LOCUS       NM_001321350            3697 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens leucine rich repeat containing 37B (LRRC37B),
            transcript variant 2, mRNA.
ACCESSION   NM_001321350 XM_011524268
VERSION     NM_001321350.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3697)
  AUTHORS   Libe-Philippot,B., Lejeune,A., Wierda,K., Louros,N., Erkol,E.,
            Vlaeminck,I., Beckers,S., Gaspariunaite,V., Bilheu,A.,
            Konstantoulea,K., Nyitrai,H., De Vleeschouwer,M., Vennekens,K.M.,
            Vidal,N., Bird,T.W., Soto,D.C., Jaspers,T., Dewilde,M.,
            Dennis,M.Y., Rousseau,F., Comoletti,D., Schymkowitz,J., Theys,T.,
            de Wit,J. and Vanderhaeghen,P.
  TITLE     LRRC37B is a human modifier of voltage-gated sodium channels and
            axon excitability in cortical neurons
  JOURNAL   Cell 186 (26), 5766-5783 (2023)
   PUBMED   38134874
  REMARK    GeneRIF: LRRC37B is a human modifier of voltage-gated sodium
            channels and axon excitability in cortical neurons.
REFERENCE   2  (bases 1 to 3697)
  AUTHORS   Giannuzzi,G., Siswara,P., Malig,M., Marques-Bonet,T.,
            Mullikin,J.C., Ventura,M. and Eichler,E.E.
  CONSRTM   NISC Comparative Sequencing Program
  TITLE     Evolutionary dynamism of the primate LRRC37 gene family
  JOURNAL   Genome Res 23 (1), 46-59 (2013)
   PUBMED   23064749
REFERENCE   3  (bases 1 to 3697)
  AUTHORS   Lango Allen,H., Estrada,K., Lettre,G., Berndt,S.I., Weedon,M.N.,
            Rivadeneira,F., Willer,C.J., Jackson,A.U., Vedantam,S.,
            Raychaudhuri,S., Ferreira,T., Wood,A.R., Weyant,R.J., Segre,A.V.,
            Speliotes,E.K., Wheeler,E., Soranzo,N., Park,J.H., Yang,J.,
            Gudbjartsson,D., Heard-Costa,N.L., Randall,J.C., Qi,L., Vernon
            Smith,A., Magi,R., Pastinen,T., Liang,L., Heid,I.M., Luan,J.,
            Thorleifsson,G., Winkler,T.W., Goddard,M.E., Sin Lo,K., Palmer,C.,
            Workalemahu,T., Aulchenko,Y.S., Johansson,A., Zillikens,M.C.,
            Feitosa,M.F., Esko,T., Johnson,T., Ketkar,S., Kraft,P., Mangino,M.,
            Prokopenko,I., Absher,D., Albrecht,E., Ernst,F., Glazer,N.L.,
            Hayward,C., Hottenga,J.J., Jacobs,K.B., Knowles,J.W., Kutalik,Z.,
            Monda,K.L., Polasek,O., Preuss,M., Rayner,N.W., Robertson,N.R.,
            Steinthorsdottir,V., Tyrer,J.P., Voight,B.F., Wiklund,F., Xu,J.,
            Zhao,J.H., Nyholt,D.R., Pellikka,N., Perola,M., Perry,J.R.,
            Surakka,I., Tammesoo,M.L., Altmaier,E.L., Amin,N., Aspelund,T.,
            Bhangale,T., Boucher,G., Chasman,D.I., Chen,C., Coin,L.,
            Cooper,M.N., Dixon,A.L., Gibson,Q., Grundberg,E., Hao,K., Juhani
            Junttila,M., Kaplan,L.M., Kettunen,J., Konig,I.R., Kwan,T.,
            Lawrence,R.W., Levinson,D.F., Lorentzon,M., McKnight,B.,
            Morris,A.P., Muller,M., Suh Ngwa,J., Purcell,S., Rafelt,S.,
            Salem,R.M., Salvi,E., Sanna,S., Shi,J., Sovio,U., Thompson,J.R.,
            Turchin,M.C., Vandenput,L., Verlaan,D.J., Vitart,V., White,C.C.,
            Ziegler,A., Almgren,P., Balmforth,A.J., Campbell,H., Citterio,L.,
