LOCUS       NM_014834               5177 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens leucine rich repeat containing 37A (LRRC37A), mRNA.
ACCESSION   NM_014834 XM_003119443 XM_003119444 XM_003119445 XM_003119446
VERSION     NM_014834.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5177)
  AUTHORS   Giannuzzi,G., Siswara,P., Malig,M., Marques-Bonet,T.,
            Mullikin,J.C., Ventura,M. and Eichler,E.E.
  CONSRTM   NISC Comparative Sequencing Program
  TITLE     Evolutionary dynamism of the primate LRRC37 gene family
  JOURNAL   Genome Res 23 (1), 46-59 (2013)
   PUBMED   23064749
REFERENCE   2  (bases 1 to 5177)
  AUTHORS   Bekpen,C., Tastekin,I., Siswara,P., Akdis,C.A. and Eichler,E.E.
  TITLE     Primate segmental duplication creates novel promoters for the
            LRRC37 gene family within the 17q21.31 inversion polymorphism
            region
  JOURNAL   Genome Res 22 (6), 1050-1058 (2012)
   PUBMED   22419166
REFERENCE   3  (bases 1 to 5177)
  AUTHORS   Hart,A.B., Engelhardt,B.E., Wardle,M.C., Sokoloff,G., Stephens,M.,
            de Wit,H. and Palmer,A.A.
  TITLE     Genome-wide association study of d-amphetamine response in healthy
            volunteers identifies putative associations, including cadherin 13
            (CDH13)
  JOURNAL   PLoS One 7 (8), e42646 (2012)
   PUBMED   22952603
REFERENCE   4  (bases 1 to 5177)
  AUTHORS   Jin,H., Selfe,J., Whitehouse,C., Morris,J.R., Solomon,E. and
            Roberts,R.G.
  TITLE     Structural evolution of the BRCA1 genomic region in primates
  JOURNAL   Genomics 84 (6), 1071-1082 (2004)
   PUBMED   15533724
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC005829.1 and AC217777.1.
            
            On or before Nov 25, 2010 this sequence version replaced
            XM_003119443.1, XM_003119444.1, XM_003119445.1, XM_003119446.1,
            NM_014834.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC040501.1, CR749232.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000320254.5/ ENSP00000326324.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2612              AC005829.1         3146-5757           c
            2613-2684           AC005829.1         1023-1094           c
            2685-2756           AC217777.1         22923-22994
            2757-2828           AC217777.1         25794-25865
            2829-2909           AC217777.1         26514-26594
            2910-2981           AC217777.1         42607-42678
            2982-3056           AC217777.1         43238-43312
            3057-3175           AC217777.1         48677-48795
            3176-4707           AC217777.1         50735-52266
            4708-4812           AC217777.1         52837-52941
            4813-4862           AC217777.1         55830-55879
            4863-4917           AC217777.1         57581-57635
            4918-5057           AC217777.1         57714-57853
            5058-5177           AC217777.1         57960-58079
FEATURES             Location/Qualifiers
     source          1..5177
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.31"
     gene            1..5177
