LOCUS       NM_001370785           27923 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens leucine rich repeat containing 7 (LRRC7), transcript
            variant 11, mRNA.
ACCESSION   NM_001370785
VERSION     NM_001370785.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 27923)
  AUTHORS   Willim,J., Woike,D., Greene,D., Das,S., Pfeifer,K., Yuan,W.,
            Lindsey,A., Itani,O., Bohme,A.L., Tibbe,D., Honck,H.H., Hassani
            Nia,F., Zech,M., Brunet,T., Faivre,L., Sorlin,A., Vitobello,A.,
            Smol,T., Colson,C., Baranano,K., Schatz,K., Bayat,A., Schoch,K.,
            Spillmann,R., Davis,E.E., Conboy,E., Vetrini,F., Platzer,K.,
            Neuser,S., Gburek-Augustat,J., Grace,A.N., Mitchell,B.,
            Stegmann,A., Sinnema,M., Meeks,N., Saunders,C., Cadieux-Dion,M.,
            Hoyer,J., Van-Gils,J., de Sainte-Agathe,J.M., Thompson,M.L.,
            Bebin,E.M., Weisz-Hubshman,M., Tabet,A.C., Verloes,A., Levy,J.,
            Latypova,X., Harder,S., Silverman,G.A., Pak,S.C., Schedl,T.,
            Freson,K., Mumford,A., Turro,E., Schlein,C., Shashi,V. and
            Kreienkamp,H.J.
  CONSRTM   Undiagnosed Diseases Network
  TITLE     Variants in LRRC7 lead to intellectual disability, autism,
            aggression and abnormal eating behaviors
  JOURNAL   Nat Commun 15 (1), 7909 (2024)
   PUBMED   39256359
  REMARK    GeneRIF: Variants in LRRC7 lead to intellectual disability, autism,
            aggression and abnormal eating behaviors.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 27923)
  AUTHORS   Stephenson,J.R., Wang,X., Perfitt,T.L., Parrish,W.P., Shonesy,B.C.,
            Marks,C.R., Mortlock,D.P., Nakagawa,T., Sutcliffe,J.S. and
            Colbran,R.J.
  TITLE     A Novel Human CAMK2A Mutation Disrupts Dendritic Morphology and
            Synaptic Transmission, and Causes ASD-Related Behaviors
  JOURNAL   J Neurosci 37 (8), 2216-2233 (2017)
   PUBMED   28130356
REFERENCE   3  (bases 1 to 27923)
  AUTHORS   Fiorentino,A., Sharp,S.I., Kandaswamy,R., Gurling,H.M., Bass,N.J.
            and McQuillin,A.
  TITLE     Genetic variant analysis of the putative regulatory regions of the
            LRRC7 gene in bipolar disorder
  JOURNAL   Psychiatr Genet 26 (2), 99-100 (2016)
   PUBMED   26901794
  REMARK    GeneRIF: The important role of this gene in the synapse and mental
            illness endophenotypes observed in animal models suggests that
            LRRC7 may play a role in susceptibility to bipolar disorder.
REFERENCE   4  (bases 1 to 27923)
  AUTHORS   Namjou,B., Keddache,M., Marsolo,K., Wagner,M., Lingren,T., Cobb,B.,
            Perry,C., Kennebeck,S., Holm,I.A., Li,R., Crimmins,N.A., Martin,L.,
            Solti,I., Kohane,I.S. and Harley,J.B.
  TITLE     EMR-linked GWAS study: investigation of variation landscape of loci
            for body mass index in children
  JOURNAL   Front Genet 4, 268 (2013)
   PUBMED   24348519
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 27923)
  AUTHORS   Shi,M., Murray,J.C., Marazita,M.L., Munger,R.G., Ruczinski,I.,
            Hetmanski,J.B., Wu,T., Murray,T., Redett,R.J., Wilcox,A.J.,
            Lie,R.T., Jabs,E.W., Wu-Chou,Y.H., Chen,P.K., Wang,H., Ye,X.,
            Yeow,V., Chong,S.S., Shi,B., Christensen,K., Scott,A.F., Patel,P.,
            Cheah,F. and Beaty,T.H.
  TITLE     Genome wide study of maternal and parent-of-origin effects on the
            etiology of orofacial clefts
  JOURNAL   Am J Med Genet A 158A (4), 784-794 (2012)
   PUBMED   22419666
REFERENCE   6  (bases 1 to 27923)
  AUTHORS   Wang,L., Xu,J., Wu,Q., Dai,J., Ye,X., Zeng,L., Ji,C., Gu,S.,
            Zhao,R.C., Xie,Y. and Mao,Y.
  TITLE     Cloning and characterization of a novel splice variant of the
            brain-specific protein densin-180
  JOURNAL   Int J Mol Med 11 (2), 257-260 (2003)
   PUBMED   12525888
  REMARK    GeneRIF: A novel splice variant, LRRC7, of densin-180 is located on
            1p31 and consists of 8 exons.  Unlike wild type, not
            brain-specific.
REFERENCE   7  (bases 1 to 27923)
  AUTHORS   Ohtakara,K., Nishizawa,M., Izawa,I., Hata,Y., Matsushima,S.,
            Taki,W., Inada,H., Takai,Y. and Inagaki,M.
  TITLE     Densin-180, a synaptic protein, links to PSD-95 through its direct
            interaction with MAGUIN-1
  JOURNAL   Genes Cells 7 (11), 1149-1160 (2002)
   PUBMED   12390249
REFERENCE   8  (bases 1 to 27923)
  AUTHORS   Izawa,I., Nishizawa,M., Ohtakara,K. and Inagaki,M.
  TITLE     Densin-180 interacts with delta-catenin/neural plakophilin-related
            armadillo repeat protein at synapses
  JOURNAL   J Biol Chem 277 (7), 5345-5350 (2002)
   PUBMED   11729199
  REMARK    GeneRIF: Densin-180 co-localized with delta-catenin/NPRAP at
            synapses in delta-catenin/NPRAP and may be involved in organization
            of the synaptic cell-cell junction through interaction with the
            delta-catenin/NPRAP-N-cadherin complex
REFERENCE   9  (bases 1 to 27923)
  AUTHORS   Walikonis,R.S., Oguni,A., Khorosheva,E.M., Jeng,C.J., Asuncion,F.J.
            and Kennedy,M.B.
  TITLE     Densin-180 forms a ternary complex with the (alpha)-subunit of
            Ca2+/calmodulin-dependent protein kinase II and (alpha)-actinin
  JOURNAL   J Neurosci 21 (2), 423-433 (2001)
   PUBMED   11160423
REFERENCE   10 (bases 1 to 27923)
  AUTHORS   Apperson,M.L., Moon,I.S. and Kennedy,M.B.
  TITLE     Characterization of densin-180, a new brain-specific synaptic
            protein of the O-sialoglycoprotein family
  JOURNAL   J Neurosci 16 (21), 6839-6852 (1996)
   PUBMED   8824323
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL359894.9, AL117353.6, AL359412.12, AL391728.19, AL158840.14,
            AL157948.10 and AL353771.8.
