LOCUS       NM_020710               4303 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens leucine rich repeat containing 47 (LRRC47), mRNA.
ACCESSION   NM_020710
VERSION     NM_020710.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4303)
  AUTHORS   Evans,D.M., Zhu,G., Dy,V., Heath,A.C., Madden,P.A., Kemp,J.P.,
            McMahon,G., St Pourcain,B., Timpson,N.J., Golding,J., Lawlor,D.A.,
            Steer,C., Montgomery,G.W., Martin,N.G., Smith,G.D. and
            Whitfield,J.B.
  TITLE     Genome-wide association study identifies loci affecting blood
            copper, selenium and zinc
  JOURNAL   Hum Mol Genet 22 (19), 3998-4006 (2013)
   PUBMED   23720494
REFERENCE   2  (bases 1 to 4303)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 4303)
  AUTHORS   Fox,C.S., Liu,Y., White,C.C., Feitosa,M., Smith,A.V.,
            Heard-Costa,N., Lohman,K., Johnson,A.D., Foster,M.C.,
            Greenawalt,D.M., Griffin,P., Ding,J., Newman,A.B., Tylavsky,F.,
            Miljkovic,I., Kritchevsky,S.B., Launer,L., Garcia,M.,
            Eiriksdottir,G., Carr,J.J., Gudnason,V., Harris,T.B., Cupples,L.A.
            and Borecki,I.B.
  CONSRTM   GIANT Consortium; MAGIC Consortium; GLGC Consortium
  TITLE     Genome-wide association for abdominal subcutaneous and visceral
            adipose reveals a novel locus for visceral fat in women
  JOURNAL   PLoS Genet 8 (5), e1002695 (2012)
   PUBMED   22589738
REFERENCE   4  (bases 1 to 4303)
  AUTHORS   Jager,S., Cimermancic,P., Gulbahce,N., Johnson,J.R., McGovern,K.E.,
            Clarke,S.C., Shales,M., Mercenne,G., Pache,L., Li,K., Hernandez,H.,
            Jang,G.M., Roth,S.L., Akiva,E., Marlett,J., Stephens,M., D'Orso,I.,
            Fernandes,J., Fahey,M., Mahon,C., O'Donoghue,A.J., Todorovic,A.,
            Morris,J.H., Maltby,D.A., Alber,T., Cagney,G., Bushman,F.D.,
            Young,J.A., Chanda,S.K., Sundquist,W.I., Kortemme,T.,
            Hernandez,R.D., Craik,C.S., Burlingame,A., Sali,A., Frankel,A.D.
            and Krogan,N.J.
  TITLE     Global landscape of HIV-human protein complexes
  JOURNAL   Nature 481 (7381), 365-370 (2011)
   PUBMED   22190034
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC031301.1, AB033011.1 and AL365330.16.
            
            On Nov 23, 2018 this sequence version replaced NM_020710.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.176383.1, BC031301.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000378251.3/ ENSP00000367498.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1886              BC031301.1         7-1892
            1887-2535           AB033011.1         1325-1973
            2536-2642           BC031301.1         2541-2647
            2643-4303           AL365330.16        9429-11089          c
FEATURES             Location/Qualifiers
     source          1..4303
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.32"
     gene            1..4303
                     /gene="LRRC47"
                     /note="leucine rich repeat containing 47"
                     /db_xref="GeneID:57470"
                     /db_xref="HGNC:HGNC:29207"
                     /db_xref="MIM:619154"
     exon            1..637
                     /gene="LRRC47"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..1774
                     /gene="LRRC47"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 47"
                     /protein_id="NP_065761.1"
                     /db_xref="CCDS:CCDS51.1"
                     /db_xref="GeneID:57470"
                     /db_xref="HGNC:HGNC:29207"
                     /db_xref="MIM:619154"
                     /translation="MAAAAVSESWPELELAERERRRELLLTGPGLEERVRAAGGQLPP