                     /gene="LRRC37A"
                     /gene_synonym="LRRC37; LRRC37A1"
                     /note="leucine rich repeat containing 37A"
                     /db_xref="GeneID:9884"
                     /db_xref="HGNC:HGNC:29069"
                     /db_xref="MIM:616555"
     exon            1..2612
                     /gene="LRRC37A"
                     /gene_synonym="LRRC37; LRRC37A1"
                     /inference="alignment:Splign:2.1.0"
     CDS             4..5106
                     /gene="LRRC37A"
                     /gene_synonym="LRRC37; LRRC37A1"
                     /note="leucine-rich repeat-containing protein 37A"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 37A
                     precursor"
                     /protein_id="NP_055649.4"
                     /db_xref="CCDS:CCDS11504.2"
                     /db_xref="GeneID:9884"
                     /db_xref="HGNC:HGNC:29069"
                     /db_xref="MIM:616555"
                     /translation="MSSAQCPALVCVMSRLRFWGPWPLLMWQLLWLLVKEAQPLEWVK
                     DPLQLTSNPLGPPESWSSHSSHFPRESPHAPTLPADPWDFDHLGPSASSEMPAPPQES
                     TENLVPFLDTWDSAGEQPLEPEQFLASQQDLKDKLSPQERLPVSPKKLKKDPAQRWSL
                     AEIIGITRQLSTPQSQKQTLQNEYSSTDTPYPGSLPPELRVKSDEPPGPSEQVGPSQF
                     HLEPETQNPETLEDIQSSSLQQEAPAQLPQLLEEEPSSMQQEAPALPPESSMESLTLP
                     NHEVSVQPPGEDQAYYHLPNITVKPADVEVTITSEPTNETESSQAQQETPIQFPEEVE
                     PSATQQEAPIEPPVPPMEHELSISEQQQPVQPSESPREVESSPTQQETPGQPPEHHEV
                     TVSPPGHHQTHHLASPSVSVKPPDVQLTIAAEPSAEVGTSLVHQEATTRLSGSGNDVE
                     PPAIQHGGPPLLPESSEEAGPLAVQQETSFQSPEPINNENPSPTQQEAAAEHPQTAEE
                     GESSLTHQEAPAQTPEFPNVVVAQPPEHSHLTQATVQPLDLGFTITPESKTEVELSPT
                     MKETPTQPPKKVVPQLRVYQGVTNPTPGQDQAQHPVSPSVTVQLLDLGLTITPEPTTE
                     VGHSTPPKRTIVSPKHPEVTLPHPDQVQTQHSHLTRATVQPLDLGFTITPKSMTEVEP
                     STALMTTAPPPGHPEVTLPPSDKGQAQHSHLTQATVQPLDLELTITTKPTTEVKPSPT
                     TEETSTQPPDLGLAIIPEPTTETGHSTALEKTTAPRPDRVQTLHRSLTEVTGPPTELE
                     PAQDSLVQSESYTQNKALTAPEEHKASTSTNICELCTCGDEMLSCIDLNPEQRLRQVP
                     VPEPNTHNGTFTILNFQGNYISYIDGNVWKAYSWTEKLILRENNLTELHKDSFEGLLS
                     LQYLDLSCNKIQSIERHTFEPLPFLKFINLSCNVITELSFGTFQAWHGMQFLHKLILN
                     HNPLTTVEDPYLFKLPALKYLDMGTTLVPLTTLKNILMMTVELEKLILPSHMACCLCQ
                     FKNSIEAVCKTVKLHCNSACLTNTTHCPEEASVGNPEGAFMKVLQARKNYTSTELIVE
                     PEEPSDSSGINLSGFGSEQLDTNDESDFISTLSYILPYFSAVNLDVKSLLLPFIKLPT
                     TGNSLAKIQTVGQNRQRVKRVLMGPRSIQKRHFKEVGRQSIRREQGAQASVENAAEEK
                     RLTSPAPREVEQPHTQQGPEKLAGNAVYTKPSFTQEHKAAVSVLKPFSKGTPSTSSPA
                     KALPQVRDRSKDLTHAISILESAKARVTNTKTSKPIVHARKKYRFHKTRSHVTHRTTK
                     VKKSPKVRKKSYLSRLMLANRLPFSAAKSLINSPSQGAFSSLGDLSPQENPFLEVSAL
                     SEHFIEKNNTKHTTARNAFEENDFMENTNMPEGTISENTNYNHPPEADSAGTAFNLGP
                     TVKQTETKWEYNNVGTDLSPEPKSFNYPLLSSPGDQFEIQLTQQLQSLIPNNNVRRLI
                     AHVIRTLKMDCSGAHVQVTCAKLISRTGHLMKLLSGQQEVKASKIEWDTDQWKIENYI
