LOCUS       NM_153260               7097 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens leucine rich repeat containing 57 (LRRC57), mRNA.
ACCESSION   NM_153260
VERSION     NM_153260.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7097)
  AUTHORS   O'Brien,H.E., Hannon,E., Hill,M.J., Toste,C.C., Robertson,M.J.,
            Morgan,J.E., McLaughlin,G., Lewis,C.M., Schalkwyk,L.C., Hall,L.S.,
            Pardinas,A.F., Owen,M.J., O'Donovan,M.C., Mill,J. and Bray,N.J.
  TITLE     Expression quantitative trait loci in the developing human brain
            and their enrichment in neuropsychiatric disorders
  JOURNAL   Genome Biol 19 (1), 194 (2018)
   PUBMED   30419947
  REMARK    GeneRIF: Increased expression of LRRC57 is associated with genetic
            risk for bipolar disorder.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7097)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA749946.1, AK094891.1, CN350663.1, BE301068.1, BQ130124.1 and
            AC018362.8.
            
            On Nov 22, 2018 this sequence version replaced NM_153260.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.261130.1,
                                           SRR1660805.65094.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000397130.8/ ENSP00000380319.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-207               DA749946.1         12-218
            208-801             AK094891.1         453-1046
            802-1200            CN350663.1         263-661
            1201-1715           BE301068.1         1-515               c
            1716-2028           AK094891.1         1961-2273
            2029-2404           BQ130124.1         13-388              c
            2405-7097           AC018362.8         74930-79622         c
FEATURES             Location/Qualifiers
     source          1..7097
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q15.2"
     gene            1..7097
                     /gene="LRRC57"
                     /note="leucine rich repeat containing 57"
                     /db_xref="GeneID:255252"
                     /db_xref="HGNC:HGNC:26719"
     exon            1..101
                     /gene="LRRC57"
                     /inference="alignment:Splign:2.1.0"
     exon            102..207
                     /gene="LRRC57"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..843
                     /gene="LRRC57"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 57"
                     /protein_id="NP_694992.2"
                     /db_xref="CCDS:CCDS10089.1"
                     /db_xref="GeneID:255252"
                     /db_xref="HGNC:HGNC:26719"
                     /translation="MGNSALRAHVETAQKTGVFQLKDRGLTEFPADLQKLTSNLRTID
                     LSNNKIESLPPLLIGKFTLLKSLSLNNNKLTVLPDEICNLKKLETLSLNNNHLRELPS
                     TFGQLSALKTLSLSGNQLGALPPQLCSLRHLDVMDLSKNQIRSIPDSVGELQVIELNL
                     NQNQISQISVKISCCPRLKILRLEENCLELSMLPQSILSDSQICLLAVEGNLFEIKKL
                     RELEGYDKYMERFTATKKKFA"
     exon            208..346
                     /gene="LRRC57"
                     /inference="alignment:Splign:2.1.0"
     exon            347..615
                     /gene="LRRC57"
                     /inference="alignment:Splign:2.1.0"
     exon            616..801
