LOCUS       NM_001010847            2168 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens leucine rich repeat containing 38 (LRRC38), mRNA.
ACCESSION   NM_001010847 XM_001713942 XM_059074 XM_943661
VERSION     NM_001010847.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2168)
  AUTHORS   Li,Q., Fan,F., Kwak,H.R. and Yan,J.
  TITLE     Molecular basis for differential modulation of BK channel
            voltage-dependent gating by auxiliary gamma subunits
  JOURNAL   J Gen Physiol 145 (6), 543-554 (2015)
   PUBMED   26009545
  REMARK    GeneRIF: Suggest that BK channel modulation by auxiliary gamma
            subunits depends on intra- and/or juxta-membrane mechanisms.
REFERENCE   2  (bases 1 to 2168)
  AUTHORS   Yan,J. and Aldrich,R.W.
  TITLE     BK potassium channel modulation by leucine-rich repeat-containing
            proteins
  JOURNAL   Proc Natl Acad Sci U S A 109 (20), 7917-7922 (2012)
   PUBMED   22547800
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL354712.19, BC016048.1 and AC243961.3.
            
            On Nov 22, 2018 this sequence version replaced NM_001010847.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.615171.1, BC016048.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2144120
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376085.4/ ENSP00000365253.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-542               AL354712.19        30003-30544         c
            543-2164            BC016048.1         202-1823
            2165-2168           AC243961.3         36446-36449
FEATURES             Location/Qualifiers
     source          1..2168
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.21"
     gene            1..2168
                     /gene="LRRC38"
                     /note="leucine rich repeat containing 38"
                     /db_xref="GeneID:126755"
                     /db_xref="HGNC:HGNC:27005"
                     /db_xref="MIM:615212"
     exon            1..1041
                     /gene="LRRC38"
                     /inference="alignment:Splign:2.1.0"
     CDS             411..1295
                     /gene="LRRC38"
                     /note="leucine-rich repeat-containing protein 38; BK
                     channel auxilliary gamma subunit LRRC38; BK channel
                     auxiliary gamma subunit LRRC38"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 38
                     precursor"
                     /protein_id="NP_001010847.1"
                     /db_xref="CCDS:CCDS53269.1"
                     /db_xref="GeneID:126755"
                     /db_xref="HGNC:HGNC:27005"
                     /db_xref="MIM:615212"
                     /translation="MRPRAPACAAAALGLCSLLLLLAPGHACPAGCACTDPHTVDCRD
                     RGLPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSG
                     SAKLVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELN
                     DNNLRSLSVAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGLDEIQCS
                     LPMESRRISLRELSEASFSECRFSLSLTDLCIIIFSGVAVSIAAIISSFFLATVVQCL
                     QRCAPNKDAEDEDEDKDD"
     exon            1042..2168
                     /gene="LRRC38"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2143..2148
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRC38"
                     /note="hexamer: AATAAA"
     polyA_site      2168
                     /gene="LRRC38"
                     /note="major polyA site"
ORIGIN      
        1 agacgtcgag tgcagcccgc ccggtgcgcg cggcgtctta ctgccagatc tcggaaatca
       61 gctgccaggg tggggccgcg ttttggcgac ggccactcgg ccacccctgc cgctcccgcc
      121 tctcccaaga gatttttcta gcgggttaat ttcctgtccg ggtaaaccct ttggtgagtc
      181 cctcgcccct ccctccccgc ccctcccctc tccatccctg ctgtcccggc tccccagtcc
      241 gtccgcgccg cgctccatcg cccccgcacg cccgggcgca cgccctcccc gcccgggccg
      301 ccctctggct ccccgcgccc ggcagccagt gcctcaccgc gccgtcccgc gccagggctc
      361 gctccgagag ccgcttcctt ctcgccgcgg ccggcgcggg ccccccggcc atgcgccccc
      421 gagccccagc ctgcgccgcc gcggcgctcg ggctctgcag ccttctgctg ctgctcgcgc
      481 ccgggcacgc gtgccccgcg ggctgcgcct gcaccgaccc gcacaccgtg gactgccgcg
      541 accgcgggct gcccagcgtg ccagaccctt tccccctgga cgtgcgcaag ctgctggtgg
      601 ccggcaaccg catccagcgg atccccgagg acttcttcat cttctacggc gacctggtct
      661 acctggactt caggaacaac tcgctgcgct cgctggagga gggcacgttc agcggctcgg
      721 ccaagctcgt gttcctcgac ctcagctaca acaacttgac ccagctgggc gccggcgcct
      781 tccgctcggc cgggaggctg gtgaagctta gcctggctaa caacaacctg gtgggcgtgc
      841 acgaggacgc cttcgagacc ctggagtcgc tgcaggtgct ggagctcaac gacaacaacc
      901 tgcgcagcct cagcgtggcc gccctggccg cgctgcccgc gctgcgctcc ctgcgtctgg
      961 acgggaaccc ctggctgtgc gactgtgact tcgcccacct cttctcctgg atccaggaga
     1021 acgcatccaa actgcccaaa ggccttgatg aaatccagtg ctccctgccc atggagagca
     1081 ggaggatatc cctgcgtgag ctgtcggagg ccagcttcag cgagtgtagg ttcagcctgt
     1141 cactcacaga cctctgcatc atcattttct ccggtgtggc cgtgtccatt gcggccatca
     1201 tctccagctt cttcctggcc actgtggtgc agtgcctcca gaggtgcgca cccaacaaag
     1261 atgcggagga tgaagacgag gacaaggatg actgagccac ctcctccctc ctgcctctta
     1321 ctctccagca ccgaaccaga agctctctcc aagacgagag ggaaatgctg aaaatggaaa
     1381 agcactggcc accatctgtg aactgaacag agcctgttcc gtgtcttggc ccctgggtac
     1441 acctgctggg accactgatc tcagagttta gaatcagcag agcacagaag cccaggaagg
     1501 atggagggaa ttattcctgg agcataacct gcctctcaga tcgaggtgtg tgttggggga
     1561 gaagatgacc gagtcaggct tcatagctga tgactaaaag cctcccccag gaaatgtgaa
     1621 gactggcagc tttcaatggc aaagatgatt ttacgccatt ctttttctga cctgtactgg
     1681 gagatcatga aacatctgcc ttcctcccaa gaaacagcag ctcaaacagt ggagattcaa
     1741 attcggatca ttcaccacaa gaacgagaac tttgatcctt atataatagg cctcagcaac
     1801 cttgggatgt tatactggga actaataaac tcgtgtgcaa tagactcaat gtttatgttc
     1861 ccccagattt tatatgttga aacctaatcc ccaatgtgat ggtatttgga ggtggggctt
     1921 ttgggaggtg attaggttta gatcatatca tgaggatggg gcccaaatga tgggattagt
     1981 gccctcatga aaggtggccc cagagagctc cttcacccct tcaatgcttg aggatgcagc
     2041 aagaaatcag ctgcccatga accgagaagc aggccctcac cagaacccag ccatgctggc
     2101 acccagatct cagacttcca gcctccagaa ctgggagaaa taaataaatg tctgttgttt
     2161 gtaagcca
//
