LOCUS       NM_001291006            3714 bp    mRNA    linear   PRI 04-AUG-2024
DEFINITION  Homo sapiens leucine rich repeat containing 74B (LRRC74B),
            transcript variant 1, mRNA.
ACCESSION   NM_001291006
VERSION     NM_001291006.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3714)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC002472.8.
            
            On Jun 2, 2019 this sequence version replaced NM_001291006.1.
            
            Transcript Variant: This variant (1) represents the shortest
            transcript and encodes the protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2148874,
                              SAMEA2158569 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000442047.3/ ENSP00000394078.2
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-180               AC002472.8         90095-90274
            181-323             AC002472.8         91505-91647
            324-456             AC002472.8         92033-92165
            457-663             AC002472.8         93100-93306
            664-773             AC002472.8         96398-96507
            774-889             AC002472.8         97509-97624
            890-968             AC002472.8         99247-99325
            969-1064            AC002472.8         101254-101349
            1065-1269           AC002472.8         104522-104726
            1270-3714           AC002472.8         105873-108317
FEATURES             Location/Qualifiers
     source          1..3714
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q11.21"
     gene            1..3714
                     /gene="LRRC74B"
                     /note="leucine rich repeat containing 74B"
                     /db_xref="GeneID:400891"
                     /db_xref="HGNC:HGNC:34301"
     exon            1..180
                     /gene="LRRC74B"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..1220
                     /gene="LRRC74B"
                     /note="leucine-rich repeat-containing protein LOC400891"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 74B"
                     /protein_id="NP_001277935.1"
                     /db_xref="CCDS:CCDS77654.1"
                     /db_xref="GeneID:400891"
                     /db_xref="HGNC:HGNC:34301"
                     /translation="MRGSCERSGEDEEQKEEAMVACGRLSGVPEAEQGPEANWDSDLE
                     TEGTDGLGELVRDTLYLRSCRAHSVVPISCFLRQGSAQELNLRHRGLGPQGARALASS
                     LSSNPYVKRLDLRDNGLCGAGAEALAGALSKSSSIHDVDLSENQLGVAGAQALCAALT
                     VNQAMRKMQLSGNGLEEQAAQHLAELLLAHTDLKSLDLSYNQLNDQAGETLGPALAEN
                     TGLTELNVSWNHLRGPGAVAFARGLEANIFLKVLDISYNGFGDPGASAVGEALKANNV
                     LEELNMSNNRISAMGALSLGLGLRVNQTLRILVVSRNPMRSEGCFGLLKSVQDNPASA
                     LELLDFSDIQVNAEFDGLASSVRGILPELCIKTGACRVEYKKELLPVFRSALPASVPK
                     "
     exon            181..323
                     /gene="LRRC74B"
                     /inference="alignment:Splign:2.1.0"
     exon            324..456
                     /gene="LRRC74B"
                     /inference="alignment:Splign:2.1.0"
     exon            457..663
                     /gene="LRRC74B"
                     /inference="alignment:Splign:2.1.0"
     exon            664..773
                     /gene="LRRC74B"
                     /inference="alignment:Splign:2.1.0"
     exon            774..889
                     /gene="LRRC74B"
                     /inference="alignment:Splign:2.1.0"
     exon            890..968
                     /gene="LRRC74B"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1064
                     /gene="LRRC74B"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1269
                     /gene="LRRC74B"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..3714
                     /gene="LRRC74B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1802..1807
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRC74B"
                     /note="hexamer: GATAAA"
     polyA_site      1823
                     /gene="LRRC74B"
                     /note="major polyA site"
     regulatory      1915..1920
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRC74B"
                     /note="hexamer: AAGAAA"
     polyA_site      1936
                     /gene="LRRC74B"
ORIGIN      
        1 gtctccgact cagtgtctga gactgcgaga gggtcgtaac catgaggggt tcctgtgaga
       61 ggtctgggga ggatgaagag cagaaagaag aggctatggt ggcctgtggg cgtctttcag