                     RLFTLPLLHYLEVSGCGSLRAPGPGLAQGLPQLHSLVLRRNALGPGLSPELGPLPALR
                     VLDLSGNALEALPPGQGLGPAEPPGLPQLQSLNLSGNRLRELPADLARCAPRLQSLNL
                     TGNCLDSFPAELFRPGALPLLSELAAADNCLRELSPDIAHLASLKTLDLSNNQLSEIP
                     AELADCPKLKEINFRGNKLRDKRLEKMVSGCQTRSILEYLRVGGRGGGKGKGRAEGSE
                     KEESRRKRRERKQRREGGDGEEQDVGDAGRLLLRVLHVSENPVPLTVRVSPEVRDVRP
                     YIVGAVVRGMDLQPGNALKRFLTSQTKLHEDLCEKRTAATLATHELRAVKGPLLYCAR
                     PPQDLKIVPLGRKEAKAKELVRQLQLEAEEQRKQKKRQSVSGLHRYLHLLDGNENYPC
                     LVDADGDVISFPPITNSEKTKVKKTTSDLFLEVTSATSLQICKDVMDALILKMAEMKK
                     YTLENKEEGSLSDTEADAVSGQLPDPTTNPSAGKDGPSLLVVEQVRVVDLEGSLKVVY
                     PSKADLATAPPHVTVVR"
     exon            638..1099
                     /gene="LRRC47"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1216
                     /gene="LRRC47"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1332
                     /gene="LRRC47"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1435
                     /gene="LRRC47"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1525
                     /gene="LRRC47"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..4303
                     /gene="LRRC47"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2622..2627
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRC47"
                     /note="hexamer: AATAAA"
     polyA_site      2642
                     /gene="LRRC47"
                     /note="major polyA site"
     polyA_site      4233
                     /gene="LRRC47"
     regulatory      4282..4287
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRC47"
                     /note="hexamer: AATAAA"
     polyA_site      4303
                     /gene="LRRC47"
ORIGIN      
        1 gcctgccagc agctgaggcg ccatggcggc ggcagcggtg tcagagtctt ggccggagct
       61 ggagctggct gagcgcgagc ggcggcggga gctgctgctg acggggcccg ggctggagga
      121 gcgagtgcgg gcggcgggtg ggcagctgcc gccgcggctt ttcaccctgc cgctgctgca
      181 ctacttggaa gtgagcggct gcgggagctt gcgcgcgccg gggcctggcc tggcgcaggg
      241 cctgccgcag ctgcacagcc tcgtgctgcg gcgcaacgcg ctggggcccg gcctgagccc
      301 cgagctcggg ccgctgcctg cccttcgggt gctcgacctg tcgggcaacg cgctggaggc
      361 gctgccgccg ggccaaggcc tgggccccgc cgagccgccg ggccttccgc agctgcagag
      421 cctcaacctc agcggcaacc ggctgcgcga gctgccagcc gacctggcgc gctgcgcccc
      481 gcgcctgcag agcctcaacc tcaccggcaa ttgcctagac tcctttcccg ccgagctctt
      541 tcgccccggc gcgctgcccc tgctcagtga actggcggct gctgacaact gcctccgaga
      601 actcagcccc gacatcgccc acctggcctc gctcaagacg ttggacctct cgaacaacca
      661 gctgagcgag atccctgcag agcttgcgga ctgccccaag ctcaaggaga tcaatttccg
      721 tgggaacaag ctgagggaca agcgcctgga gaagatggtc agcggctgcc agaccagatc
      781 catcctggag tacctgcgcg tcggaggccg tggtggcggg aagggcaagg gccgtgccga
      841 gggctcggag aaggaagaga gccggaggaa gaggagggag aggaagcaga ggcgggaagg
      901 tggtgatggg gaggagcagg acgtgggaga tgccggccgg ctgctgctca gggtcctgca
      961 cgtctctgaa aaccccgtac ctctgacagt cagagtgagc cccgaggtcc gggatgtgcg
     1021 gccctacatt gtgggggccg tggtgcgagg catggacctg cagccaggga atgcactcaa
     1081 gcgcttcctc acctcgcaga ccaagctcca cgaagatctc tgtgagaaga ggacggctgc
     1141 cacccttgcc acccacgagc tccgtgccgt caaagggccc ctgctgtact gcgcccggcc
     1201 cccacaggac ctcaagattg tccccttggg gcggaaagaa gccaaggcca aggagctggt
     1261 gcggcagctg cagctggagg ccgaggagca gaggaagcag aagaagcggc agagtgtgtc
     1321 gggcctgcac agataccttc acttgctgga tggaaatgaa aattacccgt gtcttgtgga
     1381 tgcagacggt gatgtgattt ccttcccacc aataaccaac agtgagaaga caaaggttaa
