LOCUS       NM_001195545            1350 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens leucine rich repeat containing 3C (LRRC3C), mRNA.
ACCESSION   NM_001195545 XM_001126626 XM_001126648 XM_001720021 XM_003118734
            XM_011524158
VERSION     NM_001195545.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1350)
  AUTHORS   Soderman,J., Berglind,L. and Almer,S.
  TITLE     Gene Expression-Genotype Analysis Implicates GSDMA, GSDMB, and
            LRRC3C as Contributors to Inflammatory Bowel Disease Susceptibility
  JOURNAL   Biomed Res Int 2015, 834805 (2015)
   PUBMED   26484354
  REMARK    GeneRIF: Based on our results and published findings on GSDMA,
            GSDMB, LRRC3C, and related proteins, we propose that this locus in
            part affects IBD susceptibility via effects on apoptosis and cell
            proliferation
REFERENCE   2  (bases 1 to 1350)
  AUTHORS   Zody,M.C., Garber,M., Adams,D.J., Sharpe,T., Harrow,J.,
            Lupski,J.R., Nicholson,C., Searle,S.M., Wilming,L., Young,S.K.,
            Abouelleil,A., Allen,N.R., Bi,W., Bloom,T., Borowsky,M.L.,
            Bugalter,B.E., Butler,J., Chang,J.L., Chen,C.K., Cook,A., Corum,B.,
            Cuomo,C.A., de Jong,P.J., DeCaprio,D., Dewar,K., FitzGerald,M.,
            Gilbert,J., Gibson,R., Gnerre,S., Goldstein,S., Grafham,D.V.,
            Grocock,R., Hafez,N., Hagopian,D.S., Hart,E., Norman,C.H.,
            Humphray,S., Jaffe,D.B., Jones,M., Kamal,M., Khodiyar,V.K.,
            LaButti,K., Laird,G., Lehoczky,J., Liu,X., Lokyitsang,T.,
            Loveland,J., Lui,A., Macdonald,P., Major,J.E., Matthews,L.,
            Mauceli,E., McCarroll,S.A., Mihalev,A.H., Mudge,J., Nguyen,C.,
            Nicol,R., O'Leary,S.B., Osoegawa,K., Schwartz,D.C., Shaw-Smith,C.,
            Stankiewicz,P., Steward,C., Swarbreck,D., Venkataraman,V.,
            Whittaker,C.A., Yang,X., Zimmer,A.R., Bradley,A., Hubbard,T.,
            Birren,B.W., Rogers,J., Lander,E.S. and Nusbaum,C.
  TITLE     DNA sequence of human chromosome 17 and analysis of rearrangement
            in the human lineage
  JOURNAL   Nature 440 (7087), 1045-1049 (2006)
   PUBMED   16625196
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC090844.7.
            
            On or before Jul 31, 2020 this sequence version replaced
            XM_011524158.2, NM_001195545.1.
            
            ##Evidence-Data-START##
            CDS exon combination :: DY655553.1, DY655471.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA2158188 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377924.6/ ENSP00000367157.4
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 5' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-83                AC090844.7         97262-97344         c
            84-176              AC090844.7         89182-89274         c
            177-283             AC090844.7         83527-83633         c
            284-1350            AC090844.7         80077-81143         c
FEATURES             Location/Qualifiers
     source          1..1350
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.1"
     gene            1..1350
                     /gene="LRRC3C"
                     /note="leucine rich repeat containing 3C"
                     /db_xref="GeneID:100505591"
                     /db_xref="HGNC:HGNC:40034"
     exon            1..83
                     /gene="LRRC3C"
                     /inference="alignment:Splign:2.1.0"
     exon            84..176
                     /gene="LRRC3C"
                     /inference="alignment:Splign:2.1.0"
     exon            177..283
                     /gene="LRRC3C"
                     /inference="alignment:Splign:2.1.0"
     CDS             258..1085
                     /gene="LRRC3C"
                     /note="leucine-rich repeat-containing protein 3C; putative
                     LRRC3-like protein ENSP00000367157"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 3C
                     precursor"
                     /protein_id="NP_001182474.1"
                     /db_xref="CCDS:CCDS54121.1"
                     /db_xref="GeneID:100505591"
                     /db_xref="HGNC:HGNC:40034"
                     /translation="MRMTSSSFVSYCTPGLCQFMAMLPTAGHLLPLLLVIGTGGTVPS
                     PQVPPRGCYVAKEAGERTFRCSQAGLSAVPSGIPNDTRKLYLDANQLASVPAGAFQHL
                     PVLEELDLSHNALAHLSGAAFQGLEGTLRHLDLSANQLASVPVEAFVGLQIQVNLSAN
                     PWHCDCALQEVLRQVRLVPGTGTGIVCGSGARPDLVGQEFLLLAGEEELCGSGWGGAR
                     RSTDVALLVTMGGWLTLMVAYLVHYVWQNRDETRRSLKRAPVLPVRSEDSSILSTVV"
     exon            284..1350
                     /gene="LRRC3C"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggctccgtt cccggcctct tcggggacgc acggttggaa gttgtaccgt gacgtgatgg
       61 tcagatcgga tgatagaatt ttgggaacaa caatagcaga ggcctttgtt gccctctccg
      121 cgaaactgcc cagtaacctg gcattagacg ggtccctggc tgacctgata aagaagctct
      181 acaattccgt gtccagtcct ggtcacccat agtcttccaa aatccagcaa gaaaaatcct
      241 tctcagaaag gtctccaatg cgtatgacct catcttcctt cgtatcctac tgcactccag
      301 gactatgcca atttatggcc atgctcccaa cagcaggtca cctcctgccc ctcctgctgg
      361 tgataggcac agggggtact gtgcccagcc cccaggtgcc tccccggggc tgttatgtgg
      421 caaaggaagc aggtgaacgg acgttccgct gcagccaggc aggcctcagt gctgtgccct
      481 ccggcatccc caatgacacc cgcaagctct acctggatgc caaccagctg gcatcggtgc
      541 ctgctggtgc cttccagcac ctgcctgtcc tggaggagtt ggatctgtcc cataatgccc
      601 ttgcccacct ctcaggggcg gctttccagg gcctggaggg cacattgcgc cacctcgacc
      661 tctctgccaa ccagctggcc tcagtgcccg tggaggcctt tgtggggcta cagatccaag
      721 tgaacctatc cgcaaaccca tggcactgtg actgcgccct ccaggaagtg ctccggcagg
      781 tgaggctggt gccgggcact gggacaggca tcgtgtgtgg ctcaggagcc cgaccggacc
      841 tcgtggggca ggagttcctg ctgctggcag gggaggaaga gctgtgtggg tcggggtggg
      901 gtggggcccg gaggagcacc gatgtggccc tgctggtcac catggggggc tggctgacac
      961 tcatggtggc ttatctggtg cattatgtgt ggcagaaccg agatgagacc aggcgctccc
     1021 tcaagcgggc cccagtgctg cccgtgcgtt ccgaggactc ctccatcctc agcacagtgg
     1081 tctgatgacc caggatgctc ctccagccac accccacact cctgccccta tgccctctcc
     1141 tttgctctga ccccctctgc ctcctgtgca gcttcacccc tgcccccaag cccatcccac
     1201 ccctccctcc tttattcccc ctaaatacct gtgctggttc tctctctctc tctctgtgtc
     1261 gtcttaacca acaccatctt tggtgcctgg agttttttgg tgcctactct gtgcctggat
     1321 tgtgctagac tcagaaaacc cataacagag
//
