LOCUS       NM_001006607            5415 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens leucine rich repeat containing 37 member A2
            (LRRC37A2), transcript variant 1, mRNA.
ACCESSION   NM_001006607
VERSION     NM_001006607.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5415)
  AUTHORS   Giannuzzi,G., Siswara,P., Malig,M., Marques-Bonet,T.,
            Mullikin,J.C., Ventura,M. and Eichler,E.E.
  CONSRTM   NISC Comparative Sequencing Program
  TITLE     Evolutionary dynamism of the primate LRRC37 gene family
  JOURNAL   Genome Res 23 (1), 46-59 (2013)
   PUBMED   23064749
REFERENCE   2  (bases 1 to 5415)
  AUTHORS   Bekpen,C., Tastekin,I., Siswara,P., Akdis,C.A. and Eichler,E.E.
  TITLE     Primate segmental duplication creates novel promoters for the
            LRRC37 gene family within the 17q21.31 inversion polymorphism
            region
  JOURNAL   Genome Res 22 (6), 1050-1058 (2012)
   PUBMED   22419166
REFERENCE   3  (bases 1 to 5415)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   4  (bases 1 to 5415)
  AUTHORS   Zody,M.C., Garber,M., Adams,D.J., Sharpe,T., Harrow,J.,
            Lupski,J.R., Nicholson,C., Searle,S.M., Wilming,L., Young,S.K.,
            Abouelleil,A., Allen,N.R., Bi,W., Bloom,T., Borowsky,M.L.,
            Bugalter,B.E., Butler,J., Chang,J.L., Chen,C.K., Cook,A., Corum,B.,
            Cuomo,C.A., de Jong,P.J., DeCaprio,D., Dewar,K., FitzGerald,M.,
            Gilbert,J., Gibson,R., Gnerre,S., Goldstein,S., Grafham,D.V.,
            Grocock,R., Hafez,N., Hagopian,D.S., Hart,E., Norman,C.H.,
            Humphray,S., Jaffe,D.B., Jones,M., Kamal,M., Khodiyar,V.K.,
            LaButti,K., Laird,G., Lehoczky,J., Liu,X., Lokyitsang,T.,
            Loveland,J., Lui,A., Macdonald,P., Major,J.E., Matthews,L.,
            Mauceli,E., McCarroll,S.A., Mihalev,A.H., Mudge,J., Nguyen,C.,
            Nicol,R., O'Leary,S.B., Osoegawa,K., Schwartz,D.C., Shaw-Smith,C.,
            Stankiewicz,P., Steward,C., Swarbreck,D., Venkataraman,V.,
            Whittaker,C.A., Yang,X., Zimmer,A.R., Bradley,A., Hubbard,T.,
            Birren,B.W., Rogers,J., Lander,E.S. and Nusbaum,C.
  TITLE     DNA sequence of human chromosome 17 and analysis of rearrangement
            in the human lineage
  JOURNAL   Nature 440 (7087), 1045-1049 (2006)
   PUBMED   16625196
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC138645.3.