     1441 gaaaacgact tctgatttgt ttttggaagt aacaagtgcc accagtctgc agatttgcaa
     1501 ggatgtcatg gatgccctca ttctgaaaat ggcagaaatg aaaaagtaca ctttagaaaa
     1561 taaagaggaa ggatcactct cagatactga agccgatgca gtctctggac aacttccaga
     1621 tcccacaacg aatcccagtg ctggaaagga cgggccctcc cttctggtgg tggagcaggt
     1681 ccgggtggtg gatctggaag ggagcctgaa ggtggtgtac ccgtccaagg ccgacctggc
     1741 cactgcccct ccccacgtga ctgtcgtgcg ctgacgccag ggccgcctgt ccgcgtttgt
     1801 ttggccggtt ttgcggaggt ttctatgcgg caatgctgaa ttatccgtta gattttcacc
     1861 ccagtttttt tgttggtttt tttttttgag atggagtctc gctctgtcgc caggctggag
     1921 tgcagtggcg tgatctcgag tcactgcagc ctgtgtctcc tgggttcaag cgattctcct
     1981 gcctcagcct cccaagtagc tgggactaca ggtgtgtgcc actaagctca gctaattttt
     2041 gtatttttag tagagacggg gtttcaccat tttgaccagg atggtcttga tctcttgacc
     2101 tcatgatctg tccacctctg cccctcaaag tgctgggatt acgtgatcca cccgcctcag
     2161 cctcccaaag tgctgggatt acaggcgtga gctgtgcctg gcccacccca gcatttttta
     2221 agatgtatgt attcgttgtt ctgtttttcc agatgattct gtcgtaaagt gatgctatgt
     2281 tgtcgttaca acatcaaagt gattttacgg tttttgatgg gattattcaa gtgtcagaat
     2341 taactgttca aaatgttctg aatcatgtag atacatggca ggtaactgtt tatgggagaa
     2401 aagtacagtg ctgttacgtg gcactgtaca gtcatgtgcc acgtaacagc gtctgggtca
     2461 gtgacggaca cttacctgac agcggatcca caatattctc gtgcagtgtg tttggaatcc
     2521 tggtctgggc tctcgtcgtt ggccttgtag atcaagtagg ggaagtgagt gatgttcagt
     2581 catgctgctg ggacacttgg ttttccagat gaaaacacat aaataaaact acatgcacca
     2641 tcgaggcttg tgtaaagact ctgtgatcac acagcagcgg ctaagcacac gtttctcatg
     2701 tgtcactgag cgacacgtga ctgtcactgg ttcggagacc cgaaaacttg ggaagccaac
     2761 cgatgtgcgt ttccttgaac ggcacggtca ctttctatga cgcagcatct tgtaaaacca
     2821 tatcatgcca ggatgcagct tggcatgtgc aagggcgttg ggttctccag ctggcagtga
     2881 tcataatctt ggggggaaaa gttttaatgt gaccttagaa ttggcagaat tgcgtctctt
     2941 catactgctg ttggattgct ttgtgggggt ggagatgtgg agaccccttc aggcaagcag
     3001 cctgtaggct gaaggcagtg gcagcacctc accctggctc agcggggcca agcggaggag
     3061 agcggcatcg gtggggtttc catcgtgtgc acgctggtgc tgcagtgaca ggcaggtgga
     3121 gccccaggag tggaccagac gcctctgctt gggaagcatc ggcagtcctc agccagccga
     3181 gggacagatg gtagcaaaag ctggaggatg cttaggtttt tgagccaaaa atcttcattt
     3241 atgcgccaga aaggtgggtc ctgggcgcct tctgttgtag acgtttccgt tgtgaatgtc
     3301 caggtcagac ccccacgtcc atgtgtcttc gtgtatgtcc aggcaccaca tgtgcgtgca
     3361 caccactccc gggagtcagt gtgcttggct catgaggaca cggccagcca ccgcgatgat
     3421 tttacagacc ccactgcctt acgatctggg tgccatgtga gaagcagact catcagcttt
     3481 atcgaatgac accatttgtt ctctgttcag tgtctcgatt tctgtgtctg tagaaatgac
     3541 tggtgatttt gggaagcatc tgcaagagcc ccacagccca cacaccttta gttgtcaacc
     3601 tgagaggccc ggggccctgt gcagtgggca gactaacagc tgggtggctc ttcagagcct
     3661 tgcaggacat gggccaggct gccttgagac ctggacccac ttgtctggtc accgccaggc
     3721 cttcccgtct cgcccactgt gggagggagg ggactccaga caggacgagg cccacacact
     3781 cagtgccagc tggactgccg tgggtgtgtc agatgactgc cttgccttgt gtcctcccaa
     3841 aacctgattc ctgctgctct gggcagtcaa ggcagatgcc acagttggcc aggggcctgc
     3901 cctgctggag gcttgaggcg gcacgggggc ttccccaggc caggactctg ctggagttct
     3961 ggggctgggg accccagaca gttgctctga gaggtgattt ggggctgcca tggcagaggc
     4021 tgccctttct ctgcatggcc cggcccagcc cgggaaggag gaagggagga agggagggat
     4081 gctggagctg ccatcttggc tcccggggac ttggtgtcca tgctgtaaca catctgtcac
     4141 tgcgtgggtg tggatgaggc tgccacatgc tgtgcccttt cctgatgcag cttgtgatgc
     4201 gtgagatgct ggaaatgtat ttaactcgca gcacaggtgt ctctgatgtt ttcttcaccc
     4261 caccccaccc cccgactcac taataaaaac agctccgcac ctg
//
