LOCUS       NM_001024611            3435 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens leucine rich repeat containing 66 (LRRC66), mRNA.
ACCESSION   NM_001024611 XM_291099
VERSION     NM_001024611.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3435)
  AUTHORS   Gupta,N., Sarkar,S., Mehta,P., Sankhwar,S.N. and Rajender,S.
  TITLE     Polymorphisms in the HSF2, LRRC6, MEIG1 and PTIP genes correlate
            with sperm motility in idiopathic infertility
  JOURNAL   Andrologia 54 (9), e14517 (2022)
   PUBMED   35768906
  REMARK    GeneRIF: Polymorphisms in the HSF2, LRRC6, MEIG1 and PTIP genes
            correlate with sperm motility in idiopathic infertility.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC093858.2, CR749811.1,
            BU620718.1 and CA436716.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001024611.2.
            
            Summary: This gene encodes a protein belonging to the leucine-rich
            repeat family of proteins, which are involved in diverse biological
            processes, including cell adhesion, cellular trafficking, and
            hormone-receptor interactions. [provided by RefSeq, Apr 2017].
            
            ##Evidence-Data-START##
            Transcript exon combination :: CR749811.1, SRR11853563.25223.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000682860.1/ ENSP00000508002.1
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                AC093858.2         10314-10365         c
            53-3041             CR749811.1         1-2989
            3042-3042           BU620718.1         410-410             c
            3043-3388           CR749811.1         2991-3336
            3389-3435           CA436716.1         27-73               c
FEATURES             Location/Qualifiers
     source          1..3435
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q12"
     gene            1..3435
                     /gene="LRRC66"
                     /note="leucine rich repeat containing 66"
                     /db_xref="GeneID:339977"
                     /db_xref="HGNC:HGNC:34299"
     exon            1..60
                     /gene="LRRC66"
                     /inference="alignment:Splign:2.1.0"
     exon            61..561
                     /gene="LRRC66"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..2708
                     /gene="LRRC66"
                     /note="leucine-rich repeat-containing protein 66"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 66
                     precursor"
                     /protein_id="NP_001019782.1"
                     /db_xref="CCDS:CCDS43229.1"
                     /db_xref="GeneID:339977"
                     /db_xref="HGNC:HGNC:34299"
                     /translation="MKNLYFRVITIVIGLYFTGIMTNASRKSNILFNSECQWNEYILT
                     NCSFTGKCDIPVDISQTAATVDVSFNFFRVLLQSHTKKEEWKIKHLDLSNNLISKITL
                     SPFAYLHALEVLNLSNNAIHSLSLDLLSPKSSWVKRHRSSFRNRFPLLKVLILQRNKL
                     SDTPKGLWKLKSLQSLDLSFNGILQIGWSDFHNCLQLENLCLKSNKIFKIPPQAFKDL
                     KKLQVIDLSNNALITILPMMIIALEFPHLVVDLADNNWQCDDSVAVFQNFISESWRKK
                     WNVICNRSIGSEEANGGTPQSRISRETRLPPIHLHRMKSLIRSKAERPQGGRHTGIST
                     LGKKAKAGSGLRKKQRRLPRSVRSTRDVQAAGKKEDAPQDLALAVCLSVFITFLVAFS
                     LGAFTRPYVDRLWQKKCQSKSPGLDNAYSNEGFYDDMEAAGHTPHPETHLRQVFPHLS
                     LYENQTPFWVTQPHPHATVIPDRTLGRSRKDPGSSQSPGQCGDNTGAGSGNDGAVYSI
                     LQRHPHAGNRELMSAAQDHIHRNDILGEWTYETVAQEEPLSAHSVGVSSVAGTSHAVS
                     GSSRYDSNELDPSLSGEITASLCKMLTHAEAQRTGDSKERGGTEQSLWDSQMEFSKER
                     QVSSSIDLLSIQQPRLSGARAEEALSAHYSEVPYGDPRDTGPSVFPPRWDSGLDVTPA
                     NKEPVQKSTPSDTCCELESDCDSDEGSLFTLSSISSESARSKTEEAVPDEESLQDESS
                     GASKDNVTAVDSLEENVTFQTIPGKCKNQEDPFEKPLISAPDSGMYKTHLENASDTDR
                     SEGLSPWPRSPGNSPLGDEFPGMFTYDYDTALQSKAAEWHCSLRDLEFSNVDVLQQTP
                     PCSAEVPSDPDKAAFHERDSDILK"
     exon            562..731
                     /gene="LRRC66"
                     /inference="alignment:Splign:2.1.0"
     exon            732..921
                     /gene="LRRC66"
                     /inference="alignment:Splign:2.1.0"
     exon            922..3435
                     /gene="LRRC66"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3412..3417
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRC66"
                     /note="hexamer: AATAAA"