            
            On Nov 30, 2019 this sequence version replaced NM_001370785.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2145743,
                              SAMEA2157437 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000651989.2/ ENSP00000498937.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-720               AL359894.9         91404-92123
            721-818             AL117353.6         40923-41020
            819-1021            AL359412.12        9318-9520
            1022-1139           AL359412.12        41170-41287
            1140-1218           AL391728.19        14390-14468
            1219-1308           AL391728.19        23422-23511
            1309-1365           AL391728.19        26869-26925
            1366-1429           AL391728.19        120149-120212
            1430-1504           AL158840.14        17271-17345
            1505-1649           AL158840.14        23134-23278
            1650-1722           AL158840.14        31453-31525
            1723-1852           AL158840.14        48689-48818
            1853-1968           AL158840.14        49866-49981
            1969-2038           AL158840.14        53357-53426
            2039-2138           AL158840.14        55611-55710
            2139-2263           AL158840.14        57897-58021
            2264-2512           AL158840.14        60018-60266
            2513-2713           AL158840.14        65063-65263
            2714-2825           AL158840.14        73013-73124
            2826-3006           AL158840.14        73336-73516
            3007-4687           AL158840.14        75005-76685
            4688-4828           AL158840.14        80846-80986
            4829-4948           AL157948.10        4253-4372
            4949-5170           AL157948.10        27304-27525
            5171-5263           AL157948.10        40954-41046
            5264-5338           AL157948.10        58979-59053
            5339-27202          AL157948.10        73007-94870
            27203-27923         AL353771.8         2001-2721
FEATURES             Location/Qualifiers
     source          1..27923
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p31.1"
     gene            1..27923
                     /gene="LRRC7"
                     /gene_synonym="DENSIN"
                     /note="leucine rich repeat containing 7"
                     /db_xref="GeneID:57554"
                     /db_xref="HGNC:HGNC:18531"
                     /db_xref="MIM:614453"
     exon            1..720
                     /gene="LRRC7"
                     /gene_synonym="DENSIN"
                     /inference="alignment:Splign:2.1.0"
     CDS             719..5446
                     /gene="LRRC7"
                     /gene_synonym="DENSIN"
                     /note="isoform 11 is encoded by transcript variant 11;
                     densin-180; leucine-rich repeat-containing protein 7"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 7 isoform
                     11"
                     /protein_id="NP_001357714.1"
                     /db_xref="CCDS:CCDS90975.1"
                     /db_xref="GeneID:57554"
                     /db_xref="HGNC:HGNC:18531"
                     /db_xref="MIM:614453"
                     /translation="MMENLIRGRNPPQYQRSPCKEVRAALRKRPEEELQCLEMTTKRK
                     IIGRLVPCRCFRGEEEIISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQ
                     LFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEA
                     SVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSM
                     HKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMS
                     KNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIG
                     NLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRS
                     NKLEFLPEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQSKALIPLQTE
                     AHPETKQRVLTNYMFPQQPRGDEDFQSDSDSFNPTLWEEQRQQRMTVAFEFEDKKEDD
                     ENAGKVKDLSCQAPWERGQRGITLQPARLSGDCCTPWARCDQQIQDMPVPQNDPQLAW
                     GCISGLQQERSMCTPLPVAAQSTTLPSLSGRQVEINLKRYPTPYPEDLKNMVKSVQNL
                     VGKPSHGVRVENSNPTANTEQTVKEKYEHKWPVAPKEITVEDSFVHPANEMRIGELHP
                     SLAETPLYPPKLVLLGKDKKESTDESEVDKTHCLNNSVSSGTYSDYSPSQASSGSSNT
                     RVKVGSLQTTAKDAVHNSLWGNRIAPSFPQPLDSKPLLSQREAVPPGNIPQRPDRLPM
                     SDTFTDNWTDGSHYDNTGFVAEETTAENANSNPLLSSKSRSTSSHGRRPLIRQDRIVG
                     VPLELEQSTHRHTPETEVPPSNPWQNWTRTPSPFEDRTAFPSKLETTPTTSPLPERKE
                     HIKESTEIPSPFSPGVPWEYHDSNPNRSLSNVFSQIHCRPESSKGVISISKSTERLSP
                     LMKDIKSNKFKKSQSIDEIDIGTYKVYNIPLENYASGSDHLGSHERPDKMLGPEHGMS
                     SMSRSQSVPMLDDEMLTYGSSKGPQQQKASMTKKVYQFDQSFNPQGSVEVKAEKRIPP
                     PFQHNPEYVQQASKNIAKDLISPRAYRGYPPMEQMFSFSQPSVNEDAVVNAQFASQGA
                     RAGFLRRADSLVSATEMAMFRRVNEPHELPPTDRYGRPPYRGGLDRQSSVTVTESQFL
                     KRNGRYEDEHPSYQEVKAQAGSFPVKNLTQRRPLSARSYSTESYGASQTRPVSARPTM
                     AALLEKIPSDYNLGNYGDKPSDNSDLKTRPTPVKGEESCGKMPADWRQQLLRHIEARR
                     LDRNAAYKHNTVNLGMLPYGGISAMHAGRSMTLNLQTKSKFDHQELPLQKTPSQQSNI
                     LDNGQEDVSPSGQWNPYPLGRRDVPPDTITKKAGSHIQTLMGSQSLQHRSREQQPYEG
                     NINKVTIQQFQSPLPIQIPSSQATRGPQPGRCLIQTKGQRSMDGYPEQFCVRIEKNPG
                     LGFSISGGISGQGNPFKPSDKGIFVTRVQPDGPASNLLQPGDKILQANGHSFVHMEHE
                     KAVLLLKSFQNTVDLVIQRELTV"
     exon            721..818
                     /gene="LRRC7"
                     /gene_synonym="DENSIN"
                     /inference="alignment:Splign:2.1.0"
     exon            819..1021
                     /gene="LRRC7"
                     /gene_synonym="DENSIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1139
                     /gene="LRRC7"
                     /gene_synonym="DENSIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1218
                     /gene="LRRC7"
                     /gene_synonym="DENSIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1308
                     /gene="LRRC7"
                     /gene_synonym="DENSIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1365
                     /gene="LRRC7"
                     /gene_synonym="DENSIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1429
                     /gene="LRRC7"
                     /gene_synonym="DENSIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1504
