LOCUS       NM_199340               6038 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens leucine rich repeat containing 37 member A3
            (LRRC37A3), transcript variant 1, mRNA.
ACCESSION   NM_199340 XM_351141
VERSION     NM_199340.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6038)
  AUTHORS   Giannuzzi,G., Siswara,P., Malig,M., Marques-Bonet,T.,
            Mullikin,J.C., Ventura,M. and Eichler,E.E.
  CONSRTM   NISC Comparative Sequencing Program
  TITLE     Evolutionary dynamism of the primate LRRC37 gene family
  JOURNAL   Genome Res 23 (1), 46-59 (2013)
   PUBMED   23064749
REFERENCE   2  (bases 1 to 6038)
  AUTHORS   Bekpen,C., Tastekin,I., Siswara,P., Akdis,C.A. and Eichler,E.E.
  TITLE     Primate segmental duplication creates novel promoters for the
            LRRC37 gene family within the 17q21.31 inversion polymorphism
            region
  JOURNAL   Genome Res 22 (6), 1050-1058 (2012)
   PUBMED   22419166
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI560889.1, AK294371.1, AB011135.2, AK315945.1 and AC103810.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 14, 2020 this sequence version replaced NM_199340.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.1407045.1,
                                           SRR14038193.4224004.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000584306.6/ ENSP00000464535.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                BI560889.1         9-18
            11-133              AK294371.1         1-123
            134-4626            AB011135.2         1-4493
            4627-5806           AK315945.1         2101-3280
            5807-5856           AK294371.1         2540-2589
            5857-6038           AC103810.5         90637-90818
FEATURES             Location/Qualifiers
     source          1..6038
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q24.1"
     gene            1..6038
                     /gene="LRRC37A3"
                     /gene_synonym="LRRC37; LRRC37A"
                     /note="leucine rich repeat containing 37 member A3"
                     /db_xref="GeneID:374819"
                     /db_xref="HGNC:HGNC:32427"
                     /db_xref="MIM:616557"
     exon            1..48
                     /gene="LRRC37A3"
                     /gene_synonym="LRRC37; LRRC37A"
                     /inference="alignment:Splign:2.1.0"
     exon            49..169
                     /gene="LRRC37A3"
                     /gene_synonym="LRRC37; LRRC37A"
                     /inference="alignment:Splign:2.1.0"
     exon            170..267
                     /gene="LRRC37A3"
                     /gene_synonym="LRRC37; LRRC37A"
                     /inference="alignment:Splign:2.1.0"
     exon            268..3273
                     /gene="LRRC37A3"
                     /gene_synonym="LRRC37; LRRC37A"
                     /inference="alignment:Splign:2.1.0"
     CDS             665..5569
                     /gene="LRRC37A3"
                     /gene_synonym="LRRC37; LRRC37A"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; leucine-rich repeat-containing protein 37A3"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 37A3
