LOCUS       NM_018296               2428 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens leucine rich repeat containing 36 (LRRC36), transcript
            variant 1, mRNA.
ACCESSION   NM_018296
VERSION     NM_018296.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2428)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC009061.10, BC026156.2 and BC018031.1.
            
            On Nov 23, 2018 this sequence version replaced NM_018296.5.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC026156.2, AY963267.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000329956.11/ ENSP00000329943.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                AC009061.10        23219-23247
            30-174              BC026156.2         1-145
            175-175             AC009061.10        38417-38417
            176-2422            BC026156.2         147-2393
            2423-2428           BC018031.1         1888-1893
FEATURES             Location/Qualifiers
     source          1..2428
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.1"
     gene            1..2428
                     /gene="LRRC36"
                     /gene_synonym="RORBP70; XLHSRF2"
                     /note="leucine rich repeat containing 36"
                     /db_xref="GeneID:55282"
                     /db_xref="HGNC:HGNC:25615"
     exon            1..118
                     /gene="LRRC36"
                     /gene_synonym="RORBP70; XLHSRF2"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..2313
                     /gene="LRRC36"
                     /gene_synonym="RORBP70; XLHSRF2"
                     /note="isoform 1 is encoded by transcript variant 1; heat
                     shock regulated 2; leucine-rich repeat-containing protein
                     36; ROR gamma binding protein 70"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 36
                     isoform 1"
                     /protein_id="NP_060766.5"
                     /db_xref="CCDS:CCDS32467.1"
                     /db_xref="GeneID:55282"
                     /db_xref="HGNC:HGNC:25615"
                     /translation="MAEQWELDEEGIRRLGALTLEQPELVESLSLQGSYAGKIHSIGD
                     AFRNFKNLRSLDLSRNLITSLKGIQYLCSLQDLNLYYNNIPSLVEVSRLQPLPFLKEL
                     DLRLNPVVRKDTDYRLFAVYTLQTLEKLDDRTVREGERKAAKLHFSQLGNSENFLLEV
                     EKSSREKTMKNCVTGESSASKVSANVDSRIEMDSNKGLFIPFPNREIKDSLSTSATQG
                     NGTRDQKLDTFPLGTQTQEVARREMPSDNHQEDEFRHYSPRQSTVRSPEKMTREGYQV
                     SFLDNKSSGSSPEKELIPKPDTFHLTHDASLSKCLDVGDSSQIHPYQLPSDVGLENYD
                     SCYSQTLSLHGSLGKRPQRSKNYQEYSIKPSNDIKTTASHSCGDLLTSLSNPDSSTGR
                     LLKLSSDLYATTHFNSDPAVLVNVEQQLSTSLDDLTPAHGSVPNNAVLGNRTTPLRTL
                     LLSPGTSEHRKIFTKRSLSPSKRGFKWKDNILANLNLKHGFQDATGSEPLSSDLGSLH
                     GLAGNHSPPISARTPHVATVLRQLLELVDKHWNGSGSLLLNKKFLGPARDLLLSLVVP
                     APSQPRCCSHPEDTMKAFCRRELELKEAAQLVPNDMESLKQKLVRVLEENLILSEKIQ
                     QLEEGAAISIVSGQQSHTYDDLLHKNQQLTMQVACLNQELAQLKKLEKTVAILHESQR
                     SLVVTNEYLLQQLNKEPKGYSGKALLPPEKGHHLGRSSPFGKSTLSSSSPVAHETGQY
                     LIQSVLDAAPEPGL"
     exon            119..246
                     /gene="LRRC36"
                     /gene_synonym="RORBP70; XLHSRF2"
                     /inference="alignment:Splign:2.1.0"
     exon            247..439
                     /gene="LRRC36"
                     /gene_synonym="RORBP70; XLHSRF2"
                     /inference="alignment:Splign:2.1.0"
     exon            440..536
                     /gene="LRRC36"
                     /gene_synonym="RORBP70; XLHSRF2"
                     /inference="alignment:Splign:2.1.0"
     exon            537..625
                     /gene="LRRC36"
                     /gene_synonym="RORBP70; XLHSRF2"
                     /inference="alignment:Splign:2.1.0"
     exon            626..750
                     /gene="LRRC36"
                     /gene_synonym="RORBP70; XLHSRF2"
                     /inference="alignment:Splign:2.1.0"
     exon            751..802
                     /gene="LRRC36"
                     /gene_synonym="RORBP70; XLHSRF2"
                     /inference="alignment:Splign:2.1.0"
     exon            803..1243
                     /gene="LRRC36"