                     /gene="LRRC7"
                     /gene_synonym="DENSIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1649
                     /gene="LRRC7"
                     /gene_synonym="DENSIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1650..1722
                     /gene="LRRC7"
                     /gene_synonym="DENSIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1852
                     /gene="LRRC7"
                     /gene_synonym="DENSIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1853..1968
                     /gene="LRRC7"
                     /gene_synonym="DENSIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1969..2038
                     /gene="LRRC7"
                     /gene_synonym="DENSIN"
                     /inference="alignment:Splign:2.1.0"
     exon            2039..2138
                     /gene="LRRC7"
                     /gene_synonym="DENSIN"
                     /inference="alignment:Splign:2.1.0"
     exon            2139..2263
                     /gene="LRRC7"
                     /gene_synonym="DENSIN"
                     /inference="alignment:Splign:2.1.0"
     exon            2264..2512
                     /gene="LRRC7"
                     /gene_synonym="DENSIN"
                     /inference="alignment:Splign:2.1.0"
     exon            2513..2713
                     /gene="LRRC7"
                     /gene_synonym="DENSIN"
                     /inference="alignment:Splign:2.1.0"
     exon            2714..2825
                     /gene="LRRC7"
                     /gene_synonym="DENSIN"
                     /inference="alignment:Splign:2.1.0"
     exon            2826..3006
                     /gene="LRRC7"
                     /gene_synonym="DENSIN"
                     /inference="alignment:Splign:2.1.0"
     exon            3007..4687
                     /gene="LRRC7"
                     /gene_synonym="DENSIN"
                     /inference="alignment:Splign:2.1.0"
     exon            4688..4828
                     /gene="LRRC7"
                     /gene_synonym="DENSIN"
                     /inference="alignment:Splign:2.1.0"
     exon            4829..4948
                     /gene="LRRC7"
                     /gene_synonym="DENSIN"
                     /inference="alignment:Splign:2.1.0"
     exon            4949..5170
                     /gene="LRRC7"
                     /gene_synonym="DENSIN"
                     /inference="alignment:Splign:2.1.0"
     exon            5171..5263
                     /gene="LRRC7"
                     /gene_synonym="DENSIN"
                     /inference="alignment:Splign:2.1.0"
     exon            5264..5338
                     /gene="LRRC7"
                     /gene_synonym="DENSIN"
                     /inference="alignment:Splign:2.1.0"
     exon            5339..27923
                     /gene="LRRC7"
                     /gene_synonym="DENSIN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7022..7027
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRC7"
                     /gene_synonym="DENSIN"
                     /note="hexamer: ATTAAA"
     polyA_site      7047
                     /gene="LRRC7"
                     /gene_synonym="DENSIN"
                     /note="major polyA site"
     regulatory      27900..27905
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRC7"
                     /gene_synonym="DENSIN"
                     /note="hexamer: AATAAA"
     polyA_site      27923
                     /gene="LRRC7"
                     /gene_synonym="DENSIN"
                     /note="major polyA site"
ORIGIN      
        1 gccaatcctg gcacctgtgc gccgagccac tgcaccgagg aggaccctac tccgggtgaa
       61 caccgggctt gaagccacgg acacccagcc ccagtgcagc gggttctcgc cggcgggacc
      121 tgcagccgcc cactcgggcc accgccaccg cctcctgcag ttgcggagcg ctcagcccct
      181 ccgagacgcc cgctgcgccc tggcccctgg ggatcctcgc cctgcacagg cgcggcaacg
      241 ggcaggggtt gttacggagt tgggtgcagg attcgccttt cctgcttgtc tcttctccgc
      301 ccaggattta ttgtctgtgg agccttctgg gggcggggag ggagctgcgc ctccgccacc
      361 gccgccgccg ccgccgctgc tgctgcggtc gctagcgcgg cgcgctgggc aggctgaggc
      421 tggggagtgg acgcgctcct gcctcccccg ccggcgcttc gggcttcccc tcagccgctt
      481 cccgcgggaa cctctccagc cgtccacctg aagggcactg gcatcatggt ctaacgtggc
      541 accttcctgg attcccctct atctcctgtt cttcctacct tctactcctt ccctcctctt
      601 ctcctccgaa gaccctggcg cccactccac tgcggacccc tgaacactta aggaataacc
      661 cttggcagct gcacgactac gctctccgaa acctcatggg cagtttctcc cgccggcgat
      721 gatggagaac ctaataaggg gaaggaatcc cccgcaatac cagagaagtc cttgtaaaga
      781 ggttcgtgca gcacttcgga agaggcctga agaggagttg cagtgcctgg agatgaccac
      841 caaacggaaa atcatcggcc gtctggtgcc atgccgatgt ttccgaggtg aagaagaaat
      901 catctcagtt ttagattact cccactgcag tcttcagcag gtgccaaagg aggtctttaa
      961 cttcgaacga acattagagg agctttatct agatgccaat caaattgaag aactacccaa
     1021 gcaattgttc aactgtcaag ctctacgaaa actaagtatt cctgataacg acctttcaaa
     1081 tctgccaacc actattgcta gtttagttaa tcttaaagaa ctcgacatca gtaaaaatgg
     1141 tgtacaagaa tttccagaaa acataaagtg ctgtaagtgt ttaacaatta ttgaagccag
     1201 tgtcaatccc atttctaaac tacctgatgg cttcacacag ctcctaaacc tgacccagct
     1261 ctacctgaat gacgcctttc ttgaatttct tccagccaat tttggaagac ttgtcaaatt
     1321 gcggatcttg gagttaagag aaaatcactt gaaaactcta ccaaagtcaa tgcacaaact
     1381 ggcccagttg gaaagacttg acctaggcaa taatgaattc ggtgagctgc ctgaagttct
     1441 ggatcaaata caaaatttga gggagttatg gatggataat aatgcattac aagtgttacc
     1501 tgggtctata gggaagttaa agatgttggt atacctggat atgtcaaaaa acagaataga
     1561 aacagttgac atggacattt ctggatgtga agcccttgag gacctcttat tgtcatccaa
     1621 tatgttgcaa caattgcctg attctatagg acttttgaaa aaactaacaa ctctaaaagt
     1681 agatgacaat caacttacaa tgctacccaa tacaattgga aatttatctt tattagaaga
     1741 atttgactgt agctgtaatg aactggagtc actaccttct actattggct accttcatag
     1801 tcttcggaca ttagcagttg atgagaattt ccttccagaa ttacccagag aaattggaag
     1861 ttgtaagaat gtaacagtca tgtctctacg ctccaacaaa ttagaatttc ttcctgaaga
     1921 gattggacag atgcagaaac taagagtcct aaatttgagt gacaacagat tgaagaattt
     1981 accattctca tttaccaaac ttaaagagct tgcagctttg tggctttctg acaatcagtc
     2041 caaagccctt atccctttac aaacagaagc ccatccagaa acaaagcaaa gagtattgac
     2101 taactacatg tttccccagc agcctcgtgg tgatgaagat ttccagtcag acagtgacag
     2161 ctttaaccct acactgtggg aagagcagag acaacaacgc atgactgttg cctttgaatt
     2221 tgaagacaaa aaagaagatg acgaaaatgc tgggaaagtt aaggatctct cctgccaagc
