LOCUS       NM_001142928            1815 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens leucine rich repeat containing 61 (LRRC61), transcript
            variant 1, mRNA.
ACCESSION   NM_001142928
VERSION     NM_001142928.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1815)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 1815)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC005586.2 and AW444958.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001142928.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.878976.1,
                                           SRR3476690.659282.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000359623.9/ ENSP00000352642.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-206               AC005586.2         58365-58570         c
            207-376             AC005586.2         55915-56084         c
            377-1784            AC005586.2         43800-45207         c
            1785-1815           AW444958.1         17-47               c
FEATURES             Location/Qualifiers
     source          1..1815
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q36.1"
     gene            1..1815
                     /gene="LRRC61"
                     /gene_synonym="HSPC295"
                     /note="leucine rich repeat containing 61"
                     /db_xref="GeneID:65999"
                     /db_xref="HGNC:HGNC:21704"
     exon            1..206
                     /gene="LRRC61"
                     /gene_synonym="HSPC295"
                     /inference="alignment:Splign:2.1.0"
     exon            207..376
                     /gene="LRRC61"
                     /gene_synonym="HSPC295"
                     /inference="alignment:Splign:2.1.0"
     exon            377..1815
                     /gene="LRRC61"
                     /gene_synonym="HSPC295"
                     /inference="alignment:Splign:2.1.0"
     CDS             521..1300
                     /gene="LRRC61"
                     /gene_synonym="HSPC295"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 61"
                     /protein_id="NP_001136400.1"
                     /db_xref="CCDS:CCDS5901.1"
                     /db_xref="GeneID:65999"
                     /db_xref="HGNC:HGNC:21704"
                     /translation="MDPPAEKPGEAGGLQITPQLLKSRTGEFSLESILLLKLRGLGLA
                     DLGCLGECLGLEWLDLSGNALTHLGPLASLRQLAVLNVSNNRLTGLEPLATCENLQSL
                     NAAGNLLATPGQLQCLAGLPCLEYLRLRDPLARLSNPLCANPSYWAAVRELLPGLKVI
                     DGERVIGRGSEFYQLCRDLDSSLRPSSSPGPRATEAQPWVEPGYWESWPSRSSSILEE
                     ACRQFQDTLQECWDLDRQASDSLAQAEQVLSSAGPTSSFVF"
     regulatory      1790..1795
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRC61"
                     /gene_synonym="HSPC295"
                     /note="hexamer: ATTAAA"
     polyA_site      1815
                     /gene="LRRC61"
                     /gene_synonym="HSPC295"
                     /note="major polyA site"
ORIGIN      
        1 gagctcaggc ctgcggcgct gggagaagca cgctggccaa caagttgggt ggtgggcacg
       61 cggcccaggg gtcaggggcc gccaggcggc gggcggcggg gctgcggctc ttacctgccg
      121 aggaggcgcc ggctctgcgg tgcggagttg cgccggactt cccagcttgg ccagtggctc
      181 cgcaggctgc cggctccacc cctcagattc atttggattc aaggttggct ctcaacagtg
      241 ccagctgcac tgtcatccta aagtacttct gtggaagaga acatggtggt gtcactgttg
      301 taccagtgat gacacaaaat cccagatcta cctgacgggc ctgcgagggt tgaagattgt
      361 gaagcaatag cctaagggac tggctggctt cgagcagggc atcggaacca ggcctcctgg
      421 cactggcctg ggtagagcca gggcgagcac cagctgaccc ccagtggaac cctgtgacag
      481 tcctgccagg gcccaggcca tcccaaccga cttccatctc atggaccctc cagcggagaa
      541 gccgggagag gctggcggac tgcagatcac accccagctg ctgaagtcac gcacaggcga
      601 gttctccctg gagtccatcc tgctactgaa gctgcgtggc ttgggactgg ctgacctggg
      661 ctgcctggga gagtgcctgg gcctggagtg gctggaccta tcaggcaacg cgctcaccca
      721 cctgggcccg ctggcctcct tgcgccagct agctgtgctc aatgtctcca acaatcggct
      781 gacgggcctg gagccactgg ccacctgtga gaacttgcag agtctcaatg ccgcaggcaa
      841 cctactggcc accccgggcc agctgcagtg tctggctggg ctaccgtgcc tggagtacct
      901 gcggctccga gaccctttgg cccggctcag caacccgctc tgtgccaacc cctcctactg
      961 ggctgcagtc cgggagctgc tgcctggcct gaaagtcatc gacggtgagc gtgtgattgg
     1021 gcgtggtagt gagttctacc agctgtgccg agacctggac agctccttgc gtcccagctc
     1081 cagtccaggc cccagagcca ccgaggccca gccctgggtg gagccaggct actgggagtc
     1141 ctggcccagc cggagcagct ccatcctgga ggaggcctgc cggcagttcc aggacacact
     1201 gcaggagtgc tgggacctgg accgccaggc cagcgacagc ctggcccagg cggagcaggt
     1261 actcagctct gcgggcccca cctcttcctt cgtcttctga acgtggccta tggcccagga
     1321 cagcctggca ggtggcctcg ctgcccccag ttcccctctc tgcccccaca ctcgtcttag
     1381 ttgcttcaca ctggtcactg gccctgcaca ctgggctatt gctttatccc tatcctgaga
     1441 gcagcccctc cccaccatcc ctccacatgc tgcaaggaca gactgaaggg ctgtgagcag
     1501 gtgtaagggc tcccacatcc gtgagcctgt gtccgcagct gctgccactc tgggctgctc
     1561 cagcctgcaa cttagtggaa ggaattactt cctcctgagg ctacaggcga gaaaggtagg
     1621 gatgggccag cctcccgtct cagctgttgg gagacagtag gcaggctgag tggcccagag
     1681 cactcctgga agtgggactc ccctgccttg caaatgtgcc tctccagact gctcctgcac
     1741 ttaccccctc cccgcagcac cttctctgcc cgttcttgtc cacacatcta ttaaatgctt
     1801 ctgttttcat ttgca
//