            De Grandi,A., Dominiczak,A., Duan,J., Elliott,P., Elosua,R.,
            Eriksson,J.G., Freimer,N.B., Geus,E.J., Glorioso,N., Haiqing,S.,
            Hartikainen,A.L., Havulinna,A.S., Hicks,A.A., Hui,J., Igl,W.,
            Illig,T., Jula,A., Kajantie,E., Kilpelainen,T.O., Koiranen,M.,
            Kolcic,I., Koskinen,S., Kovacs,P., Laitinen,J., Liu,J., Lokki,M.L.,
            Marusic,A., Maschio,A., Meitinger,T., Mulas,A., Pare,G.,
            Parker,A.N., Peden,J.F., Petersmann,A., Pichler,I.,
            Pietilainen,K.H., Pouta,A., Ridderstrale,M., Rotter,J.I.,
            Sambrook,J.G., Sanders,A.R., Schmidt,C.O., Sinisalo,J., Smit,J.H.,
            Stringham,H.M., Bragi Walters,G., Widen,E., Wild,S.H.,
            Willemsen,G., Zagato,L., Zgaga,L., Zitting,P., Alavere,H.,
            Farrall,M., McArdle,W.L., Nelis,M., Peters,M.J., Ripatti,S., van
            Meurs,J.B., Aben,K.K., Ardlie,K.G., Beckmann,J.S., Beilby,J.P.,
            Bergman,R.N., Bergmann,S., Collins,F.S., Cusi,D., den Heijer,M.,
            Eiriksdottir,G., Gejman,P.V., Hall,A.S., Hamsten,A., Huikuri,H.V.,
            Iribarren,C., Kahonen,M., Kaprio,J., Kathiresan,S., Kiemeney,L.,
            Kocher,T., Launer,L.J., Lehtimaki,T., Melander,O., Mosley,T.H. Jr.,
            Musk,A.W., Nieminen,M.S., O'Donnell,C.J., Ohlsson,C., Oostra,B.,
            Palmer,L.J., Raitakari,O., Ridker,P.M., Rioux,J.D., Rissanen,A.,
            Rivolta,C., Schunkert,H., Shuldiner,A.R., Siscovick,D.S.,
            Stumvoll,M., Tonjes,A., Tuomilehto,J., van Ommen,G.J., Viikari,J.,
            Heath,A.C., Martin,N.G., Montgomery,G.W., Province,M.A., Kayser,M.,
            Arnold,A.M., Atwood,L.D., Boerwinkle,E., Chanock,S.J., Deloukas,P.,
            Gieger,C., Gronberg,H., Hall,P., Hattersley,A.T., Hengstenberg,C.,
            Hoffman,W., Lathrop,G.M., Salomaa,V., Schreiber,S., Uda,M.,
            Waterworth,D., Wright,A.F., Assimes,T.L., Barroso,I., Hofman,A.,
            Mohlke,K.L., Boomsma,D.I., Caulfield,M.J., Cupples,L.A.,
            Erdmann,J., Fox,C.S., Gudnason,V., Gyllensten,U., Harris,T.B.,
            Hayes,R.B., Jarvelin,M.R., Mooser,V., Munroe,P.B., Ouwehand,W.H.,
            Penninx,B.W., Pramstaller,P.P., Quertermous,T., Rudan,I.,
            Samani,N.J., Spector,T.D., Volzke,H., Watkins,H., Wilson,J.F.,
            Groop,L.C., Haritunians,T., Hu,F.B., Kaplan,R.C., Metspalu,A.,
            North,K.E., Schlessinger,D., Wareham,N.J., Hunter,D.J.,
            O'Connell,J.R., Strachan,D.P., Wichmann,H.E., Borecki,I.B., van
            Duijn,C.M., Schadt,E.E., Thorsteinsdottir,U., Peltonen,L.,
            Uitterlinden,A.G., Visscher,P.M., Chatterjee,N., Loos,R.J.,
            Boehnke,M., McCarthy,M.I., Ingelsson,E., Lindgren,C.M.,
            Abecasis,G.R., Stefansson,K., Frayling,T.M. and Hirschhorn,J.N.
  TITLE     Hundreds of variants clustered in genomic loci and biological
            pathways affect human height
  JOURNAL   Nature 467 (7317), 832-838 (2010)
   PUBMED   20881960
REFERENCE   4  (bases 1 to 3697)
  AUTHORS   Visser,R., Koelma,N., Vijfhuizen,L., van der Wielen,M.J.,
            Kant,S.G., Breuning,M.H., Wit,J.M. and Losekoot,M.
