LOCUS       NM_018509               2880 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens leucine rich repeat containing 59 (LRRC59), mRNA.
ACCESSION   NM_018509
VERSION     NM_018509.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2880)
  AUTHORS   Zhang,P., Xie,X., Li,C., Zhang,C. and Liang,P.
  TITLE     LRRC59 serves as a novel biomarker for predicting the progression
            and prognosis of bladder cancer
  JOURNAL   Cancer Med 12 (19), 19758-19776 (2023)
   PUBMED   37706625
  REMARK    GeneRIF: LRRC59 serves as a novel biomarker for predicting the
            progression and prognosis of bladder cancer.
REFERENCE   2  (bases 1 to 2880)
  AUTHORS   Hannigan,M.M., Hoffman,A.M., Thompson,J.W., Zheng,T. and
            Nicchitta,C.V.
  TITLE     Quantitative Proteomics Links the LRRC59 Interactome to mRNA
            Translation on the ER Membrane
  JOURNAL   Mol Cell Proteomics 19 (11), 1826-1849 (2020)
   PUBMED   32788342
  REMARK    GeneRIF: Quantitative Proteomics Links the LRRC59 Interactome to
            mRNA Translation on the ER Membrane.
REFERENCE   3  (bases 1 to 2880)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2880)
  AUTHORS   Xian,H., Yang,S., Jin,S., Zhang,Y. and Cui,J.
  TITLE     LRRC59 modulates type I interferon signaling by restraining the
            SQSTM1/p62-mediated autophagic degradation of pattern recognition
            receptor DDX58/RIG-I
  JOURNAL   Autophagy 16 (3), 408-418 (2020)
   PUBMED   31068071
  REMARK    GeneRIF: LRRC59 modulates type I interferon signaling by
            restraining the SQSTM1/p62-mediated autophagic degradation of
            pattern recognition receptor DDX58/RIG-I.
REFERENCE   5  (bases 1 to 2880)
  AUTHORS   Blenski,M. and Kehlenbach,R.H.
  TITLE     Targeting of LRRC59 to the Endoplasmic Reticulum and the Inner
            Nuclear Membrane
  JOURNAL   Int J Mol Sci 20 (2), 334 (2019)
   PUBMED   30650545
  REMARK    GeneRIF: the mechanisms of membrane integration of LRRC59 and its
            targeting to the inner nuclear membrane (INM), were investigated.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2880)
  AUTHORS   Zhen,Y., Sorensen,V., Skjerpen,C.S., Haugsten,E.M., Jin,Y.,
            Walchli,S., Olsnes,S. and Wiedlocha,A.
  TITLE     Nuclear import of exogenous FGF1 requires the ER-protein LRRC59 and
            the importins Kpnalpha1 and Kpnbeta1
  JOURNAL   Traffic 13 (5), 650-664 (2012)
   PUBMED   22321063
  REMARK    GeneRIF: LRRC59 facilitates transport of cytosolic FGF1 through
            nuclear pores by interaction with Kpns and movement of LRRC59 along
            the ER and NE membranes
REFERENCE   7  (bases 1 to 2880)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   8  (bases 1 to 2880)
  AUTHORS   Bogenhagen,D.F., Rousseau,D. and Burke,S.
  TITLE     The layered structure of human mitochondrial DNA nucleoids
  JOURNAL   J Biol Chem 283 (6), 3665-3675 (2008)
   PUBMED   18063578
REFERENCE   9  (bases 1 to 2880)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   10 (bases 1 to 2880)
  AUTHORS   Gevaert,K., Goethals,M., Martens,L., Van Damme,J., Staes,A.,
            Thomas,G.R. and Vandekerckhove,J.
  TITLE     Exploring proteomes and analyzing protein processing by mass
            spectrometric identification of sorted N-terminal peptides
  JOURNAL   Nat Biotechnol 21 (5), 566-569 (2003)
   PUBMED   12665801
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA782636.1, BC017168.1 and AF119857.1.
