LOCUS       NM_033413               1885 bp    mRNA    linear   PRI 11-SEP-2024
DEFINITION  Homo sapiens leucine rich repeat containing 46 (LRRC46), mRNA.
ACCESSION   NM_033413
VERSION     NM_033413.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1885)
  AUTHORS   Jiang,L., Dai,C., Wei,Y., Zhao,B., Li,Q., Wu,Z., Zou,L., Ye,Z.,
            Yang,Z., Huang,L. and Shi,Y.
  TITLE     Identification of LRRC46 as a novel candidate gene for high myopia
  JOURNAL   Sci China Life Sci 67 (9), 1941-1956 (2024)
   PUBMED   38874710
  REMARK    GeneRIF: Identification of LRRC46 as a novel candidate gene for
            high myopia.
REFERENCE   2  (bases 1 to 1885)
  AUTHORS   Yin,Y., Mu,W., Yu,X., Wang,Z., Xu,K., Wu,X., Cai,Y., Zhang,M.,
            Lu,G., Chan,W.Y., Ma,J., Huang,T. and Liu,H.
  TITLE     LRRC46 Accumulates at the Midpiece of Sperm Flagella and Is
            Essential for Spermiogenesis and Male Fertility in Mouse
  JOURNAL   Int J Mol Sci 23 (15), 8525 (2022)
   PUBMED   35955660
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1885)
  AUTHORS   Hasson,S.A., Kane,L.A., Yamano,K., Huang,C.H., Sliter,D.A.,
            Buehler,E., Wang,C., Heman-Ackah,S.M., Hessa,T., Guha,R.,
            Martin,S.E. and Youle,R.J.
  TITLE     High-content genome-wide RNAi screens identify regulators of parkin
            upstream of mitophagy
  JOURNAL   Nature 504 (7479), 291-295 (2013)
   PUBMED   24270810
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB024018.1, BC010412.2, BM663857.1 and AC003665.1.
            
            On Nov 22, 2018 this sequence version replaced NM_033413.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK292765.1, BC010412.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000269025.9/ ENSP00000269025.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-148               DB024018.1         44-191
            149-1493            BC010412.2         85-1429
            1494-1879           BM663857.1         17-402              c
            1880-1885           AC003665.1         18088-18093         c
FEATURES             Location/Qualifiers
     source          1..1885
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.32"
     gene            1..1885
                     /gene="LRRC46"
                     /note="leucine rich repeat containing 46"
                     /db_xref="GeneID:90506"
                     /db_xref="HGNC:HGNC:25047"
                     /db_xref="MIM:620927"
     exon            1..330
                     /gene="LRRC46"
                     /inference="alignment:Splign:2.1.0"
     CDS             321..1286
                     /gene="LRRC46"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 46"
                     /protein_id="NP_219481.1"
                     /db_xref="CCDS:CCDS11518.1"
                     /db_xref="GeneID:90506"
                     /db_xref="HGNC:HGNC:25047"
                     /db_xref="MIM:620927"
                     /translation="MSGGKSAQGPEEGGVCITEALITKRNLTFPEDGELSEKMFHTLD
                     ELQTVRLDREGITTIRNLEGLQNLHSLYLQGNKIQQIENLACIPSLRFLSLAGNQIRQ
                     VENLLDLPCLQFLDLSENLIETLKLDEFPQSLLILNLSGNSCTNQDGYRELVTEALPL
                     LLDLDGQPVVERWISDEEDEASSDEEFPELSGPFCSERGFLKELEQELSRHREHRQQT
                     ALTEHLLRMEMQPTLTDLPLLPGVPMAGDSSPSATPAQGEETVPEAVSSPQASSPTKK
                     PCSLIPRGHQSSFWGRKGARAATAPKASVAEAPSTTKTTAKRSKK"
     exon            331..436
                     /gene="LRRC46"
                     /inference="alignment:Splign:2.1.0"
     exon            437..545
                     /gene="LRRC46"
                     /inference="alignment:Splign:2.1.0"
