LOCUS       NM_001369817            7664 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens leucine rich repeat containing 8 VRAC subunit B
            (LRRC8B), transcript variant 3, mRNA.
ACCESSION   NM_001369817 XM_005270701
VERSION     NM_001369817.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7664)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 7664)
  AUTHORS   Ghosh,A., Khandelwal,N., Kumar,A. and Bera,A.K.
  TITLE     Leucine-rich repeat-containing 8B protein is associated with the
            endoplasmic reticulum Ca2+ leak in HEK293 cells
  JOURNAL   J Cell Sci 130 (22), 3818-3828 (2017)
   PUBMED   28972132
  REMARK    GeneRIF: LRRC8B participates in intracellular Ca(2+) homeostasis by
            acting as a leak channel in the endoplasmic reticulum.
            Erratum:[J Cell Sci. 2018 Jan 4;131(1):jcs213447. doi:
            10.1242/jcs.213447.. PMID: 29301942]
REFERENCE   3  (bases 1 to 7664)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 7664)
  AUTHORS   Lutter,D., Ullrich,F., Lueck,J.C., Kempa,S. and Jentsch,T.J.
  TITLE     Selective transport of neurotransmitters and modulators by distinct
            volume-regulated LRRC8 anion channels
  JOURNAL   J Cell Sci 130 (6), 1122-1133 (2017)
   PUBMED   28193731
REFERENCE   5  (bases 1 to 7664)
  AUTHORS   Voss,F.K., Ullrich,F., Munch,J., Lazarow,K., Lutter,D., Mah,N.,
            Andrade-Navarro,M.A., von Kries,J.P., Stauber,T. and Jentsch,T.J.
  TITLE     Identification of LRRC8 heteromers as an essential component of the
            volume-regulated anion channel VRAC
  JOURNAL   Science 344 (6184), 634-638 (2014)
   PUBMED   24790029
REFERENCE   6  (bases 1 to 7664)
  AUTHORS   Low,S.K., Chung,S., Takahashi,A., Zembutsu,H., Mushiroda,T.,
            Kubo,M. and Nakamura,Y.
  TITLE     Genome-wide association study of chemotherapeutic agent-induced
            severe neutropenia/leucopenia for patients in Biobank Japan
  JOURNAL   Cancer Sci 104 (8), 1074-1082 (2013)
   PUBMED   23648065
REFERENCE   7  (bases 1 to 7664)
  AUTHORS   Kubota,K., Kim,J.Y., Sawada,A., Tokimasa,S., Fujisaki,H.,
            Matsuda-Hashii,Y., Ozono,K. and Hara,J.
  TITLE     LRRC8 involved in B cell development belongs to a novel family of
            leucine-rich repeat proteins
  JOURNAL   FEBS Lett 564 (1-2), 147-152 (2004)
   PUBMED   15094057
  REMARK    GeneRIF: identified four genes, named TA-LRRP, AD158, LRRC5, and
            FLJ23420, as unknown LRRC8-like genes
REFERENCE   8  (bases 1 to 7664)
  AUTHORS   Robertson,N.G., Khetarpal,U., Gutierrez-Espeleta,G.A., Bieber,F.R.
            and Morton,C.C.
  TITLE     Isolation of novel and known genes from a human fetal cochlear cDNA
            library using subtractive hybridization and differential screening
  JOURNAL   Genomics 23 (1), 42-50 (1994)
   PUBMED   7829101
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC099569.2.
