LOCUS       NP_001245348             640 aa            linear   PRI 28-APR-2025
DEFINITION  leucine-rich repeat-containing protein 4C precursor [Homo sapiens].
ACCESSION   NP_001245348
VERSION     NP_001245348.1
DBSOURCE    REFSEQ: accession NM_001258419.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 640)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (residues 1 to 640)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (residues 1 to 640)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (residues 1 to 640)
  AUTHORS   Maussion,G., Cruceanu,C., Rosenfeld,J.A., Bell,S.C., Jollant,F.,
            Szatkiewicz,J., Collins,R.L., Hanscom,C., Kolobova,I., de
            Champfleur,N.M., Blumenthal,I., Chiang,C., Ota,V., Hultman,C.,
            O'Dushlaine,C., McCarroll,S., Alda,M., Jacquemont,S., Ordulu,Z.,
            Marshall,C.R., Carter,M.T., Shaffer,L.G., Sklar,P., Girirajan,S.,
            Morton,C.C., Gusella,J.F., Turecki,G., Stavropoulos,D.J.,
            Sullivan,P.F., Scherer,S.W., Talkowski,M.E. and Ernst,C.
  TITLE     Implication of LRRC4C and DPP6 in neurodevelopmental disorders
  JOURNAL   Am J Med Genet A 173 (2), 395-406 (2017)
   PUBMED   27759917
  REMARK    GeneRIF: These data suggest that the proband's autism may be due to
            the inheritance of disruptions in both DPP6 and LRRC4C, and may
            highlight the importance of the netrin G family and potassium
            channel interacting molecules in neurodevelopmental disorders.
REFERENCE   5  (residues 1 to 640)
  AUTHORS   Deng,X., Sabino,E.C., Cunha-Neto,E., Ribeiro,A.L., Ianni,B.,
            Mady,C., Busch,M.P. and Seielstad,M.
  CONSRTM   REDSII Chagas Study Group from the NHLBI Retrovirus Epidemiology
            Donor Study-II Component International
  TITLE     Genome wide association study (GWAS) of Chagas cardiomyopathy in
            Trypanosoma cruzi seropositive subjects
  JOURNAL   PLoS One 8 (11), e79629 (2013)
   PUBMED   24324551
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 640)
  AUTHORS   Seiradake,E., Coles,C.H., Perestenko,P.V., Harlos,K.,
            McIlhinney,R.A., Aricescu,A.R. and Jones,E.Y.
  TITLE     Structural basis for cell surface patterning through NetrinG-NGL
            interactions
  JOURNAL   EMBO J 30 (21), 4479-4488 (2011)
   PUBMED   21946559
  REMARK    Publication Status: Online-Only
REFERENCE   7  (residues 1 to 640)
  AUTHORS   McClay,J.L., Adkins,D.E., Aberg,K., Bukszar,J., Khachane,A.N.,
            Keefe,R.S., Perkins,D.O., McEvoy,J.P., Stroup,T.S., Vann,R.E.,
            Beardsley,P.M., Lieberman,J.A., Sullivan,P.F. and van den Oord,E.J.
  TITLE     Genome-wide pharmacogenomic study of neurocognition as an indicator
            of antipsychotic treatment response in schizophrenia
  JOURNAL   Neuropsychopharmacology 36 (3), 616-626 (2011)
   PUBMED   21107309
REFERENCE   8  (residues 1 to 640)
  AUTHORS   Hsu,Y.H., Zillikens,M.C., Wilson,S.G., Farber,C.R., Demissie,S.,
            Soranzo,N., Bianchi,E.N., Grundberg,E., Liang,L., Richards,J.B.,
            Estrada,K., Zhou,Y., van Nas,A., Moffatt,M.F., Zhai,G., Hofman,A.,
            van Meurs,J.B., Pols,H.A., Price,R.I., Nilsson,O., Pastinen,T.,
            Cupples,L.A., Lusis,A.J., Schadt,E.E., Ferrari,S.,
            Uitterlinden,A.G., Rivadeneira,F., Spector,T.D., Karasik,D. and
            Kiel,D.P.
  TITLE     An integration of genome-wide association study and gene expression
            profiling to prioritize the discovery of novel susceptibility Loci
            for osteoporosis-related traits
  JOURNAL   PLoS Genet 6 (6), e1000977 (2010)
   PUBMED   20548944
  REMARK    Publication Status: Online-Only
REFERENCE   9  (residues 1 to 640)
  AUTHORS   Sokolowski,M., Wasserman,J. and Wasserman,D.
  TITLE     Association of polymorphisms in the SLIT2 axonal guidance gene with
            anger in suicide attempters
  JOURNAL   Mol Psychiatry 15 (1), 10-11 (2010)
   PUBMED   20029409
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   10 (residues 1 to 640)
  AUTHORS   Lin,J.C., Ho,W.H., Gurney,A. and Rosenthal,A.
