LOCUS       NM_001113567            3249 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens leucine rich repeat containing 75A (LRRC75A),
            transcript variant 1, mRNA.
ACCESSION   NM_001113567
VERSION     NM_001113567.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3249)
  AUTHORS   Miura,T., Kouno,T., Takano,M., Kuroda,T., Yamamoto,Y., Kusakawa,S.,
            Morioka,M.S., Sugawara,T., Hirai,T., Yasuda,S., Sawada,R.,
            Matsuyama,S., Kawaji,H., Kasukawa,T., Itoh,M., Matsuyama,A.,
            Shin,J.W., Umezawa,A., Kawai,J. and Sato,Y.
  TITLE     Single-Cell RNA-Seq Reveals LRRC75A-Expressing Cell Population
            Involved in VEGF Secretion of Multipotent Mesenchymal Stromal/Stem
            Cells Under Ischemia
  JOURNAL   Stem Cells Transl Med 12 (6), 379-390 (2023)
   PUBMED   37263619
  REMARK    GeneRIF: Single-Cell RNA-Seq Reveals LRRC75A-Expressing Cell
            Population Involved in VEGF Secretion of Multipotent Mesenchymal
            Stromal/Stem Cells Under Ischemia.
REFERENCE   2  (bases 1 to 3249)
  AUTHORS   Yan,D., He,D., He,S., Chen,X., Fan,Z. and Chen,R.
  TITLE     Identification and analysis of intermediate size noncoding RNAs in
            the human fetal brain
  JOURNAL   PLoS One 6 (7), e21652 (2011)
   PUBMED   21789175
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127540.10, DB460063.1, BC144381.1, AC093484.2 and AI298465.1.
            
            On May 17, 2019 this sequence version replaced NM_001113567.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.43333.1,
                                           SRR1803611.251692.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2158188 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000470794.2/ ENSP00000419502.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AC127540.10        102242-102243
            3-283               DB460063.1         3-283
            284-1045            BC144381.1         1-762
            1046-2533           AC093484.2         163082-164569       c
            2534-2821           AI298465.1         13-300              c
            2822-3249           AC093484.2         162366-162793       c
FEATURES             Location/Qualifiers
     source          1..3249
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p11.2"
     gene            1..3249
                     /gene="LRRC75A"
                     /gene_synonym="C17orf76; FAM211A"
                     /note="leucine rich repeat containing 75A"
                     /db_xref="GeneID:388341"
                     /db_xref="HGNC:HGNC:32403"
     exon            1..449
                     /gene="LRRC75A"
                     /gene_synonym="C17orf76; FAM211A"
                     /inference="alignment:Splign:2.1.0"
     CDS             204..1238
                     /gene="LRRC75A"
                     /gene_synonym="C17orf76; FAM211A"
                     /note="isoform 1 is encoded by transcript variant 1;
                     leucine-rich repeat-containing protein C17orf76;
                     leucine-rich repeat-containing protein FAM211A; family
                     with sequence similarity 211, member A; leucine-rich
