LOCUS       NM_144999               2698 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens leucine rich repeat containing 45 (LRRC45), mRNA.
ACCESSION   NM_144999 XM_938258
VERSION     NM_144999.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2698)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 2698)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2698)
  AUTHORS   Hossain,D., Shih,S.Y., Xiao,X., White,J. and Tsang,W.Y.
  TITLE     Cep44 functions in centrosome cohesion by stabilizing rootletin
  JOURNAL   J Cell Sci 133 (4) (2020)
   PUBMED   31974111
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2698)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2698)
  AUTHORS   Xia,Y., Huang,N., Chen,Z., Li,F., Fan,G., Ma,D., Chen,J. and
            Teng,J.
  TITLE     CCDC102B functions in centrosome linker assembly and centrosome
            cohesion
  JOURNAL   J Cell Sci 131 (23) (2018)
   PUBMED   30404835
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2698)
  AUTHORS   He,R., Huang,N., Bao,Y., Zhou,H., Teng,J. and Chen,J.
  TITLE     LRRC45 is a centrosome linker component required for centrosome
            cohesion
  JOURNAL   Cell Rep 4 (6), 1100-1107 (2013)
   PUBMED   24035387
  REMARK    GeneRIF: LRRC45 is a critical component of the proteinaceous linker
            between two centrioles and is required for centrosome cohesion.
REFERENCE   7  (bases 1 to 2698)
  AUTHORS   Jakobsen,L., Vanselow,K., Skogs,M., Toyoda,Y., Lundberg,E.,
            Poser,I., Falkenby,L.G., Bennetzen,M., Westendorf,J., Nigg,E.A.,
            Uhlen,M., Hyman,A.A. and Andersen,J.S.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC137723.6, BI837975.1 and BC014109.2.
            
            On Nov 23, 2018 this sequence version replaced NM_144999.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC014109.2, SRR11853560.13325.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000306688.8/ ENSP00000306760.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                AC137723.6         42289-42316
            29-136              BI837975.1         1-108
            137-2698            BC014109.2         38-2599
FEATURES             Location/Qualifiers
     source          1..2698
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.3"
     gene            1..2698
                     /gene="LRRC45"
                     /note="leucine rich repeat containing 45"
                     /db_xref="GeneID:201255"
                     /db_xref="HGNC:HGNC:28302"
     exon            1..559
                     /gene="LRRC45"
                     /inference="alignment:Splign:2.1.0"
     CDS             340..2352
                     /gene="LRRC45"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 45"
                     /protein_id="NP_659436.1"
                     /db_xref="CCDS:CCDS11797.1"
                     /db_xref="GeneID:201255"
                     /db_xref="HGNC:HGNC:28302"
                     /translation="MEEFRRSYSRLCRESGAEPQEAVLQQLHQLPRGRLDLATQSLTV
                     ETCRALGKLLPRETLCTELVLSDCMLSEEGATLLLRGLCANTVLRFLDLKGNNLRAAG
                     AEALGKLLQQNKSIQSLTLEWNSLGTWDDAFATFCGGLAANGALQRLDLRNNQISHKG
                     AEELALALKGNTTLQQLDLRWNNVGLLGGRALMNCLPSNRTLWRLDLAGNNIPGDVLR
                     AVEQAMGHSQDRLTTFQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMAKS
                     SRASAARVGQLQEALNERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAEQEQL
                     SLSQRQAKELKLEQQEAAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQLFQ
                     TRQEMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSESLRIKEVEHMTRHLEESEKA
                     MQERVQRLEAARLSLEEELSRVKAAALSERGQAEEELIKAKSQARLEEQQRLAHLEDK
                     LRLLAQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRRRLEELQQELSLKDQERV
                     AEVSRVRVELQEQNGRLQAELAAQEALREKAAALERQLKVMASDHREALLDRESENAS
                     LREKLRLREAEIARIRDEEAQRASFLQNAVLAYVQASPVRTLSPPK"
     exon            560..621
                     /gene="LRRC45"
                     /inference="alignment:Splign:2.1.0"
     exon            622..692
                     /gene="LRRC45"
                     /inference="alignment:Splign:2.1.0"
     exon            693..871
                     /gene="LRRC45"
                     /inference="alignment:Splign:2.1.0"
     exon            872..1000
                     /gene="LRRC45"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1113
                     /gene="LRRC45"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1172
                     /gene="LRRC45"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1250
