LOCUS       NM_001382280            4358 bp    mRNA    linear   PRI 04-AUG-2024
DEFINITION  Homo sapiens leucine rich repeat containing 53 (LRRC53), transcript
            variant 1, mRNA.
ACCESSION   NM_001382280 NM_001364665
VERSION     NM_001382280.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4358)
  AUTHORS   Yang,M.H., Chen,W.J., Fu,Y.S., Huang,B., Tsai,W.C., Arthur
            Chen,Y.M., Lin,P.C., Yuan,C.H. and Tyan,Y.C.
  TITLE     Utilizing glycine N-methyltransferasegene knockout mice as a model
            for identification of missing proteins in hepatocellular carcinoma
  JOURNAL   Oncotarget 9 (1), 442-452 (2017)
   PUBMED   29416626
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4358)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX470253.2 and AC105271.2.
            
            On Apr 27, 2020 this sequence version replaced NM_001364665.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA2467144 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000294635.5/ ENSP00000294635.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-86                BX470253.2         8341-8426           c
            87-200              AC105271.2         89435-89548         c
            201-1016            AC105271.2         86326-87141         c
            1017-1532           AC105271.2         81468-81983         c
            1533-4358           AC105271.2         75549-78374         c
FEATURES             Location/Qualifiers
     source          1..4358
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p31.1"
     gene            1..4358
                     /gene="LRRC53"
                     /note="leucine rich repeat containing 53"
                     /db_xref="GeneID:105378803"
                     /db_xref="HGNC:HGNC:25255"
     exon            1..86
                     /gene="LRRC53"
                     /inference="alignment:Splign:2.1.0"
     exon            87..200
                     /gene="LRRC53"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..3856
                     /gene="LRRC53"
                     /note="isoform 1 is encoded by transcript variant 1;
                     leucine-rich repeat-containing protein 53"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 53
                     isoform 1"
                     /protein_id="NP_001369209.1"
                     /db_xref="CCDS:CCDS90978.1"
                     /db_xref="GeneID:105378803"
                     /db_xref="HGNC:HGNC:25255"
                     /translation="MLRLVAACPESCVVCTKDVTLCHQLTYIVAAPMTTRVLIITDGY
                     LSSIESTNLSLLFNLALLSLSRNGIEDVQEDALHGLTMLRTLLLEHNQISSSSLTDHT
                     FSKLHSLQVLVLSNNALRTLRGSWFRNTSGLTRLQLDGNQITNLTDSSFGGTNLHSLR
                     YLDLSNNFISYIGKDAFRPLPQLQEVDLSRNRLAHMPDVFTPLKQLILLSLDKNQWSC
                     TCDLHPLARFLRNYIKSSAHTLRNAKDLNCQPSTAAVAAAQSVLRLSETNCDSKAPNF
                     TLVLKDRSPLLPGPDVALLTVLGFAGAVGLTCLGLVVFNWKLHQGKANEHTSENLCCR
                     TFDEPLCAHEARNYHTKGYCNCHLTQENEIKVMSTVGSRKEMPLLQENSHQATSASES
                     ATLDGSFRNLKKKDRGVGSTLFCQDGRLLHSECSEPPGNMRAFNEAGLLTTYNPRKVQ
                     KLWNLEPGEVQPQTLQHHIIRTEDISSDIFRRRYATPASALAGESLEKRLTNESWQPP
                     IEKEDNGLHPHRQRHFITSSSSKPCEPEEHYVQKIVQKNRSKYDDPCGLLKQSKPRYF
                     QPNNSLICKYVPCEQFEDYMKEKKPNRRQHSKPEKEQIQINSAIEKFLMSEDNIDLSG
                     LSTKTKKAYSPKRVIFHDPDLVEINRSMMSPKISTPWKRQKNQSNQLTKLDVKKFSNT