                     NESTEAQSEQKEKSLELKKEVPGYGYTDKLILALIVTGILTILIILFCLIVICCHRRS
                     LQEDEEGFSRGIFRFLPWRGCSSRRESQDGLSSFGQPLWFKDLYKPLSATRINNHAWK
                     LHKKSSNEDKILNRDPGDSEAPTEEEESEALP"
     exon            2613..2684
                     /gene="LRRC37A"
                     /gene_synonym="LRRC37; LRRC37A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2685..2756
                     /gene="LRRC37A"
                     /gene_synonym="LRRC37; LRRC37A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2757..2828
                     /gene="LRRC37A"
                     /gene_synonym="LRRC37; LRRC37A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2829..2909
                     /gene="LRRC37A"
                     /gene_synonym="LRRC37; LRRC37A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2910..2981
                     /gene="LRRC37A"
                     /gene_synonym="LRRC37; LRRC37A1"
                     /inference="alignment:Splign:2.1.0"
     exon            2982..3056
                     /gene="LRRC37A"
                     /gene_synonym="LRRC37; LRRC37A1"
                     /inference="alignment:Splign:2.1.0"
     exon            3057..3175
                     /gene="LRRC37A"
                     /gene_synonym="LRRC37; LRRC37A1"
                     /inference="alignment:Splign:2.1.0"
     exon            3176..4707
                     /gene="LRRC37A"
                     /gene_synonym="LRRC37; LRRC37A1"
                     /inference="alignment:Splign:2.1.0"
     exon            4708..4812
                     /gene="LRRC37A"
                     /gene_synonym="LRRC37; LRRC37A1"
                     /inference="alignment:Splign:2.1.0"
     exon            4813..4862
                     /gene="LRRC37A"
                     /gene_synonym="LRRC37; LRRC37A1"
                     /inference="alignment:Splign:2.1.0"
     exon            4863..4917
                     /gene="LRRC37A"
                     /gene_synonym="LRRC37; LRRC37A1"
                     /inference="alignment:Splign:2.1.0"
     exon            4918..5057
                     /gene="LRRC37A"
                     /gene_synonym="LRRC37; LRRC37A1"
                     /inference="alignment:Splign:2.1.0"
     exon            5058..5177
                     /gene="LRRC37A"
                     /gene_synonym="LRRC37; LRRC37A1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5151..5156
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRC37A"
                     /gene_synonym="LRRC37; LRRC37A1"
                     /note="hexamer: AATAAA"
     polyA_site      5177
                     /gene="LRRC37A"
                     /gene_synonym="LRRC37; LRRC37A1"
                     /note="major polyA site"
ORIGIN      
        1 agaatgtctt ctgctcagtg cccggcacta gtgtgtgtca tgtcccggct gcgtttctgg
       61 ggcccatggc ccctccttat gtggcaacta ttgtggctac tagtcaagga ggctcagcct
      121 ctggagtggg tcaaggaccc gctccagctc acctctaatc ccctggggcc gcctgagtcc
      181 tggtcttccc actcctccca tttcccacgg gaatctcccc atgcgcctac tctcccagca