  TITLE     RNF135 mutations are not present in patients with Sotos
            syndrome-like features
  JOURNAL   Am J Med Genet A 149A (4), 806-808 (2009)
   PUBMED   19291764
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 3697)
  AUTHORS   Douglas,J., Cilliers,D., Coleman,K., Tatton-Brown,K., Barker,K.,
            Bernhard,B., Burn,J., Huson,S., Josifova,D., Lacombe,D., Malik,M.,
            Mansour,S., Reid,E., Cormier-Daire,V., Cole,T. and Rahman,N.
  CONSRTM   Childhood Overgrowth Collaboration
  TITLE     Mutations in RNF135, a gene within the NF1 microdeletion region,
            cause phenotypic abnormalities including overgrowth
  JOURNAL   Nat Genet 39 (8), 963-965 (2007)
   PUBMED   17632510
REFERENCE   6  (bases 1 to 3697)
  AUTHORS   Zody,M.C., Garber,M., Adams,D.J., Sharpe,T., Harrow,J.,
            Lupski,J.R., Nicholson,C., Searle,S.M., Wilming,L., Young,S.K.,
            Abouelleil,A., Allen,N.R., Bi,W., Bloom,T., Borowsky,M.L.,
            Bugalter,B.E., Butler,J., Chang,J.L., Chen,C.K., Cook,A., Corum,B.,
            Cuomo,C.A., de Jong,P.J., DeCaprio,D., Dewar,K., FitzGerald,M.,
            Gilbert,J., Gibson,R., Gnerre,S., Goldstein,S., Grafham,D.V.,
            Grocock,R., Hafez,N., Hagopian,D.S., Hart,E., Norman,C.H.,
            Humphray,S., Jaffe,D.B., Jones,M., Kamal,M., Khodiyar,V.K.,
            LaButti,K., Laird,G., Lehoczky,J., Liu,X., Lokyitsang,T.,
            Loveland,J., Lui,A., Macdonald,P., Major,J.E., Matthews,L.,
            Mauceli,E., McCarroll,S.A., Mihalev,A.H., Mudge,J., Nguyen,C.,
            Nicol,R., O'Leary,S.B., Osoegawa,K., Schwartz,D.C., Shaw-Smith,C.,
            Stankiewicz,P., Steward,C., Swarbreck,D., Venkataraman,V.,
            Whittaker,C.A., Yang,X., Zimmer,A.R., Bradley,A., Hubbard,T.,
            Birren,B.W., Rogers,J., Lander,E.S. and Nusbaum,C.
  TITLE     DNA sequence of human chromosome 17 and analysis of rearrangement
            in the human lineage
  JOURNAL   Nature 440 (7087), 1045-1049 (2006)
   PUBMED   16625196
REFERENCE   7  (bases 1 to 3697)
  AUTHORS   Forbes,S.H., Dorschner,M.O., Le,R. and Stephens,K.
  TITLE     Genomic context of paralogous recombination hotspots mediating
            recurrent NF1 region microdeletion
  JOURNAL   Genes Chromosomes Cancer 41 (1), 12-25 (2004)
   PUBMED   15236313
REFERENCE   8  (bases 1 to 3697)
  AUTHORS   Jenne,D.E., Tinschert,S., Reimann,H., Lasinger,W., Thiel,G.,
            Hameister,H. and Kehrer-Sawatzki,H.
  TITLE     Molecular characterization and gene content of breakpoint
            boundaries in patients with neurofibromatosis type 1 with 17q11.2
            microdeletions
  JOURNAL   Am J Hum Genet 69 (3), 516-527 (2001)
   PUBMED   11468690
REFERENCE   9  (bases 1 to 3697)
  AUTHORS   Jenne,D.E., Tinschert,S., Stegmann,E., Reimann,H., Nurnberg,P.,
            Horn,D., Naumann,I., Buske,A. and Thiel,G.
  TITLE     A common set of at least 11 functional genes is lost in the
            majority of NF1 patients with gross deletions
  JOURNAL   Genomics 66 (1), 93-97 (2000)
   PUBMED   10843809
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC090616.13, DB475546.2, AK299772.1 and AK302740.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001321350.1.
