LOCUS       NM_001005210            5204 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens leucine rich repeat containing 55 (LRRC55), mRNA.
ACCESSION   NM_001005210 XM_166856
VERSION     NM_001005210.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5204)
  AUTHORS   Hu,S., Han,R., Chen,L., Qin,W., Xu,X., Shi,J., Zhu,X., Zhang,M.,
            Zeng,C., Tang,Z., Bao,H. and Liu,Z.
  TITLE     Upregulated LRRC55 promotes BK channel activation and aggravates
            cell injury in podocytes
  JOURNAL   J Exp Med 218 (3) (2021)
   PUBMED   33346797
  REMARK    GeneRIF: Upregulated LRRC55 promotes BK channel activation and
            aggravates cell injury in podocytes.
REFERENCE   2  (bases 1 to 5204)
  AUTHORS   Zhou,Y., Li,M., Xue,Y., Li,Z., Wen,W., Liu,X., Ma,Y., Zhang,L.,
            Shen,Z. and Cao,X.
  TITLE     Interferon-inducible cytoplasmic lncLrrc55-AS promotes antiviral
            innate responses by strengthening IRF3 phosphorylation
  JOURNAL   Cell Res 29 (8), 641-654 (2019)
   PUBMED   31213650
  REMARK    GeneRIF: Interferon-inducible cytoplasmic lncLrrc55-AS promotes
            antiviral innate responses by strengthening IRF3 phosphorylation.
REFERENCE   3  (bases 1 to 5204)
  AUTHORS   Li,Q., Fan,F., Kwak,H.R. and Yan,J.
  TITLE     Molecular basis for differential modulation of BK channel
            voltage-dependent gating by auxiliary gamma subunits
  JOURNAL   J Gen Physiol 145 (6), 543-554 (2015)
   PUBMED   26009545
  REMARK    GeneRIF: Suggest that BK channel modulation by auxiliary gamma
            subunits depends on intra- and/or juxta-membrane mechanisms.
REFERENCE   4  (bases 1 to 5204)
  AUTHORS   Yan,J. and Aldrich,R.W.
  TITLE     BK potassium channel modulation by leucine-rich repeat-containing
            proteins
  JOURNAL   Proc Natl Acad Sci U S A 109 (20), 7917-7922 (2012)
   PUBMED   22547800
REFERENCE   5  (bases 1 to 5204)
  AUTHORS   Zhang,Z. and Henzel,W.J.
  TITLE     Signal peptide prediction based on analysis of experimentally
            verified cleavage sites
  JOURNAL   Protein Sci 13 (10), 2819-2824 (2004)
   PUBMED   15340161
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK127591.1, AP001786.4 and AK023401.1.
            
            On May 17, 2019 this sequence version replaced NM_001005210.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.271102.1,
                                           SRR1803615.66440.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000497933.3/
                                                ENSP00000419542.2
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1103              AK127591.1         207-1309
            1104-4283           AP001786.4         98207-101386
            4284-5201           AK023401.1         926-1843
            5202-5204           AP001786.4         102305-102307
FEATURES             Location/Qualifiers
     source          1..5204
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.1"
     gene            1..5204
                     /gene="LRRC55"
                     /note="leucine rich repeat containing 55"
                     /db_xref="GeneID:219527"
                     /db_xref="HGNC:HGNC:32324"
                     /db_xref="MIM:615213"
     exon            1..731
                     /gene="LRRC55"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..967
                     /gene="LRRC55"
                     /note="leucine-rich repeat-containing protein 55; BK
                     channel auxilliary gamma snit LRRC55; BK channel auxiliary
                     gamma subunit LRRC55"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 55
                     precursor"
                     /protein_id="NP_001005210.2"
                     /db_xref="CCDS:CCDS31539.2"