            
            On Sep 3, 2021 this sequence version replaced NM_001006607.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY386262.1, SRR14038193.680626.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000576629.6/ ENSP00000459551.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2854              AC138645.3         51934-54787
            2855-2926           AC138645.3         56828-56899
            2927-2998           AC138645.3         59678-59749
            2999-3070           AC138645.3         62550-62621
            3071-3151           AC138645.3         63270-63350
            3152-3223           AC138645.3         79642-79713
            3224-3298           AC138645.3         80273-80347
            3299-3417           AC138645.3         85721-85839
            3418-4949           AC138645.3         87778-89309
            4950-5054           AC138645.3         89881-89985
            5055-5104           AC138645.3         92866-92915
            5105-5159           AC138645.3         94618-94672
            5160-5299           AC138645.3         94751-94890
            5300-5415           AC138645.3         94997-95112
FEATURES             Location/Qualifiers
     source          1..5415
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.31-q21.32"
     gene            1..5415
                     /gene="LRRC37A2"
                     /gene_synonym="LRRC37"
                     /note="leucine rich repeat containing 37 member A2"
                     /db_xref="GeneID:474170"
                     /db_xref="HGNC:HGNC:32404"
                     /db_xref="MIM:616556"
     exon            1..2854
                     /gene="LRRC37A2"
                     /gene_synonym="LRRC37"
                     /inference="alignment:Splign:2.1.0"
     CDS             246..5348
                     /gene="LRRC37A2"
                     /gene_synonym="LRRC37"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; c114 SLIT-like testicular protein; Leucine-rich
                     repeat-containing protein 37A2"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 37A2
                     isoform 1 precursor"
                     /protein_id="NP_001006608.2"
                     /db_xref="CCDS:CCDS42353.1"
                     /db_xref="GeneID:474170"
                     /db_xref="HGNC:HGNC:32404"
                     /db_xref="MIM:616556"
                     /translation="MSSAQCPALVCVMSRLRFWGPWPLLMWQLLWLLVKEAQPLEWVK
                     DPLQLTSNPLGPPDSWSSHSSHFPRESPHAPTLPADPWDFDHLGPSASSEMPAPPQES
                     TENLVPFLDTWDSAGEQPLEPEQFLASQQDLKDKLSPQERLPVSPKKLKKDPAQRWSL
                     AEIIGITRQLSTPQSQKQTLQNEYSSTDTPYPGSLPPELRVKSDEPPGPSEQVGPSQF
                     HLEPETQNPETLEDIQSSSLQQEAPAQLPQLLEEEPSSMQQEAPALPPESSMESLTLP
                     NHEVSVQPPGEDQAYYHLPNITVKPADVEVTITSEPTNETESSQAQQETPIQFPEEVE
                     PSATQQEAPIEPPVPPMEHELSISEQQQPVQPSESPREVESSPTQQETPGQPPEHHEV
                     TVSPPGHHQTHHLASPSVSVKPPDVQLTIAAEPSAEVGTSLVHQEATTRLSGSGNDVE
                     PPAIQHGGPPLLPESSEEAGPLAVQQETSFQSPEPINNENPSPTQQEAAAEHPQTAEE
                     GESSLTHQEAPAQTPEFPNVVVAQPPEHSHLTQATVQPLDLGFTITPESKTEVELSPT
                     MKETPTQPPKKVVPQLRVYQGVTNPTPGQDQAQHPVSPSVTVQLLDLGLTITPEPTTE
                     VGHSTPPKRTIVSPKHPEVTLPHPDQVQTQHSHLTRATVQPLDLGFTITPKSMTEVEP
                     STALMTTAPPPGHPEVTLPPSDKGQAQHSHLTQATVQPLDLELTITTKPTTEVKPSPT