                     isoform 1 precursor"
                     /protein_id="NP_955372.2"
                     /db_xref="CCDS:CCDS32708.1"
                     /db_xref="GeneID:374819"
                     /db_xref="HGNC:HGNC:32427"
                     /db_xref="MIM:616557"
                     /translation="MTSAQCPALACVMSPLRFWGPWPLLMWQLLWLLVKEAQPLEWVK
                     DPLQLTSNPLGPPEPWSSHSSHFPRESPHAPTLPADPWDFDHLGPSASSEMPAPPQES
                     TENLVPFLDTWDSAGELPLEPEQFLASQQDLKDKLSPQERLPVSPKKLKKDPAQRWSL
                     AEIIGIIHQLSTPQSQKQTLQNEYSSTDTPYPGSLPPELRVKSDEPPGPSEQVGPSQF
                     HLEPETQNPETLEDIQSSSLQQEAPAQLPQLLEEEPSSMQQEAPALPPESSMESLTLP
                     NHEVSVQPPGEDQAYYHLPNITVKPADVEVTITSEPTNETESSQAQQETPIQFPEEVE
                     PSATQQEAPIEPPVPPMEHELSISEQQQPVQPSESSREVESSPTQQETPGQPPEHHEV
                     TVSPPGHHQTHHLASPSVSVKPPDVQLTIAAEPSAEVGTSLVHQEATTRLSGSGNDVE
                     PPAIQHGGPPLLPESSEEAGPLAVQQETSFQSPEPINNENPSPTQQEAAAEHPQTAEE
                     GESSLTHQEAPAQTPEFPNVVVAQPPEHSHLTQATVQPLDLGFTITPESMTEVELSPT
                     MKETPTQPPKKVVPQLRVYQGVTNPTPGQDQAQHPVSPSVTVQLLDLGLTITPEPTTE
                     VGHSTPPKRTIVSPKHPEVTLPHPDQVQTQHSHLTRATVQPLDLGFTITPKSMTEVEP
                     STALMTTAPPPGHPEVTLPPSDKGQAQHSHLTQATVQPLDLELTITTKPTTEVKPSPT
                     TEETSTQLPDLGLAIIPEPTTETGHSTALEKTTAPRPDRVQTLHRSLTEVTGPPTELE
                     PAQDSLVQSESYTQNKALTAPEEHKASTSTNICELCTCGDEMLSCIDLNPEQRLRQVP
                     VPEPNTHNGTFTILNFQGNYISYIDGNVWKAYSWTEKLILRENNLTELHKDSFEGLLS
                     LQYLDLSCNKIQSIERHTFEPLPFLKFINLSCNVITELSFGTFQAWHGMQFLHKLILN
                     HNPLTTVEDPYLFKLPALKYLDMGTTLVPLTTLKNILMMTVELEKLIVPSHMACCLCQ
                     FKNSIEAVCKTVKLHCNSACLTNTTHCPEEASVGNPEGAFMKVLQARKNYTSTELIIE
                     PEEPSDSSGINLSGFGSEQLDTNDESDVTSTLSYILPYFSAVNLDVKSLLLPFIKLPT
                     TGNSLAKIQTVGKNRQRLNRVLMGPRSIQKRHFKEVGRQSIRREQGAQASVENTAEEK
                     RLGSPAPRELKQPHTQQGPEKLAGNAVYTKPSFTQEHKAAVSVLKPFSKGAPSTSSPA
                     KALPQVRDRWKDLTHAISILESAKARVTNMKTSKPIVHSRKKYRFHKTRSRMTHRTPK
                     VKKSPKVRKKSYLSRLMLSNRLPFSAAKSLINSPSQGAFSSLRDLSPQENPFLEVSAP
                     SEHFIENNNTKDTTARNAFEENVFMENTNMPEGTISENTNYNHPPEADSAGTAFNLGP
                     TVKQTETKWEYNNVGTDLSPEPKSFNYPLLSSPGDQFEIQLTQQLQSVIPNNNVRRLI
                     AHVIRTLKMDCSGAHVQVTCAKLVSRTGHLMKLLSGQQEVKASKIEWDTDQWKTENYI
                     NESTEAQSEQKEKSLEFTKELPGYGYTKKLILALIVTGILTILIILLCLIEICCHRRS
                     LQEDEEGFSRDSEAPTEEESEALP"
     exon            3274..3345
                     /gene="LRRC37A3"
                     /gene_synonym="LRRC37; LRRC37A"
                     /inference="alignment:Splign:2.1.0"
     exon            3346..3417
                     /gene="LRRC37A3"
                     /gene_synonym="LRRC37; LRRC37A"
                     /inference="alignment:Splign:2.1.0"
     exon            3418..3489
                     /gene="LRRC37A3"
                     /gene_synonym="LRRC37; LRRC37A"
                     /inference="alignment:Splign:2.1.0"
     exon            3490..3570