                     repeat-containing protein 75A"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 75A
                     isoform 1"
                     /protein_id="NP_001107039.1"
                     /db_xref="CCDS:CCDS45620.1"
                     /db_xref="GeneID:388341"
                     /db_xref="HGNC:HGNC:32403"
                     /translation="MGTRQTKGSLAERASPGAAPGPRRERPDFWASLLLRAGDKAGRA
                     GAGMPPYHRRVGMVQELLRMVRQGRREEAGTLLQHLRQDLGMESTSLDDVLYRYASFR
                     NLVDPITHDLIISLARYIHCPKPEGDALGAMEKLCRQLTYHLSPHSQWRRHRGLVKRK
                     PQACLKAVLAGSPPDNTVDLSGIPLTSRDLERVTSYLQRCGEQVDSVELGFTGLTDDM
                     VLQLLPALSTLPRLTTLALNGNRLTRAVLRDLTDILKDPSKFPNVTWIDLGNNVDIFS
                     LPQPFLLSLRKRSPKQGHLPTILELGEGPGSGEEVREGTVGQEDPGGGPVAPAEDHHE
                     GKETVAAAQT"
     exon            450..578
                     /gene="LRRC75A"
                     /gene_synonym="C17orf76; FAM211A"
                     /inference="alignment:Splign:2.1.0"
     exon            579..694
                     /gene="LRRC75A"
                     /gene_synonym="C17orf76; FAM211A"
                     /inference="alignment:Splign:2.1.0"
     exon            695..3249
                     /gene="LRRC75A"
                     /gene_synonym="C17orf76; FAM211A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2790..2795
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRC75A"
                     /gene_synonym="C17orf76; FAM211A"
                     /note="hexamer: AATACA"
     polyA_site      2811
                     /gene="LRRC75A"
                     /gene_synonym="C17orf76; FAM211A"
                     /note="major polyA site"
     polyA_site      2857
                     /gene="LRRC75A"
                     /gene_synonym="C17orf76; FAM211A"
     polyA_site      2867
                     /gene="LRRC75A"
                     /gene_synonym="C17orf76; FAM211A"
     polyA_site      2873
                     /gene="LRRC75A"
                     /gene_synonym="C17orf76; FAM211A"
     regulatory      2942..2947
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRC75A"
                     /gene_synonym="C17orf76; FAM211A"
                     /note="hexamer: ATTAAA"
     polyA_site      2962
                     /gene="LRRC75A"
                     /gene_synonym="C17orf76; FAM211A"
ORIGIN      
        1 gagcgcgccc gggtagccaa gagggaggag cgcggggagc gccgacagcc gcccgcccgc
       61 ccgcccccgc gacgcccgcg cgcaacagtt cccccaaagt tgcagcccgg gaggcgagcg
      121 cgcacgggcg gccgaggggc gggcggttgg cggggacgcg gcctcgcggc ccagagcgga
      181 gagtcccggc gggcggcggc ggcatgggca cccggcagac caagggcagc ctggcggaga
      241 gagccagccc cggcgccgcg ccgggccccc gacgcgaacg gccggacttc tgggcgtcgc
      301 tgctgctgcg cgccggggac aaggcggggc gcgcgggcgc ggggatgccc ccctaccacc
      361 ggcgagtcgg catggtccag gagctgctgc ggatggtgcg ccagggccgg cgggaggagg
      421 cggggacgct gctgcagcac ctgcgccagg acctgggcat ggagtcgacc tcgctagacg
      481 acgttctgta tcgctacgcc agcttccgga acctggtgga ccccatcaca cacgacctca
      541 tcatcagcct ggcacgctac atccactgtc ccaagccgga aggcgatgca ctgggcgcca
      601 tggagaagct gtgccggcag ctgacatacc acctcagccc ccactcccag tggaggcggc
      661 accgggggct ggtgaaaagg aagccacagg cctgcctcaa ggctgtcctg gccggaagcc