            
            Transcript Variant: This variant (2) represents use of an upstream
            promoter, differs in the 5' UTR, lacks a portion of the 5' coding
            region, and initiates translation at a downstream start codon
            compared to variant 1. The encoded isoform (2) lacks a predicted
            signal peptide compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK299772.1, SRR1803612.162222.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000543378.7/ ENSP00000443345.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-489               AC090616.13        56813-57301
            490-635             DB475546.2         1-146
            636-1186            AK299772.1         1-551
            1187-3697           AK302740.1         635-3145
FEATURES             Location/Qualifiers
     source          1..3697
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q11.2"
     gene            1..3697
                     /gene="LRRC37B"
                     /gene_synonym="LRRC37"
                     /note="leucine rich repeat containing 37B"
                     /db_xref="GeneID:114659"
                     /db_xref="HGNC:HGNC:29070"
                     /db_xref="MIM:616558"
     exon            1..750
                     /gene="LRRC37B"
                     /gene_synonym="LRRC37"
                     /inference="alignment:Splign:2.1.0"
     exon            751..833
                     /gene="LRRC37B"
                     /gene_synonym="LRRC37"
                     /inference="alignment:Splign:2.1.0"
     exon            834..940
                     /gene="LRRC37B"
                     /gene_synonym="LRRC37"
                     /inference="alignment:Splign:2.1.0"
     CDS             941..3538
                     /gene="LRRC37B"
                     /gene_synonym="LRRC37"
                     /note="isoform 2 is encoded by transcript variant 2;
                     leucine-rich repeat-containing protein 37B; C66 SLIT-like
                     testicular protein"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 37B
                     isoform 2"
                     /protein_id="NP_001308279.1"
                     /db_xref="CCDS:CCDS82102.1"
                     /db_xref="GeneID:114659"
                     /db_xref="HGNC:HGNC:29070"
                     /db_xref="MIM:616558"
                     /translation="MSALPQEPTENLAPFLKELDSAGELPLGPEPFLAAHQDLNDKRT
                     PEERLPEVVPLLNRDQNQALVQLPRLKWVQTTDLDRAAGHQADEILVPLDSKVSRPTK
                     FVVSPKNLKKDLAERWSLPEIVGIPHQLSKPQRQKQTLPDDYLSMDTLYPGSLPPELR
                     VNADEPPGPPEQVGLSQFHLEPKSQNPETLEDIQSSSLQEEAPAQLLQLPQEVEPSTQ
                     QEAPALPPESSMESLAQTPLNHEVTVQPPGEDQAHYNLPKFTVKPADVEVTMTSEPKN
                     ETESTQAQQEAPIQPPEEAEPSSTALRTTDPPPEHPEVTLPPSDKGQAQHSHLTEATV
                     QPLDLELSITTEPTTEVKPSPTTEETSAQPPDPGLAITPEPTTEIGHSTALEKTRAPH
                     PDQVQTLHRSLTEVTGPPTKLESSQDSLVQSETAPEEQKASTSTNICELCTCGDETLS
                     CVGLSPKQRLRQVPVPEPDTYNGIFTTLNFQGNYISYLDGNVWKAYSWTEKLILSENY
                     LTELPKDSFEGLLYLQYLDLSCNKIRYIERQTFESLPFLQYINLGCNLITKLSLGTFQ
                     AWHGMQFLHNLILNRNPLTTVEDPYLFELPALKYLDMGTTHITLTTLKNILTMTVELE
                     KLILPSHMACCLCQFKNSIEAVCKTVKLHCNTACLTNSIHCPEEASVGNPEGAFMKML
                     QARKQHMSTQLTIESEAPSDSSGINLSGFGGDQLEIQLTEQLRSLIPNEDVRKFMSHV
                     IRTLKMECSETHVQGSCAKLMLRTGLLMKLLSEQQEAKALNVEWDTDQQKTNYINENM
                     EQNEQKEQKSSELMKEVPGDDYKNKLIFAISVTVILIILIIIFCLIEVNSHKRASEKY
                     KDNPSISGA"
     exon            941..2373
                     /gene="LRRC37B"
