LOCUS       NM_001005214            1372 bp    mRNA    linear   PRI 20-MAY-2024
DEFINITION  Homo sapiens leucine rich repeat containing 52 (LRRC52), mRNA.
ACCESSION   NM_001005214 XM_496422
VERSION     NM_001005214.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1372)
  AUTHORS   Zhang,J., Zheng,L., Chen,Y., Luo,T., Zeng,X. and Kang,H.
  TITLE     LRRC52 is likely a functional component of human KSperdagger
  JOURNAL   Biol Reprod 110 (4), 711-721 (2024)
   PUBMED   38267364
  REMARK    GeneRIF: LRRC52 is likely a functional component of human
            KSperdagger.
REFERENCE   2  (bases 1 to 1372)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1372)
  AUTHORS   Li,Q., Fan,F., Kwak,H.R. and Yan,J.
  TITLE     Molecular basis for differential modulation of BK channel
            voltage-dependent gating by auxiliary gamma subunits
  JOURNAL   J Gen Physiol 145 (6), 543-554 (2015)
   PUBMED   26009545
  REMARK    GeneRIF: Suggest that BK channel modulation by auxiliary gamma
            subunits depends on intra- and/or juxta-membrane mechanisms.
REFERENCE   4  (bases 1 to 1372)
  AUTHORS   Yan,J. and Aldrich,R.W.
  TITLE     BK potassium channel modulation by leucine-rich repeat-containing
            proteins
  JOURNAL   Proc Natl Acad Sci U S A 109 (20), 7917-7922 (2012)
   PUBMED   22547800
REFERENCE   5  (bases 1 to 1372)
  AUTHORS   Ehret,G.B., O'Connor,A.A., Weder,A., Cooper,R.S. and Chakravarti,A.
  TITLE     Follow-up of a major linkage peak on chromosome 1 reveals
            suggestive QTLs associated with essential hypertension: GenNet
            study
  JOURNAL   Eur J Hum Genet 17 (12), 1650-1657 (2009)
   PUBMED   19536175
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 1372)
  AUTHORS   Cheung,C.L., Chan,B.Y., Chan,V., Ikegawa,S., Kou,I., Ngai,H.,
            Smith,D., Luk,K.D., Huang,Q.Y., Mori,S., Sham,P.C. and Kung,A.W.
  TITLE     Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible
            genetic association with bone mineral density variation
  JOURNAL   Hum Mol Genet 18 (4), 679-687 (2009)
   PUBMED   19064610
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL157714.8.
            
            On Aug 8, 2019 this sequence version replaced NM_001005214.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK098677.1, SRR5189667.222454.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000294818.2/ ENSP00000294818.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-919               AL157714.8         49298-50216
            920-1372            AL157714.8         68803-69255
FEATURES             Location/Qualifiers
     source          1..1372
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q24.1"
     gene            1..1372
                     /gene="LRRC52"
                     /note="leucine rich repeat containing 52"
                     /db_xref="GeneID:440699"
                     /db_xref="HGNC:HGNC:32156"
                     /db_xref="MIM:615218"
     exon            1..919
                     /gene="LRRC52"
                     /inference="alignment:Splign:2.1.0"
     CDS             298..1239
                     /gene="LRRC52"
                     /note="leucine-rich repeat-containing protein 52; BK
                     channel auxilliary gamma subunit LRRC52; BK channel
                     auxiliary gamma subunit LRRC52"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 52
                     precursor"
                     /protein_id="NP_001005214.2"
                     /db_xref="CCDS:CCDS30930.1"
                     /db_xref="GeneID:440699"
                     /db_xref="HGNC:HGNC:32156"
                     /db_xref="MIM:615218"
                     /translation="MSLASGPGPGWLLFSFGMGLVSGSKCPNNCLCQAQEVICTGKQL
                     TEYPLDIPLNTRRLFLNENRITSLPAMHLGLLSDLVYLDCQNNRIREVMDYTFIGVFK
                     LIYLDLSSNNLTSISPFTFSVLSNLVQLNIANNPHLLSLHKFTFANTTSLRYLDLRNT
                     GLQTLDSAALYHLTTLETLFLSGNPWKCNCSFLDFAIFLIVFHMDPSDDLNATCVEPT
                     ELTGWPITRVGNPLRYMCITHLDHKDYIFLLLIGFCIFAAGTVAAWLTGVCAVLYQNT
                     RHKSSEEDEDEAGTRVEVSRRIFQTQTSSVQEFPQLI"
     exon            920..1372
                     /gene="LRRC52"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1353..1358
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRC52"
                     /note="hexamer: AATAAA"
     polyA_site      1372
                     /gene="LRRC52"
                     /note="major polyA site"
ORIGIN      
        1 ccccttcact tgcaaacgca gggaaagggt gagacctttc aaagctgcca agtgggcaag
       61 cttccagcag cagtctggga gcgagcgaca gagccaccaa gctgggcggc agggcattga
      121 gcctcgcgtt tcaatttctg ttcagttctc ctgtaatgga aaattgcttt gcacaaagct
      181 aaagtgttac agttctttcc agagcccctc ccccgcccca cccccccacc ggcagccttc
      241 ggatcagagg acagagcccg caggaaggtg aaaggagggt ggttgtggct tcttactatg
      301 tcccttgctt caggccctgg ccctgggtgg ttactctttt cctttggaat ggggctggta
      361 tcagggtcaa agtgtccaaa taattgtctg tgtcaagccc aagaagtaat ctgcacaggg
      421 aagcagttaa ccgaataccc ccttgacata cccctgaaca cccggaggct gttcctgaac
      481 gagaacagaa tcactagttt gccagcaatg catctaggac tcctcagtga ccttgtttat
      541 ttggactgtc agaacaaccg gattcgagag gtgatggatt ataccttcat cggggtcttc
      601 aaactcatct accttgacct cagctccaac aacctaacct cgatctcccc attcactttc
      661 tcggtgctca gcaacctggt gcagctgaac attgccaaca accctcacct gttatcgctt
      721 cacaagttca cctttgccaa caccacctct ttgaggtacc tggacctcag aaataccggc
      781 ttgcagaccc tggacagtgc tgccttatac cacctcacta ctctggagac cctgtttctg
      841 agtggaaacc cctggaagtg caactgctct ttcctggact tcgccatctt cttaatagtg
      901 ttccatatgg acccctcaga tgatctaaat gccacatgtg tggagcccac agagctgaca
      961 gggtggccca tcacccgggt ggggaaccca ctccgataca tgtgcatcac gcacctggac
     1021 cacaaagact acatcttcct gctgctcatc ggcttctgca tcttcgccgc gggaactgtg
     1081 gctgcctggc tcacaggtgt gtgtgctgtg ctctaccaga acacccgcca caagtcgagt
     1141 gaagaagatg aggacgaggc cgggactagg gtggaagtca gccggcggat ttttcaaacc
     1201 cagacgagct cggtccagga gttccctcag cttatttagt tgccagagac cactatctta
     1261 tgtgcctccc ccaggctccc tgctttctct cttgccctcc ccatcccacc accttggagc
     1321 tgtcatagag attgaaacct tctagtaaaa taaataaaat ctctgatggc ca
//