            
            On May 20, 2020 this sequence version replaced NM_001369817.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038191.735224.1,
                                           SRR1660803.106562.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000330947.7/ ENSP00000332674.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-194               AC099569.2         15891-16084
            195-255             AC099569.2         59309-59369
            256-310             AC099569.2         59501-59555
            311-408             AC099569.2         70653-70750
            409-2573            AC099569.2         73687-75851
            2574-7664           AC099569.2         83833-88923
FEATURES             Location/Qualifiers
     source          1..7664
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p22.2"
     gene            1..7664
                     /gene="LRRC8B"
                     /gene_synonym="TA-LRRP; TALRRP"
                     /note="leucine rich repeat containing 8 VRAC subunit B"
                     /db_xref="GeneID:23507"
                     /db_xref="HGNC:HGNC:30692"
                     /db_xref="MIM:612888"
     exon            1..194
                     /gene="LRRC8B"
                     /gene_synonym="TA-LRRP; TALRRP"
                     /inference="alignment:Splign:2.1.0"
     exon            195..255
                     /gene="LRRC8B"
                     /gene_synonym="TA-LRRP; TALRRP"
                     /inference="alignment:Splign:2.1.0"
     exon            256..310
                     /gene="LRRC8B"
                     /gene_synonym="TA-LRRP; TALRRP"
                     /inference="alignment:Splign:2.1.0"
     exon            311..408
                     /gene="LRRC8B"
                     /gene_synonym="TA-LRRP; TALRRP"
                     /inference="alignment:Splign:2.1.0"
     exon            409..2573
                     /gene="LRRC8B"
                     /gene_synonym="TA-LRRP; TALRRP"
                     /inference="alignment:Splign:2.1.0"
     CDS             435..2846
                     /gene="LRRC8B"
                     /gene_synonym="TA-LRRP; TALRRP"
                     /note="leucine-rich repeat-containing protein 8B; T-cell
                     activation leucine repeat-rich protein; epididymis
                     secretory sperm binding protein; leucine rich repeat
                     containing 8 family member B"
                     /codon_start=1
                     /product="volume-regulated anion channel subunit LRRC8B"
                     /protein_id="NP_001356746.1"
                     /db_xref="CCDS:CCDS724.1"
                     /db_xref="GeneID:23507"
                     /db_xref="HGNC:HGNC:30692"
                     /db_xref="MIM:612888"
                     /translation="MITLTELKCLADAQSSYHILKPWWDVFWYYITLIMLLVAVLAGA
                     LQLTQSRVLCCLPCKVEFDNHCAVPWDILKASMNTSSNPGTPLPLPLRIQNDLHRQQY
                     SYIDAVCYEKQLHWFAKFFPYLVLLHTLIFAACSNFWLHYPSTSSRLEHFVAILHKCF
                     DSPWTTRALSETVAEQSVRPLKLSKSKILLSSSGCSADIDSGKQSLPYPQPGLESAGI
                     ESPTSSVLDKKEGEQAKAIFEKVKRFRMHVEQKDIIYRVYLKQIIVKVILFVLIITYV
                     PYFLTHITLEIDCSVDVQAFTGYKRYQCVYSLAEIFKVLASFYVILVILYGLTSSYSL
                     WWMLRSSLKQYSFEALREKSNYSDIPDVKNDFAFILHLADQYDPLYSKRFSIFLSEVS
                     ENKLKQINLNNEWTVEKLKSKLVKNAQDKIELHLFMLNGLPDNVFELTEMEVLSLELI
                     PEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEENLKILRLKFTEMGKIPRWVFH
                     LKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKSSLSRIPQVVTDLLPSLQKL