  TITLE     The netrin-G1 ligand NGL-1 promotes the outgrowth of
            thalamocortical axons
  JOURNAL   Nat Neurosci 6 (12), 1270-1276 (2003)
   PUBMED   14595443
  REMARK    GeneRIF: NGL-1 is most abundant in the striatum and the cerebral
            cortex--the intermediate and final targets, of thalamocortical
            axons; surface-bound NGL-1 stimulates, but soluble NGL-1 disrupts,
            the growth of embryonic thalamic axons.
            GeneRIF: netrin-G1 functions as an important component of the NGL-1
            receptor to promote TCA outgrowth and that membrane-bound netrins
            can participate in receiving axonal signaling pathways.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC090138.5, DQ084202.1, DQ084201.1, BX951676.1 and AB046800.1.
            
            Summary: NGL1 is a specific binding partner for netrin G1 (NTNG1;
            MIM 608818), which is a member of the netrin family of axon
            guidance molecules (Lin et al., 2003 [PubMed 14595443]).[supplied
            by OMIM, Mar 2008].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ084201.1, SRR1660807.238108.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000528697.6/ ENSP00000437132.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..640
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p12"
     Protein         1..640
                     /product="leucine-rich repeat-containing protein 4C
                     precursor"
                     /note="netrin-G1 ligand; leucine-rich repeat-containing
                     protein 4C; netrin-G ligand-1"
                     /calculated_mol_wt=67043
     sig_peptide     1..44
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=4925
     mat_peptide     45..640
                     /product="Leucine-rich repeat-containing protein 4C.
                     /id=PRO_0000015108"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9HCJ2.1)"
                     /calculated_mol_wt=67043
     Region          47..80
                     /region_name="LRRNT"
                     /note="Leucine rich repeat N-terminal domain; smart00013"
                     /db_xref="CDD:214470"
     Region          <76..325
                     /region_name="LRR"
                     /note="Leucine-rich repeat (LRR) protein [Transcription];
                     COG4886"
                     /db_xref="CDD:443914"
     Region          77..98
                     /region_name="LRR 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9HCJ2.1)"
     Region          78..101
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          101..122
                     /region_name="LRR 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9HCJ2.1)"
     Region          102..125
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          125..146
                     /region_name="LRR 3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9HCJ2.1)"
     Region          126..149
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          149..170
                     /region_name="LRR 4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9HCJ2.1)"
     Region          150..173
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          173..195
                     /region_name="LRR 5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9HCJ2.1)"
     Region          174..198
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          198..219
                     /region_name="LRR 6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9HCJ2.1)"
     Region          199..220
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          220..241
                     /region_name="LRR 7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9HCJ2.1)"
     Region          221..244
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          244..265
                     /region_name="LRR 8"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9HCJ2.1)"
     Region          245..268
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          268..289
                     /region_name="LRR 9"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9HCJ2.1)"
     Region          269..290
                     /region_name="leucine-rich repeat"
                     /note="leucine-rich repeat [structural motif]"
                     /db_xref="CDD:275380"
     Region          360..443
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          371..375
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          383..387
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          409..413
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          423..428
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          436..439
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          463..483
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9HCJ2.1)"
     Site            528..548
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9HCJ2.1)"
     Site            631
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8C031; propagated from
                     UniProtKB/Swiss-Prot (Q9HCJ2.1)"
     CDS             1..640
                     /gene="LRRC4C"
                     /gene_synonym="NGL-1; NGL1"
                     /coded_by="NM_001258419.2:718..2640"
                     /db_xref="CCDS:CCDS31464.1"
                     /db_xref="GeneID:57689"
                     /db_xref="HGNC:HGNC:29317"
                     /db_xref="MIM:608817"
ORIGIN      
        1 mlnkmtlhpq qimigprfnr alfdpllvvl lalqllvvag lvraqtcpsv cscsnqfskv
       61 icvrknlrev pdgistntrl lnlhenqiqi ikvnsfkhlr hleilqlsrn hirtieigaf
      121 nglanlntle lfdnrlttip ngafvylskl kelwlrnnpi esipsyafnr ipslrrldlg
      181 elkrlsyise gafeglsnlr ylnlamcnlr eipnltplik ldeldlsgnh lsairpgsfq
      241 glmhlqklwm iqsqiqvier nafdnlqslv einlahnnlt llphdlftpl hhlerihlhh
      301 npwncncdil wlswwikdma psntaccarc ntppnlkgry igeldqnyft cyapvivepp
      361 adlnvtegma aelkcrasts ltsvswitpn gtvmthgayk vriavlsdgt lnftnvtvqd
      421 tgmytcmvsn svgnttasat lnvtaatttp fsyfstvtve tmepsqdear ttdnnvgptp
      481 vvdwettnvt tsltpqstrs tektftipvt dinsgipgid evmkttkiii gcfvaitlma
      541 avmlvifykm rkqhhrqnhh aptrtveiin vddeitgdtp meshlpmpai ehehlnhyns
      601 ykspfnhttt vntinsihss vhepllirmn skdnvqetqi
//
