LOCUS       NM_001129890            1344 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens leucine rich repeat containing 69 (LRRC69), transcript
            variant 1, mRNA.
ACCESSION   NM_001129890 XM_001716998 XM_001717028 XM_001717145
VERSION     NM_001129890.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1344)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
REFERENCE   2  (bases 1 to 1344)
  AUTHORS   Ota,T., Suzuki,Y., Nishikawa,T., Otsuki,T., Sugiyama,T., Irie,R.,
            Wakamatsu,A., Hayashi,K., Sato,H., Nagai,K., Kimura,K., Makita,H.,
            Sekine,M., Obayashi,M., Nishi,T., Shibahara,T., Tanaka,T.,
            Ishii,S., Yamamoto,J., Saito,K., Kawai,Y., Isono,Y., Nakamura,Y.,
            Nagahari,K., Murakami,K., Yasuda,T., Iwayanagi,T., Wagatsuma,M.,
            Shiratori,A., Sudo,H., Hosoiri,T., Kaku,Y., Kodaira,H., Kondo,H.,
            Sugawara,M., Takahashi,M., Kanda,K., Yokoi,T., Furuya,T.,
            Kikkawa,E., Omura,Y., Abe,K., Kamihara,K., Katsuta,N., Sato,K.,
            Tanikawa,M., Yamazaki,M., Ninomiya,K., Ishibashi,T., Yamashita,H.,
            Murakawa,K., Fujimori,K., Tanai,H., Kimata,M., Watanabe,M.,
            Hiraoka,S., Chiba,Y., Ishida,S., Ono,Y., Takiguchi,S., Watanabe,S.,
            Yosida,M., Hotuta,T., Kusano,J., Kanehori,K., Takahashi-Fujii,A.,
            Hara,H., Tanase,T.O., Nomura,Y., Togiya,S., Komai,F., Hara,R.,
            Takeuchi,K., Arita,M., Imose,N., Musashino,K., Yuuki,H., Oshima,A.,
            Sasaki,N., Aotsuka,S., Yoshikawa,Y., Matsunawa,H., Ichihara,T.,
            Shiohata,N., Sano,S., Moriya,S., Momiyama,H., Satoh,N., Takami,S.,
            Terashima,Y., Suzuki,O., Nakagawa,S., Senoh,A., Mizoguchi,H.,
            Goto,Y., Shimizu,F., Wakebe,H., Hishigaki,H., Watanabe,T.,
            Sugiyama,A., Takemoto,M., Kawakami,B., Yamazaki,M., Watanabe,K.,
            Kumagai,A., Itakura,S., Fukuzumi,Y., Fujimori,Y., Komiyama,M.,
            Tashiro,H., Tanigami,A., Fujiwara,T., Ono,T., Yamada,K., Fujii,Y.,
            Ozaki,K., Hirao,M., Ohmori,Y., Kawabata,A., Hikiji,T., Kobatake,N.,
            Inagaki,H., Ikema,Y., Okamoto,S., Okitani,R., Kawakami,T.,
            Noguchi,S., Itoh,T., Shigeta,K., Senba,T., Matsumura,K.,
            Nakajima,Y., Mizuno,T., Morinaga,M., Sasaki,M., Togashi,T.,
            Oyama,M., Hata,H., Watanabe,M., Komatsu,T., Mizushima-Sugano,J.,
            Satoh,T., Shirai,Y., Takahashi,Y., Nakagawa,K., Okumura,K.,
            Nagase,T., Nomura,N., Kikuchi,H., Masuho,Y., Yamashita,R.,
            Nakai,K., Yada,T., Nakamura,Y., Ohara,O., Isogai,T. and Sugano,S.
  TITLE     Complete sequencing and characterization of 21,243 full-length
            human cDNAs
  JOURNAL   Nat Genet 36 (1), 40-45 (2004)
   PUBMED   14702039
REFERENCE   3  (bases 1 to 1344)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC087439.6, AC104966.4 and AC104967.4.
            
            On Aug 12, 2021 this sequence version replaced NM_001129890.1.