     2281 cccctgggaa aggggccagc gtgggattac tctccaacct gccagactgt ctggcgattg
     2341 ctgcacacca tgggccaggt gtgatcagca gatccaagat atgcccgtcc cccagaatga
     2401 cccacagctg gcatggggtt gtataagtgg cctccagcag gaaaggagca tgtgtactcc
     2461 attgccagtt gcagcacaat ccaccactct tccctctcta agtggcagac aggttgaaat
     2521 aaacctaaaa cgatatccaa ctccttaccc agaggattta aagaatatgg taaaatctgt
     2581 tcaaaatttg gtgggtaagc caagccatgg agtgcgtgtt gagaattcaa atccaactgc
     2641 taacacggag caaactgtga aagaaaaata tgaacacaag tggccggtag ccccaaagga
     2701 gattacagtg gaggattctt ttgttcatcc agctaatgaa atgaggattg gggaacttca
     2761 cccttcatta gctgagaccc ctctgtaccc acccaaactt gttctgctag ggaaggacaa
     2821 aaaagaatca actgatgagt ctgaagttga caaaactcac tgtctgaata acagtgtttc
     2881 ctcaggcact tactcagact actcgccttc ccaggcttcc tcaggatcct ctaatacccg
     2941 ggttaaagtg gggtccttgc agacaacagc taaagatgca gtacataatt ctttgtgggg
     3001 taacaggatt gcaccatctt tcccacagcc tcttgattca aagccattac tcagccagcg
     3061 ggaggctgtt cccccaggca atataccaca gcgtcctgac cggctgccca tgagtgatac
     3121 tttcactgac aactggactg atggctcgca ttatgacaac acagggtttg ttgctgagga
     3181 aaccacagcc gagaatgcca acagtaatcc tctcttaagt tcgaaatcta gaagcacatc
     3241 ttcgcatgga cgcaggcctt tgatcaggca agacaggatt gttggtgttc ccctggaact
     3301 cgagcagtct acacacagac acacaccaga aacagaagtg cctccttcca atccttggca
     3361 gaattggacc agaaccccta gtccgtttga agacaggacc gcttttcctt ccaaattaga
     3421 gacaaccccc actaccagcc cattgcctga aaggaaagaa catataaagg aatctactga
     3481 aatacctagt cctttttctc caggcgtacc atgggagtat catgattcca atcccaacag
     3541 gagtcttagt aatgtctttt ctcaaatcca ctgccgcccg gaatcttcta aaggtgttat
     3601 ttcaattagc aaaagcacag agaggctttc ccccctaatg aaagatatca agtctaataa
     3661 attcaaaaag tcacagagta tcgatgagat tgacattggt acatataagg tgtataacat
     3721 accattagaa aactatgctt ctgggagtga tcacttagga agccacgaac gaccggataa
     3781 gatgctggga ccagagcatg gtatgtccag tatgtctcga agccagtcag tcccaatgct
     3841 ggatgatgag atgctcacct acggaagtag taaggggcca caacaacaaa aagcttctat
     3901 gacaaaaaaa gtctatcagt ttgaccaaag cttcaatcct caaggatcag tggaagtgaa
     3961 agccgaaaag aggataccac ccccttttca acacaatccc gagtacgtgc aacaggccag
     4021 caaaaacatc gccaaggatt tgattagtcc tagagcttac agaggatacc caccgatgga
     4081 gcaaatgttt tcattttctc agccatctgt gaatgaggat gctgtggtga atgcccagtt
     4141 cgcaagccaa ggggccaggg cgggcttcct gagaagggcc gactccctgg tgagcgccac
     4201 agaaatggcc atgtttagaa gggtcaatga gcctcatgag ctgcccccaa ctgataggta
     4261 cggcagaccc ccatataggg gagggctgga tcgccaaagc agcgttacag tgactgagtc
     4321 ccagttcctg aaaaggaatg gcaggtatga agatgaacac ccttcatatc aagaagtgaa
     4381 agctcaggcg ggaagttttc cggttaaaaa ccttacccaa aggaggccat tgtctgcgag
     4441 aagctacagt acagagagtt acggtgcctc ccaaaccagg ccagtttcag ctaggcctac
     4501 tatggcagct cttttggaaa aaataccatc tgactataac ttgggtaact atggtgacaa
     4561 gccatcagat aacagtgatt taaagacgag gcctactcct gtgaagggag aggagagctg
     4621 tggtaaaatg cctgcagact ggagacaaca gctgcttaga catatagaag ctagacggtt
     4681 agacaggaat gctgcttaca aacacaatac agttaacctt ggcatgctgc cctatggagg
     4741 tatttcagca atgcatgcag gcagaagcat gactttaaac ttgcagacta agtctaaatt
     4801 tgatcatcaa gaactacctc ttcagaaaac cccgtcccag caaagcaaca ttttagacaa
     4861 tggacaagaa gatgtatctc ctagtggcca atggaatcct tatccacttg ggaggcggga
     4921 tgtacctccg gacaccatta ctaagaaggc aggcagccac atccagacgt tgatggggtc
     4981 ccaaagcctt cagcatcgca gccgggagca gcagccgtat gaaggaaata taaacaaagt
     5041 gaccatccag caatttcagt caccattgcc tattcagatc ccctcttcac aggccacccg
     5101 gggacctcag cctggacggt gcttaattca aactaaaggg caaaggagta tggatggata
     5161 tccagagcag ttttgtgtga gaatagaaaa gaatcctggc cttggattta gtatcagtgg
     5221 tggaattagt ggacaaggaa atccattcaa accttctgac aagggtatct ttgttactag
     5281 ggttcagcct gatgggccag catcaaacct actgcagcct ggtgataaga tccttcaggc
     5341 aaatggacac agttttgtac atatggaaca tgaaaaagct gtattactac tgaagagttt
     5401 ccagaacaca gtagacctag ttattcaacg tgagcttact gtctaaatat tttttataaa
     5461 tagtgaagat acgtctagcc agacctaatg ttcaaaaata aatttataca tagaaacaaa
     5521 ttttgccaat tgctggacca atggcaaaca ttagtgccaa atgtataata ctatatgtta
     5581 gcactgacca tccttaaaaa atgttaactc tataaatatg atgttcatgt ggttatgtat
     5641 tagttttaat tgtcagcctc tggctgtgca ttggtgcagt tttgtttctg tttttgtttt
     5701 tgtttttaat caaataagtt tcttctcaaa atggatttca tataatttcg gagcacggaa
     5761 gcacacacaa gctctttatg aattctgctc tccatcagaa acactgcctc aaagttgtat
     5821 atgcctttat atagaaaata caaatataaa gaattgtaat tcccataaaa tatttctagc
     5881 acaaggtata tgttggcata tatacaaaaa gaatatagag aaaaacaata ttttcataaa
     5941 ctaaacatct cagatagaga aaaaatatat cttaaaataa gactttacta tattgaatct
     6001 ttttcaataa aaattacatg ataatgcctt atgaaagtaa ctgtacatat ggtataaagt
     6061 gtttatattt ggttccatat tcatttgcta aattctcatg acacagagtg aaatatttca
     6121 taaattagcc atttatctct gggacccaaa taaaaatagg atgaactaat ttgttcaatg
     6181 cctttagcta attacaatac atgcagagtt tagaaacaga ctaaaggtca ttgtagttaa
     6241 gtctttttca ccacaaattt aagcagtgga tgatgggtgg caggaaaggt attgctttat
     6301 ttctttcaag ttcatgttga ttataaactg tagcccctgt gatttcttta cttgtaaatg
     6361 tggaatttat ttgtgtgttg cttaatctaa tttgctgctt tttaaattat ttaaaacgaa
     6421 ttttggaaat tgataaaatt tatcattacg aaagactgct gttagaaagt tatggtaggt
     6481 gattttaaat ccttggtatt taaatatgaa acttcaaata taatttctca gagctgtggt
     6541 ctacctgtat cattaatttc aatggctgtt tttctgggca gaaatagata aaatactttt
     6601 tttccaaaaa cagtttcaag gtatgtaaaa tcctgaatgc tttttcactg aagagaaaga
     6661 caagcatggt taatgtagaa ttatttactt ttccattgaa actattttcc tgcataaatg
     6721 atcaaaattt attttataat cctttaaaat acttatcttt catattagtc attaatttaa
     6781 ttacaatatt aatttgaatt tccaggataa tttcccggag ttggttgcat gcattatctt
     6841 tcataatttt acatagttct tttgttatat aatgaattta ctttacatgc tagtgtttca
     6901 agtattgtat gaggattttc acaatagtat cactgaatga tgtcaccaga gctctgagaa
     6961 taatatttgt aagttaactg ttttatgggg acattgaaaa tattgtattt ttgtagggtc
     7021 tattaaaatg agtgtcactt attagaagta cagtggtatt ttttggcaat agaatttgtc
     7081 acttgggaga aaataatact tcactttata gatgatgcac taattttgat gttgctttat
     7141 gtcagggtga cattatacca tgattttata gggtttgaca attagctaat gattaactga
     7201 ttggcctatt tagtatgttt cccagaagta acttttaaat gcattttaat atattgagag
     7261 tttcagatga gaaatgtctt tcagagacta attttctttg ttgaaaactc atgtcaagcc
     7321 accatatcca gatattatag gatgatcatc attaatcaag acagaggcct ttactggcct