                     TEETSTQPPDLGLAIIPEPTTETRHSTALEKTTAPRPDRVQTLHRSLTEVTGPPTELE
                     PAQDSLVQSESYTQNKALTAPEEHKASTSTNICELCTCGDEMLSCIDLNPEQRLRQVP
                     VPEPNTHNGTFTILNFQGNYISYIDGNVWKAYSWTEKLILRENNLTELHKDSFEGLLS
                     LQYLDLSCNKIQSIERHTFEPLPFLKFINLSCNVITELSFGTFQAWHGMQFLHKLILN
                     HNPLTTVEDPYLFKLPALKYLDMGTTLVPLTTLKNILMMTVELEKLILPSHMACCLCQ
                     FKNSIEAVCKTVKLHCNSACLTNTTHCPEEASVGNPEGAFMKVLQARKNYTSTELIVE
                     PEEPSDSSGINLSGFGSEQLDTNDESDFISTLSYILPYFSAVNLDVKSLLLPFIKLPT
                     TGNSLAKIQTVGQNRQRVKRVLMGPRSIQKRHFKEVGRQSIRREQGAQASVENAAEEK
                     RLGSPAPREVEQPHTQQGPEKLAGNAVYTKPSFTQEHKAAVSVLKPFSKGAPSTSSPA
                     KALPQVRDRWKDLTHAISILESAKARVTNTKTSKPIVHARKKYRFHKTRSHVTHRTPK
                     VKKSPKVRKKSYLSRLMLANRLPFSAAKSLINSPSQGAFSSLGDLSPQENPFLEVSAP
                     SEHFIENNNTKHTTARNAFEENDFMENTNMPEGTISENTNYNHPHEADSAGTAFNLGP
                     TVKQTETKWEYNNVGTDLSPEPKSFNYPLLSSPGDQFEIQLTQQLQSLIPNNNVRRLI
                     AHVIRTLKMDCSGAHVQVTCAKLISRTGHLMKLLSGQQEVKASKIEWDTDQWKIENYI
                     NESTEAQSEQKEKSLELKKEVPGYGYTDKLILALIVTGILTILIILFCLIVICCHRRS
                     LQEDEEGFSRGIFRFLPWRGCSSRRESQDGLSSFGQPLWFKDMYKPLSATRINNHAWK
                     LHKKSSNEDKILNRDPGDSEAPTEEEESEALP"
     exon            2855..2926
                     /gene="LRRC37A2"
                     /gene_synonym="LRRC37"
                     /inference="alignment:Splign:2.1.0"
     exon            2927..2998
                     /gene="LRRC37A2"
                     /gene_synonym="LRRC37"
                     /inference="alignment:Splign:2.1.0"
     exon            2999..3070
                     /gene="LRRC37A2"
                     /gene_synonym="LRRC37"
                     /inference="alignment:Splign:2.1.0"
     exon            3071..3151
                     /gene="LRRC37A2"
                     /gene_synonym="LRRC37"
                     /inference="alignment:Splign:2.1.0"
     exon            3152..3223
                     /gene="LRRC37A2"
                     /gene_synonym="LRRC37"
                     /inference="alignment:Splign:2.1.0"
     exon            3224..3298
                     /gene="LRRC37A2"
                     /gene_synonym="LRRC37"
                     /inference="alignment:Splign:2.1.0"
     exon            3299..3417
                     /gene="LRRC37A2"
                     /gene_synonym="LRRC37"
                     /inference="alignment:Splign:2.1.0"
     exon            3418..4949
                     /gene="LRRC37A2"
                     /gene_synonym="LRRC37"
                     /inference="alignment:Splign:2.1.0"
     exon            4950..5054
                     /gene="LRRC37A2"
                     /gene_synonym="LRRC37"
                     /inference="alignment:Splign:2.1.0"
     exon            5055..5104
                     /gene="LRRC37A2"
                     /gene_synonym="LRRC37"
                     /inference="alignment:Splign:2.1.0"
     exon            5105..5159
                     /gene="LRRC37A2"
                     /gene_synonym="LRRC37"
                     /inference="alignment:Splign:2.1.0"
     exon            5160..5299
                     /gene="LRRC37A2"
                     /gene_synonym="LRRC37"
                     /inference="alignment:Splign:2.1.0"
     exon            5300..5415
                     /gene="LRRC37A2"
