LOCUS       NM_001098519            2022 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens leucine rich repeat containing 43 (LRRC43), transcript
            variant 1, mRNA.
ACCESSION   NM_001098519
VERSION     NM_001098519.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2022)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
REFERENCE   2  (bases 1 to 2022)
  AUTHORS   Kimura,K., Wakamatsu,A., Suzuki,Y., Ota,T., Nishikawa,T.,
            Yamashita,R., Yamamoto,J., Sekine,M., Tsuritani,K., Wakaguri,H.,
            Ishii,S., Sugiyama,T., Saito,K., Isono,Y., Irie,R., Kushida,N.,
            Yoneyama,T., Otsuka,R., Kanda,K., Yokoi,T., Kondo,H., Wagatsuma,M.,
            Murakawa,K., Ishida,S., Ishibashi,T., Takahashi-Fujii,A.,
            Tanase,T., Nagai,K., Kikuchi,H., Nakai,K., Isogai,T. and Sugano,S.
  TITLE     Diversification of transcriptional modulation: large-scale
            identification and characterization of putative alternative
            promoters of human genes
  JOURNAL   Genome Res 16 (1), 55-65 (2006)
   PUBMED   16344560
REFERENCE   3  (bases 1 to 2022)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA951767.1, BC029245.2 and AK124107.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001098519.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968968,
                              SAMEA2148093 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000339777.5/ ENSP00000344233.4
            RefSeq Select criteria    :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-173               DA951767.1         4-176
            174-765             BC029245.2         1-592
            766-787             AK124107.1         1038-1059
            788-1009            BC029245.2         615-836
            1010-1693           AK124107.1         1282-1965
            1694-2022           BC029245.2         1521-1849
FEATURES             Location/Qualifiers
     source          1..2022
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.31"
     gene            1..2022
                     /gene="LRRC43"
                     /note="leucine rich repeat containing 43"
                     /db_xref="GeneID:254050"
                     /db_xref="HGNC:HGNC:28562"
     exon            1..172
                     /gene="LRRC43"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..1993
                     /gene="LRRC43"
                     /note="isoform 1 is encoded by transcript variant 1;
                     leucine-rich repeat-containing protein 43"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 43
                     isoform 1"
                     /protein_id="NP_001091989.1"
                     /db_xref="CCDS:CCDS45001.1"
                     /db_xref="GeneID:254050"
                     /db_xref="HGNC:HGNC:28562"
                     /translation="MEASYESESESESEAGPGTQRPGTGTVSAAVREHLRKLCLREFP
                     CGAGSWNKSRFLPQTWRTWRELVPREEDVVSPGEETVEALLGLVRSRHSPWALLNNSN
                     AEDSFLRELAIRNPLTITDTFFYSYFRSLRVIDKKVTLVDKDLLKFLKLEELVLSANR
                     IKEVDATNLPPTLKVLELYGNEISSMECLCAHPPAGLQHLGLGHNKLLGPLESLYVTA
                     NHWPNLVSLDLGFNDLTDLQSMVTSLRTLRHLRLLVLQGNPLALVPYYRGLTIDSLAQ
                     LCVLDDITVSPNEKHLFRGLSLNGDLLAQEAQFVVTIGNIRGVLDTSVLDPEPRPEGP
                     FITYNYYVTYDFVKDEEGEMNESAGVLAEIVKPSPSLELLVEESPEEVVEDVIEDIVE
                     EVTEEVEGSLESEVEESGESELSVISGPSTILQMPRASAEELAKLRLRIDPRLCPSPG
                     TVLFSTAHKPWAEVIPCSYEMQHSLRDLVPLKAFLLAGTTVTIVEEKILSWPVVLPAV
                     DSPLSAKKGKGEKDKKGKEKDRTGKGEKEPAKEWKVLKKKKEPPKELRQDPPILQVLG
                     RGLVILEPLLAGEPLVSTVCNFGVVRTLTSDRLTLARDSKKIKKVAKKEKPKAVIPIY
                     EGDYHPEPLTVEVQIQLNQCRSAEEALRMFAV"
     exon            173..433
                     /gene="LRRC43"
                     /inference="alignment:Splign:2.1.0"
     exon            434..544