                     SLDNEGSKLVVLNNLKKMVNLKSLELISCDLERIPHSIFSLNNLHELDLRENNLKTVE
                     EIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLH
                     YLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNL
                     SPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRNCLIVEENLLNTLPLPVTERLQT
                     CLDKC"
     exon            2574..7664
                     /gene="LRRC8B"
                     /gene_synonym="TA-LRRP; TALRRP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6356..6361
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRC8B"
                     /gene_synonym="TA-LRRP; TALRRP"
                     /note="hexamer: ATTAAA"
     polyA_site      6376
                     /gene="LRRC8B"
                     /gene_synonym="TA-LRRP; TALRRP"
                     /note="major polyA site"
     regulatory      7642..7647
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRC8B"
                     /gene_synonym="TA-LRRP; TALRRP"
                     /note="hexamer: AATAAA"
     polyA_site      7664
                     /gene="LRRC8B"
                     /gene_synonym="TA-LRRP; TALRRP"
ORIGIN      
        1 attggccagc ggaacgcgtc gcgtcacaat ggagccggtc ggaggcggcg agccggacag
       61 cgccggggct tcccgctgag cccgcagcct ccggcagccg ggaaagtgcg ggcgcggggc
      121 cgcagcctgc ccgcccggag cggcccagga gcacgccgcg gggagcgcgg gcgtccgggg
      181 ctggagtcgc gcaggtaata gttaacctct tctgtgagaa gtcagaaggt gatctcttta
      241 atgctttctt tttaagaatt tttcaaattg agactaattg cagaggttcc agttgaccag
      301 cattcatagg aatgaagaca aacacagaga tggtgtgtct aagaaacttc aaaaggtgta
      361 gacctcctga ctgaagcata ttggatttat ttaatttttt tcactgtatt tctgtcctcc
      421 tacaagggaa agtcatgatt acactaactg agctaaaatg cttagcagat gcccagtcat
      481 cttatcacat cttaaaacca tggtgggacg tcttctggta ttacatcaca ctgatcatgc
      541 tgctggtggc cgtgctggcc ggagctctcc agctgacgca gagcagggtt ctgtgctgtc
      601 ttccatgcaa agtggaattt gacaatcact gtgccgtgcc ttgggacatc ctgaaagcca
      661 gcatgaacac atcctctaat cctgggacac cgcttccgct ccccctccga attcagaatg
      721 acctccaccg acagcagtac tcctatattg atgccgtctg ttacgagaaa cagctccatt
      781 ggtttgcaaa gtttttcccc tatctggtgc tcttgcacac gctcatcttt gcagcctgca
      841 gcaacttttg gcttcactac cccagtacca gttccaggct cgagcatttt gtggccatcc
      901 ttcacaagtg cttcgattct ccatggacca cccgcgccct ttcagaaaca gtggctgagc
      961 agtcagtgag gcctctgaaa ctctccaagt ccaagatttt gctttcgtcc tcagggtgtt
     1021 cagctgacat agattccggc aaacagtcat tgccctaccc acagccaggt ttggagtcag
     1081 ctggcataga aagcccaact tccagtgtcc tggacaagaa ggagggtgaa caggccaaag
     1141 ccatctttga aaaagtgaaa agattccgca tgcatgtgga gcagaaggac atcatttata
     1201 gagtatatct gaaacagata atagtcaaag tcattttgtt tgtgctcatc ataacttatg
     1261 ttccatattt tttaacccac atcactcttg aaatcgactg ttcagttgat gtgcaggctt
     1321 ttacaggata taagcgctac cagtgtgtct attccttggc agaaatcttt aaggtcctgg
     1381 cttcatttta tgtcattttg gttatacttt atggtctgac ctcttcctac agcctgtggt
     1441 ggatgctgag gagttccctg aagcaatatt cctttgaggc gttaagagaa aaaagcaact
     1501 acagtgacat ccctgatgtc aagaatgact ttgccttcat ccttcatctg gctgatcagt
     1561 atgatcctct ttattccaaa cgcttctcca tattcctatc agaggtcagt gagaacaaac
     1621 tgaaacagat caacctcaat aatgaatgga cagttgagaa actgaaaagt aagcttgtga
     1681 aaaatgccca ggacaagata gaactgcatc tttttatgct caacggtctt ccagacaatg
     1741 tctttgagtt aactgaaatg gaagtgctaa gcctggagct tatcccagag gtgaagctgc
     1801 cctctgcagt ctcacagctg gtcaacctca aggagcttcg tgtgtaccat tcatctctgg
     1861 tcgtagacca tcctgcactg gcctttctag aggagaattt aaaaatcctc cgcctgaaat