                     /db_xref="GeneID:219527"
                     /db_xref="HGNC:HGNC:32324"
                     /db_xref="MIM:615213"
                     /translation="MGDTWAQLPWPGPPHPAMLLISLLLAAGLMHSDAGTSCPVLCTC
                     RNQVVDCSSQRLFSVPPDLPMDTRNLSLAHNRITAVPPGYLTCYMELQVLDLHNNSLM
                     ELPRGLFLHAKRLAHLDLSYNNFSHVPADMFQEAHGLVHIDLSHNPWLRRVHPQAFQG
                     LMQLRDLDLSYGGLAFLSLEALEGLPGLVTLQIGGNPWVCGCTMEPLLKWLRNRIQRC
                     TADSQLAECRGPPEVEGAPLFSLTEESFKACHLTLTLDDYLFIAFVGFVVSIASVATN
                     FLLGITANCCHRWSKASEEEEI"
     exon            732..5204
                     /gene="LRRC55"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5180..5185
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRC55"
                     /note="hexamer: AATAAA"
     polyA_site      5204
                     /gene="LRRC55"
                     /note="major polyA site"
ORIGIN      
        1 acagactctc gattccatgg acacagtcct catgggctcc ctccagcact gctgttgcct
       61 gctgcctaag atgggtgaca cttgggccca gcttccctgg cccgggccac cccacccagc
      121 aatgctgctg atctccctcc tcttggcagc cgggttgatg cactcggatg ccggcaccag
      181 ctgccccgtc ctttgcacat gccgtaacca ggtggtggat tgtagcagcc agcggctatt
      241 ctccgtgccc ccagacctgc caatggacac ccgaaacctc agcctggccc acaaccgcat
      301 cacagcagtg ccgcctggct acctcacatg ctacatggag ctccaggtgc tggatttgca
      361 caacaactcc ttaatggagc tgccccgggg cctcttcctc catgccaagc gcttggcaca
      421 cttggacctg agctacaaca atttcagcca tgtgccagcc gacatgttcc aggaggccca
      481 tgggctagtc cacatcgacc tgagccacaa cccctggctg cggagggtgc atccccaggc
      541 ctttcagggc ctcatgcagc tccgagacct ggacctcagt tatgggggcc tggccttcct
      601 cagcctggag gctcttgagg gcctaccggg gctggtgacc ctgcagatcg gtggcaatcc
      661 ctgggtgtgt ggctgcacca tggaacccct gctgaagtgg ctgcgaaacc ggatccagcg
      721 ctgtacagca gattctcagc tggctgagtg ccggggccct cctgaagtcg agggcgcccc
      781 gctcttctca ctcactgagg agagcttcaa ggcctgccac ctgaccctga ccctggatga
      841 ttacctattc attgcgttcg tgggcttcgt ggtctccatt gcttctgtgg ccaccaactt
      901 cctcctgggc atcactgcca actgctgcca ccgctggagc aaggccagtg aagaggaaga
      961 gatctgacat gcctgcctct catccctcca tgctgctgac cgccacagct gctggccacc
     1021 agacgccctc cctgactgct cactctggtt ccatggtgac ctggctgcct cagtcatggt
     1081 tcaagcaagg tggggacact cattttgtat gagcatctgc tttgggccag gcggcacgct
     1141 aggaattggg aacatcagat gaactgactc agtccctgcc ctcaaggcac ttccctctgg
     1201 tcaaggagag agatccaaaa actattccct ttaagactat atgtcaggac tctgagcacg
     1261 tcattatgga ggcccagagg aggagccatc atctgtatct agcaatgtcc atgagaatta
     1321 taagattaga gtgatttgtg aactgggtca tcaggaaata tctactttgt caggtaggca
     1381 aagaagggtg tctgcacatg gcagaggcca gaatatgcat agtgtgctgt gttgagaaga
     1441 gtgaacagtt cctggtcact tacttgtata gagggggtgt ggcacagaac tcaaacctac
     1501 ccctcacctc ctgacaccaa aactgtcagc tctcagcaat gccagccact gcctacaggg
     1561 agtaagaaca cctctatgac agcccctggc ctccttccac cagcagctac caggtgagac
     1621 cacctcccag tgactgcccc catatgacca aatgtcacca gttggtgagg tcccaggcag
     1681 caggctgagg atggacactt tcaatgccct tgctcctgcc tctcactcaa gttttgcttc
     1741 agaagagaga ggcaggaggc ccagcaactg gggcagcaag agtcctggca ccttgggatc
     1801 ctaatcatgt gactgttctt gccacagtgc tcatgccaca gggtctcacc aggaaagtgc
     1861 actgtgggcc acagacccac agcctggcag cacccagagc taaaagggga caaaggcagc
     1921 acagttatga ccatatgagg ctttgcattt tcttctaagc aacttaccca cgttaagcat
     1981 gagggtgaga gagctattaa atactaagcc cttgccagtg tcaggtactt tgaaaagctc
     2041 tctgcacaaa ccattccctt tgacacacac acacacaaat cttttgaggt gaacgctgtt
     2101 gttcccattt tacggatgag gcaactaagg ctcagagagg ttaaagtcac atgccactat
     2161 gagcaagata aagtctgtgc tctttctact gccccatcca agttggggaa catcaccatt