                     /gene="LRRC37A3"
                     /gene_synonym="LRRC37; LRRC37A"
                     /inference="alignment:Splign:2.1.0"
     exon            3571..3642
                     /gene="LRRC37A3"
                     /gene_synonym="LRRC37; LRRC37A"
                     /inference="alignment:Splign:2.1.0"
     exon            3643..3717
                     /gene="LRRC37A3"
                     /gene_synonym="LRRC37; LRRC37A"
                     /inference="alignment:Splign:2.1.0"
     exon            3718..3836
                     /gene="LRRC37A3"
                     /gene_synonym="LRRC37; LRRC37A"
                     /inference="alignment:Splign:2.1.0"
     exon            3837..5368
                     /gene="LRRC37A3"
                     /gene_synonym="LRRC37; LRRC37A"
                     /inference="alignment:Splign:2.1.0"
     exon            5369..5473
                     /gene="LRRC37A3"
                     /gene_synonym="LRRC37; LRRC37A"
                     /inference="alignment:Splign:2.1.0"
     exon            5474..5523
                     /gene="LRRC37A3"
                     /gene_synonym="LRRC37; LRRC37A"
                     /inference="alignment:Splign:2.1.0"
     exon            5524..6038
                     /gene="LRRC37A3"
                     /gene_synonym="LRRC37; LRRC37A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5777..5782
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRC37A3"
                     /gene_synonym="LRRC37; LRRC37A"
                     /note="hexamer: ATTAAA"
     polyA_site      5804
                     /gene="LRRC37A3"
                     /gene_synonym="LRRC37; LRRC37A"
                     /note="major polyA site"
     polyA_site      6038
                     /gene="LRRC37A3"
                     /gene_synonym="LRRC37; LRRC37A"
ORIGIN      
        1 gcgctccggt aacggaagaa acaagatggc ggctgaaggc gatccgcata gagatggagt
       61 ttcaccgtgt tgcccaggct ggtgtcgaac tcctgagctc aggcgatccg cccgcctcag
      121 cttcccaaag tgttgggatt ataggcgtga gccactgcac ctggcacagg ctgaagtgca
      181 atgttgtgat ctcggctcac tgcaacctct gcctcccagg ttcaagcgat tctcctgctt
      241 tggcctcctg agtagctggg attgcaggtc agttgctctc cctggaagga agagtgttct
      301 cggatttcac cttaaaggag gaaggctgcc agaactgaac tagcacttct gaatatcctg
      361 aggcgaggtc cggtgacttc cttgggaagc tctgccgcgc ccccatccca ccctacccca
      421 ccctacccca ccacagcagg cgctggagtc ctgggaccac caggatctga ggcccaaatc
      481 cttcctcact aaggggagga gaggggtgct ccggcagggc aggatgggaa ggcgtgcttg
      541 ggcgggattg tgacataaga gtgccctggt gacatggagc agatctgtgg cataaataaa
      601 ggtgtcataa agacagggcg ggactcatgc ttacaagggg cacgagcgtc tcggagctgc
      661 cagaatgact tccgctcagt gcccggcact agcgtgtgtc atgtccccgc tgcgtttctg
      721 gggcccatgg cccctcctta tgtggcaact attgtggcta ctagtcaagg aggctcagcc
      781 tctggagtgg gtcaaggacc cgctccagct gacctctaac cccctggggc cgcctgagcc
      841 ctggtcttcc cactcctccc atttcccacg ggaatctccc catgcgccta ctctcccagc
      901 agacccgtgg gactttgatc acctggggcc ctctgcttcc tcagagatgc cagccccacc
      961 ccaggaatcg actgaaaatt tggttccatt cctggacacc tgggattcag ctggagagct
