LOCUS       NM_006369               4136 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens leucine rich repeat containing 41 (LRRC41), mRNA.
ACCESSION   NM_006369
VERSION     NM_006369.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4136)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 4136)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   3  (bases 1 to 4136)
  AUTHORS   Woo,J.S., Imm,J.H., Min,C.K., Kim,K.J., Cha,S.S. and Oh,B.H.
  TITLE     Structural and functional insights into the B30.2/SPRY domain
  JOURNAL   EMBO J 25 (6), 1353-1363 (2006)
   PUBMED   16498413
REFERENCE   4  (bases 1 to 4136)
  AUTHORS   Wan,D., Gong,Y., Qin,W., Zhang,P., Li,J., Wei,L., Zhou,X., Li,H.,
            Qiu,X., Zhong,F., He,L., Yu,J., Yao,G., Jiang,H., Qian,L., Yu,Y.,
            Shu,H., Chen,X., Xu,H., Guo,M., Pan,Z., Chen,Y., Ge,C., Yang,S. and
            Gu,J.
  TITLE     Large-scale cDNA transfection screening for genes related to cancer
            development and progression
  JOURNAL   Proc Natl Acad Sci U S A 101 (44), 15724-15729 (2004)
   PUBMED   15498874
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 Dec 14:101(50):17565]
REFERENCE   5  (bases 1 to 4136)
  AUTHORS   Kamura,T., Burian,D., Yan,Q., Schmidt,S.L., Lane,W.S., Querido,E.,
            Branton,P.E., Shilatifard,A., Conaway,R.C. and Conaway,J.W.
  TITLE     Muf1, a novel Elongin BC-interacting leucine-rich repeat protein
            that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin
            ligase
  JOURNAL   J Biol Chem 276 (32), 29748-29753 (2001)
   PUBMED   11384984
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL122001.32, AK291283.1 and AL121602.34.
            
            On Jul 8, 2020 this sequence version replaced NM_006369.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK291283.1, BX537366.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000617190.5/ ENSP00000477792.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-267               AL122001.32        120333-120599
            268-2972            AK291283.1         1-2705
            2973-4136           AL121602.34        48009-49172         c
FEATURES             Location/Qualifiers
     source          1..4136
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.1-p33"
     gene            1..4136
                     /gene="LRRC41"
                     /gene_synonym="MUF1; PP7759"
                     /note="leucine rich repeat containing 41"
                     /db_xref="GeneID:10489"
                     /db_xref="HGNC:HGNC:16917"
                     /db_xref="MIM:618753"
     exon            1..493
                     /gene="LRRC41"
                     /gene_synonym="MUF1; PP7759"
                     /inference="alignment:Splign:2.1.0"
     CDS             295..2733
                     /gene="LRRC41"
                     /gene_synonym="MUF1; PP7759"
                     /note="elongin BC-interacting leucine-rich repeat protein;
                     MUF1 protein (MUF1); protein Muf1"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 41"
                     /protein_id="NP_006360.3"
                     /db_xref="CCDS:CCDS533.1"
                     /db_xref="GeneID:10489"
                     /db_xref="HGNC:HGNC:16917"
                     /db_xref="MIM:618753"
                     /translation="MAAPEAWRARSCWFCEVAAATTMEATSREAAPAKSSASGPNAPP
                     ALFELCGRAVSAHMGVLESGVWALPGPILQSILPLLNIYYLERIEETALKKGLSTQAI
                     WRRLWDELMKTRPSSLESVTCWRAKFMEAFFSHVLRGTIDVSSDRRLCDQRFSPLLHS
                     SRHVRQLTICNMLQGATELVAEPNRRVLETLASSLHTLKFRHLLFSDVAAQQSLRQLL
                     HQLIHHGAVSQVSLYSWPVPESALFILILTMSAGFWQPGPGGPPCRLCGEASRGRAPS
                     RDEGSLLLGSRRPRRDAAERCAAALMASRRKSEAKQMPRAAPATRVTRRSTQESLTAG
                     GTDLKRELHPPATSHEAPGTKRSPSAPAATSSASSSTSSYKRAPASSAPQPKPLKRFK
                     RAAGKKGARTRQGPGAESEDLYDFVFIVAGEKEDGEEMEIGEVACGALDGSDPSCLGL
