LOCUS       NM_001099678            7918 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens leucine rich repeat containing 58 (LRRC58), mRNA.
ACCESSION   NM_001099678 XM_057296 XM_938862
VERSION     NM_001099678.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7918)
  AUTHORS   Benjamin,D.J., Cesarini,D., van der Loos,M.J., Dawes,C.T.,
            Koellinger,P.D., Magnusson,P.K., Chabris,C.F., Conley,D.,
            Laibson,D., Johannesson,M. and Visscher,P.M.
  TITLE     The genetic architecture of economic and political preferences
  JOURNAL   Proc Natl Acad Sci U S A 109 (21), 8026-8031 (2012)
   PUBMED   22566634
REFERENCE   2  (bases 1 to 7918)
  AUTHORS   Lingappa,J.R., Petrovski,S., Kahle,E., Fellay,J., Shianna,K.,
            McElrath,M.J., Thomas,K.K., Baeten,J.M., Celum,C., Wald,A., de
            Bruyn,G., Mullins,J.I., Nakku-Joloba,E., Farquhar,C., Essex,M.,
            Donnell,D., Kiarie,J., Haynes,B. and Goldstein,D.
  CONSRTM   Partners in Prevention HSV/HIV Transmission Study Team
  TITLE     Genomewide association study for determinants of HIV-1 acquisition
            and viral set point in HIV-1 serodiscordant couples with quantified
            virus exposure
  JOURNAL   PLoS One 6 (12), e28632 (2011)
   PUBMED   22174851
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC063952.15 and BC013757.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001099678.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.108909.1,
                                           SRR1660805.52164.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA2149876
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000295628.4/ ENSP00000295628.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AC063952.15        83849-83863         c
            16-46               BC013757.1         1-31
            47-47               AC063952.15        83817-83817         c
            48-1795             BC013757.1         33-1780
            1796-7698           AC063952.15        59238-65140         c
            7699-7918           AC063952.15        59018-59237         c
FEATURES             Location/Qualifiers
     source          1..7918
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q13.33"
     gene            1..7918
                     /gene="LRRC58"
                     /note="leucine rich repeat containing 58"
                     /db_xref="GeneID:116064"
                     /db_xref="HGNC:HGNC:26968"
     exon            1..611
                     /gene="LRRC58"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..1227
                     /gene="LRRC58"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 58"
                     /protein_id="NP_001093148.1"
                     /db_xref="CCDS:CCDS46892.1"
                     /db_xref="GeneID:116064"
                     /db_xref="HGNC:HGNC:26968"
                     /translation="MEEAGAAVVTAGEAELNWSRLSVSTETLESELEARGEERRGARE
                     ALLRLLLPHNRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNR
                     LGGPSALPKGLAQSPLCRSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPA
                     EIENLQSLECLYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLS
                     LHNNLLTYLPREILNLIHLEELSLRGNPLVVRFVRDLTYDPPTLLELAARTIKIRNIS
                     YTPYDLPGNLLRYLGSASNCPNPKCGGVYFDCCVRQIKFVDFCGKYRLPLMHYLCSPE
                     CSSPCSSASHSSTSQSESDSEDEASVAARRMQKVLLG"
     exon            612..740
                     /gene="LRRC58"
                     /inference="alignment:Splign:2.1.0"
     exon            741..1018
