LOCUS       NM_001385106            1861 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens leucine rich repeat containing 74A (LRRC74A),
            transcript variant 2, mRNA.
ACCESSION   NM_001385106 XM_024449499
VERSION     NM_001385106.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1861)
  AUTHORS   Rose,J.E., Behm,F.M., Drgon,T., Johnson,C. and Uhl,G.R.
  TITLE     Personalized smoking cessation: interactions between nicotine dose,
            dependence and quit-success genotype score
  JOURNAL   Mol Med 16 (7-8), 247-253 (2010)
   PUBMED   20379614
  REMARK    GeneRIF: Clinical trial of gene-disease association and
            gene-environment interaction. (HuGE Navigator)
            Erratum:[Mol Med. 2012;18(1):729]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF111169.2.
            
            On Jul 8, 2020 this sequence version replaced XM_024449499.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.197631.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000689127.1/ ENSP00000509938.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-327               AF111169.2         55341-55667
            328-456             AF111169.2         57224-57352
            457-629             AF111169.2         60136-60308
            630-737             AF111169.2         65140-65247
            738-834             AF111169.2         66808-66904
            835-884             AF111169.2         73356-73405
            885-966             AF111169.2         73753-73834
            967-1052            AF111169.2         81298-81383
            1053-1247           AF111169.2         82149-82343
            1248-1343           AF111169.2         86313-86408
            1344-1490           AF111169.2         89626-89772
            1491-1598           AF111169.2         94901-95008
            1599-1681           AF111169.2         96289-96371
            1682-1861           AF111169.2         99058-99237
FEATURES             Location/Qualifiers
     source          1..1861
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.3"
     gene            1..1861
                     /gene="LRRC74A"
                     /gene_synonym="C14orf166B; LRRC74"
                     /note="leucine rich repeat containing 74A"
                     /db_xref="GeneID:145497"
                     /db_xref="HGNC:HGNC:23346"
     exon            1..327
                     /gene="LRRC74A"
                     /gene_synonym="C14orf166B; LRRC74"
                     /inference="alignment:Splign:2.1.0"
     CDS             291..1706
                     /gene="LRRC74A"
                     /gene_synonym="C14orf166B; LRRC74"
                     /note="isoform 2 is encoded by transcript variant 2;
                     leucine-rich repeat-containing protein 74; leucine rich
                     repeat containing 74; leucine-rich repeat-containing
                     protein 74A"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 74A
                     isoform 2"
                     /protein_id="NP_001372035.1"
                     /db_xref="CCDS:CCDS91911.1"
                     /db_xref="GeneID:145497"
                     /db_xref="HGNC:HGNC:23346"
                     /translation="MDNDKPLQPETEDEIEIEPVRQSSDKMLYCEAESPPTVEKVKPA
                     RENSETDLEIEDDEKFFTTGQKELYLEACKLMGVVPVSYFIRNMEESYVNLNHHGLGP
                     RGTKAIAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNISNNHLGLEG
                     ARIISDFFERNSSSIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHNQFSDVGG
                     EHLGQMLAINVGLTSLDLSWNNFHTRGAVALCNGLRGNVTLTKLDLSMNGFGNEVALA
                     LGEVLRLNRCLVYLDIGGNDIGNEGASKISKGLESNESLRVLKLFLNPINMDGAILLI
                     LAIKRNPKSRMEELDISNVLVSEQFMKTLDGVYAVHPQLDVVFKAVQGLSPKKTIFLL
                     TNPMKLIQSYADQHKITIVDFFKSLNPTGTMKMSVDEFQKVMIEQNKVPLNQYQVREV
                     IKKLDEKTGMVNFSFLNTMKP"
     exon            328..456
                     /gene="LRRC74A"
                     /gene_synonym="C14orf166B; LRRC74"
                     /inference="alignment:Splign:2.1.0"
     exon            457..629
                     /gene="LRRC74A"
                     /gene_synonym="C14orf166B; LRRC74"
                     /inference="alignment:Splign:2.1.0"
     exon            630..737
                     /gene="LRRC74A"
                     /gene_synonym="C14orf166B; LRRC74"