     1921 ttactgaaat gggaaaaatc ccacgctggg tatttcacct caagaatctc aaggaacttt
     1981 atctttcggg ctgtgttctc cctgaacagt tgagtactat gcagttggag ggctttcagg
     2041 acttaaaaaa tctaaggacc ctgtacttga agagcagcct ctcccggatc ccacaagttg
     2101 ttacagacct cctgccttca ttgcagaaac tgtcccttga taatgaggga agcaaactgg
     2161 ttgtgttgaa caacttgaaa aagatggtca atctgaaaag cctagaactg atcagctgtg
     2221 acctggaacg catcccacat tccattttca gcctgaataa tttgcatgag ttagacctaa
     2281 gggaaaataa ccttaaaact gtggaagaga tcattagctt tcagcatctt cagaatcttt
     2341 cctgcttaaa gttgtggcac aataacattg cttatattcc tgcacagatt ggggcattat
     2401 ctaacctaga gcagctctct ttggaccata ataatattga gaatctgccc ttgcagcttt
     2461 tcctatgcac taaactacat tatttggatc taagctataa ccacttgacc ttcattccag
     2521 aagaaatcca gtatctgagt aatttgcagt actttgctgt gaccaacaac aatattgaga
     2581 tgctaccaga tgggctgttt cagtgcaaaa agctgcagtg tttacttttg gggaaaaata
     2641 gcttgatgaa tttgtcccct catgtgggtg agctgtcaaa ccttactcat ctggagctca
     2701 ttggtaatta cctggaaaca cttcctcctg aactagaagg atgtcagtcc ctaaaacgga
     2761 actgtctgat tgttgaggag aacttgctca atactcttcc tctccctgta acagaacgtt
     2821 tacagacgtg cttagacaaa tgttgactta aagaaaagag acccgtgttt caaaatcatt
     2881 tttaaaagta tgctcggccg ggcgtggtgg ctcatgccta taatcccagc actttgggag
     2941 gccaagatgg gcggattgct tgaggtcagg agttcgagac cagtctggcc aacctggtga
     3001 aaccccatct ctgctaaaac tacaaaaaaa ttagccaggc gtggtggcgt gcgcctgtaa
     3061 tcccagctac ttgggaggct gacgcagggg aattgcttga accagggagg tggaggttgc
     3121 agtgagccga gattgtgcca ctgtacacca gcctgggtga cagagcaaga ctcttatctc
     3181 aaaaaaaaaa aaaaaatgct ccagggcttt aaatgagaag taaaattttc taagttaata
     3241 aagatgaaga atgggtgact attatgatga accataacta aatgtcttat taaagcaact
     3301 gagtgtctag ccctaaatta accaggtaaa aactgttaac actaacctga agttttgtga
     3361 ataactgttc tttaacttat tgagatgttg caagaaatgc acatccaggg tggactggga
     3421 gctatgaaat gactaaattc ctccttgcag tgtttacctt caagattgta taggtattct
     3481 ctcctcttct tcccccagtc cccattactt atttgcacac ttgttttaac tgacttcctg
     3541 ttttgatatt tatcaccaag accataaact catcaatatg aattttcttg atgtatactc
     3601 acgactgtct ttgatttatg ttcctaaatt tttttagata gggtatgttg tgcttggcag
     3661 aattcttttt tggcttaatt tttacttcct ttcccagctt gcttgagtct tccttaacct
     3721 ggttttctct taacaccaat gatgaaccct gagaaaatgc ctgcatttgg cctttgccta
     3781 gaacaggagc tgagtattta agatgtatta tcctcggggc atcctgaaaa ttaatgtatt
     3841 ccctaaaatt tcttcttgtc tatcatcaag gccttttttt atttgttaag aatttttata
     3901 ttaaatgtaa aacatataaa tattttctat tgtataatct tggattcaac atctgtgagg
     3961 atcatttttg taagatacat agaatttgtg catttcttta tgaacttact gttagtgttc
     4021 ttggtttcgg ctgtttatga ctcatgttta tgtacattct gctccaaaat gtttttgtac
     4081 tctgcaacta attacttttg gataacaaaa gccttgtgtt taatgcccta aagtatttgg
     4141 gggtttcctt gtgagagggt ggccgaatca tctacctctc tcttccatag ttgctgtgca
     4201 atcgtacggg taaaattctt aattacttac aaaaactgtg atagagggga gaggtacaga
     4261 tttggttttt aaattgattt taaaatactt tatagaaatt tagtaagagt taaagcaaaa
     4321 gacttttttt ccctccatct atgtaatctc tagctatgat tataatgtaa aacagcctct
     4381 attcagtgtc taaaatgagt tctcaaaacc cacaaagaaa tagatccatt taactgaaat
     4441 tcatctcatg cctttatcta actcttctgg aaaatacatt ttgctccttt ttataaagag
     4501 ctttgtgctt ggccttttat tatgcatatt tttaatgaat aaaatcaact gactcatttt
     4561 tgggaaatgt acatctttaa tatgtttttc cctaagggtc taggcattat gatgccacct
     4621 cttcattttg gatataacta tgaagaaatc tattaactgc acctacacaa aactggaaaa
     4681 cactataggt aaacagtact gtgtatatgg aattgtggtg cgtggtatgt gttttctctt
     4741 gctttgttcc agaaagatga aagtgagtct ttaaagcata gcaaatagag cttcccctca
