LOCUS       NM_181506               2163 bp    mRNA    linear   PRI 10-FEB-2024
DEFINITION  Homo sapiens leucine rich repeat containing 70 (LRRC70), mRNA.
ACCESSION   NM_181506 XR_042302 XR_042452 XR_042494
VERSION     NM_181506.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2163)
  AUTHORS   Wang,W., Yang,Y., Li,L. and Shi,Y.
  TITLE     Synleurin, a novel leucine-rich repeat protein that increases the
            intensity of pleiotropic cytokine responses
  JOURNAL   Biochem Biophys Res Commun 305 (4), 981-988 (2003)
   PUBMED   12767927
  REMARK    GeneRIF: Synleurin, a novel leucine-rich repeat protein that
            increases the intensity of pleiotropic cytokine and growth factor
            responses.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK123022.1 and BC110838.1.
            
            On Nov 23, 2018 this sequence version replaced NM_181506.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK123022.1, SRR1660807.178781.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000334994.6/ ENSP00000399441.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1995              AK123022.1         85-2079
            1996-2163           BC110838.1         1932-2099
FEATURES             Location/Qualifiers
     source          1..2163
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q12.1"
     gene            1..2163
                     /gene="LRRC70"
                     /gene_synonym="SLRN"
                     /note="leucine rich repeat containing 70"
                     /db_xref="GeneID:100130733"
                     /db_xref="HGNC:HGNC:35155"
     exon            1..117
                     /gene="LRRC70"
                     /gene_synonym="SLRN"
                     /inference="alignment:Splign:2.1.0"
     exon            118..2163
                     /gene="LRRC70"
                     /gene_synonym="SLRN"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..2024
                     /gene="LRRC70"
                     /gene_synonym="SLRN"
                     /note="synleurin; leucine-rich repeat-containing protein
                     70"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 70
                     precursor"
                     /protein_id="NP_852607.3"
                     /db_xref="CCDS:CCDS47218.1"
                     /db_xref="GeneID:100130733"
                     /db_xref="HGNC:HGNC:35155"
                     /translation="MCGLQFSLPCLRLFLVVTCYLLLLLHKEILGCSSVCQLCTGRQI
                     NCRNLGLSSIPKNFPESTVFLYLTGNNISYINESELTGLHSLVALYLDNSNILYVYPK
                     AFVQLRHLYFLFLNNNFIKRLDPGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQY
                     LNLQRNRLTVLGSGTFVGMVALRILDLSNNNILRISESGFQHLENLACLYLGSNNLTK
                     VPSNAFEVLKSLRRLSLSHNPIEAIQPFAFKGLANLEYLLLKNSRIRNVTRDGFSGIN
                     NLKHLILSHNDLENLNSDTFSLLKNLIYLKLDRNRIISIDNDTFENMGASLKILNLSF
                     NNLTALHPRVLKPLSSLIHLQANSNPWECNCKLLGLRDWLASSAITLNIYCQNPPSMR
                     GRALRYINITNCVTSSINVSRAWAVVKSPHIHHKTTALMMAWHKVTTNGSPLENTETE
                     NITFWERIPTSPAGRFFQENAFGNPLETTAVLPVQIQLTTSVTLNLEKNSALPNDAAS
                     MSGKTSLICTQEVEKLNEAFDILLAFFILACVLIIFLIYKVVQFKQKLKASENSRENR