      721 ccccagacaa cacagtggac ctgtcgggaa tcccactgac ctcccgagac ctggagcggg
      781 tgaccagcta cctacagcgc tgtggggagc aggtagacag cgtggagctg ggcttcacag
      841 gcctcacgga cgacatggtc ctgcagctgc tgccagcact cagcaccctg ccccgcctca
      901 ccacactggc actcaatggc aaccggttga cccgggccgt gctgcgcgac ctcactgaca
      961 tccttaagga tcccagcaag ttccccaatg tcacgtggat tgacctgggc aacaacgtgg
     1021 acatcttctc cttgccccag cccttcctgc tcagcctgcg caagcgctcc ccaaagcagg
     1081 gccacctacc caccatcctg gagctgggtg agggcccagg cagtggggag gaggtccggg
     1141 aagggacagt aggccaggag gaccctggag ggggccctgt ggcacctgcc gaagaccacc
     1201 atgagggcaa ggagactgta gctgcagctc agacgtgaca tggaagtgaa gggcctcacc
     1261 agggagtcct tgttgggtag aatgggcaag gcaggcaggg gagggcgctt ctcctatcag
     1321 gtgggttaag gatattgcca aaaattggcc tgggccaccc acctacagaa aggcaaacca
     1381 tatcatctgg ggaaggggat ttgtgttaaa acttcccgtt ggtcctctgc atctgccccc
     1441 tatcccatta tctgccattt ggttcttaag tcatcccagg ccccagagaa ccctctcagc
     1501 tcagctcatg gccttcccca aagacttgtg gaaatgggca catggctgga ggtactgtaa
     1561 gcctgagcca ttgtgaacac caagagcttt cccccagaaa aagaatacag tagggcccct
     1621 acatgtactg cattacattt ttcatttagg ggaacaagct ccaaccagag gaatgtgtcc
     1681 ccactcaagg aaggtgggaa tctttagcaa aattcctgta actcctggtt gcccgagacc
     1741 ccagttccat ctatgctagg ggtggactga acgtggccta cctccttatg gagacccagc
     1801 cctatttctg aggcccacct tgattctagg catctgccca taggaccagc tatcgctata
     1861 tcctttgaca gagcagccta cgatgccatg tggtagtgct caggacagac atggtgccca
     1921 tgcatacagg cataaagtcc tgttcagaaa tcccctatcc accttcccta cccactgctg
     1981 gctgaaaaac taccagactt ctatgtgggc tctgatgtcc ttagcatgca gggtaagtga
     2041 caaacctggc ttccttcttg tcacttgcca gtatgacttc actgacctag acaggccgta
     2101 agaactcttt ccccataact cttaagtaat ccaccaacac attccagaaa accgactgca
     2161 gaaggtgggc tttaaaacct taaaaaccta ggacaatgaa ggagtccaat cccttggcag
     2221 atccaacaag atggctgggg agagggagaa acaaactgga ggctcccaaa ggaacctaac
     2281 ttagcaaagg ttctcatctt ataccctccc cttacccaaa tactgtccta ctgaaagggc
     2341 cctaccagtt aagggatctc ttctaaataa caggcaaccc ctagatccaa gtagttcagt
     2401 ccaggaagac tgggagccaa tcactcttga accttgtggg caaacagtat gggggaggac
     2461 cctcttgaca ggccttggta ggcaagattc caacacagga agacagcaag atggggccta
     2521 gagtatgggg ccctacatgc tgttaaggtt gtggttagga atggtgcaat gctgcaggag
     2581 ctggaacaaa gctacaccaa ggaacagagc acagagcagc aggggccgaa attgaggagg
     2641 ccttaaatgc tttgagcttt tgccttcagt ctaaagctgt agaatagggg gttaagagct
     2701 taggctgacc acagggaagt ttacaagcta gagcgaatat ctggactgct aatatctgac
     2761 aacagtaggc gaaatttact ttttcttcaa atacacattt tcaagaattg acacccaaga
     2821 ccatccttta ttgtagtatt agttcatggt aactgcatga aaaaacattt caggaggaat
     2881 ttacaatttc cagcttaaag aactttgccc accaacataa ccaatttatg aaagtcaatt
     2941 cattaaaagg tatagaacct cttgttgggc atgatggcaa gggacaaagc tacaacttgg
     3001 cctgtgcctt tggaagctga ggcaggagga ccatctgagc ccaggagcct gagaccagcc
     3061 tgggcaacat agagaatccg tctcaacaaa aaaaaaattt tagccaggtg tgctgtgagc
     3121 tgtagtccca gctacaaggt gggaggattg cttaggcctg ggtgattgag gatgcaatga
     3181 gctgtgattg tgccaccaca ctccagcctg ggcaatacag caagactgtc tcaaaaaaaa
     3241 aaaaaaaaa
//