                     /gene="LRRC57"
                     /inference="alignment:Splign:2.1.0"
     exon            802..7097
                     /gene="LRRC57"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2310..2315
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRC57"
                     /note="hexamer: AATAAA"
     polyA_site      2340
                     /gene="LRRC57"
                     /note="major polyA site"
     regulatory      2384..2389
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRC57"
                     /note="hexamer: AATAAA"
     polyA_site      2404
                     /gene="LRRC57"
                     /note="major polyA site"
     regulatory      7071..7076
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRC57"
                     /note="hexamer: AATAAA"
     polyA_site      7097
                     /gene="LRRC57"
                     /note="major polyA site"
ORIGIN      
        1 acagggcgtt cccgcccggg actaagccgg ggagcgcatc ccggctactg cgggtcctgg
       61 gtcttcacct gcggagcctt acggcagctg agcggtggga gggacctgag ccgcggcgct
      121 aggatgggaa acagtgcgct ccgcgctcat gtggaaacgg cgcagaaaac tggtgtcttt
      181 cagcttaagg accgagggct gaccgagttc cccgcagact tgcagaagct gacgagcaat
      241 ctcaggacca tcgacttgtc caacaacaag atcgaaagcc taccgccttt gctgatagga
      301 aagttcactc tgctgaagag cctctccctg aacaacaaca aactgactgt tctgcctgat
      361 gagatatgca atctgaaaaa actagagacg ctaagcctaa acaacaatca ccttagagag
      421 ctgccgtcta cctttgggca actctctgcc ctcaagaccc tgagcctctc tgggaaccaa
      481 ctgggagcat tacctcccca actttgtagc ctacggcacc tggatgtgat ggatctctct
      541 aagaaccaga ttcgaagtat acctgactca gtgggagagc tgcaagtcat cgaactcaac
      601 ctcaaccaga atcagatatc tcagatctca gtgaagatat cttgctgtcc acgccttaaa
      661 attcttcgcc tggaagagaa ttgtcttgag ctcagcatgc ttccccagag catcctcagt
      721 gattcccaga tctgtctgct tgctgtggaa ggcaatcttt ttgaaataaa gaaacttcga
      781 gaactggaag gctatgataa gtacatggag aggttcacag ccaccaagaa gaagtttgcg
      841 tgaagttctc caggactatg gaaaccttac aggatactga cttagaacct ctgttggaat
      901 gtggctgagt caaagcctcc tgttgttgtt aggggtatct acagtaagga gatgatactt
      961 caggagatta tatttcactc aatgatcttt tctcatttca gggctcttct caaataagct
     1021 aaaagaaaaa ggatcaggag acaggaaaag tcttccgttt tgagtcatga gtagggcaat
     1081 agacaaggtt ctcttcaaaa ccatcattag tttggcttta agaaaccagt agctagctgc
     1141 tatttatatg gtgagggggt gctgcctggt aacagaatag ctccacacca cagcttgaga
     1201 ttttgtttag tttcactgtg tgagctttca taaagtctgt tgccattcca tctctgtgtt
     1261 aacacttcat atttttatga aattcagata atttgtgaga ggctggcatg gatctaagga
     1321 tttattattt ttattctagt ccatcagttc agtcgcagtt tttatactag gactttagga
     1381 tgtacataaa tgtgtgactg tttgtcttga ttaaaagtgc actttggcct gggcatggtg
     1441 gctcatgcct ataatcccag cactttggga ggccaaggcg ggtggctcac ttgaggctag
     1501 gagttcaaga ctagcgtggc caacatgagg aaaccctgtc tctactaaaa atacaaaaat
     1561 tagctgggtg tgttggtgca tgcttataat cccagctact tgggaggctg aggcaggaga
     1621 atcgcttgaa cccaggaggt ggaggttgca gtgagccgag attatgccac tgtactccag
     1681 cgtgggtgac agagtgagac tctgtctcaa attaaaaaaa taaaaaataa tttttttttt
     1741 ttaaagtacg ctttgttggc tgggcacggc gactcacgcc tgtaatccca gcacattggg
     1801 aggccaaggc aggcagatca cgaggttagg agttcgagac cagcctggcc aacatggtga