      241 gacccgtggg actttgatca cctggggccc tctgcttcct cagagatgcc agccccaccc
      301 caggaatcga ctgaaaattt ggttccattc ctggacacct gggattcagc tggagagcag
      361 cccctggagc cagagcagtt cttggcttca cagcaggatt taaaggacaa gctgagtcca
      421 caggaaaggc tccctgtttc gcccaagaag ctgaagaaag atccagctca gcgttggagc
      481 cttgctgaga ttattggaat tacacgccaa ttatccacac ctcagagtca gaaacagact
      541 ttgcagaatg aatattccag tacagataca ccgtatcccg gtagcctgcc tccagaactc
      601 cgggtgaagt cagatgagcc tccagggccc tctgagcaag ttggaccttc tcaattccat
      661 ctagagcccg aaactcaaaa tccagagacc cttgaagaca tccagtcctc ttcactccag
      721 caagaagccc cagcacagct tccacagctc cttgaggaag aaccttcttc aatgcagcag
      781 gaggccccag ctctgcctcc agagtcctct atggagagtc taactctacc gaatcatgag
      841 gtgtcagttc aacctccagg tgaggatcaa gcttattatc acttgcccaa cattacagtt
      901 aaacctgcag atgtggaggt taccataact tcagagccta ccaatgagac agaatcttcc
      961 caagcccagc aggagacccc aattcagttt ccagaggagg tggaaccttc tgcaacccaa
     1021 caggaggccc caattgagcc tccagttcct cctatggagc atgaactttc catcagtgag
     1081 cagcagcagc cagttcagcc ttctgagtct cctagggagg tcgaatcttc tccgacccag
     1141 caggagaccc caggtcagcc tccagaacat catgaagtca cagtttcacc tccaggtcac
     1201 catcaaactc atcatttagc ttcacccagt gtctctgtga agcctccaga cgtgcagctc
     1261 accatagcag cagagcctag tgcagaggtg ggaacttctc tagtccacca ggaggctaca
     1321 actcggctct cagggtcagg taatgatgta gaacctcccg ccatccagca cgggggccca
     1381 cctctgcttc cagagtcatc agaagaagct ggacctttag cagttcaaca ggagacttca
     1441 tttcaatctc cggaacctat taataatgag aacccctctc caacccagca ggaggctgca
     1501 gctgagcatc cacagaccgc tgaggagggt gagtcttccc taacccatca ggaggcccca
     1561 gctcagactc cagagttccc taatgtagtt gtagctcaac ctccagagca ttcacacctg
     1621 actcaagcca cagttcaacc tttggatctg gggtttacca tcactccaga atccaagaca
     1681 gaggttgaac tttctccaac catgaaggag accccaactc agcctcctaa gaaagttgta
     1741 ccccaacttc gagtatatca aggggtaaca aatccaacac caggtcagga tcaagctcag
     1801 catccagtgt cacccagcgt tacagttcaa cttttggacc tgggacttac catcactcca
     1861 gaacctacta cggaggttgg acattctaca cccccgaaga ggactatagt ttctccaaag
     1921 catcctgagg tgacacttcc acatccagac caggttcaga ctcagcattc acacctgact
     1981 cgagccacag ttcaaccttt ggacctgggg tttaccatca ctccaaaatc catgacagag
     2041 gttgaacctt ctacagccct gatgactaca gctcctcctc caggacaccc tgaggtgaca
     2101 cttccacctt cagacaaggg tcaggctcag cattcacacc tgactcaagc caccgttcaa
     2161 cctctggacc tggagcttac cataactaca aaacctacta cagaggttaa accatctcca
     2221 accacggagg agacctcaac tcagcctcca gacctgggac ttgccatcat tccagaaccc
     2281 actacagaga ctggacattc tacagccctg gagaagacta cagctcctcg tccagaccgg
     2341 gttcagactc tgcatcgaag cctgactgaa gtcacaggtc cacctactga actagaacct
     2401 gctcaggatt cactggtgca gtctgaaagt tacacccaaa ataaggcttt aactgcacca
     2461 gaggaacaca aggcctccac aagcaccaac atatgtgagc tctgtacctg cggagatgag
     2521 atgttgtcat gtattgatct caacccagag cagaggctcc gccaagtgcc tgtgccagag
     2581 cccaacaccc acaatggcac cttcaccatc ttaaatttcc aaggaaacta tatttcttac
     2641 attgatggaa atgtatggaa agcatacagt tggactgaga aactaattct cagagaaaat