                     /gene_synonym="LRRC37"
                     /inference="alignment:Splign:2.1.0"
     exon            2374..2445
                     /gene="LRRC37B"
                     /gene_synonym="LRRC37"
                     /inference="alignment:Splign:2.1.0"
     exon            2446..2517
                     /gene="LRRC37B"
                     /gene_synonym="LRRC37"
                     /inference="alignment:Splign:2.1.0"
     exon            2518..2589
                     /gene="LRRC37B"
                     /gene_synonym="LRRC37"
                     /inference="alignment:Splign:2.1.0"
     exon            2590..2670
                     /gene="LRRC37B"
                     /gene_synonym="LRRC37"
                     /inference="alignment:Splign:2.1.0"
     exon            2671..2742
                     /gene="LRRC37B"
                     /gene_synonym="LRRC37"
                     /inference="alignment:Splign:2.1.0"
     exon            2743..2817
                     /gene="LRRC37B"
                     /gene_synonym="LRRC37"
                     /inference="alignment:Splign:2.1.0"
     exon            2818..2936
                     /gene="LRRC37B"
                     /gene_synonym="LRRC37"
                     /inference="alignment:Splign:2.1.0"
     exon            2937..3077
                     /gene="LRRC37B"
                     /gene_synonym="LRRC37"
                     /inference="alignment:Splign:2.1.0"
     exon            3078..3370
                     /gene="LRRC37B"
                     /gene_synonym="LRRC37"
                     /inference="alignment:Splign:2.1.0"
     exon            3371..3475
                     /gene="LRRC37B"
                     /gene_synonym="LRRC37"
                     /inference="alignment:Splign:2.1.0"
     exon            3476..3697
                     /gene="LRRC37B"
                     /gene_synonym="LRRC37"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3589..3594
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRC37B"
                     /gene_synonym="LRRC37"
                     /note="hexamer: ATTAAA"
     polyA_site      3613
                     /gene="LRRC37B"
                     /gene_synonym="LRRC37"
                     /note="major polyA site"
     regulatory      3679..3684
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRC37B"
                     /gene_synonym="LRRC37"
                     /note="hexamer: AATAAA"
     polyA_site      3697
                     /gene="LRRC37B"
                     /gene_synonym="LRRC37"
                     /note="major polyA site"
ORIGIN      
        1 gaccgcgctc ctgtagaggg aagaaacaag gtggcggttg aaggcgatct tgagtggggc
       61 cccagcaatt cggttgagcc ttctccctcc actcgcttcc gccggccggg cccctcccgc
      121 ccagcccctc gggcctccca acccggcccc ggcgctcccc accgccgcca ctgcgcccgg
      181 ccctccccgt cagctttccc ttctcccgcc gcctgggctc caacaagagg ggccggcggg
      241 gcaggccgac caagcagccc gcggctcccg ctgcggagcg ctgcgccccg gccccgccgc
      301 cgccgccgcc cacgtccgga cccatcgggg gctcccctcg ccgatacgcg gtagtagccg
      361 gggcaggtgg gcagccgcca ggctgaggtg gcgcccaaga cgcggctgag ctcgcccagg
      421 gtgggcagca gtagccggag gaagccaccg ccgccggccc gccccgcgcc ggcaccagcg
      481 cacgggcccg gcgggggcgc gggggcagcc acctagcccg gaccaccgca gcccggaggg
      541 ctgtcaacag agtggtgtat gatgactacg agagcgagga ggaggagtaa gaggaggggg
      601 gcggcgatgc cgaggagacc caggagtctg aggacaacta ggaggatgac atggaggagg
      661 acgacgatga ctccgattat ccggaggagc tggaagatga cgacgaggac gccagttact
      721 ccacggaaag cagcttcagc agcactccag aaagtggtaa aatagctgtg gagtgcagac
      781 ccagtgaaga gattgtagat gtcagatggg aagaactaca cagtttaatt caagtcagtt