     exon            546..592
                     /gene="LRRC46"
                     /inference="alignment:Splign:2.1.0"
     exon            593..702
                     /gene="LRRC46"
                     /inference="alignment:Splign:2.1.0"
     exon            703..772
                     /gene="LRRC46"
                     /inference="alignment:Splign:2.1.0"
     exon            773..915
                     /gene="LRRC46"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1885
                     /gene="LRRC46"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1374..1379
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRC46"
                     /note="hexamer: AGTAAA"
     polyA_site      1396
                     /gene="LRRC46"
                     /note="major polyA site"
     regulatory      1461..1466
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRC46"
                     /note="hexamer: AATACA"
     polyA_site      1493
                     /gene="LRRC46"
     regulatory      1861..1866
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRC46"
                     /note="hexamer: AATAAA"
     polyA_site      1885
                     /gene="LRRC46"
ORIGIN      
        1 actcggcgtc cagtctctta gcaacgactc cggcttccta ggaactgctc ctttctcaac
       61 cattcctgcc cacaacaccc cagcttgctg ccagcaaagc ccctccacac ccctcaaact
      121 ccagaccctt cacatcaatt tactgttttc ttcgacctca ccccagcaat tttctctgaa
      181 tcaaccccct ttcctcctct cctaagtctc tgagtttctc tctcctcctg ccatcctgag
      241 ttctgccatc cttaggggcc gccaagacct ctcttttcgt tcctctcccg cctcagacca
      301 gcagcctttt attttagatc atgtctggag ggaagtcagc ccagggtcca gaggaagggg
      361 gcgtctgcat cactgaagcc cttatcacta agcggaactt gactttccct gaagatgggg
      421 aactgtcaga gaagatgttt cacactcttg atgaactgca gactgtccgc ctggaccggg
      481 aggggattac tactatcagg aacttagaag gcctccagaa tcttcacagt ctctatctgc
      541 aagggaataa gatccagcaa attgagaacc tggcttgcat cccctccttg cgcttcctgt
      601 ctctggcagg aaaccaaatc aggcaggtgg aaaacctcct cgacctccca tgcctccagt
      661 ttctggacct ttctgagaac ctgatagaaa cattgaagct ggatgagttc ccccagagcc
      721 ttctcatcct caacctgtct ggaaacagct gcaccaacca ggatggctac cgcgagctgg
      781 tgacagaagc cctgccactt ctcctggacc tggacgggca gcctgtggtg gagcgctgga
      841 tttcggatga ggaggatgaa gcctcaagcg atgaggagtt cccagagctg agtggcccat
      901 tctgctcaga acgaggcttc ctcaaggagc tggagcagga gctgagcagg cacagggagc
      961 accggcaaca gacggccctg acagagcacc tgctgaggat ggagatgcag cccaccctca
     1021 ccgacctgcc cctgctacct ggggtgccca tggctgggga cagcagccct tctgccactc
     1081 ctgcgcaagg ggaggagaca gtccctgagg ccgtctcctc accccaggcc tcctctccca
     1141 ccaagaaacc atgcagtctg attcccaggg gccaccaaag ctctttctgg ggaaggaagg
     1201 gggcacgagc agccacagcc cccaaggcct ctgtggctga ggcccccagc acaaccaaaa
     1261 ctacggccaa gagaagcaag aaatgattct ctgtcaacct ttctctacta gtggagagga
     1321 gtggggcctg cccctcttct cagacctctg acctgtgaca gaagcccatc cccagtaaag
     1381 tgtctctagg ccctgagtat gcttttcatg tcacttgggg tatctcaggg gaagaaacca
     1441 gtgaaagctc caggaaacaa aatacagagc tcagtgagcc acctgattct aaagagcgag
     1501 tctggaatct ttcgggagct acccacaggg caggcatgcc tcaggccccc gctggcttcc
     1561 tggctcccac ttgggcagga agcgggcacc acctcatgga agaggcatgc catctcactg
     1621 ccacccctag cgagtgccct tccccggtcc aagccaagga ccaaggagct gtggtcctag
     1681 tcatccccaa cagcagccag ctcctgtccc ctccctgtcc tcctgcccag tccccatcac
     1741 tcacccactc ataggaatga gtacacaacc acaggccccg cagccagccc acagctgcct
     1801 ttgggcctca cttggctctc ccacccccac tggtcctggg ataaagttca ctgaagagaa
     1861 aataaagcac atttattaag gcaaa
//