     2701 aacttgactg aattacacaa ggattcattt gaaggcctgc tatccctcca gtatttagat
     2761 ttatcctgca ataaaataca gtctattgaa agacatacat ttgaaccact accatttttg
     2821 aagtttataa atcttagttg caatgtaatt acagaactca gctttggaac atttcaggcc
     2881 tggcacggaa tgcagttttt acataagtta attctcaatc acaatcctct gacaactgtt
     2941 gaagatccgt atctctttaa attgccagca ttaaaatatc tagacatggg aacaacgcta
     3001 gtcccactta caacacttaa gaacattctc atgatgactg ttgaactgga aaaactgatc
     3061 ttacctagcc atatggcctg ctgcctctgc caatttaaaa acagcattga ggctgtctgc
     3121 aagacagtca agctgcattg caacagtgca tgtctgacaa acaccacaca ttgtcctgaa
     3181 gaagcatcgg tagggaatcc agaaggagcg ttcatgaagg tgttacaagc ccggaagaac
     3241 tacacaagca ctgagctgat tgttgagcca gaggagccct cagacagcag tggcatcaac
     3301 ttgtcaggct ttgggagtga gcagctagac accaatgacg agagtgattt tatcagtaca
     3361 ctaagttaca tcttgcctta tttctcagcg gtaaacctag atgtgaaatc actgttacta
     3421 ccgttcatta aactgccaac cacaggaaac agcctggcaa agattcaaac tgtaggccaa
     3481 aaccggcaga gagtgaagag agtcctcatg ggcccaagga gcatccagaa aaggcacttc
     3541 aaagaggtag gaaggcagag catcaggagg gaacagggtg cccaggcatc tgtggagaac
     3601 gctgccgaag aaaaaaggct cacgagtcca gccccaaggg aggtggaaca gccccacaca
     3661 cagcaggggc ctgagaagtt agcgggaaac gccgtctaca ccaagccttc gttcacccaa
     3721 gagcataagg cagcagtctc tgtgctgaaa cccttctcca agggcacgcc ttctacctcc
     3781 agccctgcaa aagccctacc acaggtgaga gacagatcga aagacttaac ccacgctatt
     3841 tccattttag aaagtgcaaa ggctagagtt acaaatacga agacgtctaa accaatcgta
     3901 catgccagaa aaaaataccg ctttcacaaa actcgctccc acgtgaccca cagaacaacc
     3961 aaagtcaaaa agagtccaaa ggtcagaaag aaaagttatc tgagtagact gatgctcgca
     4021 aacaggcttc cattctctgc agcgaagagc ctcataaatt ccccttcaca aggggctttt
     4081 tcatccttag gagacctgag tcctcaagaa aacccttttc tggaagtatc tgctctttca
     4141 gaacatttta tagagaagaa taatacaaaa cacacaactg caagaaatgc ctttgaagaa
     4201 aatgatttta tggaaaacac taacatgcca gaaggaacca tctctgaaaa cacaaactac
     4261 aatcatcctc ctgaggcaga ttccgctggg actgcattca acttagggcc aactgttaaa
     4321 caaactgaga caaaatggga atacaacaac gtgggcactg acctgtcccc cgagcccaaa
     4381 agcttcaatt acccattgct ctcgtcccca ggtgatcagt ttgaaattca gctaacccag
     4441 cagctacagt cccttatccc caacaacaat gtgagaaggc tcattgctca tgttatccgg
     4501 accttgaaga tggactgctc tggggcccat gtgcaagtga cctgtgccaa gctcatctcc
     4561 aggacaggcc acctgatgaa gcttctcagt gggcagcagg aagtaaaggc atccaagata
     4621 gaatgggata cggaccaatg gaagattgag aactacatta atgagagcac agaagcccag
     4681 agtgaacaga aagagaagtc gcttgagctc aaaaaagaag ttccaggata tggctatact
     4741 gacaaactca tcttggcatt aattgttact ggaatactaa cgattttgat tatacttttc
     4801 tgcctcattg tgatatgttg tcaccgaagg tcattacaag aagatgaaga aggattctca
     4861 aggggcattt tcagatttct gccatggagg ggatgctctt cgcgaaggga gagtcaggat
     4921 ggactttcct catttggaca gccgctctgg tttaaagatc tgtacaaacc tctcagtgcc
     4981 acaagaataa ataatcatgc atggaagctg cacaagaagt catctaatga ggacaagatc
     5041 ctcaacaggg accctgggga cagcgaagcc ccaacggagg aggaggagag tgaagccctg
     5101 ccataggagg agaacacagc ccacctcagg cctcctgcaa aaatacatag aataaacaac
     5161 aacagttact aaatgaa
//