      841 gctctcccct gaaggaagag tattctcgga tttcacctca gaggaggaag aattcaggct
      901 gccagaactg gactagcact tctgaagatc ccaaggccag atgtcagccc tgcctcagga
      961 accaactgaa aatttggctc cattcctgaa ggaattggat tcagctggag agctgcccct
     1021 ggggccagag ccgttcttgg ctgcacatca ggacttaaat gacaagcgga ctccagaaga
     1081 aaggctccca gaggtggttc cgcttctcaa ccgggatcag aaccaggccc tagttcagct
     1141 tcctcgcctc aagtgggttc aaactacaga tctagatcgg gctgcaggtc atcaggcaga
     1201 tgaaatactt gttccactag acagtaaggt ttcaagacca accaaatttg ttgtttcgcc
     1261 caagaacctg aagaaagatc tagctgaacg ttggagcctt cctgagattg ttgggattcc
     1321 acaccaatta tccaaacctc agcgtcagaa acagactttg ccagatgatt atttgagtat
     1381 ggacacactg tatcccggca gcctacctcc agaactccgg gtgaacgcag atgagcctcc
     1441 agggcctcct gagcaagttg gactttctca attccatcta gagcccaaaa gtcaaaatcc
     1501 agagaccctt gaagacatcc agtcctcttc actccaggaa gaagccccag cgcagcttct
     1561 acagctccct caggaggtag aaccttcaac ccagcaggag gccccagctc tgcctccaga
     1621 gtcctctatg gagagtctag ctcaaactcc actgaatcat gaagtgacag ttcaacctcc
     1681 aggtgaggat caagctcatt ataatttgcc caagtttaca gtcaaacctg cagatgtgga
     1741 ggttaccatg acttcagagc ctaaaaatga gacagaatct acccaagccc agcaggaggc
     1801 cccaattcag cctcccgagg aggcggaacc ttcttctaca gccctgagga ctacagatcc
     1861 tcctccagaa caccctgagg tgacacttcc accttcagac aagggtcagg ctcagcattc
     1921 acacctgact gaagccacag ttcaacctct ggacctggag cttagcataa ctacagagcc
     1981 tactacagag gttaaaccgt ctccaaccac ggaggaaacc tcagctcagc ctccagaccc
     2041 ggggcttgcc ataactccag aacccactac agagattgga cattccacag ccctggagaa
     2101 gactagagct cctcatccag accaggttca gactctgcat cgaagcctga ctgaagtcac
     2161 aggtccacct acaaagttag aatcttcgca ggattcattg gtgcagtctg aaactgcacc
     2221 agaggaacag aaggcctcca caagcaccaa catatgtgag ctctgcacct gcggagatga
     2281 gactctgtca tgtgttggtc tcagcccaaa gcagaggctc cgccaagtgc ctgtgccaga
     2341 gcccgacacc tacaatggca tcttcaccac cttaaatttc caaggaaact atatttcata
     2401 ccttgatgga aatgtatgga aagcatacag ttggaccgag aaactaattc tcagtgaaaa
     2461 ttatttgact gaattaccta aggattcatt tgaaggcctg ctatacctcc agtatttaga
     2521 tttatcctgc aataaaatac gatatattga aagacaaaca tttgaatcac taccattttt
     2581 gcagtatata aatctgggct gcaatttaat tacaaaactg agccttggaa catttcaggc
     2641 ctggcacgga atgcagtttt tacacaactt aattctcaat cgcaatcctc tgactactgt
     2701 cgaagatcca tatctctttg aactgccggc attaaaatat ctagacatgg gaacaacaca
     2761 catcacactt acaacactta agaacattct cacgatgact gttgaactgg aaaaactgat
     2821 cttacctagc catatggcct gctgcctctg ccaatttaaa aatagcattg aggctgtctg
     2881 caagacagtc aagctgcatt gcaacactgc atgtctgact aacagcatac attgtcctga
     2941 agaagcatct gtagggaatc cagaaggagc gttcatgaag atgttacaag cccggaagca
     3001 gcacatgagc actcagctga ctattgagtc ggaggcgccc tcagacagca gtggcatcaa
     3061 cttgtcaggc tttgggggtg atcagcttga aattcagcta accgagcagc tacggtccct
     3121 catccccaac gaggatgtga gaaagttcat gtctcatgtt atccggacct tgaaaatgga
     3181 atgttcagaa acacatgtgc aagggagctg tgccaagctc atgttgcgaa caggcctcct
     3241 gatgaagctt ctcagcgagc agcaggaagc aaaggcattg aatgtagaat gggatacgga
     3301 ccaacaaaaa acaaattata ttaatgagaa catggaacag aatgaacaga aagagcagaa
     3361 gtcaagtgag ctcatgaaag aagttccagg agatgactat aagaacaaac tcatcttcgc
     3421 aatatctgtg actgtaatac taataatttt gattataatt ttttgtctta tagaggtgaa
     3481 ttcacataaa agggcatcag aaaaatacaa agacaaccca tcaatatcag gagcctgagc
     3541 atgagttaaa gcatgtggat ggcctggagc tatgttttta aaattgttat taaatattgg
     3601 ttttttactt aaatcaatga aaactttctt tactttgtgg ttgtgttcct caaaatgaga
     3661 atttttaaca ataataaaaa taaagcttgt tagatca
//