                     PALEASQRFRSISTLELFTVPLSTEAALTLCHLLSSWVSLESLTLSYNGLGSNIFRLL
                     DSLRALSGQAGCRLRALHLSDLFSPLPILELTRAIVRALPLLRVLSIRVDHPSQRDNP
                     GVPGNAGPPSHIIGDEEIPENCLEQLEMGFPRGAQPAPLLCSVLKASGSLQQLSLDSA
                     TFASPQDFGLVLQTLKEYNLALKRLSFHDMNLADCQSEVLFLLQNLTLQEITFSFCRL
                     FEKRPAQFLPEMVAAMKGNSTLKGLRLPGNRLGNAGLLALADVFSEDSSSSLCQLDIS
                     SNCIKPDGLLEFAKRLERWGRGAFGHLRLFQNWLDQDAVTAREAIRRLRATCHVVSDS
                     WDSSQAFADYVSTM"
     exon            494..580
                     /gene="LRRC41"
                     /gene_synonym="MUF1; PP7759"
                     /inference="alignment:Splign:2.1.0"
     exon            581..651
                     /gene="LRRC41"
                     /gene_synonym="MUF1; PP7759"
                     /inference="alignment:Splign:2.1.0"
     exon            652..1789
                     /gene="LRRC41"
                     /gene_synonym="MUF1; PP7759"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..2050
                     /gene="LRRC41"
                     /gene_synonym="MUF1; PP7759"
                     /inference="alignment:Splign:2.1.0"
     exon            2051..2215
                     /gene="LRRC41"
                     /gene_synonym="MUF1; PP7759"
                     /inference="alignment:Splign:2.1.0"
     exon            2216..2314
                     /gene="LRRC41"
                     /gene_synonym="MUF1; PP7759"
                     /inference="alignment:Splign:2.1.0"
     exon            2315..2437
                     /gene="LRRC41"
                     /gene_synonym="MUF1; PP7759"
                     /inference="alignment:Splign:2.1.0"
     exon            2438..2513
                     /gene="LRRC41"
                     /gene_synonym="MUF1; PP7759"
                     /inference="alignment:Splign:2.1.0"
     exon            2514..4136
                     /gene="LRRC41"
                     /gene_synonym="MUF1; PP7759"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3177..3182
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRC41"
                     /gene_synonym="MUF1; PP7759"
                     /note="hexamer: AATAAA"
     polyA_site      3198
                     /gene="LRRC41"
                     /gene_synonym="MUF1; PP7759"
                     /note="major polyA site"
     regulatory      4109..4114
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRC41"
                     /gene_synonym="MUF1; PP7759"
                     /note="hexamer: AATAAA"
     polyA_site      4136
                     /gene="LRRC41"
                     /gene_synonym="MUF1; PP7759"
ORIGIN      
        1 agattggcat gtactaccag ccgcaggcag aggttagggg tagctgatgt ttgcacccga
       61 ggaggctttg ctaagaaaca tccccttagt cataccacac ccaagtataa ttgatctagg
      121 agtttatcta aaatagtagc tcctaagaga cttggaaagt gtgctaattt cttcgaaatt
      181 tctttagaat aattcacatt cttccccata tcgcttatgg agccgtccta actgctgacc
      241 ttttcaagat ggcggtccgc gggcgacact ctcgggctcg cgcacctccc caagatggcg
      301 gcgcccgagg cctggcgcgc ccggagttgc tggttctgtg aggtagcggc ggcaacgacc
      361 atggaggcca cgtcccggga ggcggcgcca gcgaagagct cggcctcggg ccccaacgct
      421 ccccccgccc tgttcgagct gtgcgggcgg gcggtgagcg cccatatggg ggttctggag
      481 agcggggtgt gggccctccc aggcccaata cttcaaagca tcctacctct gctcaatata
      541 tattacttgg agaggattga ggaaactgcc ctcaagaaag gcctctcaac tcaggccatc
      601 tggcgccgac tctgggatga actgatgaag acaaggcctt ccagtttgga aagtgtgaca
      661 tgttggcgag ccaagtttat ggaggccttt ttttcccatg ttctacgtgg gaccattgat
      721 gtgtcttctg acaggcgtct ttgtgatcag cggttctcac ctcttctgca cagctcccgc
      781 catgtccgac agctcaccat ctgtaacatg ctgcagggtg caaccgagct ggtggctgag
      841 cccaaccgca gggttctgga gaccctggcc agctccctgc acactctcaa gttccgccac
      901 ctgctgttct ctgatgtggc tgctcagcag tcacttcggc agctgttgca tcagctcatt
      961 caccatgggg ctgtcagtca agtgtcgcta tactcctggc ctgtgcctga gtcagccctt