                     /gene="LRRC43"
                     /inference="alignment:Splign:2.1.0"
     exon            545..684
                     /gene="LRRC43"
                     /inference="alignment:Splign:2.1.0"
     exon            685..923
                     /gene="LRRC43"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1111
                     /gene="LRRC43"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1371
                     /gene="LRRC43"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1513
                     /gene="LRRC43"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..1642
                     /gene="LRRC43"
                     /inference="alignment:Splign:2.1.0"
     exon            1643..1831
                     /gene="LRRC43"
                     /inference="alignment:Splign:2.1.0"
     exon            1832..1865
                     /gene="LRRC43"
                     /inference="alignment:Splign:2.1.0"
     exon            1866..2022
                     /gene="LRRC43"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2003..2008
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRC43"
                     /note="hexamer: AGTAAA"
     polyA_site      2022
                     /gene="LRRC43"
                     /note="major polyA site"
ORIGIN      
        1 gccgggcaac gcggcccggg ccatggaggc gtcgtacgag tccgagtccg agtccgagtc
       61 tgaggccggg cctgggactc agcggcccgg gaccgggacc gtgagcgcgg ccgtgcgcga
      121 gcacttgcgg aagctgtgtc tgcgcgagtt cccgtgcggt gccggcagct ggaataagtc
      181 gcgctttctt cctcaaactt ggcgaacttg gagggagctt gtccccagag aggaggatgt
      241 ggtgagcccc ggagaggaga cggtggaggc cctgctgggc ctggtccgca gccgccactc
      301 cccctgggct ctgctgaaca actcgaatgc agaagacagt ttcctgagag aattggccat
      361 ccggaacccg ctgacgatca cagacacctt cttctactcc tacttccggt ccctgcgggt
      421 aatagacaag aaggtcaccc tggtggataa agacctcctg aaatttctaa agctggagga
      481 gttggtactg agcgccaatc gaatcaagga ggtggatgcc accaatctgc cccccacact
      541 caaggtgctg gagctctacg gcaatgagat cagcagcatg gagtgtctgt gtgcccaccc
      601 acccgccggc ctgcagcact tggggttagg ccacaacaaa cttctaggcc ccttggaaag
      661 tctctacgtc accgctaatc actggcccaa cctcgtctcc ctggacctgg gcttcaacga
      721 cctgacagac ctgcagagca tggtcaccag cctgaggacc ctccggcacc tgcgactcct
      781 ggtgctgcag ggaaacccac tggccttggt gccctactac cgcggcctca ccatcgacag
      841 cctggcccag ctctgcgtgc tggacgacat caccgtgtct cccaatgaga agcatctctt
      901 ccgggggctc agcctcaatg gcgatctctt ggcacaggag gcgcagtttg tggtgaccat
      961 cggaaacatc agaggagtcc tggacacctc tgtcttagac ccggaaccca ggcccgaagg
     1021 ccctttcatc acttacaact attacgtgac ctatgatttt gtgaaagatg aagaaggcga
     1081 aatgaatgag tccgcgggcg tcctggccga gatcgtcaag ccctctccca gcttagaatt
     1141 attagttgag gaatctcctg aagaggtcgt ggaagacgtc atcgaagaca ttgttgaaga
     1201 ggttactgaa gaggtcgaag ggtctctgga gtctgaggtg gaggagtcag gagagtcgga
     1261 gctgtctgtc atctcggggc cttcgaccat cttgcagatg ccgagggcct ctgcagaaga
     1321 gctggccaag ttgaggctgc gtatagatcc ccggctctgc ccgtccccag ggactgtcct
     1381 cttcagcact gcccacaagc cctgggctga ggtcatcccc tgcagttacg agatgcagca
     1441 ctctctcagg gacctggtcc cactgaaggc cttcctgctg gcggggacca ccgtgaccat
     1501 cgtggaggag aagattctct cctggcctgt ggtgctacct gctgttgaca gtcccctgtc
     1561 tgccaagaaa ggaaaggggg agaaagacaa gaaagggaag gagaaagaca ggacggggaa
     1621 aggagagaaa gagccggcca aggagtggaa ggtgctgaag aagaagaaag agccgcccaa
     1681 ggagctccgg caggaccccc ccatcctcca ggtgctgggc cggggcctgg tgatcctgga
     1741 gcccctgctc gccggggagc ccctggtgtc caccgtgtgc aacttcggcg tggtccgcac
     1801 attgacatct gacaggctga cgttggccag ggattcaaag aagattaaga aagttgccaa
     1861 aaaagaaaag ccgaaagccg tgattccgat ctacgaaggc gattaccacc ctgagcccct
     1921 gaccgtagag gtgcagatcc agctgaacca gtgccgctcg gcggaggagg ctctgcgcat
     1981 gttcgccgtg tagggcgtgg gcagtaaagg ctgttcccag ca
//