      121 gggtccccga ggccgagcag ggtcccgagg ccaattggga ctccgacctg gagacggaag
      181 gcaccgatgg gcttggagaa ctggtcaggg acacactgta cctgaggtct tgccgggccc
      241 atagtgttgt gcccatctcc tgctttctgc gccaagggag cgcccaagag ctgaacctcc
      301 ggcaccgtgg cctggggccc cagggcgccc gggctctggc ttcctcattg agctccaatc
      361 catatgtcaa gcggctggac cttcgagaca atgggctctg tggggcaggt gcagaggccc
      421 tggcaggtgc cctgagcaaa agcagcagca tccatgatgt ggacctgtcg gagaaccagc
      481 tgggagtggc aggagcccag gccctctgtg ccgccctcac agtgaaccag gccatgcgga
      541 agatgcagct gtcagggaat ggcctggagg agcaggcggc ccagcacctt gccgaactcc
      601 tgctggccca cacagacctg aagtccctgg acctgagcta caaccagctg aatgaccaag
      661 caggggagac acttggacca gccctggcag aaaacacagg actcaccgag cttaacgtga
      721 gctggaatca cctccggggc ccaggagctg tggcatttgc caggggactg gaggcaaaca
      781 tcttccttaa agttctagac atctcataca atggctttgg ggatcctgga gcctctgcgg
      841 tgggtgaggc tctgaaggcc aacaacgtgt tggaggaact caacatgagt aacaaccgca
      901 tctctgcgat gggagccctg agcctgggcc tgggcctccg ggtcaaccag acgctgagga
      961 ttcttgtagt gtccaggaat cccatgcgaa gtgaaggctg ctttggtctc ctcaagtctg
     1021 tccaggacaa tccagcctct gccctggaac tgctggattt ctcagatatc caggtgaacg
     1081 cagagtttga tggccttgct agctcagtga ggggaattct tccagaactc tgcataaaga
     1141 ctggcgcttg cagagtggag tataaaaagg agttgctgcc agtcttcaga tcagccctgc
     1201 cagcgtctgt ccctaagtga ccttggagtg tggcttcctc atctccaatc agctgctttg
     1261 acctccaggg tatatacttg aaagaaatga agacatatgt ccccacaaga actcgtgcat
     1321 gaatatccat agcaacatta tttataatat tctaagagtg aaaatgccca ccagtggata
     1381 aatgcaatgt ggtatatcca tacagtggaa tattatttgg caataaaaag gaatttgagg
     1441 tgataccaat gttctaaaat gtattgtggt gatggctacg taactgtgca tattctaaag
     1501 gcaattgaat tacagatgct ttacatgaat gaaccgtatg gtatgtgaac ggcatctcaa
     1561 taaaactgtt tcgaaaagaa ggaaaaggac ggacacatgc tgaaaacggg tgaaactaga
     1621 aaacatggcg ctaagtgaaa gaagccagcc acaagatcac gtgtcgcatg accgcattta
     1681 tgtgaaacat ccggagtatg caaatctata cagacagaaa gtagattata cattgcctag
     1741 gtgcagagaa atggaagtat tggaggttga cggctaaagg atgtggattt ctttgggggg
     1801 tgataaaagt gttctaaaat tgattgtggt gatgtgcgac tctatgaata cgctaaaaac
     1861 cgctcgattg tacattttaa atgggtgatt tatgcggtat gtgaaataca tctcaagaaa
     1921 gctgctgcaa aaaatatcat acgggttgag cctagtggta ttaaaaaagt ataaatatgg
     1981 ccaggcgcgg tggctcacgc ccataatccc agcactttgg gaggccgagg cgggcggatc
     2041 acgaggtcag gagatcgaga ccatcctggc taacatggtg aaaccccgtc tctaccaaaa
     2101 atacaaaaat tagccgggtg tggtggtggg cggctataat cccagccact cgggaggctg
     2161 aggcaagaga gttacttgaa cacagaaggt ggaggttgca gtgagccaag ctcacttcac
     2221 tgcactccag tctgggtgac agagcaagac tcggtctcaa aaaaaaaaaa aaaaaaaaaa
     2281 aggaagaatc aggctcagcg cactggcaca tgcttataat cccagaaatt tgggaggcca
     2341 agatgggagg atcacttgaa gccaggagtt ccagaccagc ctgggcagca tcgtgagacc
     2401 cccgtttcta caaaaaacat ttaaaaatta gctgggcatg gtggcatgtg cctgtcgttc
     2461 cagctacctg ggatgctgag gtgggaggat cactcaaacc tgggagtttg aagctgcagt
     2521 gagccatgat tgcaccactg cactccagtc tggttgagag agtgggaacc tgtctcgaaa
     2581 aaaaaaaaaa aagaatggaa ggatcaaact gggcatggtg atgcatgctt gcctgtaggc
     2641 ccagcctaca agggacgctg aggcaggagg atcatttgag cctgggaatt tgagcccagc
     2701 ttgagcaaca tagtgaaatc ctgtctaaaa aagaaaaaaa ggaagaatca aataattgtt
     2761 ccaaagtctt tcaaaaggag tattgagtcc caactcggca ctttcctgag cagggatatg
     2821 tctcctctcc ttctcactaa ggagccagaa actcacccct tctcactaaa aaagtgagaa
     2881 aaataaaaat agctcagaga actttgagct atgtgaggca cgcagaattt atcaggtccg
     2941 gagacatgaa tatgggactt caggcagggc atgatggctc acgcctgtag actcaggagg
     3001 ccaaggtgag cccaaggtgg gaggatcact ttagtccagg agttttgaga ccagcctggg
     3061 caacatcagg agatccttgt ctcctcaaaa acttaaaaaa aaaaaaagct gggcatggtg
     3121 gcacacacct gtggtcctga gtcaggaggt tgaggctgca gtgagctatg accataccag
     3181 tgcattccag cctgggtaca cagcgagacc ctgtctcaaa ataataataa caataatatg
     3241 ctgggtgcag aggctcattc ctgtaatccc agctctttgg gaggctgaag tgggtgaatc
     3301 acttgaggtc aggagttcga gactagcctg gccaacatgg taaaacccta tcttttctaa
     3361 aaatacaaaa attagccagg tatggtggtg catgcctgta atcccagcta cttgggaggc
     3421 tgaggcagga gaatcgctgg agcccgagag gtggaggttg cagtgagccg agatcatgcc
     3481 actgcactcc agcctggatg acagagcaag actctgtctc aaaacaaaac aaaacaaaac
     3541 aaaaaaataa taattataat aatgaaaaga aaaagaaatg aatatgggac ttcagtaaca
     3601 tatttcttat ccatgcccgg gggcaattgt ttaaaggcat tttgttcctg actagcttaa
     3661 cccattatct tcctgtttct ggaatttatg atacaaagaa taatgtatag acaa
//