                     GERNKGEKWFTNSWVLKRKRTPQSDLKGKIKGQNLKLNLHPFRKVRVHPEKSLSSLPK
                     QCKQVLLPPKKLSKTSETEAKINTVCSADFLQQSESSNYVRLTSKRLPLKHDSKQTPY
                     YQRNTKRAPLLSANNLRVVNQSSIESSCYSAGHIPDGNTSKLPQPTPTDAEHRHSHSQ
                     FSTEQMEDATQLESKVLSYLATTWENTGSDVLPFQHSRRATDQGTTESTEHMGQNVSK
                     TSELNQFSLSPRNQTQLLDAHKTDSYNKEYTLDQNEALQHREQNSSHAQLENKEKTLM
                     TKPQISHQIVENCIMDKEENDVEKKLSKTETYDSSLIPQTQSKNNLSFMKTNSIPYQN
                     RIELPKDISTSPVSSQAVWHLTNSSEKGIDSTNALPRNDGTEALEIKIVGKEEKNMLD
                     ESKTDSSMLTQISQMTLKGITKERQQTWENGTSEKYILHDASSAEETITAKDLSITSS
                     HETQNRILCSEVDPEVNSNVHNFREVQNIQPDKDSAHKEGAMTVETHEALSFLPGLKD
                     SFEAENEVFLVPSRINEAENSAPKPVLYPPSAEYATTSPLETE"
     exon            201..1016
                     /gene="LRRC53"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1532
                     /gene="LRRC53"
                     /inference="alignment:Splign:2.1.0"
     exon            1533..4358
                     /gene="LRRC53"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4332..4337
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRC53"
                     /note="hexamer: AATAAA"
     polyA_site      4358
                     /gene="LRRC53"
                     /note="major polyA site"
ORIGIN      
        1 gctggacagt taactcagta ggtctcagat tcatcatcca ccttttaatg tagagattca
       61 caaactacaa gctgtgagac ctttgggtgg atggctggta ctctttgcca tcatgttgcg
      121 gttggtggca gcttgccctg agtcatgtgt ggtgtgcacc aaagatgtaa ccctctgtca
      181 ccagctaacc tatatagtag cagcccctat gaccacgagg gttttaatca tcaccgatgg
      241 atatctctcc tctattgaga gcacaaacct gtctctcttg tttaatcttg ccctgctctc
      301 cctaagcaga aatggtatcg aggatgttca ggaagatgcc ctgcatgggc ttacgatgtt
      361 gcggaccttg ttgctggagc acaaccaaat atccagctct tcgctcactg atcacacctt
      421 cagcaagctt cacagcctgc aggtactggt gctgagcaat aatgctctcc gcaccctacg
      481 agggtcttgg ttccgaaaca caagcggcct gacccggctc cagctggatg ggaatcagat
      541 tactaatctc acagacagtt ctttcggagg cacgaatctc cacagtctca ggtatctgga
      601 tttatccaac aattttattt cctacattgg gaaagatgcc ttccggcccc tgcctcaact
      661 acaggaagtg gacctttccc gaaataggtt agcccacatg ccggatgtgt ttactccact
      721 gaagcagtta atccttctga gcttagataa gaaccagtgg agctgcactt gtgatctcca
      781 tccccttgct cggtttttaa gaaactacat taagtcttct gctcacacgc tcaggaatgc
      841 caaggaccta aattgccagc catctaccgc agctgtggca gctgcacaga gtgtgctgag
      901 gctgtctgag accaactgtg attccaaagc tcccaacttc actctggttc taaaggacag
      961 aagtcccctc ctcccaggac cagatgtggc cctgctgact gtccttggct tcgcaggagc
     1021 tgttggtctc acttgcctag gtttagttgt atttaactgg aaactccacc aaggcaaagc
     1081 aaatgaacac acatcagaaa acctttgttg cagaaccttc gatgaacccc tgtgtgctca
     1141 tgaggcaaga aattaccaca ctaagggata ctgcaactgc cacttaactc aggaaaacga
     1201 gataaaggtc atgtccactg tggggtccag aaaagaaatg ccacttttac aggaaaatag
     1261 ccatcaagca acatcggcct ctgagtctgc aacccttgac ggatcattta gaaacctgaa
     1321 aaagaaagac cgtggggtag gcagcacttt attttgccag gatggtagat tgctgcattc
     1381 ggaatgttca gagcctcctg gaaatatgag agcttttaat gaagcaggct tacttacaac
     1441 atataatcca aggaaagttc aaaagctatg gaatcttgag cctggagaag tccagcctca
     1501 aactctgcaa caccatataa taagaacaga agatatcagc agtgacatat ttagaagaag
     1561 atatgcaaca cccgcttcag ccttggcagg agaaagtctt gagaagcgtt taacaaatga
