LOCUS       NM_017768               2843 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens leucine rich repeat containing 40 (LRRC40), mRNA.
ACCESSION   NM_017768
VERSION     NM_017768.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2843)
  AUTHORS   Pijuan,J., Ortigoza-Escobar,J.D., Ortiz,J., Alcala,A., Calvo,M.J.,
            Cubells,M., Hernando-Davalillo,C., Palau,F. and Hoenicka,J.
  TITLE     PLXNA2 and LRRC40 as candidate genes in autism spectrum disorder
  JOURNAL   Autism Res 14 (6), 1088-1100 (2021)
   PUBMED   33749153
  REMARK    GeneRIF: PLXNA2 and LRRC40 as candidate genes in autism spectrum
            disorder.
REFERENCE   2  (bases 1 to 2843)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2843)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2843)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 2843)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA310461.1, BC008586.1 and AI015897.1.
            
            On Nov 22, 2018 this sequence version replaced NM_017768.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.397792.1,
                                           SRR1660803.41347.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370952.4/ ENSP00000359990.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                DA310461.1         100-145
            47-2837             BC008586.1         44-2834
            2838-2843           AI015897.1         17-22               c
FEATURES             Location/Qualifiers
     source          1..2843
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p31.1"
     gene            1..2843
                     /gene="LRRC40"
                     /gene_synonym="dJ677H15.1"
                     /note="leucine rich repeat containing 40"
                     /db_xref="GeneID:55631"
                     /db_xref="HGNC:HGNC:26004"
     exon            1..190
                     /gene="LRRC40"
                     /gene_synonym="dJ677H15.1"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..1848
                     /gene="LRRC40"
                     /gene_synonym="dJ677H15.1"
                     /note="testicular tissue protein Li 109"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 40"
                     /protein_id="NP_060238.3"
                     /db_xref="CCDS:CCDS646.1"
                     /db_xref="GeneID:55631"
                     /db_xref="HGNC:HGNC:26004"
                     /translation="MSRLKRIAGQDLRAGFKAGGRDCGTSVPQGLLKAARKSGQLNLS
                     GRNLSEVPQCVWRINVDIPEEANQNLSFGATERWWEQTDLTKLIISNNKLQSLTDDLR
                     LLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKILPEEITNLRNLKCLYLQH
                     NELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPAEINR
                     MKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLPEFPSCSLLKELHVGENQ
                     IEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNL
                     HLKFLALEGNPLRTIRREIISKGTQEVLKYLRSKIKDDGPSQSESATETAMTLPSESR
                     VNIHAIITLKILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEM
                     VSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFK
                     MLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPPELGNCVN
                     LRTLLLDGNPFRVPRAAILMKGTAAILEYLRDRIPT"
     exon            191..372
                     /gene="LRRC40"
                     /gene_synonym="dJ677H15.1"
                     /inference="alignment:Splign:2.1.0"
     exon            373..446
                     /gene="LRRC40"
                     /gene_synonym="dJ677H15.1"
                     /inference="alignment:Splign:2.1.0"
     exon            447..576
                     /gene="LRRC40"
                     /gene_synonym="dJ677H15.1"
                     /inference="alignment:Splign:2.1.0"
     exon            577..700
                     /gene="LRRC40"
                     /gene_synonym="dJ677H15.1"
                     /inference="alignment:Splign:2.1.0"
     exon            701..843
                     /gene="LRRC40"
                     /gene_synonym="dJ677H15.1"
                     /inference="alignment:Splign:2.1.0"
     exon            844..1016
                     /gene="LRRC40"
                     /gene_synonym="dJ677H15.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1104
                     /gene="LRRC40"
                     /gene_synonym="dJ677H15.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1150
                     /gene="LRRC40"
                     /gene_synonym="dJ677H15.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1259
                     /gene="LRRC40"