                     /gene_synonym="LRRC37"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 accctacccc accacagcag gcgctggagt cctgggacca ccagggtctg aggcccaaat
       61 ccttcctcac taaggggagg agaggggtgt tccggcaggg caggatggga aggcgtgctt
      121 gggcgggatt gtgacataag agtgccctgg tgacatggag cagatctgtg acataaataa
      181 aggtgtcata aagacagggc ggggctcacg cttagaaggg gcacgagcgt ctcggagctg
      241 ccagaatgtc ttctgctcag tgcccggcac tagtgtgtgt catgtcccgg ctgcgtttct
      301 ggggcccatg gcccctcctt atgtggcaac tattgtggct actagttaag gaggctcagc
      361 ctctggagtg ggtcaaggac ccgctccagc tcacctctaa tcccctgggg ccgcctgact
      421 cctggtcttc ccactcctcc catttcccac gggaatctcc ccatgcgcct actctcccag
      481 cagacccgtg ggactttgat cacctggggc cctctgcttc ctcagagatg ccagccccac
      541 cccaggaatc gactgaaaat ttggttccat tcctggacac ctgggattca gctggagagc
      601 agcccctgga gccagagcag ttcttggctt cacagcagga tttaaaggac aagctgagtc
      661 cacaggaaag actccctgtt tcgcccaaga agctgaagaa agatccagct cagcgttgga
      721 gccttgctga gattattgga attacacgcc aattatccac acctcagagt cagaaacaga
      781 ctttgcagaa tgaatattcc agtacagata caccgtatcc cggtagcctg cctccagaac
      841 tccgggtgaa gtcagatgag cctccagggc cctctgagca agttggacct tctcaattcc
      901 atctagagcc cgaaactcaa aatccagaga cccttgaaga catccagtcc tcttcactcc
      961 agcaagaagc cccagcacag cttccacagc tccttgagga agaaccttct tcaatgcagc
     1021 aggaggcccc agctctgcct ccagagtcct ctatggagag tctaactcta ccgaatcatg
     1081 aggtgtcagt tcaacctcca ggtgaggatc aagcttatta tcacttgccc aacattacag
     1141 ttaaacctgc agatgtggag gttaccataa cttcagagcc taccaatgag acagaatctt
     1201 cccaagccca gcaggagacc ccaattcagt ttccagagga ggtggaacct tctgcaaccc
     1261 aacaggaggc cccaattgag cctccagttc ctcctatgga gcatgaactt tccatcagtg
     1321 agcagcagca gccagttcag ccttctgagt ctcctaggga ggtcgaatct tctccgaccc
     1381 agcaggagac cccaggtcag cctccagaac atcatgaagt cacagtttca cctccaggtc
     1441 accatcaaac tcatcattta gcttcaccca gtgtctctgt gaagcctcca gacgtgcagc
     1501 tcaccatagc agcagagcct agtgcagagg tgggaacttc tctagtccac caggaggcta
     1561 caactcggct ctcagggtca ggtaatgatg tagaacctcc cgccatccag cacgggggcc
     1621 cacctctgct tccagagtca tcagaagaag ctggaccttt agcagttcaa caggagactt
     1681 catttcaatc tccggaacct attaataatg agaacccctc tccaacccag caggaggctg
     1741 cagctgagca tccacagacc gctgaggagg gtgagtcttc cctaacccat caggaggccc
     1801 cagctcagac tccagagttc cctaatgtag ttgtagctca acctccagag cattcacacc
     1861 tgactcaagc cacagttcaa cctttggatc tggggtttac catcactcca gaatccaaga
     1921 cagaggttga actttctcca accatgaagg agaccccaac tcagcctcct aagaaagttg
     1981 taccccaact tcgagtatat caaggggtaa caaatccaac accaggtcag gatcaagctc
     2041 agcatccagt gtcacccagc gttacagttc aacttttgga cctgggactt accatcactc
     2101 cagaacctac tacggaggtt ggacattcta cacccccgaa gaggactata gtttctccaa
     2161 agcatcctga ggtgacactt ccacatccag accaggttca gactcagcat tcacacctga
     2221 ctcgagccac agttcaacct ttggacctgg ggtttaccat cactccaaaa tccatgacag
     2281 aggttgaacc ttctacagcc ctgatgacta cagctcctcc tccaggacac cctgaggtga
     2341 cacttccacc ttcagacaag ggtcaggctc agcattcaca cctgactcaa gccaccgttc
     2401 aacctctgga cctggagctt accataacta caaaacctac tacagaggtt aaaccatctc
     2461 caaccacgga ggagacctca actcagcctc cagacctggg acttgccatc attccagaac
     2521 ccactacaga gactagacat tctacagccc tggagaagac tacagctcct cgtccagacc
     2581 gggttcagac tctgcatcga agcctgactg aagtcacagg tccacctact gaactagaac
     2641 ctgctcagga ttcactggtg cagtctgaaa gttacaccca aaataaggct ttaactgcac
