LOCUS       NM_001363434            2011 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens leucine rich repeat containing 61 (LRRC61), transcript
            variant 4, mRNA.
ACCESSION   NM_001363434
VERSION     NM_001363434.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2011)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 2011)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC005586.2, AK098061.1 and BM126106.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK098061.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                AC005586.2         72385-72426         c
            43-647              AK098061.1         1-605
            648-648             AC005586.2         45132-45132         c
            649-949             AK098061.1         607-907
            950-950             AC005586.2         44830-44830         c
            951-1143            AK098061.1         909-1101
            1144-1144           AC005586.2         44636-44636         c
            1145-1948           AK098061.1         1103-1906
            1949-2011           BM126106.1         11-73               c
FEATURES             Location/Qualifiers
     source          1..2011
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q36.1"
     gene            1..2011
                     /gene="LRRC61"
                     /gene_synonym="HSPC295"
                     /note="leucine rich repeat containing 61"
                     /db_xref="GeneID:65999"
                     /db_xref="HGNC:HGNC:21704"
     exon            1..402
                     /gene="LRRC61"
                     /gene_synonym="HSPC295"
                     /inference="alignment:Splign:2.1.0"
     exon            403..572
                     /gene="LRRC61"
                     /gene_synonym="HSPC295"
                     /inference="alignment:Splign:2.1.0"
     exon            573..2011
                     /gene="LRRC61"
                     /gene_synonym="HSPC295"
                     /inference="alignment:Splign:2.1.0"
     CDS             717..1496
                     /gene="LRRC61"
                     /gene_synonym="HSPC295"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 61"
                     /protein_id="NP_001350363.1"
                     /db_xref="CCDS:CCDS5901.1"
                     /db_xref="GeneID:65999"
                     /db_xref="HGNC:HGNC:21704"
                     /translation="MDPPAEKPGEAGGLQITPQLLKSRTGEFSLESILLLKLRGLGLA
                     DLGCLGECLGLEWLDLSGNALTHLGPLASLRQLAVLNVSNNRLTGLEPLATCENLQSL
                     NAAGNLLATPGQLQCLAGLPCLEYLRLRDPLARLSNPLCANPSYWAAVRELLPGLKVI
                     DGERVIGRGSEFYQLCRDLDSSLRPSSSPGPRATEAQPWVEPGYWESWPSRSSSILEE
                     ACRQFQDTLQECWDLDRQASDSLAQAEQVLSSAGPTSSFVF"
     regulatory      1986..1991
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRC61"
                     /gene_synonym="HSPC295"
                     /note="hexamer: ATTAAA"
     polyA_site      2011
                     /gene="LRRC61"
                     /gene_synonym="HSPC295"
                     /note="major polyA site"
ORIGIN      
        1 agagctgcaa ctgcttgcgc ctgctgtaag acaaacccca gccatgcctt cagcacacaa
       61 aaacttcaga acaaccaaac cacagcctcc agctactcct ttaaatcctc ctcatggacc
      121 ttgattcaag tgccgcaaaa ctggccacta gaccaagaaa tgcccacagc ccaggattct
      181 tcctaagccg tgtcccacct gtgcgggacc ccactggaaa tcggactgtc caactaatat
      241 cacagccact tctagggccc ctggagctct ggatcaaagc tctctggctg actgcttctc
      301 agatctcggc tttgcggctg aagactgatg ctgcccgatc acctgggaaa gccccctgga
      361 ccatcatgga cgccgagctt cgggtaactt ttacagtgga ggattcattt ggattcaagg
      421 ttggctctca acagtgccag ctgcactgtc atcctaaagt acttctgtgg aagagaacat
      481 ggtggtgtca ctgttgtacc agtgatgaca caaaatccca gatctacctg acgggcctgc
      541 gagggttgaa gattgtgaag caatagccta agggactggc tggcttcgag cagggcatcg
      601 gaaccaggcc tcctggcact ggcctgggta gagccagggc gagcaccagc tgacccccag
      661 tggaaccctg tgacagtcct gccagggccc aggccatccc aaccgacttc catctcatgg
      721 accctccagc ggagaagccg ggagaggctg gcggactgca gatcacaccc cagctgctga
      781 agtcacgcac aggcgagttc tccctggagt ccatcctgct actgaagctg cgtggcttgg
      841 gactggctga cctgggctgc ctgggagagt gcctgggcct ggagtggctg gacctatcag
      901 gcaacgcgct cacccacctg ggcccgctgg cctccttgcg ccagctagct gtgctcaatg
      961 tctccaacaa tcggctgacg ggcctggagc cactggccac ctgtgagaac ttgcagagtc
     1021 tcaatgccgc aggcaaccta ctggccaccc cgggccagct gcagtgtctg gctgggctac
     1081 cgtgcctgga gtacctgcgg ctccgagacc ctttggcccg gctcagcaac ccgctctgtg
     1141 ccaacccctc ctactgggct gcagtccggg agctgctgcc tggcctgaaa gtcatcgacg
     1201 gtgagcgtgt gattgggcgt ggtagtgagt tctaccagct gtgccgagac ctggacagct
     1261 ccttgcgtcc cagctccagt ccaggcccca gagccaccga ggcccagccc tgggtggagc
     1321 caggctactg ggagtcctgg cccagccgga gcagctccat cctggaggag gcctgccggc
     1381 agttccagga cacactgcag gagtgctggg acctggaccg ccaggccagc gacagcctgg
     1441 cccaggcgga gcaggtactc agctctgcgg gccccacctc ttccttcgtc ttctgaacgt
     1501 ggcctatggc ccaggacagc ctggcaggtg gcctcgctgc ccccagttcc cctctctgcc
     1561 cccacactcg tcttagttgc ttcacactgg tcactggccc tgcacactgg gctattgctt
     1621 tatccctatc ctgagagcag cccctcccca ccatccctcc acatgctgca aggacagact
     1681 gaagggctgt gagcaggtgt aagggctccc acatccgtga gcctgtgtcc gcagctgctg
     1741 ccactctggg ctgctccagc ctgcaactta gtggaaggaa ttacttcctc ctgaggctac
     1801 aggcgagaaa ggtagggatg ggccagcctc ccgtctcagc tgttgggaga cagtaggcag
     1861 gctgagtggc ccagagcact cctggaagtg ggactcccct gccttgcaaa tgtgcctctc
     1921 cagactgctc ctgcacttac cccctccccg cagcaccttc tctgcccgtt cttgtccaca
     1981 catctattaa atgcttctgt tttcatttgc a
//