     1861 aaccctgtct ctactgaaaa tacaaaaatt agctgggcgt ggtggtgggt acctgtaatc
     1921 ccagctactt gggaggctga ggcaggagaa ttgcttgaac ccaggaggca gaggttgcag
     1981 tgagccgaga tcatgccatt gcactccgac tctgggcaac agagcaagac tctgtctcgg
     2041 gggaaacaaa aaaaaagtgt gctttgtcaa gagaagcacc agcagacctc taagaactgc
     2101 tctctaaggc tgcggtagca aattatctac tattgcaggt gccttattgg tagagggctc
     2161 tgaagagcca aaactgtata tgcaacactt gtaagataaa agggacttta ataatcaaga
     2221 ttttcttgaa gatttgttag aaataatgtc ttatttctgg taacctttcc ctttttgtat
     2281 ttataactct actaaccaaa ttacctatca ataaaccatt actataatat tttaaaacaa
     2341 cctatgttta tcaagcttac tctctgagtg acagaatata ctaaataaag aattttttaa
     2401 tgaactttgg ctggaagcaa ggttaatcct ttaaaggagg aggacaggag aacttaaacc
     2461 tataaataga ttaggaagac atgtttcatg cttatgttca gattgtatga gtagtgaaat
     2521 gccttcatgt gacataaaca ttttgtgata ctagaactat gcttattaag agaatctgag
     2581 gttgggcgcg gtggctcacg cctgtaatcc cagcactttg ggaggctgag gtgggtggat
     2641 cacgaggtca ggagttcaag accagcctga ccaatgtggt gataccccat ctctactaaa
     2701 aatacaaaaa ttagctgggt gtggtggcac gtgcctgtaa tcccagatac tcaggaggct
     2761 gaggcaggag aattgcttga aaccgggagg cggagcttgc agtgagggtg ccattgaact
     2821 ccagcctggg caatagagtg agactgcgtc tcaaaaaaaa aaaaaaaggc cgggcgcggt
     2881 ggctcacgcc tgtaatccca gcactttggg aggccgaggc gggcagatca cgaggtcaag
     2941 agatcgagac catcctggct aacacggtga aaccctgtca ctactaaaaa tacaaaaaat
     3001 tagccgggcg tagtggtggg cgcctgtagt ctcagctaca tgggaggctg aggcaggaga
     3061 atggcgtgaa cccgggaggc ggagcttgca gtgagcggag atcttgccac tgcactccag
     3121 cctgggtgac agagccagac tccatctcaa aaaaaaaaaa aaaagaatct gaaggtacaa
     3181 aggtagagga tttcagacta ccactaacat caacatttag aaagctacca ttttggtcat
     3241 tttctgattt tatcttagtc acaaagctat tactaactat atatcaacag ttctcaataa
     3301 tggttaaacc tagcttatcc attaagtcaa gagatcacac aaacctacta tttaacctcc
     3361 acgacaaaat ctttctgacg taaatctggt ctaggtgttc tctttttccc atatgttact
     3421 ttcttttttg agacagaatt tcattccaga ctggagcgca gtagcactat cttggctcac
     3481 tgcaacctcc acctaccagg ttcaactgat tcttgtgcct cattctcctg agtaattggg
     3541 attacaggca tgcaccacca cacccagctc atttttgtat ttttagtaga gacagggttt
     3601 caccgtgttg gccagactgg tcttgaactc ctggcttcag gtgatccacc cacctcagcc
     3661 tcccaaagtg ctgggattac aggtgggagc caacacaccc agcctcccat atgtcatttt
     3721 ctatttctca ctttgaaagg ggtactagtt tatccatacc agtttaggag ttttgttttt
     3781 tctaaatttt aatgtttatt aatcttattg atctactgaa caattaacat ttctgtgttt
     3841 tatcagtact tctcatctaa taaatcagaa cttatacatt tttttttttt ttctgagacg
     3901 gagtctcatt ctttcaccca ggctggagtg cagtggtgcg atcttggctc attgcaacct
     3961 ctgcctccca ggttcaagca attctcctgc ctcagcctcc tgagtagctg gtactacagg
     4021 caggcgcacg ccaccacgcc ctgctaattt tttgtatttt agtagagatg gggtttcacc
     4081 atgttggcca ggctagtctc gaactcctga cctcaggtga tccacccgcc ttggtctccc
     4141 aaagggctgg gattacaggc gtgagccacc acgcctggcc agaacttata catttaacaa
     4201 tttaaatgtt cccatttaat tattaattgg agtttaatcc acactcttat cagaatccac
     4261 aactaccacc cttcacaatt tgggcctaga cttattgccc tttcttcact ctcatttgcc
     4321 tgcccaccca tatcagatta ttctctctaa acccacagtg cagtcttttc tgacctcctt
     4381 tatacagctt gtccctcagt gtccatggag gattggtttc aatacctcca tggataccaa
     4441 gtccatgatg ctcaagtccc ttatacaaaa tgacatagta tcttcctgat actttaaatt