                     /gene="LRRC45"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1386
                     /gene="LRRC45"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1464
                     /gene="LRRC45"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..1576
                     /gene="LRRC45"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..1647
                     /gene="LRRC45"
                     /inference="alignment:Splign:2.1.0"
     exon            1648..1740
                     /gene="LRRC45"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..1833
                     /gene="LRRC45"
                     /inference="alignment:Splign:2.1.0"
     exon            1834..2007
                     /gene="LRRC45"
                     /inference="alignment:Splign:2.1.0"
     exon            2008..2155
                     /gene="LRRC45"
                     /inference="alignment:Splign:2.1.0"
     exon            2156..2698
                     /gene="LRRC45"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2672..2677
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRC45"
                     /note="hexamer: AATACA"
     polyA_site      2698
                     /gene="LRRC45"
                     /note="major polyA site"
ORIGIN      
        1 gttcttcctg gatactgagg ccccgacgcg gctgtcgcga gggcgggggt cggggctgca
       61 ggcggggcag ggctgggtgg gggcgcgcga cgcacctgcc tgcttcctgc acgggtggtc
      121 cccaagcact gcggggcccc agcccaaagc ggaccttgac taccgcccag ccccgcgctc
      181 ccaggacctc ccgcccgcgg agcccactcg gattgctctc cgcccgggtc ggcggaggcc
      241 ccgtctcctg tacccggcgc tgggactgct ccgcaccgcg cggctccctt tcagcagctg
      301 cgggagcatg cggaggaggc cctgccggcc ccgcgggtca tggaggagtt ccggcgctcc
      361 tacagccgcc tgtgcaggga gagtggggcc gagccccagg aggctgtcct gcagcagctg
      421 caccagcttc ccaggggccg gctggacctg gccacgcaaa gcctgacggt ggagacctgc
      481 agggccctgg gcaagctgct gccgagggag acgctgtgca cggagctggt cctgagtgac
      541 tgcatgctca gcgaggaagg ggccacactg ctgctccgag gcctgtgtgc caacaccgtg
      601 ctgcgctttc tggacttaaa gggcaacaac cttcgggctg caggggccga ggctctggga
      661 aaactcctcc aacagaacaa gtccattcag agcctcacgc tggagtggaa cagcctgggc
      721 acgtgggacg atgccttcgc caccttctgc gggggcctgg cggccaacgg cgccctgcag
      781 cggctggacc tccgcaacaa ccagatcagt cacaagggcg cggaggagct ggccctagcc
      841 ctgaagggca acaccaccct ccagcagctg gacctgcgct ggaataacgt tggcctcctg
      901 gggggccggg ccctcatgaa ctgtctcccc agcaacagaa ccctgtggag actggacctg
      961 gctgggaaca acatccctgg agacgtcctc agagccgtgg agcaagccat gggccacagc
     1021 caggaccggc tcaccacctt ccaggagaac caagcccgca ctcacgtcct cagcaaggag
     1081 gtccagcacc tccgggagga gaagtccaag cagttcctcg acttgatgga gactattgat
     1141 aagcagcgag aagagatggc caagagcagc agggcgtcgg cagcccgtgt agggcagctt
     1201 caggaagccc tgaatgagag gcactccatc atcaacgctc tcaaggccaa gctgcagatg
     1261 acagaggccg ccctggctct gtcggagcag aaggcccagg acctggggga gctcctggcc
     1321 acagcggagc aggagcagct gagcctgtca cagaggcagg ccaaggagct caagctggag
     1381 cagcaggaag ctgcagagcg ggagtctaaa ctcctcagag acttgtctgc tgccaatgaa
     1441 aagaacctgc ttctgcaaaa ccaggtagac gagttggagc ggaagttcag gtgtcagcag
     1501 gagcagctgt tccagaccag gcaggagatg accagcatgt cagctgagct gaagatgcgg
     1561 gccatccagg ccgaggagcg cctggacatg gagaagagaa gatgcagaca gagcctggag
     1621 gactccgaaa gcctgcgcat caaggaggtg gagcatatga cccgtcacct ggaggagagt
     1681 gagaaggcca tgcaggagcg ggtgcagagg ctggaggcgg cgcggctgtc cctggaggag
     1741 gagctgagcc gagtgaaagc agcggcactc agcgagcgtg gccaggctga ggaggagctg
     1801 atcaaggcca agagccaggc ccgcctggag gagcaacagc gcctggctca cctggaggac
     1861 aagctgagac tgctggcgca ggcacgggac gaggcgcagg gcgcttgcct acagcagaag
     1921 caggtggtgg ccgaggccca gacccgggtc agccagctgg gcctgcaagt tgagggcctg
     1981 cggcggcgcc tggaagagct gcagcaggag ctgagcctca aggaccagga aagggtggcc
     2041 gaggtgagca gggtgcgcgt ggagctgcag gagcagaacg gccggctgca ggcggagctg
     2101 gcggctcagg aggcgctgag ggagaaggcg gcggccctgg agcgccagct gaaagtgatg
     2161 gcgagcgacc accgagaggc gctgctggac agggagagcg agaacgcgtc tctccgggag
     2221 aagctgcggc tccgggaggc ggagatcgcc cgcatccggg acgaggaggc ccagagggcg
     2281 agcttcctgc agaacgccgt cctggcttac gtgcaggcgt cccccgtgag gaccctgagc
     2341 cccccaaagt gagacaggcc gggaggaccc gggcgcagta ggagtgcatc aggcggcgcc
     2401 cgagatggac caggggctgc gtcccgcccg cgccgcctct ttgagacccg ggtcgtctgt
     2461 tccacgcggc ggttgcggcg actgttggtg gtgtcgcggc tgcgggggaa ccccgtggga
     2521 ggcgcctggg aagggctccc taccggcccc ttcttcccgg tcgacgccac gtgggagcac
     2581 accgggaagg ggtcccgcgg gcgcgtctcc ccctcgcctt ttgcgatgtc accgtgaacg
     2641 ctgcggccgc ctgcgcgcgg cggggtttgg aaatacagcg cgtttgcact ttgtgata
//