                     /gene_synonym="dJ677H15.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1367
                     /gene="LRRC40"
                     /gene_synonym="dJ677H15.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1478
                     /gene="LRRC40"
                     /gene_synonym="dJ677H15.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1556
                     /gene="LRRC40"
                     /gene_synonym="dJ677H15.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..1742
                     /gene="LRRC40"
                     /gene_synonym="dJ677H15.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1743..2843
                     /gene="LRRC40"
                     /gene_synonym="dJ677H15.1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2816..2821
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRC40"
                     /gene_synonym="dJ677H15.1"
                     /note="hexamer: AATAAA"
     polyA_site      2843
                     /gene="LRRC40"
                     /gene_synonym="dJ677H15.1"
                     /note="major polyA site"
ORIGIN      
        1 acgggtgggg ctgcagcttc tggacctagg actttgaaca tgtcgcgcct gaagcggata
       61 gcggggcagg atctccgcgc tggtttcaaa gcaggtggaa gagactgcgg tacctcggta
      121 ccccaagggc tgttgaaggc agcgaggaag agcggccagt taaacctgtc gggtagaaac
      181 ctcagtgaag tgccgcagtg tgtctggaga ataaatgtgg atatccctga ggaagctaat
      241 cagaatcttt cgtttggtgc tactgaaaga tggtgggagc agacagattt gaccaaacta
      301 ataatatcaa acaataaact tcagtcactt acagatgacc tgcgactctt gcctgcactg
      361 actgttcttg atatacatga taatcagttg acatcccttc cttctgctat aagagagcta
      421 gaaaatcttc agaaacttaa tgtcagccat aataaactga aaatactccc tgaagaaatt
      481 acaaacctaa gaaacctgaa gtgcctgtat ctccagcata atgaattaac ctgcatatca
      541 gagggatttg aacaactttc caatttagaa gatttagatc tttcaaacaa tcatcttaca
      601 actgttcctg ctagtttttc ttctctgtcc agtctggtgc gactcaatct ttctagtaat
      661 gaactgaaga gtttgccagc agaaataaat agaatgaaaa ggttgaagca tttggattgt
      721 aattcaaatc tcttggaaac tatacctcct gaattggctg gcatggaatc actagaattg
      781 ctttatttgc ggaggaataa attacgtttt ctaccagaat ttccttcttg tagtctattg
      841 aaggaattgc acgtaggtga aaaccagatt gaaatgttag aggcagaaca tcttaaacat
      901 ctgaattcaa ttcttgtgct agacctgagg gataacaagt taaaatctgt tccagatgaa
      961 attatactac tacggtcctt ggaaaggctt gacctaagca acaatgatat tagtagtctt
     1021 ccctattcat tggggaacct tcatttgaaa tttttggcat tagaaggaaa tcctttgaga
     1081 acaattcgaa gagaaattat aagtaaagga acacaagaag tcctaaaata tctacgaagc
     1141 aagatcaaag atgatggacc tagccaaagt gagtctgcta ctgagactgc catgacacta
     1201 ccaagtgaat ccagagtcaa tatacatgcc atcattacat taaaaatatt agactatagt
     1261 gataaacaag caactttgat tcctgatgag gtgtttgatg cagtaaaaag caacatcgtc
     1321 acttctatta acttcagtaa gaatcaacta tgtgaaattc caaaaaggat ggtagaactg
     1381 aaggaaatgg tttctgatgt cgatctcagt tttaataaac tttcctttat atccttggag
     1441 ttatgtgtgc ttcagaaatt gactttttta gatctcagga acaatttttt aaattctttg
     1501 ccagaagaaa tggaatcact ggtaagactg caaacgatca atctttcctt taataggttt
     1561 aaaatgctac ctgaagttct atatcgtatc ttcacacttg aaacaattct gattagtaat
     1621 aatcaggttg gatctgtgga ccctcagaaa atgaagatga tggaaaatct gaccacgttg
     1681 gaccttcaaa ataatgacct cttacaaatt ccaccagagc tcggtaattg tgtaaactta
     1741 agaacattac tactggatgg aaatccattc cgagttcctc gagcagccat attaatgaaa
     1801 ggaacagctg ctatacttga atatttgaga gaccgaattc ctacttaaca tggagttgct
     1861 ttataaccct tgtcatgtat tattaaccct ggttaattct aaggaggatg taacatttgt
     1921 tttagtatca tcttaaaagg tgattattgt aattgatctt gtagtttccc agtatcacct
     1981 acctgttggt ataattagcc tgggccatat tcactgccag taaatatttt tacattttta
     2041 tttaagattt ttgtaaggtg ttgtatacat ttgtaatggt gataaccaca atgtgttcat
     2101 acatttgttc taaatgtttt gcttatgatt tatcctgcta actttcattt tcttatagca
     2161 agcagttttt tcaaaaatga atttttattt aatgtggttc agtattataa taacaaagca
     2221 tttttgtaga actggttttt tttctcattt atttttgtat tccatacaat gtgaccaatt
     2281 gacttgaata tgactagcca gtttctatgt ttttgttaga tataaaatta aatcgaattt
     2341 tgttgaatac tgttctttgg catttaaaaa ataagacctt cttatcttgg gccacatgtc
     2401 aaaagaaaaa ggaaacaaaa atatattaaa aataagactt ttcattaccc atgataggac
     2461 ttttgtgata tggctaatct cagtacacat ttcaacttaa aaccttttta tttacagcac
     2521 cataatttta aaatttactt gcaatcttgg taagactaaa cttgcagtgt ttttctaaaa
     2581 gggaatttga taggtaaact tgatttaata aaaattaaat atcatttttg tttacaccaa
     2641 aattatcaga agtaggttga ttagtcatta taacacttac catatgattc tattaagaag
     2701 tcaattcagt agcatgtata tcaatttata tagataggta gatagctttt ggatgattga
     2761 ggcatgctta tattatgaaa aaaattgcta ataaagataa atactacatg ttcagaataa
     2821 aagttacatt tttcaaatat tga
//