                     /inference="alignment:Splign:2.1.0"
     exon            738..834
                     /gene="LRRC74A"
                     /gene_synonym="C14orf166B; LRRC74"
                     /inference="alignment:Splign:2.1.0"
     exon            835..884
                     /gene="LRRC74A"
                     /gene_synonym="C14orf166B; LRRC74"
                     /inference="alignment:Splign:2.1.0"
     exon            885..966
                     /gene="LRRC74A"
                     /gene_synonym="C14orf166B; LRRC74"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1052
                     /gene="LRRC74A"
                     /gene_synonym="C14orf166B; LRRC74"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1247
                     /gene="LRRC74A"
                     /gene_synonym="C14orf166B; LRRC74"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1343
                     /gene="LRRC74A"
                     /gene_synonym="C14orf166B; LRRC74"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1490
                     /gene="LRRC74A"
                     /gene_synonym="C14orf166B; LRRC74"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..1598
                     /gene="LRRC74A"
                     /gene_synonym="C14orf166B; LRRC74"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1681
                     /gene="LRRC74A"
                     /gene_synonym="C14orf166B; LRRC74"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1861
                     /gene="LRRC74A"
                     /gene_synonym="C14orf166B; LRRC74"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1836..1841
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRC74A"
                     /gene_synonym="C14orf166B; LRRC74"
                     /note="hexamer: AATAAA"
     polyA_site      1861
                     /gene="LRRC74A"
                     /gene_synonym="C14orf166B; LRRC74"
                     /note="major polyA site"
ORIGIN      
        1 acagggctcc cagcaataga gcagtcccac tctcccagat gagctggaga agtagctacc
       61 tctcccagac agagttgggg tcaaattcat gcacatccaa ttcccatcaa agcctactct
      121 tcccagggct tgctgggagg gaaggataac tgcaggctcc cctgggatgc ccccaggtga
      181 gggaagttca cagagtttga gacagaggtg aatggacagg tgtgcttctt agggaagcag
      241 tcgagaggtg gcaagaagtt ggcagctgcc ctcaagaggg tcctggcacc atggacaatg
      301 acaagcctct tcagcctgag acagaagatg agattgaaat tgagccagta cgacagagca
      361 gcgataaaat gctctactgt gaggccgaat ccccgccgac tgttgaaaaa gtgaaaccag
      421 cccgggagaa ttcggaaaca gacctggaga ttgaagatga tgagaaattt ttcaccactg
      481 gacaaaagga gctgtacctg gaggcctgca agctgatggg tgtagtgcct gtctcctact
      541 tcattcggaa catggaggag tcctacgtga acctcaacca ccacggcctg ggccccaggg
      601 gtaccaaggc tattgctata gccctggtgt ccaacatggc tgttaccaaa ctggagctgg
      661 aagacaattg catcatggag gagggcgtct tgagcctggt ggagatgcta caagagaact
      721 actacctcca ggagatgaat atttccaaca atcaccttgg tttggagggg gccagaatca
      781 tctcagattt ctttgagaga aacagttctt ctatctggag ccttgagctt tcaggaaatg
      841 acttcaagga agactccgca gcactgctct gccaagccct gtcgaccaat taccaaatta
      901 aaaagctgga tctcagtcac aaccaattct ctgatgtagg aggggagcac ctgggccaga
      961 tgctggccat caacgtgggg ctcacgtcac tggatctgag ctggaataac ttccacacaa
     1021 ggggagctgt ggccttgtgc aatggtctcc ggggtaatgt gaccctgaca aagctggatc
     1081 tctccatgaa tggctttggg aatgaggtgg ctctggccct aggggaagtc ctccgactca
     1141 accgctgcct ggtctacctg gatatcggtg gcaatgacat cggcaatgaa ggggcctcca
     1201 aaatcagcaa aggactggaa tccaatgaaa gcctcagagt tctgaagctt ttcctgaatc
     1261 ccataaatat ggatggggct attttactta tcctggctat caagaggaac cccaaatcca
     1321 ggatggaaga gcttgatatt tccaacgtgc tggtgtccga gcagttcatg aaaacgttgg
     1381 acggagtgta tgccgttcac ccgcagctgg acgtggtatt caaggcagta caaggcctct
     1441 ctcccaagaa aaccatcttc ttgttgacaa accccatgaa actgatccag agctatgcag
     1501 accaacacaa aatcacgatc gtggacttct tcaagagctt gaaccccact gggacaatga
     1561 agatgtctgt ggatgagttc cagaaagtga tgatagagca aaacaaggtc cccctgaacc
     1621 agtaccaggt cagggaggtg ataaagaagc tcgatgagaa gacaggcatg gtgaacttca
     1681 gtttcttgaa cacgatgaag ccatagcaac aagtctggtc tagaaagaag tctcggcgag
     1741 aggagtcctc gcaagtcgga tggtggcagg gaggagagca agaggtggct gaaatctcga
     1801 tggacagatg ctgtggcagg ggctgggcac aagcaaataa agtctggctt ggttctgggt
     1861 g
//