     2221 ccctctagag ttatataaat tcaaattcaa ctagagctga caaagttcct cataaggtcc
     2281 aggcactcct ctgggcactt ttatatctat tgactcactt ctttcaattc tcacagcaac
     2341 actgcctggt ggtttttatt atccccattt gacagatgaa ttaatcgtag agagttgagt
     2401 gacttaccca aggttgtctg gataagccct agaaggaagg cggtaggcag ctccattcag
     2461 ggaaactgca tctaatcagt cagtcaaaaa tcaagtaact ttacgagcaa agcacaatta
     2521 tcatcatcgt ggtcttcttc atcagtttcg tcagcagcat cattatcttc cctctatttg
     2581 ttcagcaccg gatagttcat gagtattttt gcatcattct ccttgacttt tcacatccct
     2641 gtgcaggagg taaatcaaac atcagtaatc ctgttttaca gatggggaaa aaagtctcaa
     2701 ggttggatat gacttgctat gtggcaaggt tggggctcaa ccctaacaca gttctctttc
     2761 cagtgctttc tcaagtgctt ggggaagaga atgcctcaga aggctgggta gtggggccct
     2821 ggaattcagc atccatgaat gtgctagtgg ataagctaaa tagaaggcag ccaaacccat
     2881 ctgctgtaca gattgaacta tgctcacggt agggcaaatt gcaggctctg aaacagagac
     2941 tacacaggta acacctgaat aggagactcc tgctttacaa tgtgtagata aaacatcagc
     3001 aatggtggcc atggtggcag tcatgtgaaa agtaagatct ttgggaatca agaaaggaag
     3061 ctgtgttaac cactcctgct caagccctgc tgcgtgtgtt gcaagagata ctaagagagc
     3121 aagaaagcta taggtgagaa cctctgcagt ttaggagaag aacatcaagg cacagtccaa
     3181 catgctgata agtctggcca ggaggagaat taaaacaggg gctttccaca cctcccttgc
     3241 cccaagctcc agcggtattc tatcagccca tcctcctgga aagcctgaaa ggaatgaagg
     3301 aggctaataa gtcatcttcc aggaaggcat ccctcactcg tgcttccctg agctagtcaa
     3361 ccaaaagagt cttcagaaac tttgctagac ctgaagtact tgaacctgtg tcccctgaat
     3421 ctttcttaca acatctggga caaatccctg gccctgtgac atccgaagca gaactgtgcc
     3481 ctgctctctc cttctgtgat gaccaaggat ggtgaactca agttgttctc tacaagccag
     3541 gccagcaacc taaatacttg gagaggaact tttagaaact ataatcctga caaaatagaa
     3601 aagtttccca taggggcata ccataatact ataataacct cccaggaact attgtttgcc
     3661 aaaatgtagt taatatattt taagatatat gcttttttgc ataggactag aaccagaaaa
     3721 gacaccaaat gcccccttga catcaatgtc ctttctagtg ggacaatttg gtctccatta
     3781 atgccaagcc tttctgaaca ggatacatgg cttttaaagg acagatgttt ctcctgctgc
     3841 tagaagttcc tcagtttact agagcacaat gaggaaagta ttcaacctcc ctactgccaa
     3901 ggaattccct gcttctcccc caccgccatc atcttgtcca agctatcaga agcaaccttc
     3961 tagagataat ctaacaatcc tgattagaat tgctcccata tccctggtga ccacaggctt
     4021 cattcaaatt gtccaaactg gttaacatgt atgtgatggg gtatctctgc atctgtatgt
     4081 ctgtctgcga ggttccttgt atattggctg tccgctgact tgggacagat ctctctagaa
     4141 cttgggttca gttctctgac atagtccact cagccatagg ctgagtggct aaatatgcat
     4201 aaataagcat gcctaaatag gcatatatag gttggtgcaa aagtaattgc ggtttttgcc
     4261 attaaaaatg atagcaaaaa tcccaattac ttttgcgtca atctaatatt acattgcttg
     4321 atagattaag atggaatccc accaggttta gggtaggact ggatgctcaa aaaataaaga
     4381 aggagaaaaa tctgtggcag aggcatccta atgagaacct gacttctcct tgcttccctc
     4441 tgctctctcc tgcgcctcag agacttgtcc ccattgcaga agcttcctcc atgctaggcc
     4501 agaggatatc aaagtttagt ttggtcaaga tttgggccaa gaaaattcct ttttagaaga
     4561 gccctcatat ctgaatcaca tcactttggg ccagttatct ctggtcaccc tcagacaaac
     4621 cctcgtctct ttttctccct tcctagagga attcccaggg aactttgcag aaataggtct
     4681 ccagagttgc tacagaggtt catggctcct ttcgaggagg gacatgtatg aaatttgaac
     4741 agatcaagac aggtgtttgt cttcaaccat gggggaagac ctccagcttc cattttcccc
     4801 tatacgtgtc tgtgctgaca tcctttccag cagtagaaga ctaaaaagat atatcttaac
     4861 ccattcctca aaaggacatc ttcctaaagc cagagaaaat tgtctgcgct tccccacccc
     4921 aggaagaggc aaaagggaag tgagggcgtc acaaggtctt ttgtaaatca ctattgtgtt
     4981 tgtcacagca ctgggcggag agctggatcc acagagctct cagtttttct aagcactgtc
     5041 ctgtaatgtg ctaatgtctg ggggtgggag ggctggggag gggtggggtt agagggaaga
     5101 tgccaacctt tgtatggaga tgattttata accatgcact tttgtaactg tgcagaattt
     5161 ttcataaatg tacattaata ataaagagtg tatagtttaa caaa
//
