga ttctccccta aatataagtg aagatgagat
      781 cattgataga atgccagtga taacagcacc tatcgatgag ttagttccct tggaacagtt
      841 tgcaagtaca ccaagtgatg ctgtgttgac gtcttttatg tctgtgtgtc aatcttctga
      901 gccagagaaa aataatcatg aaaacgattt gcagaatgag ataaaacttc agaaattaga
      961 tgaccaaatt ctacaacttc taaatgaaac ttctaattca atagataacg ttcttgagaa
     1021 agaccccaga ccaaaaagag acacagatat aacttctgaa agtgactatg gaaacagaaa
     1081 agaatgcaat agaaaagttc ctcgaagatc aaaaatccct tatgatgcca aaaccattca
     1141 aactattaag caccacaata aaaactacaa ctcttttgta agttgtaatc gtaaaatgaa
     1201 accaccttac cttaaagaat tatatgtaag ctcatcttta gcaaactgtc ctatgttaca
     1261 agaatcagaa aagccaaaga ctgaaataat taaagtagac caaagtcact cagaagacaa
     1321 cacttaccag tcccttgttg aacagctaga ccaagagaga gagaagagat ggagagctga
     1381 gcaagccgaa aataaactca tggattatat tgatgagctg cataaacatg caaatgaaaa
     1441 agaggatatt catagtctgg ctctacttac cacagatagg ctaaaggaaa ttatttttag
     1501 agagagaaat tccaaaggac aactcgaagt tatggttcac aaacttcaaa atgaaattaa
     1561 aaaactgact gttgaactaa tgaaagcaaa agatcaacaa gaggatcacc ttaaacactt
     1621 aagaaccctc gaaaaaacat tagaaaaaat ggagagacaa aaaaggcagc agcaggcagc
     1681 acagataaga ctgatccaag aggtggaact caaagcttca gctgccgata gagaaatata
     1741 cttacttaga acttcccttc atcgagaaag agaacaagcg caacaacttc atcaacttct
     1801 tgcattgaaa gaacaggaac acaggaagga acttgaaaca agggagtttt ttactgatgc
     1861 tgacttccag gatgccttag ctaaagaaat agccaaagaa gagaaaaagc atgagcaaat
     1921 gataaaagaa taccaagaga aaattgacgt gttaagccag cagtatatgg atttagaaaa
     1981 tgaattccgt attgctttaa ctgttgaagc cagaagattt caagatgtta aagatggttt
     2041 tgaaaatgtt gcaactgagt tagcaaagag caaacatgct cttatttggg ctcaacgaaa
     2101 agaaaatgag tcttcctctt taattaaaga tctgacctgt atggtaaagg aacaaaaaac
     2161 aaaactggca gaagtttcta aattgaaaca agaaacagca gcaaatttac agaatcaaat
     2221 caacaccctt gaaattttaa ttgaagatga caagcagaag agtattcaaa tagaacttct
     2281 caagcacgaa aaagtccagc ttatttctga gctagcagcc aaggaatcac taatatttgg
     2341 tttaaggaca gaaagaaaag tatggggaca tgagctggca caacaaggat cttctctagc
     2401 ccaaaatcgt ggaaaattgg aggctcaaat tgagagttta tctagagaga atgaatgtct
     2461 gcgaaagaca aatgaaagtg atagtgatgc attaagaata aagtgcaaaa tcatagacga
     2521 ccaaactgaa actattagaa aattaaaaga ttgtttacaa gaaaaagatg aacacatcaa
     2581 aagattacaa gaaaagatca cagaaataga aaaatgcact caagaacaac ttgatgaaaa
     2641 atcttcacaa ctggatgagg tacttgagaa gttggaaagg cacaatgaaa gaaaagaaaa
     2701 actaaaacaa cagttgaaag gaaaggaagt agaacttgaa gaaatcagaa aagcttacag
     2761 tacactgaat cggaagtggc atgataaagg agaacttcta tgtcatcttg aaacacaagt
     2821 aaaagaagtg aaagaaaaat ttgaaaacaa ggaaaagaaa cttaaagcgg aaagagacaa
     2881 aagtattgaa ctacaaaaga atgcaatgga aaaacttcat agtatggatg atgcctttaa
     2941 aagacaagtt gatgcaattg ttgaagctca tcaagctgaa atagcacagc tggccaatga
     3001 aaagcagaag tgtattgatt ctgcaaattt aaaggtccat caaattgaaa aagaaatgcg
     3061 tgaacttttg gaagaaacat gcaagaacaa aaaaacaatg gaagcaaaaa ttaagcaact
     3121 tgcttttgct ttaaatgaaa ttcagcaaga tatgtgatgg ttctgagaat gaatttaatt
     3181 gaaatagacc agcagaccta ttgtaaaaat gattaaatat tgtaatagta gtaactgcta
     3241 tgactttgaa atgtctcttt ctatacattt cattatgaat atatttttaa agacttttga
     3301 tcaagtattt attaattgta taggtttttt ataataaatt gttgacaatt ttgtctatta
     3361 gaaaaaacta tcataactag acttacaata tttttcttgt ttctgtacta tacattgttt
     3421 ggtaattaca catttgccta caaatttgtg aatgaaaaga ttagtatttt caccatatga
     3481 ggtaaaacat tttaatcatt gttatcttat tgtgatgatg aagaactaat tatatttgtt
     3541 atttaattga tgtagctcaa ttcttttaaa gtacttatgt agccaaaaag catttgaaat
     3601 ctgtatgata aaagatgtgg cattcttaag aaagtatatg tagccatctc cacatcactc
     3661 attatgaccc cttcttttat aatgcttata tcttttcatt aaagattaca tttaaggttt
     3721 tataaa
//