     4801 cctgccacac actcctgcac taaagttcaa agaaaagaat tattcaaatc aaatgaaatt
     4861 tgaataatat tagctatcag gaatatagga caccaaacac actgcctcac acattattgt
     4921 ttattctgaa cggaaaggaa cagtgtaaaa ataaactact taccaaaact tgcctttagt
     4981 cagaacattc agctctcagg gaagcaggta taactgatga aacttctagg acttcagaaa
     5041 acagattcta attatatcca tgtttttcgt tgttattttc attttttaaa gtgtgagttg
     5101 atgtttattt tagtgtttca caatagaatt atcatgtata ctgattccag tgtggcatgt
     5161 gattaagttt tggacatgaa tatgccaaaa gtgcttaaat gtttttggcc acataactag
     5221 ctagaatttc aaaacaaaat tcagatttgc taccattcac ctgacgaact tctccatggc
     5281 tcgtcactgg tttggttcaa ctgcagaagt cattggctaa attttcctta tcacctacgt
     5341 aaatttctag aagaatttac tagcaggatt aataatgaat attataaact gctttccaca
     5401 cactagggta taattattgg tgcaatctat gttgttcttg atgccatggt tttacatctt
     5461 ttaatttaaa ccttatacac cagtgtttag gtcgcttttg agacaaggta gccctgatgc
     5521 aaggaaaaat gaggctacta cttcacataa aaaatagggt gttaatacca cctttactgt
     5581 actgttggag cagatcttta ttttacaagt gttcatattc acataagaga attttaaatg
     5641 aagaaaatta agtttgttaa attataatta tgagactttc gttggcattt gatttcaaga
     5701 atacatatgc attttccaaa aaataaatgt ggaggttatt cagaacaaaa ttcatagctt
     5761 acggtagtaa tggcatggat taattttatt tgcatgcaca cacagacaca catacttcat
     5821 atatgcaaat tatagcatta gtttttgata tatctagtgg tttttttttc aaaattgcag
     5881 gaggttgtag attaaattaa gtatgatagc acgtttttta attcattaat catgaagtgc
     5941 tctgttccct aagttatgac atttagaaga aatcacatgc tcaaccttaa tctgagaacc
     6001 taagtgtttt tgagcattcc agtaaaggag tagtgttctt ttcctaactt acatcagggt
     6061 acatctgtgt ggcacacaga tactatcttt tcattcttca ctcccagtct taatttcttt
     6121 cccctgtatg tcactgtatt ttatgtcact tcacattgtg ttaaacaggg taaatagaga
     6181 tcctcagtat ctcagtgctg tggcatagct ccaataggtg tgctgtggtg cactgcagtg
     6241 atgtatttgc ataacattgt ttgatagtga aaaatttttt ttcggttcaa gtgttttgtg
     6301 attaaaattt tatgtttaat taaaatattg cataatattg atgggttcaa aaaccattaa
     6361 aataatcaaa caattattct gtgcccttaa cattattttc ttgtgttttc aataaaattt
     6421 tcttttcatc tttccatctt cacattctct tagcatcatc ctatgcacat aaggtatgtt
     6481 gttttccttc tccactcacc taccgcacta aatttgatca gcaattgtac agtaacagaa
     6541 tatatttgtg ccagaagatt tgcaatgata tttgagcatg tatttattta ggaggaagcc
     6601 agtgcctgta attatgtctc attgagtagt tttactttgc ccatcctgca gtatttagag
     6661 ctgatctgta cccaaagcag gacaatgtaa ctgtagatct gctttgtttt cagtaactgt
     6721 acattgcatc agaatctgtt tatttctatc tggaaacaga cagaatggtg ggggagggaa
     6781 ggagttattt tgcatcctag tttgtattat gaagtcatca tatatatatt tgaaatagta
     6841 taagctaatt actgttgcag aatgccctcg atataattat ttcttttcag ctggatgtga
     6901 aaagctgaag cagtgaaaac ctgcagtctt atttcactgg tttccttctg tttcttgtcc
     6961 atcacttctg tatccacagg gagctatcta ctacatacct ttggtaacag gctacattct
     7021 cttcagattt tttatatgaa taatttcatc agcactaaag cattaacata gaataatgag
     7081 ccaaagtact gagtcgagat ggctttcagt tgagtttaat ttcatattta acttttgcat
     7141 ttaacttgta taatacacta ctgctgagaa aaacaattat gaatgccttc tgcatgttgt
     7201 acattatctc taacagagat ggtgcaattt taagaataca aaggggtata gagttagaat
     7261 ggatgtgttc gtgcatatat atgttgtatt taaatattaa tgtttacaag aagatttttt
     7321 ttaaattctt caaatacttc acttagtgaa ataatgggcc aatctggaat agagacattt
     7381 tatttggtta gtgcaagagt gaaagctagc atttgttaac cttcacatat ttatctgtgt
     7441 acaattgttt ttgcttctgg taatgaatta ttagaaaatg gaagattttg ttcaatgttt
     7501 ttggccctca ggtttactgt gtaaatctgc atttttggtg gtaaatccct ttgccacaga
     7561 ttcagtagct tttggtaaac ttcactgttt ttaaagtacc ttttgtgtaa aataaagatc
     7621 caatttttat aacaaatggc aaataaaaac agtaaatgct ggaa
//