     1021 gcccctggag ccagagcagt tcttggcttc acagcaggat ttaaaggaca agctgagtcc
     1081 acaggaaagg ctccctgttt cgcccaagaa gctgaagaaa gatccagctc agcgttggag
     1141 ccttgctgag attattggaa ttatacacca attatccaca cctcagagtc agaaacagac
     1201 tttgcagaat gaatattcca gtacagatac accgtatccc ggtagcctgc ctccagaact
     1261 ccgggtgaag tcagatgagc ctccagggcc ctctgagcaa gttggacctt ctcaattcca
     1321 tctagagccc gaaactcaaa atccagagac ccttgaagac atccagtcct cttcactcca
     1381 gcaagaagcc ccagcacagc ttccacagct ccttgaggaa gaaccttctt caatgcagca
     1441 ggaggcccca gctctgcctc cagagtcctc tatggagagt ctaactctac cgaatcatga
     1501 ggtgtcagtt caacctccag gtgaggatca agcttattat cacttgccca acattacagt
     1561 taaacctgca gatgtggagg ttaccataac ttcagagcct accaatgaga cagaatcttc
     1621 ccaagcccag caggagaccc caattcagtt tccagaggag gtggaacctt ctgcaaccca
     1681 acaggaggcc ccaattgagc ctccagttcc tcctatggag catgaacttt ccatcagtga
     1741 gcagcagcag ccagttcagc cttctgagtc ttctagggag gtcgaatctt ctccgaccca
     1801 gcaggagacc ccaggtcagc ctccagaaca tcatgaagtc acagtttcac ctccaggtca
     1861 ccatcaaact catcatttag cttcacccag tgtctctgtg aagcctccag acgtgcagct
     1921 caccatagca gcagagccta gtgcagaggt gggaacttct ctagtccacc aggaggctac
     1981 aactcggctc tcagggtcag gtaatgatgt agaacctccc gccatccagc acgggggccc
     2041 acctctgctt ccagagtcat cagaagaagc tggaccttta gcagttcaac aggagacttc
     2101 atttcaatct ccggaaccta ttaataatga gaacccctct ccaacccagc aggaggctgc
     2161 agctgagcat ccacagaccg ctgaggaggg tgagtcttcc ctaacccatc aggaggcccc
     2221 agctcagact ccagagttcc ctaatgtagt tgtagctcaa cctccagagc attcacacct
     2281 gactcaagcc acagttcaac ctttggatct ggggtttacc atcactccag aatccatgac
     2341 agaggttgaa ctttctccaa ccatgaagga gaccccaact cagcctccta agaaagttgt
     2401 accccaactt cgagtatatc aaggggtaac aaatccaaca ccaggtcagg atcaagctca
     2461 gcatccagtg tcacccagcg ttacagttca acttttggac ctgggactta ccatcactcc
     2521 agaacccact acggaggttg gacattctac acccccgaag aggactatag tttctccaaa
     2581 gcatcctgag gtgacacttc cacatccaga ccaggttcag actcagcatt cacacctgac
     2641 tcgagccaca gttcaacctt tggacctggg gtttaccatc actccaaaat ccatgacaga
     2701 ggttgaacct tctacagccc tgatgactac agctcctcct ccaggacacc ctgaggtgac
     2761 acttccacct tcagacaagg gtcaggctca gcattcacac ctgactcaag ccaccgttca
     2821 acctctggac ctggagctta ccataactac aaaacctact acagaggtta aaccatctcc
     2881 aaccacggag gagacctcaa ctcagcttcc agacctggga cttgccatca ttccagaacc
     2941 cactacagag actggacatt ctacagccct ggagaagact acagctcctc gtccagaccg
     3001 ggttcagact ctgcatcgaa gcctgactga agtcacaggt ccacctactg aactagaacc
     3061 tgctcaggat tcactggtgc agtctgaaag ttacacccaa aataaggctt taactgcacc
     3121 agaggaacac aaggcctcca caagcaccaa catatgtgag ctctgtacct gcggagatga
     3181 gatgttgtca tgtattgatc tcaacccaga gcagaggctc cgccaagtgc ctgtgccaga
     3241 gcccaacacc cacaatggca ccttcaccat cttaaatttc caaggaaact atatttctta
     3301 cattgatgga aatgtatgga aagcatacag ttggaccgag aaactaattc tcagagaaaa
     3361 taacttgact gaattacaca aggattcatt tgaaggcctg ctatccctcc agtatttaga
     3421 tttatcctgc aataaaatac agtctattga aagacataca tttgaaccac taccattttt
     3481 gaagtttata aatcttagtt gcaatgtaat tacagaactc agctttggaa catttcaggc