     1621 atcatggcag cctccaatag aaaaagaaga caatggctta caccctcata ggcaaagaca
     1681 ttttattaca agctcatcat ccaagccttg tgagcctgag gaacactatg tacaaaagat
     1741 cgtacaaaaa aatagatcaa aatatgatga tccttgtgga ctgttaaaac agagcaaacc
     1801 taggtatttt cagccaaaca attctcttat ctgtaaatat gtgccctgtg agcaatttga
     1861 agattacatg aaagaaaaga agccaaatcg tagacaacac tcaaagcctg agaaagagca
     1921 aatccaaatt aacagtgcaa tagaaaaatt tcttatgagt gaggacaaca tagatttatc
     1981 aggattatca acaaaaacca agaaagcata ttccccaaag agggttatct tccatgatcc
     2041 tgatttagta gaaataaata ggtcgatgat gtcacccaaa atatcaaccc cttggaaacg
     2101 acagaaaaat caaagtaacc aactgactaa gttggatgtt aaaaaattta gcaacactgg
     2161 ggagagaaac aaaggagaaa aatggtttac taattcatgg gttctgaaaa ggaagagaac
     2221 ccctcagtct gacctcaaag ggaaaattaa aggacaaaac ttaaaattaa atttacatcc
     2281 ttttagaaaa gtcagagtcc atccagaaaa atccttgtca agtctcccaa agcaatgcaa
     2341 gcaggtattg ttgcctccta agaaattatc caaaacttct gagacagaag ccaaaataaa
     2401 tactgtgtgt tctgcagatt ttcttcaaca gtcagagagt agcaactatg ttagactcac
     2461 ttcaaagagg ctgcctctga aacatgactc aaagcagacc ccatattatc aacgaaacac
     2521 taaacgtgcc cccctgctca gtgctaacaa cttgcgtgta gtcaaccaga gctctataga
     2581 aagcagctgt tactcagctg gccacattcc tgatggaaac acatcaaaat tgccccaacc
     2641 tacacccact gatgctgagc acaggcactc acattctcaa ttctcaactg agcaaatgga
     2701 agatgcaact cagcttgaat caaaagtgct tagttattta gcaactactt gggaaaatac
     2761 aggaagtgat gttttaccat tccaacattc caggagggct actgaccaag ggacaacgga
     2821 gtccactgag cacatgggac agaatgtatc aaagaccagt gagttaaatc agttttcttt
     2881 gtccccgagg aatcaaacac aacttttaga tgctcacaag actgacagct acaacaagga
     2941 atacacttta gaccaaaatg aagccttaca acacagagag caaaattcaa gtcatgcaca
     3001 gcttgaaaat aaagaaaaaa cattaatgac aaaaccccaa atatcacatc aaattgtgga
     3061 aaattgtatt atggataagg aagaaaatga tgtagaaaaa aaactttcaa aaacagaaac
     3121 ttatgattcc tctctcattc cccaaacaca atccaagaac aacctatcat ttatgaagac
     3181 aaattcaatt ccataccaaa atagaataga acttcccaag gatatcagta cttctcctgt
     3241 tagtagtcaa gccgtttggc acctaaccaa tagtagcgaa aaaggaattg acagcacaaa
     3301 tgcattgccc agaaatgacg gcactgaagc actagagata aaaatagtag ggaaagaaga
     3361 gaaaaatatg cttgatgaaa gcaagacaga ttctagtatg ttaactcaga tctcacaaat
     3421 gaccttaaaa ggcatcacaa aagaaaggca gcaaacttgg gaaaatggaa caagtgaaaa
     3481 atatatatta catgatgcaa gctctgccga ggagaccatt acagctaaag atttaagtat
     3541 cacaagttcc catgaaaccc aaaatagaat actttgcagt gaagtagatc ctgaagttaa
     3601 cagtaatgta cataatttta gagaagttca aaatattcaa ccagataaag atagtgcaca
     3661 taaagaaggc gcaatgacag tggagacaca tgaagcgctt tccttcttac cagggttaaa
     3721 agacagtttt gaggcagaaa atgaggtgtt tttagttcct agcagaataa atgaagctga
     3781 aaactctgct ccaaaacctg tactgtatcc accatctgct gaatatgcta ctacatcacc
     3841 tttagaaaca gaataaagtg aacaaaataa ctcaaataat aatccttttc tactttagct
     3901 ttcttcaaga ggacaaacac ccactagcct ttgcatgcat tagaagtgga tcattttgga
     3961 ggacaacaac gtcctcagta actctttgtt atcaataaaa taaaaccaga gttgaatata
     4021 tgacaaaaat caaagatgga gtcataggat acgtctgaca caattaactg agtatgcttc
     4081 tctaaggaat gaaaaaacaa gtaagaaaag ttttgccaag tcttgcaaaa gcaagcaaac
     4141 attgaaaaaa aaaaagcctt aaacaaatga aaaactacat aagaagagta tttgagcaga
     4201 tttacatttg atgtttattt catgtaaatt attatacata tctcaattag tggtattaca
     4261 atattgcttt ctacatggat aattatatat tcatatttgt gtttgatctg ttttcctaat
     4321 tatagtatga aaataaaaat tcagctttgt taactgta
//