     7381 cataagatca cttaaagaaa aaaaactcat ggctgtagtt tggtggcaat gaaacatctg
     7441 aaatcatccc atcagttttt cttaatcttt tatgggagaa gtgggagaag agccagatat
     7501 agaactgccc caagtctttt tcttatggtt tctatatcaa acccagggct tcaggagatc
     7561 cttctaagac acacagctga aaggatcata atcctagtaa acacctctgc cactcctgat
     7621 gtgacaacat tgtcctgagc cacttcttta gtacttcctg ttctgcagtt cagaaatgag
     7681 gaaaagagaa aagggatcct tgaccaactg gaaaagttat ctgatatgcc aaagcacctc
     7741 actgtcaata gtactgccat gttgcatact gagaacaggc aggtaataat gaaaacaggc
     7801 aggccaggcg tggtggctca cactagtaat ccccacactt tgggaggcca aggtgggcgg
     7861 atcacttgag gtcagttcaa gaccagcctg gccaacatgg tgaaacgcca tctctactaa
     7921 aaatacaaaa attagctgag catggtggcg ggcacctata atcccagcta tttgggaggc
     7981 tgaggcatga gaatcaatcg cttgacctgg gaggcggagg ttgcagtgag ctgagattgt
     8041 gccactgcac tccggcctgg gcaacagagc gaaactctgt ctcaaaataa ataaataaat
     8101 tatttattta agtagaaaag aggcaatttt ttttaggttg actgaataga atcactaaac
     8161 acttgagggg tataaacctc actaattcta taggtgatga aaaccaatta tacattgatt
     8221 tttgattatt gactttttgc agtaactgat tttgctgcct gaaattagaa tctggttatt
     8281 ttaacaataa aaaaaagtca agggtgtgcc ttttaaaaaa aaaaaagaaa aatcaataac
     8341 aacaaaaaga actggaattc atgatggctc cagtagattc tacctcttgg tctttaattt
     8401 ttattggact gtttctgagg aaggtgttta tatgtgataa gtcagtaaga tctaatggag
     8461 gagactgaga aacattagag gtagaaagag caagtgatga aaattactag taaaattgca
     8521 aattttgcaa gacaaataga tattagtgga caatttttaa aactatttac aaggctcata
     8581 atattttgtc attaaagctc tgctatgata actccagcct tctgatgaca acacagtaac
     8641 ctaaacatac atagtaactc caaagtataa gtgcattttt gacaaggaat attcaaagtc
     8701 agtatgaaat aaaacattat gctaatgtat tgctcattga agcctataaa agatatgtat
     8761 ctccattact tagaattgta attattaggt tgctgaaaaa gtaattgcgg tttttaccat
     8821 taaaagtgca ggcaaaaacc acaattactt ttgttccaac ctagtacata gatgtaaaac
     8881 aatctcagtt gtttctggac cttaccttgg atcacgacct ttgagatgga aaacagcttt
     8941 gaggagagac tgacaagcca atgttaattt gctcttaatc ttaaagatga ttgcacacat
     9001 atcactaatg taattactta tttaaaaata ggactgacat atctttcaac tggtgagcta
     9061 aagagagagg gccgggcgcg gtggctcacg cctgtaatcc cagcactttg ggaggccgag
     9121 gcgggcggat cacgaggtca ggagatcgag accatcccag ctaaaacggt gaaaccccgt
     9181 ctctactaaa aatacaaaaa attagccggg cgtagtggcg ggcgcctgta gtcccagcta
     9241 cttgggaggc tgaggcagga gaatggcgtg aacccaggag gcggagcttg cagtgagccg
     9301 agatcccgcc actgcactcc agcctgggcg acagagcgag actccgtctc aaaaaaaaaa
     9361 aaaaaaaaaa agagaagatt cagaggggag aaaacatgga agaaattaga tttatatatt
     9421 caaatattaa gtgaaaagta tctgaatttg tcaaaatggt tagatgaaag aaaccaaaaa
     9481 aaccatttta tttttaatca taaaatctat ttaatatata tttaatatct attaatattt
     9541 aagctttcca gtgtaaagct ttggaaaatg tagtgtgctt gccaccttgt ctttccgttt
     9601 agtatgttta ctaactgtta aggacagtct taacgctgtc cctaaccaat ttctacccct
     9661 cattagcaca ccgatcaaat atgtctgatg aatacattct catcaagagg caagaataca
     9721 acataaccag gtcaaaagcc atactgaaat aggactacca ctcaaagtct ttgataaatt
     9781 cgatcaaaca acatatttga ctaatttgtg atatgccgac caaacagcaa gtttattggc
     9841 acactgggtc aataaaaagt tatgcaaata atgaaatcca ataggttaag aagatgggtc
     9901 ctttatctag tataaagaaa agcggggttg aagttccact gtagttcctt tcacagaaat
     9961 gctaaatctt actgagctta actaaatgtt caaactctgg gttggtaatg tgtcctctct
    10021 tcacacttgt agctacctga tcatctggga cttggggggc atctccaggt tggtgatcac
    10081 ttgcatgaac atttttcctt agcaatacaa ccaccttctg ttaagaaaag catcttgcct
    10141 tggctcagaa tatttcccat cacccaccaa caccataccc aaagaataca ttatagcaag
    10201 aaaacagaat gtgggctgtg gacaaataga tgtgcgctat gtatagaaag catgtgggtc
    10261 actattacag gagatcctga gtgtcagctc cattttgatc taaactgttc aggaaatcta
    10321 ttttccaaga tgcaccactt gtacaaacta aggtagatgc aatcaagttt tccagtcata
    10381 tcctgaacct tctgggggca tttctgtttc tagcgtgtaa aactgacctg tcttcattgc
    10441 tgcagttgct gctatagatc cgtccctcca actccccatg tttttccaaa ggcagtggat
    10501 gtctgcttct atcctgctga aacacagata agagaccctc ttagagtgat agctgttcgg
    10561 agagccttga gtatcaacag atggttacag ctcccaattt gggaggaact ttcttgggta
    10621 acgcaggaac ctggagtagt agcattaact aaggcccaaa gatggagtgc ttataatgtt
    10681 actgacaaca acaaacaaag cctgtgtgca atggtggggg tggcaatgcc tttataaaac
    10741 tgtttctgct tctgttttta aaatgttggg ttttgctgtg ttgaggaact ttctctaagc
    10801 ctctcagctt cttactgaga caggttccaa tcttccttac tttcaacact gcctgcaaga
    10861 gaatggtttg gaaacactcc ctggtaagga tataaattgc acagcttcta ctttggagaa
    10921 ttcagagatt tttgaaaaac cgagggggca agtctactct aagtttttat ttaaaaacat
    10981 acagttaaag tataggaata ttgagtccct tgggatttta accatgtgat tatgtcaacc
    11041 ttccctaaga acagttctat gggaagtaag gagaaaagac ctgagagagg agaaaattta
    11101 ctggttaact tcagaggcat ttcttcagct ggtagagtct tcccagttgg gttctgagct
    11161 catgctcttt gtaacaacac actgagcact aagcaatgta agaaatgggc ctggattaag
    11221 gcatgcagaa atgagaagga tacctctgca gctctgtcaa tacttccaca aattgtctgc
    11281 aaaacacccc ttttgtgcct aattttgtta tggcagcacc tcaaaaggtg gaaggttgtg
    11341 aaattcacgc agcatttatg taaacattcc atgactctta ttagtctacg gttggaacca
    11401 ctatgtagtc ctacccaaag acaaggtctg ggtcaaattt ccacaggtga gattttgaaa
    11461 cctggcataa ttttctcttc tccttttttg aaaaaaagac ttttatgtga ctttttcttt
    11521 tctttctttt tttttcttga gacagagtct tgctgtgtca cccaggctgg agtgcagtag
    11581 cgctatcttg gctcactgta acttccacct cccgagttca ggcaattctc atgtctcagc
    11641 ctcctgagta gctgggatta caggtgcgtg ccaccacact gggctaattt ttgtattttt
    11701 agtagggaca gggtttcacc gtgttggcca ggctggtctc gaacacctgg cctcaaaaga
    11761 tccacctgcc tcgacctccc aaagtgctgg gattacaggc gtgagccact gtgcccagca
    11821 ttttttcatt ctttaagcta gcatagattt cactgggtgt agaaattggt gttgaaagaa
    11881 agttaaatga atcacccaat ctttctctag ttttgaaagt gtattttttt atcactgttg
    11941 cacaagtgta ttgtttgtgc ttattttttt tccttcttta aaataacagg ttgaataagc
    12001 agcctaacaa atagccaagt atctttacat ccagagtaaa gtatcttagt acagggaact
    12061 ttattttcat agcaaactct tgtacttcct ccacaggaaa acatttactg tagctgaatc
    12121 tctgaggcct aaagtatatt attcataaac tgaaaacatt tggagacatt tcattgaaga
    12181 atataacaaa aacattaaat attatgatta taaatattaa aataaatatt tgttgggcat
    12241 caactacata tcaggtacta tgagggatgt aatgtggtcc cctcagcaca gaatctcaca
    12301 gtccagagga aagatgagag aagttccaca tcaaagacag tacaaggcaa tgtggtgagt
    12361 ccctttattc ctgccctcaa ccatcctatt gcaaaaggaa atcgagtctt tatctagtca
    12421 aatctgtttc agtttgagca tggttttttc catttggagc tacagatagg tcttctgctg
    12481 gttcttgtga ccttcacaca gctcacataa agagtgtcac gaagccgggt gcggtgactt