     2701 cagaggaaca caaggcctcc acaagcacca acatatgtga gctctgtacc tgcggagatg
     2761 agatgttgtc atgtattgat ctcaacccag agcagaggct ccgccaagtg cctgtgccag
     2821 agcccaacac ccacaatggc accttcacca tcttaaattt ccaaggaaac tatatttctt
     2881 acattgatgg aaatgtatgg aaagcataca gttggaccga gaaactaatt ctcagagaaa
     2941 ataacttgac tgaattacac aaggattcat ttgaaggcct gctatccctc cagtatttag
     3001 atttatcctg caataaaata cagtctattg aaagacatac atttgaacca ctaccatttt
     3061 tgaagtttat aaatcttagt tgcaatgtaa ttacagaact cagctttgga acatttcagg
     3121 cctggcacgg aatgcagttt ttacataagt taattctcaa tcacaatcct ctgacaactg
     3181 ttgaagatcc gtatctcttt aaattgccag cattaaaata tctagacatg ggaacaacgc
     3241 tagtcccact tacaacactt aagaacattc tcatgatgac tgttgaactg gaaaaactga
     3301 tcttacctag ccatatggcc tgctgcctct gccaatttaa aaacagcatt gaggctgtct
     3361 gcaagacagt caagctgcat tgcaacagtg catgtctgac aaacaccaca cattgtcctg
     3421 aagaagcatc ggtagggaat ccagaaggag cgttcatgaa ggtgttacaa gcccggaaga
     3481 actacacaag cactgagctg attgttgagc cagaggagcc ctcagacagc agtggcatca
     3541 acttgtcagg ctttgggagt gagcagctag acaccaatga cgagagtgat tttatcagta
     3601 cactaagtta catcttgcct tatttctcag cggtaaacct agatgtgaaa tcactgttac
     3661 taccgttcat taaactgcca accacaggaa acagcctggc aaagattcaa actgtaggcc
     3721 aaaaccggca gagagtgaag agagtcctca tgggcccaag gagcatccag aaaaggcact
     3781 tcaaagaggt aggaaggcag agcatcagga gggaacaggg tgcccaggca tctgtggaga
     3841 acgctgccga agaaaaaagg ctcgggagtc cagccccaag ggaggtggaa cagccccaca
     3901 cacagcaggg gcctgagaag ttagcgggaa acgccgtcta caccaagcct tccttcaccc
     3961 aagagcataa ggcagcagtc tctgtgctga aacccttctc caagggcgcg ccttctacct
     4021 ccagccctgc aaaagcccta ccacaggtga gagacagatg gaaagactta acccacgcta
     4081 tttccatttt agaaagtgca aaggctagag ttacaaatac gaagacgtct aaaccaatcg
     4141 tacatgccag aaaaaaatac cgctttcaca aaactcgctc ccacgtgacc cacagaacac
     4201 ccaaagtcaa aaagagtcca aaggtcagaa agaaaagtta tctgagtaga ctgatgctcg
     4261 caaacaggct tccattctct gcagcgaaga gcctcataaa ttccccttca caaggggctt
     4321 tttcatcctt aggagacctg agtcctcaag aaaacccttt tctggaagta tctgctcctt
     4381 cagaacattt tatagaaaac aataatacaa aacacacaac tgcaagaaat gcctttgaag
     4441 aaaatgattt tatggaaaac actaacatgc cagaaggaac catctctgaa aacacaaact
     4501 acaatcatcc tcatgaggca gattccgctg ggactgcatt caacttaggg ccaactgtta
     4561 aacaaactga gacaaaatgg gaatacaaca acgtgggcac tgacctgtcc cccgagccca
     4621 aaagcttcaa ttacccattg ctctcgtccc caggtgatca gtttgaaatt cagctaaccc
     4681 agcagctaca gtcccttatc cccaacaaca atgtgagaag gctcattgct catgttatcc
     4741 ggaccttgaa gatggactgc tctggggccc atgtgcaagt gacctgtgcc aagctcatct
     4801 ccaggacagg ccacctgatg aagcttctca gtgggcagca ggaagtaaag gcatccaaga
     4861 tagaatggga tacggaccaa tggaagattg agaactacat taatgagagc acagaagccc
     4921 agagtgaaca gaaagagaag tcgcttgagc tcaaaaaaga agttccagga tatggctata
     4981 ctgacaaact catcttggca ttaattgtta ctggaatact aacgattttg attatacttt
     5041 tctgcctcat tgtgatatgt tgtcaccgaa ggtcattaca agaagatgaa gaaggattct
     5101 caaggggcat tttcagattt ctgccatgga ggggatgctc ttcgcgaagg gagagtcagg
     5161 atggactttc ctcatttgga cagccgctct ggtttaaaga tatgtacaaa cctctcagtg
     5221 ccacaagaat aaataatcat gcatggaagc tgcacaagaa gtcatctaat gaggacaaga
     5281 tcctcaacag ggaccctggg gacagcgaag ccccaacgga ggaggaggag agtgaagccc
     5341 tgccatagga ggagaacaca gcccacctca ggcctcctgc aaaaatacat agaataaaca
     5401 acaacagtta ctaaa
//