            
            Sequence Note: This RefSeq record was created from genomic sequence
            data to make the sequence consistent with the reference genome
            assembly. This transcripts is predicted based on homologous
            transcript alignments, including mouse AK161371.1 and X. laevis
            BC087488.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2148874,
                              SAMEA2158188 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000448384.3/ ENSP00000400803.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-226               AC087439.6         6749-6974           c
            227-353             AC104966.4         16904-17030
            354-426             AC104966.4         19499-19571
            427-622             AC104966.4         25521-25716
            623-694             AC104966.4         28079-28150
            695-796             AC104966.4         81933-82034
            797-976             AC104966.4         93024-93203
            977-1344            AC104967.4         19289-19656
FEATURES             Location/Qualifiers
     source          1..1344
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q21.3"
     gene            1..1344
                     /gene="LRRC69"
                     /note="leucine rich repeat containing 69"
                     /db_xref="GeneID:100130742"
                     /db_xref="HGNC:HGNC:34303"
     exon            1..226
                     /gene="LRRC69"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..1087
                     /gene="LRRC69"
                     /note="isoform 1 is encoded by transcript variant 1;
                     leucine-rich repeat-containing protein 69"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 69
                     isoform 1"
                     /protein_id="NP_001123362.1"
                     /db_xref="GeneID:100130742"
                     /db_xref="HGNC:HGNC:34303"
                     /translation="MTERLLIKALSGGKNTKIITLNGKKMTKMPSALGKLPGLKTLVL
                     QNNLIPKVCPELCNLTQLTTLNLGNNLLEEVPEEMKYLTSLKNLHLSGNRICRFAPGA
                     CDGLQNLILLNLNNNHLTQLPQEVSRLKSLTYMSINYNQLASIPRELCFLENLVELQL
                     NYNQLICIPEEIKFLKKLQKLLLARNNIGVLPEELCDLKKLRILDIAGNIIQIFPSGF
                     QDLKLREFYCEGNPLFLQQPVISTQQENVWSLQEITSRFVMNQLAENNPFLMDDIERY
                     PQVRSMISQGKTCAICGQYFITVWLECVRFVPPPKDWKISKNLKLVPLQVLICSYKCF
                     TQRDPNLFGIAQV"
     exon            227..353
                     /gene="LRRC69"
                     /inference="alignment:Splign:2.1.0"
     exon            354..426
                     /gene="LRRC69"
                     /inference="alignment:Splign:2.1.0"
     exon            427..622
                     /gene="LRRC69"
                     /inference="alignment:Splign:2.1.0"
     exon            623..694
                     /gene="LRRC69"
                     /inference="alignment:Splign:2.1.0"
     exon            695..796
                     /gene="LRRC69"
                     /inference="alignment:Splign:2.1.0"
     exon            797..976
                     /gene="LRRC69"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1344
                     /gene="LRRC69"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1321..1326
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRC69"
                     /note="hexamer: AATAAA"
     polyA_site      1344
                     /gene="LRRC69"
                     /note="major polyA site"
ORIGIN      
        1 gaactctaat ggttaccttg ttttctactt cttttccaag atcatgactg agagattgtt
       61 aataaaagca ttgagtggtg gtaaaaatac gaagatcatt actttgaatg ggaagaagat
      121 gacaaagatg ccctcagcat taggaaaact gcctggcctg aagactctag tccttcagaa
      181 taacctaatc cccaaagtgt gtccagagtt atgcaacttg acccagttga caacactaaa
      241 tctgggaaac aaccttttag aagaagttcc ggaagagatg aaatatctta catctctgaa
      301 gaatctccat ttatctggaa ataggatctg tagatttgca cctggagcct gtgatggctt
      361 acaaaattta atcctgctta atctgaacaa caatcatctt acgcagcttc ctcaagaagt
      421 cagcagatta aaaagtctta cttatatgag tataaattat aaccaactag ccagcattcc
      481 tagagaactt tgttttcttg agaatcttgt tgaacttcaa cttaactaca atcagctgat
      541 atgcatacct gaagagatta aattcttgaa gaagcttcag aagcttttgc tagccagaaa
      601 caacattgga gttttgccgg aggaactttg tgatcttaaa aaactaagaa tcctagacat
      661 agctggaaat attattcaga tatttccatc aggatttcag gatctgaagc tgagggaatt
      721 ctactgtgag ggaaacccac tgttcctgca gcagccagtg atttctacac agcaggagaa
      781 cgtctggagt ctacaggaaa taacatcaag atttgtaatg aatcagctag cagaaaataa
      841 ccctttccta atggatgaca tagaacggta cccacaagtc aggagcatga tctctcaggg
      901 aaaaacatgt gcaatatgtg gacagtactt tataaccgta tggctggaat gtgttcgatt
      961 tgttcctcca ccaaaggact ggaagataag caagaatctg aagctggtgc ctctccaagt
     1021 attaatttgt tcttacaaat gttttactca acgtgaccct aacctctttg gaattgctca
     1081 ggtgtagaac aggtgaggtg ctcattcata gcctcactcc acttgccctg tcagctctgc
     1141 atacacagat tatgccctac ttaagatacc atgcctgttc tctttgtcaa cacattaaat
     1201 aaaggaagaa aaataattcc attataacgt tcccaatcta agcactacaa tctgccttca
     1261 gcttgcttag attctaggtg tgcttttttt ggcttaaaaa agtacaaaaa aaaattgaaa
     1321 aataaagatt tgtgtggcaa gtga
//