                     /gene="LRRC58"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..7918
                     /gene="LRRC58"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7805..7810
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRC58"
                     /note="hexamer: AATAAA"
     polyA_site      7829
                     /gene="LRRC58"
                     /note="major polyA site"
     regulatory      7837..7842
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRC58"
                     /note="hexamer: ATTAAA"
     polyA_site      7858
                     /gene="LRRC58"
                     /note="major polyA site"
     regulatory      7897..7902
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRC58"
                     /note="hexamer: ATTAAA"
     polyA_site      7918
                     /gene="LRRC58"
ORIGIN      
        1 acttccgact cagccctcgg ttcaggttcc ggggcgccgc agagctcccg gcctctggac
       61 cgcgcgcggc gctctgggga atccggcgcc acgcgccgtg cggtggccag gatggaggag
      121 gccggagcag cggtggtcac ggccggggag gccgaactga actggtcccg cctcagcgtg
      181 tccaccgaga cgctggagtc tgagctggag gcgcgggggg aggagcggcg cggggcgcgg
      241 gaggcgctgc tgcggctgct gctgcctcac aaccgtctgg tgtcgctgcc acgggcgctg
      301 ggcagcggct tcccgcacct ccagctgctg gacgtgagcg gcaacgcgtt gaccgcgctc
      361 gggccggagc tgctcgctct gcgcggcctg cgcacgctgc tggccaagaa caaccggctc
      421 ggcgggccca gtgcgctgcc caagggcctg gcccagtcgc cgctctgccg cagcctccag
      481 gtgctcaacc tcagcggcaa ctgtttccag gaggtgcctg cctcgctctt agagctgcgc
      541 gcgctgcaga ccctgagcct gggcggcaac caactgcaga gcatcccggc tgagatcgag
      601 aacttgcaga gtttagagtg tttatatctt ggaggaaatt tcattaaaga aatcccacca
      661 gaattaggaa atctgccttc tctgaattat ttggtattat gtgacaacaa aatccaaagc
      721 atacctcctc aactttcaca gttacattca cttcgttccc taagtcttca caataacttg
      781 ctgacatatc tgcctcgaga gatcctcaac cttattcatt tggaagagtt gagtttacga
      841 ggaaatccat tggttgttcg ttttgttaga gatttaacct atgatcctcc aactctcctg
      901 gaattagctg cacggaccat taagattcga aatatttcct acactcccta tgatcttcct
      961 ggaaatcttc ttagatactt gggttcagcc agcaattgcc caaacccaaa gtgtggagga
     1021 gtctactttg actgctgtgt cagacaaatt aaatttgtgg acttctgtgg gaagtatcgc
     1081 ctcccactga tgcactactt gtgttcacca gaatgttctt ccccttgcag ttctgcctct
     1141 cacagctcca cttcccagag tgaatctgac tcagaagatg aagctagtgt tgctgcacgc
     1201 agaatgcaga aagttcttct tggttgaaca ggagtgcaca gtgttgtgaa atacttaaaa
     1261 aactgagcaa aatggttaga caagaaaata gagcttgaag ttcactagaa atcttatctt
     1321 catcttaagt gttcatcaaa gagtctggga tgatataaaa cattttgtgt ttcatctacc
     1381 cattcagcaa gaatgagtcc agtcccatgt ttagattatt ttaacataat ttgtgaatga
     1441 tagtttcaca tttggctgat ggtttgcagt tttcactcaa gttttgcatg aatcacaaag
     1501 cagaatggta ccttttgaag agcagttctg caataagtca tgagtagtat aacttttgga
     1561 cattgagatg gagaaagtga gaaattatca aagctataat tgccagagtt gcccttgggt
     1621 ttaggtagaa cactgtatac catatatact atataccata tatactatat ataccatata
     1681 tattatatgc cataaacagg attaaccctc ccttttctaa ttgcctgtat gtctagatta
     1741 cagaactatt caaagaagct cacagatggt tacatgggac aaacctttct gacaaactaa
     1801 ctggtaaagt aaggcatata acatttacat gagatattaa aactttttca ttattatcct
     1861 ttgttctata tgattgctat taaccttatg taatctagca atgactgtta tagtgcctta
     1921 atccagcaag gatataaaaa tgtattcaag aagtaatgcc agagcaacct ataacctgac
     1981 ataccatgca gaacattgta aaatattctt taacagaact aggtaaataa ctgtgtatct
     2041 aatatccgat ctcatggccc tcttaacatt tttttgttta aatgtgcact catcccttat
     2101 aagcacatta cttttacact taatggtagg ccacaatctt catcaatctg ttcatcataa
     2161 gacagagtaa gaatttttaa cagaaaattc taaaagagat agaagctagg aaagcttctt