     polyA_site      3435
                     /gene="LRRC66"
                     /note="major polyA site"
ORIGIN      
        1 aaatccctac ctggcttgat ccagatatcc acccatttga taaccactta ggatacgaag
       61 gcattatgaa aaacctctat ttcagagtca ttaccatagt tataggtctt tattttactg
      121 gaataatgac aaatgcatca agaaaaagca atattttatt caattctgaa tgccaatgga
      181 atgaatatat tctgacaaat tgttctttta ccggaaagtg tgatatacct gtggacatat
      241 cacagacagc agccactgtg gatgtaagtt tcaatttctt tagagttctc ttacagtctc
      301 acacgaaaaa agaagagtgg aaaataaaac atctggacct cagtaacaat ctcatatcaa
      361 aaataacctt aagccctttt gcatatttac atgctttgga agtgttaaac ctcagcaaca
      421 atgccatcca ctccctctca ttggatctac tcagtcctaa gtcctcatgg gtgaaacgcc
      481 acagaagcag cttcagaaac aggtttccat tgctgaaggt gctcattctt caaagaaata
      541 aactcagtga cactcccaag ggactgtgga aactgaagtc attgcagagt ttggatctgt
      601 cattcaatgg gatattgcaa atagggtggt ctgattttca caactgcctg caactggaga
      661 atctctgttt aaagagcaac aagatattca aaattccccc acaagccttc aaggacctca
      721 aaaaattaca ggtcatagac cttagcaaca atgctctgat taccatccta ccaatgatga
      781 tcatagctct agaatttccc catctagtgg ttgacttggc tgataataac tggcagtgtg
      841 atgatagtgt ggcagtcttt caaaatttta tttctgaatc ctggaggaaa aagtggaatg
      901 tcatttgcaa caggtctata gggagtgagg aggccaacgg gggcactccc cagagcagga
      961 tttccaggga aacccgcctt cctcccattc atctgcatcg catgaaaagc ctcataagga
     1021 gcaaagcaga gaggccccag ggaggaaggc acacgggcat ttctactctg gggaagaagg
     1081 caaaggccgg ctctggtctc aggaagaagc agagacggct gccaaggagt gttagaagca
     1141 cccgcgatgt gcaggctgcc ggcaaaaaag aggacgctcc ccaggacctg gctctggcgg
     1201 tgtgcctgtc agtgttcatc acattccttg tcgccttcag cctgggggct ttcacaaggc
     1261 cttatgttga cagactgtgg caaaaaaagt gccagagcaa aagccctggc ctggacaacg
     1321 cgtattcaaa cgagggcttc tacgatgaca tggaagctgc ggggcacaca ccacacccag
     1381 agacccatct gcgccaagta tttcctcatc taagcctcta cgagaaccag acccctttct
     1441 gggtgacaca gccacaccca cacgccaccg taattcctga tagaactctg ggaaggagca
     1501 gaaaggatcc tggcagttcg cagagcccag gacagtgcgg ggacaacacc ggggcaggaa
     1561 gtggaaatga tggtgcagtc tattccattc tccagagaca tccacatgcc ggtaaccgtg
     1621 aactaatgtc agcagcgcag gaccacatcc ataggaatga tattctcgga gaatggactt
     1681 atgaaactgt ggcccaggaa gagcctctca gtgcacattc agtgggcgtc tcttctgtag
     1741 ctggcacgtc tcacgctgtc tctggctcaa gccgttatga ttccaatgaa ttagaccctt
     1801 ccctctccgg agaaataaca gcttccctct gtaaaatgct aacacatgca gaagcacaga
     1861 ggactggaga tagtaaggaa agagggggca ctgaacagtc actttgggac tcgcagatgg
     1921 aattttctaa ggaaaggcaa gtgagttcat ccattgattt gctgagcata cagcagccaa
     1981 ggctgtccgg ggcaagggct gaggaagcgc tttcagccca ctacagcgag gttccatacg
     2041 gtgacccaag agacacaggc ccatcagtct ttcctccaag atgggacagt ggcctggatg
     2101 tcactcctgc taacaaggaa ccagtgcaga aatccactcc ttctgacact tgctgtgagt
     2161 tggagagtga ctgtgactct gatgaggggt ctctgttcac tctgagctcc ataagttcag
     2221 agagtgcaag gagcaagact gaagaggcag tgcctgatga ggagtccctg caggacgaga
     2281 gctcaggggc aagcaaggac aatgtgacgg ctgtagacag tcttgaggaa aatgttacct
     2341 tccaaacaat tccagggaaa tgcaagaatc aagaagatcc ctttgaaaaa cctctcattt
     2401 ctgctccaga ctctggcatg tacaagactc atctggaaaa tgcctctgac actgatagat
     2461 ctgagggcct gtcaccctgg cccaggtcac cagggaatag tcccttaggg gatgagtttc
     2521 cgggcatgtt cacttatgat tatgacacag ctcttcaatc caaggcagca gaatggcatt
     2581 gctcacttag agacttagaa ttttcaaatg tggacgtttt acagcaaaca ccaccatgtt
     2641 ctgctgaagt tccctcagat cctgataagg ctgccttcca tgaaagagac tcagacattt
     2701 taaaataaga atctttcatt aaggaaatat tcacagctct aaacaatatt cttttaaaga
     2761 tcatggcagg ggaaaactaa agccttcaca acaagatcct gaaggagaca acatgaattc
     2821 caaccaagtg gacactgatg caaatgaggg ttttgtgggc ccacttgagg gcgatgattc
     2881 tagaagggtt ataagctaaa cacacttgtt aacatcctat ggggatgaac ctgctcttca
     2941 gtgtgaaaga gaaagagggg aatattttga gatcattcca agaaccatgc accattatta
     3001 caagagctcc aaacaaaacc agttcactga gaacacagga gcacttcatc aataggttgg
     3061 ggtaaatatt cagaagagaa tctgttgcag ttagacgaag tggttctaac tttccttctc
     3121 aaatacagac ctggagcaat ctgatgggat ttggctctct gaaaagaaca gctttaggat
     3181 gacaaagaca aggatgttca acttgatcat caaagagaat tcaaatgaca ttttttcata
     3241 catattgaag cacttaagtg gaaatgctgg atagatttta atgaattctg aacacacact
     3301 agcacaactt tttggaggct gatcgtgaaa ctgcaaaatt ggaaaagttc tgagtaaata
     3361 taaatgtttt taaataagtt atgttaaaag agaagagggg ccacttttta gaataaagtg
     3421 taaattaaaa atcaa
//