     4501 atctctagat tacttataat acctaatatg cctacacata acttcatttg catagattca
     4561 acatagtatt tgatgcatgc taaattaagg ttttgttttt tagaaatttg aggcattttc
     4621 ccgctcaaat atttctgacc tgcagttgaa tccacagatg tggaacccat ggatacttag
     4681 ggccaactgt attgttcact cagttgggaa tgcccttttt tttttttttt ttggtccaga
     4741 ggctcactct tgcccacgct ggagtacaat ggcgcgatct tggctcactg caacctccgc
     4801 ctcccgggtt caagtgattc tcctgcctca gcctcctgag tagctgggat tacaggcagg
     4861 tgccaccaca cctggctaat ttttgtattt ttagtagaga cggggtttca ccatgttggt
     4921 caggctgatc tcaaactcct gacctcagtt gatccacctg ccttggcctc ccaaaatgct
     4981 gggaattgca ggcgtgagct aacgtgccca gcctgccctc tcttaattaa tatgctcatt
     5041 ctgtatgtct aagcctcttt cctgcgtcta agccgaatta actgctcacc catctgttac
     5101 tatagcactt ctcacattct atatttatct ttcatgatag actaactctt tgagggcaag
     5161 ggctatatac agtaatatgc ccaaagttac agcaaacaag atttagattt aaatatgagc
     5221 taatcaagta aactagcttg tggtctaaag acccagattt gaatctggcc actagtccaa
     5281 gtcacctaat tttttttttc tttttttgcg acagatcttg ctgtgttgcc tgggctagtc
     5341 ttaaactgga ctcaagtgat cctcccatct tggcctccca aagtattgag attacaggtg
     5401 tgagccactg cctggctttt aagtctcttt tttttttttt ttttttttga gacagaggct
     5461 gtctgtttcg cccaggttgg aatgcagtgg cacaatctcg ggtcactgca acctccactt
     5521 cctgagttct agcaattctc ctgcctcagc ctcctgaata gctgggatta caggtgccca
     5581 ccaccacgcc cagctaattt ttgtattttt agtaaaatgg ggtttcacta tgttagccag
     5641 gcttatctca gactcctggc ctcaggtgat ccccctgcct tggcttccca tagtgctggg
     5701 attacaggtg ttagccacca cgcccagcct atatgtattt tttgagacag ggtcttgctc
     5761 tattgcccag gctgaagtgc agtggcatga tcacagctca caaatgcctt gatctcctgg
     5821 gctcaagcta tctcctccca cctcagcctc ttaagtagct ggagctacag gttatctgcc
     5881 accacactca gctaattttt aattttttag aaagacgggg tcttcctgtg ttccccaggc
     5941 tggccccaaa ctcctgggct caagcaatcc tgccttacct cccaaagtgc tgggattaca
     6001 ggtgtgagcc accacatctg gcccaagtca cccaaatttt ttacagcttg gtttggaagg
     6061 caatgtagta tattaaaatt atgggccctg gagtcagaaa gatccaggtt tgaatacaga
     6121 gtccgtcatt tattagcttt atgaatttga gcaatttcgt ctcacttgta aatataggga
     6181 atagctccta cctctcaggt atgttgcaaa aaactatata aaagcactta gcatagtggc
     6241 catgacagag taagcactca gtaaatcatg ccatttatct catctataag gcatgaaagt
     6301 agaattttac aagttgtaca gaaatagaag gcttggagtg gacactacat taaaaggata
     6361 aaaaaatgga gccaggcaga ggcaggcatc tatagtccca gctattgagg aggcctgagg
     6421 ctggaggatc ccttgaacct aggagtttga ggccagcctg gacaacaatg tgagattgtg
     6481 gctccaaaaa aataataaaa aataggctgc tctgcctatg gagtagccat tcttttattc
     6541 ctttactttt ttaataaact tgcttttact ttatggaaaa aataaatttt taaatgacta
     6601 gatgagaaac ttgaatatca atctgagaaa taaaatctga ttaggaatgt aattgggata
     6661 acctgaagtt ttggtaagag tgacctaaag aaaacagcac ttagataagc tactttgttt
     6721 tcctttttca ctttactatt tttctgatat atatttgttc atatttatgg ggtacttgtg
     6781 atattctgag acatgcatag aatgtataat gatcaagtca ggatatttat gttattcatt
     6841 atctcaaaca tttatcattt gtttgtgttg ggaacatttc aaatcttcta gccattttga
     6901 aacttacatt aagtatagtc accgtactat gctatcaagc attaaaactt attccttcta
     6961 tctaactgta tgtttgtatc tacccattaa cctaccttcc ttcatcgccc caccctgtac
     7021 acccactacc cagcctctgg taactatcat tctactctct acctccatga aataaatttt
     7081 ttagctcaca tgagtaa
//