    12541 atgcctgtaa tcccagcact tagggaggcc gaggcaggtg gatcacttga ggtcaggaat
    12601 tggataccag cctgaccaac atgctgaaac ctcatctcta ctaaaaatat gaaaaattag
    12661 ccgggcattg tggcgcgcac ctgtaatcct agttactggg gaggctgagg caggagaatt
    12721 gcttcaaccc agcaggcgga ggttgcagtg agctgagatg gcgccacagc tctccagcct
    12781 gggtgacaga gtgagactcc atcttaaaaa aaaaaaaaaa agtgtcacga aaagtgtgag
    12841 ctagatgaat atttgccagg atttagggca acatttgata ggctaaacgt ggcaagtgtg
    12901 aatgccttgc tagacaagat aaatagcaac cagaatctct tgaatctctg gaagaggagc
    12961 gagaattttg ccaatttgtt ctaaagagga aaggaaatga agaaaggtgt tcctcaactt
    13021 ggtccagcac tgagtctgta tgcccctgac gttacgggag aaggagatgg aattcaacac
    13081 tttaaaaagt gtgggggggt tgcttgaaaa gagtcttcta ggttcagcgg ccccaaaaag
    13141 tccctcctat gaccactgtc agggagcgtg ggaatccatg ctgtccaatg ttagaatgac
    13201 ccactccgaa atgcaaggag ttgaacaatc attcagctgg ctgcatttca tgtttattta
    13261 cttcactttt tgggtggaga acattttcac tacacgctgc tcaagtgatc ccctgaaaat
    13321 actgtttgca tgagattgga tcacacatac catgtatcat caacatctat tcttctaagg
    13381 agttctgatc ctctgaatct ggaaattgtt ttcttttctt caccctatgc atactcagtg
    13441 ttttagacac atataaatcc ttacttttcc aagtattcgc tgtgttttat atttcagctt
    13501 ttgcccacac tatccctcta ctggaatgcc ttcctctccc tattcccttt ctaaattatt
    13561 aaaatcatat gcagccttca gagcccagct caaacagcac tagaaccatg aaaccctccc
    13621 tagtcttcat ggaaaaaaat ttctgtactc agcactacca tattaatttt ttcttatgtt
    13681 ttttagtatc tttcccattc tgcctgagat catagctatt tggtgtttgt ttttcctatg
    13741 aactttaagc tttttgagag agaggatcag acaatactta acaaaggact tctagacaga
    13801 agagcctcag gagaggtaaa atgaccagat gttttgttta ccatatatcc ttaatgcctg
    13861 tcatagtgtc agaaacatag tataggttct caataaatat ttgtgtaatt attaagtgga
    13921 tgacaggcct ggcacatagt gcactttata aatattgaac taaacagcaa attgatcttc
    13981 agtttgtgta accttaaact accaaccttt catcttctca gttgactcaa aattcccagt
    14041 taaaaaaaat ttctcctttt taaatcagtc ttcctcctct cttcagcatt ttttctaaga
    14101 catttttggt cttttctgct gtgtttcagc agttacattt aattttcctt ttgtgtgttc
    14161 taaggacctt aacactatcc aaaaagtaac accattcaaa aagtttaaga agtggctttt
    14221 atttaattgg agcacaccat atctatcctt ttgatttgat tgggtttcct ttctctttga
    14281 gaagaagtca tgcacattgt cactagatta cgttacctaa gcaattttta caatttggat
    14341 gtggagggaa gaataaaaga tgtcatgaga gagacgaggc tacggaagtg tagttgagag
    14401 aaaggggtct ccacctacct atttagctct aaattttaat caaactgctg ccaaatgctg
    14461 cccgtccttt aagtagataa aagaatagtc tgtctacagg ctgttggcca cagttgagca
    14521 tgacaatgtt tacacactgc attttggcat catttcatga atagatccca ccccctatat
    14581 ccctaaagtg aagatgtcat atagttcagc caaaattatc aagccactgt aaaagctata
    14641 taattgatat gattaactat ttagatagag cacagaaaaa aaatcagggt taccttgaca
    14701 aaaccatgtt acccctccca aacttttata gagatagaat ctggcctgtt gatctcaaag
    14761 tagaaagaaa gcatgctatt tatactgcca tgatctttgg cttcattaga tccttcccct
    14821 gaagggacaa aaaatggaat ccagcccctt aaaacaaaaa tgatatctaa ctgggaatct
    14881 aatgatatct aagaccccca ggttggtaag ctcctaacca caatcccttt attacctcat
    14941 gggaccttaa tttcctttca agtaaaacat ttctgtccta gctttctcac aaaactattt
    15001 cccatgtctt tctatttggg tttcatagct aagtaactcc agaattgagt gaaatattcc
    15061 gaaacattaa atgttttgtc attgactctt ttacttatac tattaatatt aattactctt
    15121 attctacctc tgctttttaa tttctttgta taaagagaac ttgataacta tcaagttaat
    15181 tatgtcttct tctcataaaa tttttgattt agaaagattt agataaagtc atagtatatc
    15241 ttgaaggaaa cagccaccat tgctgtcttt gatagcatga tgcctcaaac tctccagggg
    15301 cctactcttt ggtatcttat agcccagtgt ctatacattt acatgggtaa aagaatgcca
    15361 atgtctcttt gaacaaaaat aaatgaaaaa tgaactggaa aagtgaaata ttaattgaga
    15421 gagtgacatt atcttaggat agtaagaata ttttagaata gtaagagtac tttaatgaaa
    15481 tatttttaag taagagcatt ttagaataat gagaataatg agtgagtaag gaacaagaac
    15541 agactagggc tgggaaagag gggaattaat aagttattaa ggaagaaaga atgagaaaga
    15601 caaaagaagg gcaatagagg actgatacag agaatcagag aggaactgga taaaagaaat
    15661 cagattcagg catatcctcc agtctcttcg ttctggtgac catgcccctt cttcagacag
    15721 ccctgaattc ccttcctctc tctctgctct ctcttggcca gaggagtaat cgttcagctc
    15781 ttcttggttt ctgccttccc tcctgctctt ccagatgtca aaagaagaat ttacagtgaa
    15841 aaataaggtg catattagaa atatatttag tttaattgct attcatttct agaaactatt
    15901 tttgtctaac gtcataggta atgctttagt catacaactt ctcagaacaa ggaaaaaagt
    15961 tatctcattt ttaaaaatta ccagagtact tttctttttt cttttctttt cttttctttt
    16021 tttttttttt tttttttttt ttgagacgga gtctcactct gtcatcaggc tggaggctgg
    16081 agtgcagtgg cacgatctca gcttactgca acctccgccc tccgagttca agcgattctc
    16141 ctgcctcagc ctcccgagta gctgggatta caggcgcctg ccactgcacc cggctaattt
    16201 tttgtatttt tagtagagac ggagtttcac cttcttggcc aggttggtct tgaactcctg
    16261 acctcgtgat ccacctgcct cggactccca aagtacgggg attacaggcg tgagacaccg
    16321 cgcccggccg tacttttctt aaataaagac taatgtcaga cagtgtggct acaggtaaaa
    16381 gctctgtgga gaaaggagca aaattattgt cctatcataa gacagaaagg gaccttgaga
    16441 ggatctggtt catttgtcta tcttcaggga aggattcatg ctattcttaa attcctggag
    16501 cgaaggggtg aacatttccc tctgtaaccc acccttataa agcaacaaat tgtgtttcat
    16561 ctcaataaaa tcctctagtt taaattactg cgttcaactc tgacaaatac tatcctcata
    16621 tttagttgta cacatccgca tactctttta aagaaacatg tgtctgcagt tcagaagagc
    16681 caccactaga tggagacctc atatctacat tttaaatccc agccttggca attctctggc
    16741 ttgggggagc acagtccgat ttttgttgtt gtcgtgggtg ttttttgttt gtttgtattg
    16801 agacagtgtc gctctgtcgc ccaggctgga gtgcagtggc gcgatctcgg ctcactgcaa
    16861 cctccacctc ctgggttcaa acgattttcc tgcctcagcc tcccgagtag ctgggactac
    16921 aggcatgcac caccacgccc ggctaatttt tgtattttta gtaaagacag gttttctcca
    16981 tgttgcccag gctggtcttg aacacctggg ctctatcgat ccgaccgcct cggcctccca
    17041 aagtgctggg atggccttac acagtctgtt tttatgcccc ttgtgctgat acaattgcta
    17101 acaacacccc tttcctttct cctttgagaa aatttgaaac aatgctctaa atttacacaa
    17161 tttaagaaaa aaacaagagc tttgagctta ttttaggcag tttatatgtt tttttactaa
    17221 acctctcaga ttgtatcaat cacccaaaac ctaatgagac agaaaccact ttctcagtga
    17281 ggcttgattg tttaaagttt tgatgttcct taattgttca gtttaattat tatacccacc
    17341 agtttaatag ttcttctcta acttgtgttt tccaaatatt ttgctcctat ctcccattat
    17401 tttagccaca cttccttcag gtatgcccat tccaagtatg tgggaataga tttgtctcaa
    17461 gttactcaaa atttattttt aaagttaact ttccaaaact taaacatcag gaactgtggt
    17521 taagtttgcc tagccttctt tatgtaattc taaaactagt ccaatctgaa tatgtgtgca
    17581 tctgggtata gctttatttc catctggcaa taactaggca tctacaataa acgcctaatt