                     LEYYSFYQSARYNVTASICNTSPNSLESPGLEQIRLHKQIVPENEAQVILFEHSAL"
     regulatory      2143..2148
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRC70"
                     /gene_synonym="SLRN"
                     /note="hexamer: ATTAAA"
     polyA_site      2163
                     /gene="LRRC70"
                     /gene_synonym="SLRN"
                     /note="major polyA site"
ORIGIN      
        1 gtggaggtca gcagtgccac agaacaaact ggagttaaga aatgtcgttc ttcagattta
       61 aaaagaaaac ctttactgaa tcagctgagt gttaataata cgaatttcct tttcttgcca
      121 attctgatct gaacagaaaa tccaagaaca gggatatgtg tggattacag ttttctctgc
      181 cttgcctacg actgtttctg gttgttacct gttatctttt attattactc cacaaagaaa
      241 tacttggatg ttcgtctgtt tgtcagctct gcactgggag acaaattaac tgccgtaact
      301 taggcctttc gagtattcct aagaattttc ctgaaagtac agtttttctg tatctgactg
      361 ggaataatat atcttatata aatgaaagtg aattaacagg acttcattct cttgtagcat
      421 tgtatttgga taattctaac attctgtatg tatatccaaa agcctttgtt caattgaggc
      481 atctatattt tctatttcta aataataatt tcatcaaacg cttagatcct ggaatattta
      541 agggactttt aaatcttcgt aatttatatt tacagtataa tcaggtatct tttgttccga
      601 gaggagtatt taatgatcta gtttcagttc agtacttaaa tctacaaagg aatcgcctca
      661 ctgtccttgg gagtggtacc tttgttggta tggttgctct tcggatactt gatttatcaa
      721 acaataacat tttgaggata tcagaatcag gctttcaaca tcttgaaaac cttgcttgtt
      781 tgtatttagg aagtaataat ttaacaaaag taccatcaaa tgcctttgaa gtacttaaaa
      841 gtcttagaag actttctttg tctcataatc ctattgaagc aatacagccc tttgcattta
      901 aaggacttgc caatctggaa tacctcctcc tgaaaaattc aagaattagg aatgttacta
      961 gggatgggtt tagtggaatt aataatctta aacatttgat cttaagtcat aatgatttag
     1021 agaatttaaa ttctgacaca ttcagtttgt taaagaattt aatttacctt aagttagata
     1081 gaaacagaat aattagcatt gataatgata catttgaaaa tatgggagca tctttgaaga
     1141 tccttaatct gtcatttaat aatcttacag ccttgcatcc aagggtcctt aagccgttgt
     1201 cttcattgat tcatcttcag gcaaattcta atccttggga atgtaactgc aaacttttgg
     1261 gccttcgaga ctggctagca tcttcagcca ttactctaaa catctattgt cagaatcccc
     1321 catccatgcg tggcagagca ttacgttata ttaacattac aaattgtgtt acatcttcaa
     1381 taaatgtatc cagagcttgg gctgttgtaa aatctcctca tattcatcac aagactactg
     1441 cgctaatgat ggcctggcat aaagtaacca caaatggcag tcctctggaa aatactgaga
     1501 ctgagaacat tactttctgg gaacgaattc ctacttcacc tgctggtaga ttttttcaag
     1561 agaatgcctt tggtaatcca ttagagacta cagcagtgtt acctgtgcaa atacaactta
     1621 ctacttctgt taccttgaac ttggaaaaaa acagtgctct accgaatgat gctgcttcaa
     1681 tgtcagggaa aacatctcta atttgtacac aagaagttga gaagttgaat gaggcttttg
     1741 acattttgct agcttttttc atcttagctt gtgttttaat catttttttg atctacaaag
     1801 ttgttcagtt taaacaaaaa ctaaaggcat cagaaaactc aagggaaaat agacttgaat
     1861 actacagctt ttatcagtca gcaaggtata atgtaactgc ctcaatttgt aacacttccc
     1921 caaattctct agaaagtcct ggcttggagc agattcgact tcataaacaa attgttcctg
     1981 aaaatgaggc acaggtcatt ctttttgaac attctgcttt ataactcaac taaatattgt
     2041 ctataagaaa cttcagtgcc atggacatga tttaaactga aacctcctta tataattata
     2101 tactttagtt ggaaatataa tgaattatat gaggttagca ttattaaaat atgtttttaa
     2161 taa
//