            
            On Nov 23, 2018 this sequence version replaced NM_018509.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK025328.1, SRR3476690.623316.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000225972.8/ ENSP00000225972.7
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                DA782636.1         31-42
            13-1445             BC017168.1         1-1433
            1446-2880           AF119857.1         834-2268
FEATURES             Location/Qualifiers
     source          1..2880
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.33"
     gene            1..2880
                     /gene="LRRC59"
                     /gene_synonym="p34; PRO1855"
                     /note="leucine rich repeat containing 59"
                     /db_xref="GeneID:55379"
                     /db_xref="HGNC:HGNC:28817"
                     /db_xref="MIM:614854"
     exon            1..311
                     /gene="LRRC59"
                     /gene_synonym="p34; PRO1855"
                     /inference="alignment:Splign:2.1.0"
     CDS             207..1130
                     /gene="LRRC59"
                     /gene_synonym="p34; PRO1855"
                     /note="ribosome-binding protein p34"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 59"
                     /protein_id="NP_060979.2"
                     /db_xref="CCDS:CCDS11566.1"
                     /db_xref="GeneID:55379"
                     /db_xref="HGNC:HGNC:28817"
                     /db_xref="MIM:614854"
                     /translation="MTKAGSKGGNLRDKLDGNELDLSLSDLNEVPVKELAALPKATIL
                     DLSCNKLTTLPSDFCGLTHLVKLDLSKNKLQQLPADFGRLVNLQHLDLLNNKLVTLPV
                     SFAQLKNLKWLDLKDNPLDPVLAKVAGDCLDEKQCKQCANKVLQHMKAVQADQERERQ
                     RRLEVEREAEKKREAKQRAKEAQERELRKREKAEEKERRRKEYDALKAAKREQEKKPK
                     KEANQAPKSKSGSRPRKPPPRKHTRSWAVLKLLLLLLLFGVAGGLVACRVTELQQQPL
                     CTSVNTIYDNAVQGLRRHEILQWVLQTDSQQ"
     exon            312..371
                     /gene="LRRC59"
                     /gene_synonym="p34; PRO1855"
                     /inference="alignment:Splign:2.1.0"
     exon            372..530
                     /gene="LRRC59"
                     /gene_synonym="p34; PRO1855"
                     /inference="alignment:Splign:2.1.0"
     exon            531..635
                     /gene="LRRC59"
                     /gene_synonym="p34; PRO1855"
                     /inference="alignment:Splign:2.1.0"
     exon            636..708
                     /gene="LRRC59"
                     /gene_synonym="p34; PRO1855"
                     /inference="alignment:Splign:2.1.0"
     exon            709..882
                     /gene="LRRC59"
                     /gene_synonym="p34; PRO1855"
                     /inference="alignment:Splign:2.1.0"
     exon            883..2880
                     /gene="LRRC59"
                     /gene_synonym="p34; PRO1855"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2859..2864
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRC59"
                     /gene_synonym="p34; PRO1855"
                     /note="hexamer: ATTAAA"
     polyA_site      2880
                     /gene="LRRC59"
                     /gene_synonym="p34; PRO1855"
                     /note="major polyA site"
ORIGIN      
        1 acggaagtgg tcgtcgtcgc ggcaccggtg ggagctaggc gcgaggctcg gagtgcggcc
       61 agcgggcgga ggcggtctcg catcggcggc gacggagggc tcaggcgtcg tcgtttgggt