    17641 tttcatttta tttatgtgta tgagtaatca gcataatatg acaatcagat tttattttat
    17701 tatgaagtga ataagaaatg tatttcgaaa tgtatttcaa aatgtctctc acaaagtgat
    17761 cattggattc ccaaggtagt ttgcaatctc cccagcctct ctcctttcag tgggaatatc
    17821 tgggtgctga aggcagagaa cccctggcgg ccttggtgac atgtgtcctc aagctatttt
    17881 ggttcttctt agtcatttga aattccaggg cctctgatgg ctggatcatt gctaaaaagg
    17941 ccaaatgttt ttgtttactt cctctaagct aattatatcc tcaccctcac agcttagcca
    18001 gcctcctggt ctgagcttct tctttgctaa ttccatcaaa gccctactta tatgggtttc
    18061 aggtgttccc ctgccaacca tttaatcttt ttttcttcca acccggagca aaggtagagg
    18121 gaagacaagg tgttctttcc caaagtttat gtgaagccat ttatatcctc tggtgttttc
    18181 ctccaaaaaa aacaatttcc ttctagccac atgatcacca gatactaata cagaatactc
    18241 tttcttagca aattcaattt aaccttcttt gggggttaat attttgtaag ttctttctga
    18301 cctcaagcct gccaatttta gtgcaccatt ttgggtttgt ttaccaagtg ttcttcctct
    18361 cttttcagag aagttaaata tctccttaac aaatttaaat tgtacacaac agtgccaccc
    18421 attttaaagc aaatacggca ggtgtccacc attgttttgg atacagcttt tgagtttttg
    18481 atttgcctga tgttctattt catctttttt attccttcta ttttccataa ccttttaatg
    18541 ataggtttag ttgtaaaatc cagaactatt taaatactag aatgaaaatt acatagaatt
    18601 ttactgaaga gtataagaga aaacgtcttg aaagtttgta tgtatgtatt ccagttgcgc
    18661 tttttatttc ttttttcctt tcttttcttt tgcactacct cagatttttg gtatccacta
    18721 ttagcgaagt atttttttct ttgtcttcta tggataatct taatttttta ttcctaggag
    18781 caacctctag gtcagtgctt gctatccagc cactagcata gttccccagg agcaggctat
    18841 gatcatctcc tcaaagcacg ggggcttgtg gcttattctt ttcacttttt tacccatctc
    18901 cgtgccatac tgtagaacaa acatcatttt tttagttctg tcatgaggta aagatgtaaa
    18961 gatgtaaaaa gctctgcttt taggtacaac aaatggaaat atcatctagg ctgggttggg
    19021 gtgcaggacc cccagcagct gtgggaagag aagagagcag gagaagctgt cacttaaaat
    19081 gcactgagat ccttttgaaa catctcacgc actcctcccc aaccccgact ccaagggtgc
    19141 tgcttgtcca actgtgtcac ctccctgaca aataagtgaa tatccatcat attcaagact
    19201 tcacttttat tgatgatcat taagctagaa tctgtaaaag agaaagttgt tagatagtga
    19261 acaagtccca ttctctaaaa gtgatttttt ctctaggata tcatcatcca aactattctt
    19321 gccctgtaat atttgtctat actgtcttga ttgttttaaa ccagccatct ttgatagcca
    19381 gttttgggat ataaatcttc agccatactt gtagaatcgt ttgactaagc aacgggtatc
    19441 ttgcacttga taggttctca cagtctcatt atgatcaaga cagatattct agcaggacat
    19501 cactgctata ttctttataa aaccatgaat gttgctagca aacagttcag gcatttcttt
    19561 gtggccattt cccagagaaa ttcaaacttg ggaattaata tctctctctc tctgtgtgtg
    19621 tctgtgtgtg tgtctgtgtg tgtgtgtgtg tgtgtgtcta tatatcttat caggcaattt
    19681 tttttttttt tgcatttcca cgtttcccaa aaaatgatag ttactatccc tgtcacctag
    19741 ggccctaggt catcataaac tactcaaagt gaagggacta tattttcttc ttttgcttgg
    19801 tcttgccata aatatgcccc gcaggttcac ctatacccca aaatatatac ttatattttg
    19861 agtattcatc cagacctgta ggtttgaatc gagagatgtt taagtaattc tcttgtaagt
    19921 ctgcctccgg accattctaa ggtttgtcct ctagccaatc tatatgttta tcctttttta
    19981 aaaaattatt taactgttaa aacaatttgc ctttttctca ctgtgcattc aatttaatca
    20041 acaaatgtta atgaacaagg ggttatgttc aaaattctat tataagaaca atggaagata
    20101 taaataagcc atggtcctac ccctcaagaa acacagtcta gtggggagac acacaaaaag
    20161 tctaataaat gctatcgtgt aggtacaaaa tatgaggaaa gaacactgta ttgtcacctt
    20221 ctctcacagt ttaataaaat ggcaaatgct ttctttctgc tttattgctt ttttaatgcc
    20281 tttttttttt tttttttttt ttttctgaga cagggtcttg ctctgtcacc caggttggag
    20341 tgcagtggca tgatcatggc ccactgcagc cttgaccacc tgggctcaag tgatccacct
    20401 cagcctcctg agtagctggg actataggca tgcaccacca ctcctggcta attttttatt
    20461 ttttgcagag acagagtctt gctatgttgc ccaggctggt ctcgaactcc tgagctcaag
    20521 tgatcctccc acctcagcct cccaaagtgc tgggatgata ggcatgagcc accatcctcg
    20581 gctctattgc ttttataata tgacccaagg aacgttttct gttatctcag gaaggaaagt
    20641 tcttgtccct tgtatatatg tatcttgtca aaaaggacaa ggctcaggtg acagtgggga
    20701 cgtaaataac tgcagtatca tcctgaataa atcatatcac ggagagatag tcacaggtta
    20761 gctaagctcc agcttttcac ttttcttgac tctgtctttc caaggagtaa cccttttggg
    20821 tcaaagtcag agggggcttg ctggaatcaa gggcagctcc tcctttctgg aggaaggaac
    20881 ttcatcttaa ggcttgataa caaaggctta ctgttccact taaagggatc aatctgaggg
    20941 aagaagagaa gttaaccttt agtgaccctt gaaagcttta aaataattct tttgtgtttt
    21001 agacacctaa gaaaaatgta cgtacatctg gtggacttgc atatctttaa cacttatcat
    21061 gtacctacat acaaggaaaa cattagtctt tactgttagc aaacactcca ccactggggg
    21121 ttgctttgtg tttaagtacc taatagaccc accagagttc agtaagaaat gcaacttgaa
    21181 cagcccctga gataaaattt tctaggaagt ataaaaacta aagaatgcct ggaactatgc
    21241 agacatagat caagtctcat gcatgtcatt tagacagaca gctgaaatgc tgacatggcc
    21301 tatccagcca gagccttcaa ttaagagttc tccaatgttg acaatttcag ctgccctagc
    21361 agcctctcta agcactaaga agtatagcca tctaaatcct tacaacttat tctaagggaa
    21421 gaatctcttt agagattaca ttacaccagc aagagaatat taatagtcca tatggcttta
    21481 tttccaacaa aatcccagag tttttgcttg ctctttgagg ttaaaatcaa agatttttca
    21541 ctcaggatta gcctagatgt agaacagcga ctgtataata aagttgagtt caaaaagtgt
    21601 atgaattcag ttatggtctg gaaaattagc tgccattttg tgatgaagtg tttggttttt
    21661 ccttgtagaa acttagtgtc attgcgcatc aacttagaaa atgtgaattg attaaaaata
    21721 tgtgatggat tgtgcagcat gcttacattt gaaaatggag attgtgcctt taaatactta
    21781 atcaaaggac tcctgacctt caagtaccag tttgggcata ttactggaga tccaggttga
    21841 aaggtattga aaaaaaagct ctgtatcttt gtatattcag ttgtcaacat ggagaagcca
    21901 ccttttaaaa aagatcagtt ctgtaaagca taatgcctac tacacagaca tcattattct
    21961 acttaaaagt ctttttttaa aattccaaat acttgtggta gtagaaagca ataaatattc
    22021 taaaatgagg gatattggtc cttttgtgac tgagctatat gataaactaa ggaaaactac
    22081 agaagttatg tctattaact ctttaaggta catgatatag caaataatca tttgtacaac
    22141 ctcatagaaa gttgagagga ttaatcaaat tgtttcaaaa tttttaagga gccaaattta
    22201 aattctcaat accctatgag attttttaaa ctattttaga ttcttaccag aagaatgcat
    22261 agatgtagta aaaccattaa atacagtagt atctggtggc ctttctgtgt ggaggagctc
    22321 gtttgtccaa ggtatgatct accagtgaga agatcagtgc caggtcacag aaaaagctaa
    22381 tcatttttag tttaatcctg accagctagt cttcctccag gcatcagcta cctgatttta
    22441 aagagaccat attagaaatg aaaagcagca gtctctatca tatgttaaat tcaaaggcat
    22501 agctgctcgt gaagacccta ttatgtttta tttgcctatc ggagaaagag atctgcctac
    22561 ctgcctttag gaaaaagcaa tgctttatgt agcttcaatt agtcctgcat caggttattc
    22621 taatgcttcc tactgcaaaa accaagccca caagtctcca atcctaaaag tcactagaat
    22681 attgatataa ggaattctgt gtcagcagta tctcagtatt caaacctctg tttagggtcc
    22741 tgcatgtact atcaaacagc aagtgataga acattcaggc gttttattgg atttcagaat