     1021 ttcatcctta ttctcaccat gagtgctggc ttctggcaac cagggcctgg tggcccaccc
     1081 tgccgcctct gtggagaggc ctcccgaggc cgggccccat cccgagatga agggtccctc
     1141 ttattgggct cacgtcggcc ccgccgggat gctgctgagc gatgtgctgc agccctgatg
     1201 gccagccggc gtaagagtga agccaagcag atgcccagag ctgcacctgc cactcgggta
     1261 acacgccgga gcacacagga gagcctgaca gcaggcggaa cagaccttaa gagggagctg
     1321 caccccccag ccacctccca tgaggctcct ggcaccaagc ggtcaccttc tgctccagca
     1381 gccacctcct ctgcctcttc ttctacatcc tcatacaaac gggcaccagc tagctcagcc
     1441 ccacagccta agcccctaaa gcgtttcaag cgagctgcag ggaagaaggg tgctcgcacc
     1501 cgtcaggggc ctggtgcaga gtctgaagac ctgtatgact tcgtttttat tgtggctggc
     1561 gagaaggagg atggcgaaga gatggagatt ggggaagtgg cttgtggagc tttggatgga
     1621 tcagatccca gctgcctggg gcttccagca ctggaagctt cacaaagatt ccgcagcatc
     1681 tccaccttgg agctattcac agttccactc tccacagagg cagccctgac actatgccac
     1741 ctgctgagct cctgggtgtc actggagagc ctcacactct cctacaatgg cctgggctct
     1801 aacatcttcc gcctgctaga cagcctgcgg gccctgtcag gccaggctgg atgtcgcctc
     1861 cgtgccctgc atctcagtga cctgttctca ccactgccca tcctggagct gacacgtgct
     1921 atcgtgcgag cactgcccct gctacgggtc ctctctattc gtgttgacca cccaagccag
     1981 cgggacaacc ctggtgtgcc agggaatgca gggcccccta gccacataat aggcgatgag
     2041 gagataccag aaaactgcct ggagcagttg gagatgggat ttccacgggg agcccagcca
     2101 gccccactgc tgtgctccgt tctgaaggcc tcgggttctc tgcagcagct gtccctggat
     2161 agtgccacct ttgcctctcc ccaggatttt gggcttgttt tgcaaacact caaagagtac
     2221 aacctagccc tgaaaagact gagcttccat gacatgaatc tcgctgactg tcagagcgag
     2281 gtgctctttt tgctacagaa tctgactctg caagagatta ccttctcctt ctgccgtctg
     2341 tttgagaagc gcccagccca atttctgcct gagatggttg ctgctatgaa gggcaactcc
     2401 acactgaagg gcctccggct gccagggaac cgcctgggga atgctggcct gctggccttg
     2461 gcagatgttt tctcagagga ttcatcctcc tctctctgtc agctggacat cagttccaac
     2521 tgcatcaagc cagatgggct tctggagttc gccaagcggc tggagcgctg gggccgtgga
     2581 gcctttggtc acctgcgcct cttccaaaac tggctggacc aggatgcagt cacagccagg
     2641 gaagccatcc ggcggctccg ggctacctgc catgtggtta gcgactcatg ggactcatcc
     2701 caggccttcg cagattatgt tagcaccatg tgatggggcc cgtacctcac agtctcatgc
     2761 tcggtaccat cagcttgcag gggctgaagc atgggctgcc cagaacccca accaccagtt
     2821 ctatctttct ctttctgtca ccttttttct cttttttcct tcttcccttg cactgaggtc
     2881 ctggaggcct tgatgaggcc cagcaaacag gcattctcac agctgggttt atagtctttg
     2941 ggccccttac tcagtatcct gggaaccctg ggccaggagg ttacagtggt catcataatt
     3001 gctgaagaga tcccctcccc tgcccctggg ttcctgcctt ccctcctcaa gcaggcaccc
     3061 aggctttaga gaagtatagg gggcttcttc cctgctgggc ttaccacact gctctcaggc
     3121 ctcaaaccct ttcatacctt tattcttttt tttaaccaaa aaagtttttc ttataaaata
     3181 aattttgggc aaacatcatg cagcccttct tgatgatttt ctcccagaga acaaaattca
     3241 acagggccct gtggagcaag gagccccttt tccctatctc cttcctctaa gagctacacc
     3301 cagaccagct ggttatcagc ggaggccccg ctgctcctca tgagaacgct ggtggaagac
     3361 gaaggtgatg gcagtggagg cagcatccca ggcagcctgg agtacctcat cccggagccc
     3421 ccacttatca gtgcagtggt tccaccctgc caggtctgaa gtgcagtcag aaccatcagg
     3481 gggtggccgg atctgacggc tgttgacaca acgtcggcag tgcaacctag ggacagaagg
     3541 cacagctgaa gtcactacag atcccatctc cctactgtgt gggtagctta gagataatgg
     3601 ttagggcact tccccacctg tcatgtgtgt cactgaggct agcttcatcc aggataaaca
     3661 gctccttcaa ctcgcccaga gagaagtggc gctctacatc ctgctcctca tccaccacac
     3721 agctgctcag tgccttcttg tggctctgac gctggaagat cttctcctca atggtccctg
     3781 cctggggaag aggaggtggg gaatgtcaaa agatacagcg cttagccatc ctcataaaaa
     3841 gggagcagga aaaccaaagg gttgaaacta cagctacccg agaagaggag atgaataaaa
     3901 agtatgagtc ccagaacatt atctctactc agctgaggtc cattttccca gtctgtctcc
     3961 tgagaacatg acatgaatag tctgcccacc caggctactt tctatactaa tgaagggtcc
     4021 cagggcctgg ctaaatcccg tcagggtgaa ctgaggtttg tctgctgcag cttcagattt
     4081 ctgcaccaag cccaactcta actcattcaa taaatatcat ttaggtatct attcta
//