      121 ggggggccgc tgaactgaca agcgacattt cagctccttt cacccgccgg aaccccggag
      181 ccggggcccg ctcagccggc gttaccatga ccaaggccgg tagcaagggc gggaacctcc
      241 gcgacaagct ggacggcaac gaactggacc tgagcctcag cgacctgaat gaggtcccgg
      301 tgaaggagct ggctgccctt ccaaaggcca ccatcctgga tctgtcttgt aataaactga
      361 ctactctacc gtcggatttc tgtggcctca cacacctggt gaagctagac ctgagtaaga
      421 acaagctgca gcagctgcca gcagactttg gccgtctggt caacctccag cacctggatc
      481 tcctcaacaa caagctggtc accttgcctg tcagctttgc tcagctcaag aacctgaagt
      541 ggttggacct gaaggataac cccctggatc ctgtcctggc caaggtggca ggtgactgct
      601 tggatgagaa gcagtgtaag cagtgtgcaa acaaggtgtt acagcacatg aaggccgtgc
      661 aggcagatca ggagcgggag aggcagcggc ggctggaagt agaacgtgag gcagagaaga
      721 agcgtgaggc taagcagcga gctaaggaag ctcaggagcg ggaactgcgg aagcgggaga
      781 aggcggaaga gaaggagcgc cggagaaagg agtatgatgc cctcaaagca gccaagcggg
      841 agcaggagaa gaaacctaag aaggaagcaa atcaggcccc gaaatctaag tctggctccc
      901 gtccccgcaa gccaccaccc cggaagcaca ctcgttcctg ggctgtgctg aagctgctgc
      961 tgctgctgct gctatttggt gtggcgggag ggctggttgc ttgtcgggtg acagagctgc
     1021 agcagcagcc cctctgcacc agcgtgaaca ccatctatga caatgcggtc cagggtctac
     1081 gccgccatga gatcctccag tgggtcctcc agaccgactc tcagcagtga gcttgtcccc
     1141 agcacctgct gcctcccagc cttggagttt ggattcctat ggaattgggt tctgctggac
     1201 acaacctctt tttagcatca gacctacctg ccatcatcaa atggctgcag attggtacat
     1261 gagacctcct ctttgtagga cttcttcatt ccttagtcag ggttccctga aggaatgagg
     1321 agaaatggga ggtggcgggg gggcgtgggg ggcagttacc tgcatgccta aaggagtagg
     1381 cttgggggtg gggagagaga aaacatagcc ttttctagtt gttatataaa gctgtgtaaa
     1441 ggcaaggctc gtttctacta aatggtcagc tgtcactaca tttatacttt tgtatgccac
     1501 aaaccctttc attcctccct gggaatcagg gtagatcagg aggaactggg ggggactaga
     1561 acaccacgct cagtaaatcc agtctaaact gggaggtagg ggtattcctg ttttctttag
     1621 gacctcagag atgtaagcat tttagcagcc acacaaaatc tctggctatg aaagggactt
     1681 catgaccatc cagtccaata taacacttgc agacagagaa actgaggtct tccatgactt
     1741 gcctagtctc ccagctagtt tgaggcaaaa ctggattccc actctggtat tctttcttcc
     1801 ctttacatca ttttccctcc tttataatgt cctgagagac cagaactcac accagaatcg
     1861 attattcctc aggtgaagca tagactcttt catggtagac agatttcacg actcagagat
     1921 agaaatctct tgctatcatc aggtcacggg cagctcctgt ggagtcctgc ccaacttatg
     1981 tggcttccat aaaatggcaa cagtccaggc tccttgccta attttagagc attaactccc
     2041 taattgccag taagcaagga ggtggatctc tgcaaaccta cactgtctat gacagctcta
     2101 gttgtacttg gtgtgactaa atacctcaaa ggcaacctgc ttctgcaggt tttgaagtgt
     2161 cagcttcata agacactgag gtttagaatt gtttgattct agaccataac tgaagggcat
     2221 aaatggaaac aggatatgaa gggaaacaag tagcatcatg gagctgaaaa gtggtgcatc
     2281 acccaatggc tagcacaaac aaggatcaca ctgtccattc tcttgtctgc taaattaagc
     2341 attttcttgc ctcctttgct tcatcttttc acaacagctg gatagaggga tcagaaatga
     2401 ctgtgtcatg gtgctcattc actgcaaact cccagttgca agctccttgg ctcccccgga
     2461 gggagcaaga atctcatagt tcagagacac agagggcctt ttagccctaa tgaccttttg
     2521 gatgggactg caactcatga ctatcctgat attggaagaa aggactttgt taatcttctc
     2581 ccccatagct ctgctgcgta ggtctacatc ttactcagaa tcactacaca ttcctttagt
     2641 cttcctccaa gctccagagc cattggtaca aatgctttat tgaaactaaa tacataatac
     2701 acacaatgag atgaagacaa tatagaagtc cgcatagtca tcataatccc gttccttggc
     2761 cggttgaggc agctcagtgg ctgagcccag tcaagccaac ccgcagcttc actcacgact
     2821 tcaagatttg atgctaattc ttttggattt ctacagttat taaataagtg tctgagtgga
//