     2221 tatatcttgc attaaatggg tagggaaaaa atatgactct cacccatgtc atgtactgga
     2281 ccatctttct ctacttttta aagaaaaact aatacaacta gaaaaacatc acaacaagcc
     2341 aaataaaaat ggagaaaagg agtcattgtc cttataccta atggaacagt ttccagaact
     2401 actttaacta tggaagcatt tttgaaaata aagtattaat aaaatagaaa aaaattatta
     2461 aatatattgt atccttaatg tatagcagga aaatagtttc acaaattaat tgctattaga
     2521 aattaccaaa tttttattaa gtactttaat atgcaataca aattgaataa tagtacaact
     2581 ataagttgat ataaagtaag tgcttactgg taatcattaa ataactaata acatgacttg
     2641 ttggttaatg ttaaacctac agtaagaaat gttatacaga tcagataggc attagaacat
     2701 caggtgtacc ttttctgatt tctggcattc atggcacacc atttcttaaa agcagattgt
     2761 tgtataataa catatacatg tattagggtt tttttcatat atatttttta ttttagaaga
     2821 aactagcata attcagggtt tatgtgttta tttgtatatt aattcatgaa acatgagagt
     2881 ttcatgaact gcagatgtga aacgctgcta tagaatgaat cccttcacct ttaccttgtt
     2941 ataatgtagt aagattttgt tttccttttg actcagaaat tttctatgtc tatagaggta
     3001 atctaatatg ttcctactgc ctagaagagt aatacatagg tgattatatc ataaaataga
     3061 ggtataaagt ctttgcttac ttctccatgt gggccacagc aagctgcaga ctgtacagtt
     3121 atgaaaggta aagatgactt aggctgtgcc taagtgacaa atgtaaaatg ttttgtaaat
     3181 aagtgactta cctaagatac ataagatatt ttcatagaaa ataatgtatt catagtaaaa
     3241 tactcaaatt gataggacca attttttctg gcctaaatgc ttatgcctac ttcctaatca
     3301 attaccagct tgacttaagt aactgcttga gtagtcttct aagagttagt cttcgtaaaa
     3361 taaatggata ggtatgtaaa tatataatct tacataccct ttccagcttc ctagaaaggt
     3421 ctactgcttc atcttttaca gatgtaaata ggtccaacca gagacagttt ctggcctttg
     3481 catataagaa tatagatgta taccacagta ttatttcaac aaaatgttat ggttctatgt
     3541 atagttgaaa actctatgat cagcatacaa ctgtcttttg gtaattttta atgaagtcta
     3601 catttagccg tcggttttat ctttcttaaa tctttgacct aaacttttgt aagagcagct
     3661 aataatttct aagattttcc ctgtttcttt ttcctacctt tccttttctc ataactgatt
     3721 ggagaaatta atcagaagtc aaatacaagg gacttcataa tctagaaacc agataatcag
     3781 ctcccaagtc atgtagctaa ctatgcattt aaaataagtc tgtctcttta gttcttaagt
     3841 catatatttg tttgttaatt acagtaaatg aactttaatt ggggttttta aaagacagaa
     3901 ttagcgaagt ctaattttta taatgaaata agtttttgat attgctctac ttggacgatt
     3961 ttagtgacca aaactatgga taaaactgcc taagcataac attaatatat ttagaatggc
     4021 attcttcagt gctagtattt gaaattggaa ttagtacatt gtgcattctt agtagtcttt
     4081 atccctagaa tcaattctct cagcatcacc aaactgaatt ggtgaaatag tgctaagatt
     4141 ctgggcaata ggaagattag tgaatatgat acattgattc cagggtgcca gggattggct
     4201 gacattaagg accagctggc tatggtcctc aggctacggt cctcagtatt ctagtatttg
     4261 agtagtggag gtaaatccaa aggcgactgg ttatatttta cttctaaatg tgtgctgaag
     4321 tgtctcttgt tcaaaaattc ttgatattta gagcttcaag ttaccacatt taaaagtaaa
     4381 gacttggcac ggtggcacac acctataatc ttagcacttt gggaggccga agtggatgga
     4441 tcatatgcag tcaggaattt gagaccagcc tggccaacat ggtgaaacct catctttact
     4501 aaaaatacaa aaattagccg ggcgttgtga cgcacaccca tagtcccagc taactccgga
     4561 ggctaagaca agagaatcac ttgaacttgg gagacagagg ttgcagtaat ctgagatcac
     4621 tccgctgcac tccagcctga gtgagagtga gactgtgtct caaacaaaca aacaaaaaac
     4681 aaacaaaaaa atttgcattg taaattgtac ctcaaatttg agcagttttt gtgtttgtgt
     4741 aaattaaagt aaaaagcagt ccacaataat gttttgtaat actgcacacc agttctacca
     4801 gattttgtaa ctatcagatt taaatgaaaa aagagaagga agaggctgat tgctggagtg
     4861 ttaaagaaat cttggccggg cgtggtggct cacgcttgta atcccagcac tttgggaggc
     4921 cgaggcgggt ggatcacgag gtcaggagat cgagaccatc ctggctaaca cggtgaaacc
     4981 ccgtctctac taaaaataca aaaaaaaatt agccgggcgt gatggcgggc gcctgtagtc