                     /gene_synonym="RORBP70; XLHSRF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1542
                     /gene="LRRC36"
                     /gene_synonym="RORBP70; XLHSRF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1708
                     /gene="LRRC36"
                     /gene_synonym="RORBP70; XLHSRF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1709..1854
                     /gene="LRRC36"
                     /gene_synonym="RORBP70; XLHSRF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1855..1978
                     /gene="LRRC36"
                     /gene_synonym="RORBP70; XLHSRF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1979..2093
                     /gene="LRRC36"
                     /gene_synonym="RORBP70; XLHSRF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2094..2428
                     /gene="LRRC36"
                     /gene_synonym="RORBP70; XLHSRF2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2410..2415
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRC36"
                     /gene_synonym="RORBP70; XLHSRF2"
                     /note="hexamer: AAGAAA"
     polyA_site      2428
                     /gene="LRRC36"
                     /gene_synonym="RORBP70; XLHSRF2"
                     /note="major polyA site"
ORIGIN      
        1 gtgcgccggg tggtctcgcg ggcggtggca ggtgagcggc gggcggggat ggcggagcaa
       61 tgggagctgg acgaggaagg cattcgccgc ctgggggcgc tgacgctgga gcagccggaa
      121 ctggtggagt ctctttcatt gcagggatct tatgctggca aaatccattc cattggtgat
      181 gccttcagaa attttaaaaa tctccgatcc ttagatttat caaggaattt gatcactagc
      241 cttaagggaa tccagtattt atgttcactc caagacctga atttatatta taacaacatt
      301 ccttcattag tggaagtgtc ccgtctacaa ccgttaccct tcctcaaaga actggatttg
      361 agacttaatc ctgttgtaag gaaagataca gattataggc tctttgctgt atatacacta
      421 caaactctgg agaaattaga tgaccgaact gtacgtgaag gtgagagaaa agctgccaag
      481 ctgcatttta gtcagttggg caacagtgaa aattttcttt tagaggtgga aaaaagctct
      541 agggagaaga caatgaaaaa ctgtgtaaca ggtgagagct ctgcatcaaa agtcagtgct
      601 aatgttgaca gcaggattga aatggactca aacaaaggac tttttattcc cttccccaac
      661 cgggaaataa aggattccct aagtacttct gcaactcagg gcaatggtac acgtgatcag
      721 aaattagaca ccttcccact ggggacacag acacaggaag tagcaagaag ggagatgcca
      781 agtgacaatc accaggaaga tgagttcaga cactactcgc ctcgtcagtc cacagtccga
      841 tccccagaga agatgactag agaagggtac caagtatctt ttttggacaa taagtcttca
      901 ggttcttctc cagaaaagga attgatacca aaacctgata cttttcatct tacccatgat
      961 gcctcattga gtaaatgcct ggatgtgggt gattctagcc agatccatcc ctatcagtta
     1021 ccttcagatg ttggtctgga aaattatgac agttgttatt ctcaaactct atccctgcat
     1081 ggaagtcttg gtaaaaggcc tcagagaagc aagaactatc aagagtatag cataaagcct
     1141 tcaaatgaca taaagaccac cgcttcacat tcctgtggag acttattaac ttctctgtca
     1201 aaccctgact ccagcactgg aaggcttttg aagcttagtt cagatctgta tgccacaacc
     1261 catttcaaca gtgaccctgc tgtacttgtc aatgtagagc aacaattatc taccagcctg
     1321 gatgatttaa caccagcaca tggttctgtc ccaaacaacg ctgtcctggg aaacaggaca
     1381 actcctctgc ggacactgct gttgtctcct gggacttcag aacacagaaa gatttttacc
     1441 aagaggtcac taagcccatc gaagagagga ttcaaatgga aggacaatat ccttgccaac
     1501 ctgaatctaa agcatggttt ccaagatgct acaggcagcg agcctctctc tagtgacctg
     1561 ggtagtttgc acggtttggc tggaaaccac agtcccccca tctctgccag aaccccccat
     1621 gtggccactg tcctcagaca gctcctggag cttgtggata agcactggaa tggctccggc
     1681 tccctcctcc tcaacaagaa gtttctcggt cctgcccgag atttgcttct gtctttggta
     1741 gtcccggctc cttctcagcc gaggtgttgc tcacatcctg aagacacgat gaaagcattc
     1801 tgcaggaggg agcttgaact gaaggaggct gcgcagctgg tccctaatga catggaaagt
     1861 ttgaagcaaa aactggtcag agtgctggag gaaaacctca ttttgtcaga aaaaattcaa
     1921 cagttggagg aaggtgctgc catctcaatt gtgagtgggc aacagtcaca tacttatgat
     1981 gatcttctgc acaaaaacca acagctgacc atgcaggtgg cttgcctgaa ccaggagctt
     2041 gcccagctga aaaagctgga gaagacagtt gccattctcc atgaaagtca gagatccctg
     2101 gtggtaacta atgagtatct gctgcagcag ctgaataagg agccaaaagg ttattccggg
     2161 aaagcgctcc tgcctcctga gaagggtcat catctgggga gatcatcgcc ctttgggaaa
     2221 agcacgttgt cttcctcctc accagtggca catgagactg gtcagtatct aatacagagc
     2281 gtcttggatg ctgccccaga gcctggctta tagagctagc atggaactca caccacagct
     2341 tccctggtcc acagaggctc tcaccgccat tgccaccagt atggtggtat gtactcacaa
     2401 agattaagaa agaaatgtat tctgatta
//