     3541 ctggcacgga atgcagtttt tacataagtt aattctcaat cacaatcctc tgacaactgt
     3601 tgaagatcca tatctcttta aattgccagc attaaaatat ctagacatgg gaacaacgct
     3661 agtcccactt acaacactta agaacattct catgatgact gttgaactgg aaaaactgat
     3721 cgtacctagc catatggcct gctgcctctg ccaatttaaa aacagcattg aggctgtctg
     3781 caagacagtc aagctgcatt gcaacagtgc atgtctgaca aacaccacac attgtcctga
     3841 agaagcatct gtagggaatc cagaaggagc gttcatgaag gtgttacaag cccggaagaa
     3901 ttacacaagc actgagctga ttattgagcc ggaggagccc tcagacagca gtggcatcaa
     3961 cttgtcaggc tttgggagtg agcagctaga caccaatgac gagagtgatg ttaccagtac
     4021 actaagttac atcttacctt atttctcagc cgttaaccta gatgtgaaat cactgttact
     4081 accgttcatt aaactgccaa ccacaggaaa cagcctggca aagattcaaa ctgtaggcaa
     4141 aaaccggcag agactgaata gagtcctcat gggcccaagg agcatccaga aaaggcactt
     4201 caaagaggta ggaaggcaga gcatcaggag ggaacagggt gcccaggcat ctgtggagaa
     4261 cactgccgaa gaaaaaaggc tcggaagtcc agccccaagg gagctgaaac agcctcacac
     4321 acagcagggg cctgagaagt tagcgggaaa cgccgtctac accaagcctt cgttcaccca
     4381 agagcataag gcagcagtct ctgtgctgaa acccttctcc aagggcgcgc cttctacctc
     4441 cagccctgca aaagccctac cacaggtgag agacagatgg aaagacttaa cccacgctat
     4501 ttccatttta gaaagtgcaa aggctagagt tacaaatatg aagacatcta aacccatcgt
     4561 acattccaga aaaaaatacc gctttcacaa aactcgctcc cgcatgaccc acagaacacc
     4621 caaggtcaaa aagagtccaa aggtcagaaa gaaaagttat ctgagtagac tgatgctctc
     4681 aaacaggctt ccgttctctg cagcgaagag cctcataaat tccccttcac aaggggcttt
     4741 ttcatcctta agagacctga gtcctcaaga aaatcctttt ctggaagtat ctgctccttc
     4801 agaacatttt atagaaaaca ataatacaaa agacacaact gcaagaaatg cctttgaaga
     4861 aaatgttttt atggaaaaca ctaacatgcc agaaggaacc atctctgaaa acacaaacta
     4921 caatcatcct cctgaggcag attccgctgg gactgcattc aacttagggc caactgttaa
     4981 acaaactgag acaaaatggg aatacaacaa cgtgggcact gacctgtccc ccgagcccaa
     5041 aagcttcaat tacccattgc tctcgtcccc aggtgatcag tttgaaattc agctaaccca
     5101 gcagctgcag tccgttatcc ccaacaacaa tgtgagaagg ctcattgctc atgttatccg
     5161 gaccttgaag atggactgct ctggggccca tgtgcaagtg acctgtgcca agctcgtctc
     5221 caggacaggc cacctgatga agcttctcag tgggcagcag gaagtaaagg catccaagat
     5281 agaatgggat acggaccaat ggaagactga gaactacatt aatgagagca cagaagccca
     5341 gagtgaacag aaagagaagt cgcttgagtt cacaaaagaa cttccaggat atggctatac
     5401 caaaaaactc atcttggcgt taattgtgac tggaatacta acgattttga ttatacttct
     5461 ctgcctcatt gagatctgtt gtcaccgaag gtcattacaa gaagatgaag aaggattctc
     5521 aagggacagc gaagccccaa cggaggagga gagtgaagcc ctgccatagg aggagaaccc
     5581 agcccacctc aggcctcctg caaaaataca tagcgtaaac aacggccatc aaaaaagcag
     5641 gactgaagcc agcggcccac acatccacag aggcagcggg cagagcaagc acagggccat
     5701 cgttcctgcc cttgtttccc agtctaatta gtcacccaga cctgaaaaca tatgctcagg
     5761 gggtggagat tttacaatta aataacattg tttttggtgc cctctccctt ggttcatcaa
     5821 gcaccagtca tataatacca catacttgaa ctcctgccca caggggacct cccatctcct
     5881 ggcccctatc ataggatcac tgggcctacc tgcactgtgg ggccaagccc tgtctttttc
     5941 ccaagccctc aagcacacgc atgaatgttc atcccgactt ggtagggggc ttttcaccct
     6001 tacaagatgg caaaagattc acattgcttt ttttaaaa
//
