LOCUS       NM_207644               1233 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens leucine rich repeat containing 75B (LRRC75B), mRNA.
ACCESSION   NM_207644
VERSION     NM_207644.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1233)
  AUTHORS   Kim,Y.J., Go,M.J., Hu,C., Hong,C.B., Kim,Y.K., Lee,J.Y.,
            Hwang,J.Y., Oh,J.H., Kim,D.J., Kim,N.H., Kim,S., Hong,E.J.,
            Kim,J.H., Min,H., Kim,Y., Zhang,R., Jia,W., Okada,Y., Takahashi,A.,
            Kubo,M., Tanaka,T., Kamatani,N., Matsuda,K., Park,T., Oh,B.,
            Kimm,K., Kang,D., Shin,C., Cho,N.H., Kim,H.L., Han,B.G., Lee,J.Y.
            and Cho,Y.S.
  CONSRTM   MAGIC consortium
  TITLE     Large-scale genome-wide association studies in East Asians identify
            new genetic loci influencing metabolic traits
  JOURNAL   Nat Genet 43 (10), 990-995 (2011)
   PUBMED   21909109
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1233)
  AUTHORS   Yuan,X., Waterworth,D., Perry,J.R., Lim,N., Song,K., Chambers,J.C.,
            Zhang,W., Vollenweider,P., Stirnadel,H., Johnson,T., Bergmann,S.,
            Beckmann,N.D., Li,Y., Ferrucci,L., Melzer,D., Hernandez,D.,
            Singleton,A., Scott,J., Elliott,P., Waeber,G., Cardon,L.,
            Frayling,T.M., Kooner,J.S. and Mooser,V.
  TITLE     Population-based genome-wide association studies reveal six loci
            influencing plasma levels of liver enzymes
  JOURNAL   Am J Hum Genet 83 (4), 520-528 (2008)
   PUBMED   18940312
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP000356.1, BI544432.1 and BC032388.1.
            
            On Nov 22, 2018 this sequence version replaced NM_207644.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.563559.1, BC108684.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000318753.13/ ENSP00000320520.8
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AP000356.1         85368-85372         c
            6-44                BI544432.1         13-51
            45-1233             BC032388.1         1-1189
FEATURES             Location/Qualifiers
     source          1..1233
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q11.23"
     gene            1..1233
                     /gene="LRRC75B"
                     /gene_synonym="C22orf36; FAM211B"
                     /note="leucine rich repeat containing 75B"
                     /db_xref="GeneID:388886"
                     /db_xref="HGNC:HGNC:33155"
     exon            1..211
                     /gene="LRRC75B"
                     /gene_synonym="C22orf36; FAM211B"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..982
                     /gene="LRRC75B"
                     /gene_synonym="C22orf36; FAM211B"
                     /note="leucine-rich repeat-containing protein C22orf36;
                     leucine-rich repeat-containing protein FAM211B; family
                     with sequence similarity 211, member B"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 75B"
                     /protein_id="NP_997527.2"
                     /db_xref="CCDS:CCDS42991.1"
                     /db_xref="GeneID:388886"
                     /db_xref="HGNC:HGNC:33155"
                     /translation="MGARLGRRAGPEAGSEAGAAAGCGPAPYERRVRWLREIQSTLRE
                     RRPERARQLLRLLRQDLGLERTLLPDILYRDVAFLNPVDPISHDLLVNLARDLQCPKK
                     DYELWKSSDKICRQLIYHLTPHSKQQQGSSLRQRKTQSCLKSSLQKTLLAGETVDLSG
                     IPLSTQDVQHITRYLSSHGAVLAVLDLSFTGLSDELLHLLLPSLWALPRLTQLLLNGN
                     RLTRATARKLTDAIKDTTKFPALAWVDLGNNVDVASLPQPLLVGLRRRLSQRTSLPTI
                     YEGLDLEPEGSAAGATTPASTWDSTAAGLGPEPQACCAR"
     exon            212..340
                     /gene="LRRC75B"
                     /gene_synonym="C22orf36; FAM211B"
                     /inference="alignment:Splign:2.1.0"
     exon            341..456
                     /gene="LRRC75B"
                     /gene_synonym="C22orf36; FAM211B"
                     /inference="alignment:Splign:2.1.0"
     exon            457..1233
                     /gene="LRRC75B"
                     /gene_synonym="C22orf36; FAM211B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1215..1220
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRC75B"
                     /gene_synonym="C22orf36; FAM211B"
                     /note="hexamer: AATAAA"
     polyA_site      1233
                     /gene="LRRC75B"
                     /gene_synonym="C22orf36; FAM211B"
                     /note="major polyA site"
ORIGIN      
        1 ctcctgtggg ttcggcgacc atcgcgcggc ggccatgggg gcgcggctgg gccggcgggc
       61 cgggcccgag gctggctctg aggccggggc ggcggccggc tgcgggcccg cgccctacga
      121 gcgccgggtg cggtggctcc gcgagatcca gtccacgctc cgcgagcggc ggccggagcg
      181 cgcccggcag ctgctgcgcc tcctgcgcca ggacctgggc cttgagagga ccctccttcc
      241 tgatatcctc tacagagatg tggccttcct caacccggtc gaccccatct cccatgacct
      301 gcttgtgaac ctggcccggg acctgcagtg ccccaagaag gactatgagc tctggaagtc
      361 ctcggacaag atctgccgac agctcatcta ccacctcacc cctcactcga agcagcagca
      421 agggtccagc ctgcgccaga ggaagaccca gagctgcctc aagagcagcc tccagaagac
      481 tctgctggca ggggagactg tggacctctc aggcatcccg ctgtcgacac aggacgtgca
      541 acacatcaca cgctacctga gcagccatgg tgctgtgctg gcggtgctgg acctgagctt
      601 cacggggctg agtgatgagc tgctgcacct cctgctgccc agcctgtggg cgctgccccg
      661 cctcacccag ctcctgctca acggcaaccg actgacgcgg gccactgccc gcaagctcac
      721 tgatgccatc aaggacacca ccaagttccc tgctttggct tgggtggacc tgggcaacaa
      781 cgtggatgtg gcttccctgc cccagcccct gctggtcggc ctgcgccggc ggctgagcca
      841 gcgcacctca ctccccacca tctacgaggg cctggacctt gagcctgagg gcagtgcggc
      901 cggggccacc acccctgcct ccacctggga ctccacagct gctgggctgg gacccgagcc
      961 ccaggcctgc tgtgccaggt gacccaccac ccacctggct cattgctact gacttgtgat
     1021 gctctcaagc acatgatagt gggcgatgaa ggtcaaggag gactcacagg cccccagaaa
     1081 tccagtgtaa atgctcagcc tgagattaag gggacagaag aatggactca taggtggcca
     1141 ggtggccagc cctggctaga ggctcagcct tccctcagtg ggaggggccc cagcacccac
     1201 agtgtggacc ccgcaataaa gagtgacacc cgc
//