     5041 ccagctactc gggaggctga ggcaagagaa tggcgtgaac ccgggaggcg gagcttgcag
     5101 tgagccgaga ttgcgccact gcactcccgc ctgggccaca gagcgagact ccgtctcaaa
     5161 aaaaaaaaaa aaaaaaaaag aaatctttag aagccacagg gctagaagag aagtcaccaa
     5221 acacctaggg acagtcctag gcctagaaag ccctttaaag taatagtgaa ttgttttaaa
     5281 attaagttat tgagtggcct actgactacc atccaaaaac ctttatcacc aaatttgttc
     5341 agtgtttgct attgggagat tgtccatatc cctccgtaat taagggccag caagtaatac
     5401 gatcttctta cagccaacct tgctcttccc aaagggagaa agtaatacat cattaacctg
     5461 gaatttgtga tataacaggt agccttggtt aatgtttacc ttttcactat gtaaaaaaga
     5521 aaaaacacac agcaaatagt gcaaataaaa tttggtcttt taaagcattt tagcagtagc
     5581 tatgtaaaaa aagttaatgg ttattattcc taaattttca taagaccctt ggtagacaaa
     5641 actatcggtt atattatgta tatatgaggt tagttaagct gcatttagtt aggaacattt
     5701 aatttttacc taaatgatcc ttttttcatc cagaggtaga gattttattg tcattatgaa
     5761 tgttactccc catttagtcc aaaatagtga gcttttaagt tgtgccaggt acttaacaat
     5821 agtaaaagct attgtataga tttttattca atgtgaccta taatacattt ctgattcctt
     5881 ctgtattgaa tgtcccagtt tccatattaa gtgctatgcc ctgtataaca ttaatgaatt
     5941 taatagtgta caattttggg ccaggcatgg tggctcacgc cagtaatcct ggcactttgg
     6001 gaggcagagg caggcagatc acctgaggtc aggggttcga gatcagcctg gccaacatgg
     6061 caaaatcaca tctctactaa aaatacaaaa attagccagg cgtggtggtg catgcctgta
     6121 gtcccagcta ctcaggaggc tgaggcagga gaatcgcttg aacccaggag gcggaggttg
     6181 cagtgagccg agatcatgcc attgcactcc agcctgggag acagagcaag actctatctc
     6241 aaaaataaaa ataaaaaaaa aattgcgtgc aattttgtat tttcatagtc gtatcttttt
     6301 aaaggtatca tgatttcagt tgtggtcagg aagtatgtgc cttaaatcct ctactctaga
     6361 cccaaagttt ggagagctat attatttaat aagttgtttg tgacagcctt gttacctttt
     6421 tcatttgatt tgagggagaa agactgtgat cctgacagat tccttctcat aaaatggcct
     6481 aatgtgtatc agtctaggac ttctggggag ggaacctcta ccatgcattc tgtcccagga
     6541 tgtcaaagtc ataagaatca gggtcccctg aaataaaatc actgaaaaga tatgttctgt
     6601 tatatattat ttaaaaaatt tatctggtgc caccaaagaa tgacagcagt ttctaaccaa
     6661 cttcatattt atagcatctt atgaagatat tgtaaggctt agcatatttt gccactggtt
     6721 ttctttgtaa tataggttga aagtgagaca tgtttgaata cttttgtatg taaatatctc
     6781 ccattctttt tctatctctt cttggtctat atttactaag aattgatatt taaaaaacag
     6841 ttcactaatg aactctacat attattgaac actcacaggg caatattgat ttgggtgcta
     6901 ctagactttt acctaacatt agtctttctc aatagttgtt gtaaaggata gtattcaatc
     6961 cagtaaatat taaagtgtat tagtttaatg aaggttattt atatactgtc ataccacaaa
     7021 cctatggtgg aaagaacatc tgcattcacc agaatgtact tgttcctttg gctgtgaata
     7081 aattggataa gactttttta ttgtaagttc cagctgttgg aagatacggg gataagattg
     7141 acattgctgt tgcagtattg caaaaacatg actaaattgg ttaattatgt ctaccgctta
     7201 tgtttaagag aatcctttca ctaacttaaa ttgttaacat tgttgtgata ttgagaaaga
     7261 atattaacct aaacagtcac tttacaacaa tcatgtaaag acgtgtgcct gcagttgagg
     7321 ttttttgcat ttctgagcct gctttgtatt catgagaaac aaaaacataa tgggagaaaa
     7381 gttttagata agcagcattg taagtttttg taaagtttgg gatgtcaaag tattaacgaa
     7441 gggtactgaa aacatacttt tacttgggtc aaattacttt ttatgatctg atttcttaat
     7501 tttctgtatt tgaaatcttg caaattagga atatctacat ctatagataa ataagtaaaa
     7561 cttaatggta gaaataagtg taattcagca acatgattca acaattttta tatttaggat
     7621 aagttattgt ttattatatt aatatcaaat ttatatattg ccttgtaatg ctaaatgctc
     7681 ttaaaagaat atatgggcta cttcaattct accaccttct tccccctccc ccaggacgta
     7741 caaaagatct tatattaacc aatcctctgt gaattttgcc atatcaaaca ttgtgcctta
     7801 ttttaataaa actgttttgt tggaatccag ttctatatta aagtctctat aatgttgata
     7861 tttgcctgat tacttgttac atcattgaat acatacatta aatatgtact aacattga
//