    22801 tcagattcag aattaagtac tcttgggata aaggaaatta acgagctttt gacatttcaa
    22861 gaactcattg agattgtcaa aggcttcagt aatgaactct aacaaataga tccagaagtc
    22921 ataagtgaga aagaaaacaa gcatgtctag tgaaatctgt ccagtgtacg taacactgca
    22981 caaagagcat attttattca gaccatttgg attcagatgt accctaaaga caactatgct
    23041 ataatggctt gtctcctact tcctggcctc tagccctacc cattgcccag gtggacgtta
    23101 tgtttttagt ttttcctttg tgggtgaggg aagaagagga catcaggtga agtgtgccat
    23161 tactatttga aaactagctc tgcaggaagg gttaaatcaa atcctttaca gggtgacctt
    23221 cctacatctc cttagagcaa ctgcatttca aaataggcca aagctgaagt cataggaatg
    23281 agacattaat tgtaggtttt caggaaagct tcggagacac ggcaggtaca gtctccttag
    23341 agcctttgaa aatacaacat gtaggtcctt ctcagattat gctgaaactc caaatccttg
    23401 ttaaaggttt tcctggactc ctacagtctg gtttgatcag tttattatta agtactgaat
    23461 gacagagaag ggtacacagg gaggacttgt atcacatgaa gtaaaataat tatttcctta
    23521 atgagaaact taattctagg gtacttacaa tagctgcctt attgggggaa gggaggcata
    23581 gatttgcaaa tggtgggttt tttcgttttt ttgtgtgttg gagtaattga aaagatacat
    23641 caagcaataa taaactagat gtgcaataat cttgtcgagt agtatgtgct ggttttggaa
    23701 aggtgaaaag aaaattgtta catcaggctg cttttatcaa gctaagcatg ggcatgcctt
    23761 tccaaagggt atatttgatc ctacagttaa ttttaacatt gggctgcaag cttaacctca
    23821 tcaggagtgg aattagattt tacaaagttc cccttatcca aactacagca cgcttactac
    23881 tttctccttc cattttccac acctcagccc cctaggacca gctactggta agtcattttg
    23941 tccattttca ttgatctggc cacataagga acatcctgtt tctttaaatc ctcaatgctt
    24001 aaattgccat gtagaaatca actccctatc aattttctac atttaatcct tggcttcttg
    24061 tcatattttc atttttctgc actggttccc atggcaacaa gtctgttggc agagaaagta
    24121 tgactctgct tttagccttc tgcacaagac aaaatccttc tggtgatcct caggcaagta
    24181 taatataaaa agtcaggaat tgactacagt tcccttggct aatgcctcta atcctttact
    24241 ctcttgcatg cattttccac cttattccca aaccaggctt gagaaaaaaa gcattcaagg
    24301 gccctgccca gtatctcttt actgatacaa gtattcaaag gccctcctat ccaatcacag
    24361 ccacaaagac tgaatatttt ggttcagatg gctttccctt ctccctaagt gtcagtgact
    24421 taactgacat aaatgcataa ttaatgacaa ggaccactgg gagcagcatc gagaagcaac
    24481 tttcagtcat ttttctataa acaactttcc tcagttcgca actgaggtgt agcccaggga
    24541 ataagtatgt cctgaattga gccttaaatc agtgactaat aaggcaatgg aacactcaag
    24601 cagattttcc tctaatgagt agttaagtgg cacaggagga gaggccaagg agtcatccca
    24661 gagttctaag ctcataaaga ggaagagata acaaaagatg tagataagag gacattgtta
    24721 actggtggct gcaaatgagc aagggagctt cattcagttg ggacaattca gggttcaggt
    24781 acgaaaaggg tatgaagcct actgaaaaat aaggaaatgg agcatggaga aagaaagggt
    24841 ttttaagagt taagtcagta gaaagggagc ctgcaaatga gacaatagct tcatgcagac
    24901 tttggcccaa ctctgtctac aaatactttt gcaaataatg tttctcttaa taaaatgata
    24961 tattttgttt tgaactttgg aattccattg tggcttggca ctaaattata ggcctagcaa
    25021 tcctaaatct cctatgtcct caatatctag aaacaagcag gaactgtttg tcagaaatta
    25081 aacaggactt atttgaatgt gctttaaaaa aaaaatcaat gaattcaggg gaatgaaaat
    25141 acatgttaga aattaaaatg tggttatctc agctatagtt aagaaaatta tcaaatgtaa
    25201 atgatccctt ttttgctgga tcttataaaa tatgtgatac ttaagtacac tgaagtttta
    25261 aagttagctg cttatattgt acaaagatat ttttggctct ttaaaggtta ttttcctata
    25321 ttaagaaaag gtttcttata ttgaaaactt ttatggtgac tcaggttttg tgtctatgta
    25381 taggcacaca taaataggag gtgtttttct ttgcacattt gttttgcaca gctaaaataa
    25441 tgaggttaaa taatgcccag gtatgcaggt caattgacct ttttaatagc ttaacgaaag
    25501 catttgacaa atggacaaaa gaaatcacat tgtatttctt tgtatctctc cattcctctt
    25561 acccttcccc aaccctctac taaagaatat ttcttattta gtcaggaaat cttatgtaat
    25621 atttttggac ggtccatagg aaaagcaaga tgaaactctc aggcagacaa cataaagcag
    25681 ctcccatatc tgctagaaag gtcattaatt ttcagaatat attgttgaaa taatttttat
    25741 tttcaatact tgtagtcttt ccactcagag gactcttatt tggcttgaat gtggaaaagg
    25801 catctggttc aggtcagtaa ggactgttgt atgtaagttt tactctagaa aatttggttt
    25861 tagctttgat gacacctagc gtcagtggaa tgcaatgaat gcttaatact tcggctttat
    25921 aatgtttggg catttctctt taacatcctc aaatacactt tcatccttga aaacacaagc
    25981 ctattttctg tttgaaatga agagaaaggt aattgacaga taaacagata gtttttgttt
    26041 gaagagccaa tcaagtttct ctttgtactc agtagggact aaaggaagct taaggataat
    26101 gacattgtct tcatatgaag aagaaatttt ttactagtgg aaaattagaa gtaaatctac
    26161 caaattctgt ttgtaaattt taaagaccac cacaaaagac cttgaaaaaa gtgaaactac
    26221 tgcaagatta ctgttgctta ttgaaagtaa taatacagtt ttattttttc cactttataa
    26281 ctgcccaagg gctcccccaa ccagctatat ataagaaaac cataacatga actagggtct
    26341 ttctattcaa aaaagaaata ttaaactaac ataagcaatt ctgaaggaag acagtggtag
    26401 gttttcagat ggtttgttaa gaattatatg taaaaggata ctagatatta tgttttggat
    26461 gttttctaag tatctatgaa aattattttt tcctaaacga tttcataatt gattactttt
    26521 gacctcagtt attttggggc ataatccttt tactactcta taaagaagtt ctacttctac
    26581 ctatatgaat ttgtattttc ccatatgcca aacacacaca cataaatttt ctttttctca
    26641 tttcagctca tataattcag ttagtgaaat atttcactct tctgtaagtt taagaaaaat
    26701 tcctaagcag tgatacaact ttgggtcgct attttagtaa aatgaagagt ctctagactt
    26761 tttttttttt tttaatgatc tctgacttca ctaccatatg tgcagcacaa cagtgacatc
    26821 ttaaggccaa gtaaccagag ctcctttagc cagagaaaga acttgaattg ggatctgatt
    26881 tcaaagaaat cccattatat tatcaagtcg ttttcaaatt tacaatattc gactggtaaa
    26941 gaaagtgctt ctttatgact tcttttgcag tctttgtgaa ccttttaatg tgcaatagta
    27001 aacattgaca ttttacatag acatattgta tattaatgca tgcatttcac tgcatagttt
    27061 attgacacta cccttgtaaa gcttttatgg aagaaccaac aagccacagc agtatagcaa
    27121 aagaggctta atctttataa attggggcct tttctgtctc tttgctagcc taggtggctg
    27181 tatacaaatt cgggtgggag ggggcaggaa acacctcttc acatttaagg ttttctactt
    27241 gggtgtactc tagccaattc aaaacaaatt gcttacttta ataatacaat tttaccattt
    27301 tataaaaaaa atcaaatcac aacatgttta actgaaatgg ctgtattgta attaatattt
    27361 tgagataatt gtgattttga gcttaaatta tatataaaaa attgtcattt ttgtatgtgt
    27421 taaaaagact actatatcac aattaaaagt actttttagt tgaactacat attgatgtaa
    27481 ataaaactga atgaagacat atttactact ttattaacat agatcgtgaa tgtacttact
    27541 ggtttttttg cagtatgaga ccataacaac cttgaaagct gcttcatttt atgtgcaaag
    27601 aagtcctatg aatctatatt ttaaatttac tgaaccagtg aaattaatta ctgtcagtta
    27661 atttgcaaat gcaagctgta ttctccagtt ttattttatg tactgacact aattggtaaa
    27721 ggtgtacaat gtgattagaa tgcattttga agatgctttc tgtacagata caaaatacag
    27781 ggactaaaat aatgctgtgc agtgtatagc agagccattt ttcggctttg gtgtactcaa
    27841 ctttttcagt atttaaaaaa gtgttttgaa taacataaaa gtctccttat tgtataaata
    27901 ataaaatgtc accttattgt aaa
//
