LOCUS       NM_001012974            1782 bp    mRNA    linear   PRI 12-JUN-2024
DEFINITION  Homo sapiens leucine rich repeat containing 73 (LRRC73), transcript
            variant 1, mRNA.
ACCESSION   NM_001012974 XM_168060
VERSION     NM_001012974.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1782)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1782)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL355802.13.
            
            On Jul 7, 2021 this sequence version replaced NM_001012974.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC108661.1, SRR14038194.189467.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968189,
                                           SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372441.2/ ENSP00000361518.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-833               AL355802.13        22271-23103         c
            834-994             AL355802.13        21517-21677         c
            995-1117            AL355802.13        21055-21177         c
            1118-1218           AL355802.13        20583-20683         c
            1219-1441           AL355802.13        20213-20435         c
            1442-1782           AL355802.13        19725-20065         c
FEATURES             Location/Qualifiers
     source          1..1782
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.1"
     gene            1..1782
                     /gene="LRRC73"
                     /gene_synonym="C6orf154"
                     /note="leucine rich repeat containing 73"
                     /db_xref="GeneID:221424"
                     /db_xref="HGNC:HGNC:21375"
     exon            1..833
                     /gene="LRRC73"
                     /gene_synonym="C6orf154"
                     /inference="alignment:Splign:2.1.0"
     CDS             562..1512
                     /gene="LRRC73"
                     /gene_synonym="C6orf154"
                     /note="isoform 1 is encoded by transcript variant 1;
                     leucine-rich repeat-containing protein 73"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 73
                     isoform 1"
                     /protein_id="NP_001012992.1"
                     /db_xref="CCDS:CCDS34456.1"
                     /db_xref="GeneID:221424"
                     /db_xref="HGNC:HGNC:21375"
                     /translation="MLPSSIQISGEPLSGAEVRDICRGLRDNAVRLLSLRGCRLCDRD
                     FGRICRALAGATSLAQLNLNLGVVSSPSRIKQLAEALRTNRSIQSLFLHGSPLTDAGL
                     ALLNPALALHPALVALDLGDCMLGDEAINLICGLLPPDGAKSGLKELTLSANPGITPK
                     GWSRLAIAVAHSSQVRVLNLDYNPLGDHVAGMLAVAVASSRTLEVLDLEGTGLTNQSA
                     QTLLDMVENYPTALRSLVLAENSISPELQQQICDLLSEGEEEEEVAGGAGDTQEWERG
                     REPAAHQRGSSSWMCPSDPSSQMVLMTSGLGDSLLAETEM"
     exon            834..994
                     /gene="LRRC73"
                     /gene_synonym="C6orf154"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1117
                     /gene="LRRC73"
                     /gene_synonym="C6orf154"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1218
                     /gene="LRRC73"
                     /gene_synonym="C6orf154"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1441
                     /gene="LRRC73"
                     /gene_synonym="C6orf154"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1782
                     /gene="LRRC73"
                     /gene_synonym="C6orf154"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1782
                     /gene="LRRC73"
                     /gene_synonym="C6orf154"
                     /note="major polyA site"
ORIGIN      
        1 ctctggagct ggagccggag ctgccgccag ccgcccgcct caggctctct ctgccagccg
       61 tgcggccagg cccgcggggt ggtcgggggg agccgggcgg cagagaagga gggagcgggt
      121 acggcctcct agccgagacc ggtaagccga agcccttgag ccgctcgctg ccgctgccgc
      181 cgccgccgcc gcgaccgcga gggacaagga caagcgccga gcagcgcctg cccaaccccc
      241 ggaacgcgca cccgccccaa cgcccagaca cggaccgtgc gggccgcccc cgccccagcg
      301 ccgccccact tcagcccggc ccgcgccctg gacgcctccg cacctctggc cggctccggc
      361 tcagtcccgg tagctcttct ccgcccccgc cgcagcctcc gccgcagccg cagcctccgc
      421 cacagccgcc gcctccaccc ccggccccac tccgcccgcg acccctgccg gggccccgac
      481 cccggcccta tccccggccc cgcccgcggc cccaccaacc tccgttccgg ccccgtaccc
      541 ggaggcccag ccgtgggcac gatgctgccc agctccatcc agatttcggg ggagccgctg
      601 tccggcgccg aggtgcggga catctgccgc ggccttcgcg acaacgccgt gcgcctgctc
      661 tcactgcgcg gctgccgcct ctgcgaccgc gactttggcc gcatctgccg ggccctggcc
      721 ggggccacgt ccctggcgca gctcaacctt aacctgggcg tcgtgtccag ccccagccgc
      781 atcaagcagc tggctgaggc tctgcggacc aaccgctcca tccagtccct cttcctgcat
      841 gggagccccc tgacagatgc ggggctggcc ttgctgaacc cagccctggc cctccaccct
      901 gccctcgtgg ctctggacct gggggactgc atgctgggtg atgaagccat caacctcatc
      961 tgtggcctcc tgcccccaga tggggccaaa tctggcttga aggagctaac gctgagtgcc
     1021 aaccctggca tcacccctaa gggctggagc cgccttgcca ttgccgtggc ccacagctcc
     1081 caggtccgcg tcctcaatct ggattacaac cccctgggtg accatgtggc aggaatgctg
     1141 gctgtagctg tggcctctag tcgtacccta gaggtcctag acttggaggg cacagggctc
     1201 accaaccagt cagctcagac cctgctggac atggtagaaa attaccccac agctttgcgg
     1261 agcctggtgt tggctgagaa cagcattagc ccagagctgc agcaacagat ctgtgacctc
     1321 ctctctgagg gagaggagga ggaggaagtg gcaggagggg ctggcgacac ccaggaatgg
     1381 gagagagggc gggagcctgc tgcccaccag agaggcagca gctcctggat gtgccccagc
     1441 gatcccagct ctcagatggt gctaatgacg tcaggactag gggacagtct gttggctgag
     1501 accgagatgt gactctccac tgggcctctg cacaccattt cacttatcta tgtcccgagc
     1561 accttgcccc agatatcagg gtcaggccct gggacttggg agggaactgg ggtcaggggc
     1621 tgcatggggg ctctggcagc tcctggcagt gtggtgggaa ggaagctctg gaagctgtga
     1681 ctgagcaaca gccttggggg gcacttgaac ccacggcaat gcctttgaac ttggcagctc
     1741 tggctgcaac ccgctggctc ggaaaagatt ttatgaactc ca
//
