LOCUS       NM_001172779            2383 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens leucine rich repeat containing 34 (LRRC34), transcript
            variant 2, mRNA.
ACCESSION   NM_001172779
VERSION     NM_001172779.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2383)
  AUTHORS   Comiskey,D.F. Jr., He,H., Liyanarachchi,S., Sheikh,M.S.,
            Genutis,L.K., Hendrickson,I.V., Yu,L., Brock,P.L. and de la
            Chapelle,A.
  TITLE     Variants in LRRC34 reveal distinct mechanisms for predisposition to
            papillary thyroid carcinoma
  JOURNAL   J Med Genet 57 (8), 519-527 (2020)
   PUBMED   32051256
  REMARK    GeneRIF: Variants in LRRC34 reveal distinct mechanisms for
            predisposition to papillary thyroid carcinoma.
REFERENCE   2  (bases 1 to 2383)
  AUTHORS   Ou,J.H., Li,Y.R., Wang,Z.P., Jin,C., Li,K., Lu,Y., Zou,D.F.,
            Li,P.Y., Li,M.Z., Miao,S.Y., Wang,L.F. and Song,W.
  TITLE     Lrrc34 Is Highly Expressed in SSCs and Is Necessary for SSC
            Expansion In Vitro
  JOURNAL   Chin Med Sci J 35 (1), 20-30 (2020)
   PUBMED   32299535
REFERENCE   3  (bases 1 to 2383)
  AUTHORS   Luhrig,S., Siamishi,I., Tesmer-Wolf,M., Zechner,U., Engel,W. and
            Nolte,J.
  TITLE     Lrrc34, a novel nucleolar protein, interacts with npm1 and ncl and
            has an impact on pluripotent stem cells
  JOURNAL   Stem Cells Dev 23 (23), 2862-2874 (2014)
   PUBMED   24991885
  REMARK    GeneRIF: LRRC34 is a novel nucleolar protein that is predominantly
            expressed in pluripotent stem cells.
REFERENCE   4  (bases 1 to 2383)
  AUTHORS   Figueroa,J.D., Ye,Y., Siddiq,A., Garcia-Closas,M., Chatterjee,N.,
            Prokunina-Olsson,L., Cortessis,V.K., Kooperberg,C., Cussenot,O.,
            Benhamou,S., Prescott,J., Porru,S., Dinney,C.P., Malats,N.,
            Baris,D., Purdue,M., Jacobs,E.J., Albanes,D., Wang,Z., Deng,X.,
            Chung,C.C., Tang,W., Bas Bueno-de-Mesquita,H., Trichopoulos,D.,
            Ljungberg,B., Clavel-Chapelon,F., Weiderpass,E., Krogh,V.,
            Dorronsoro,M., Travis,R., Tjonneland,A., Brenan,P.,
            Chang-Claude,J., Riboli,E., Conti,D., Gago-Dominguez,M.,
            Stern,M.C., Pike,M.C., Van Den Berg,D., Yuan,J.M., Hohensee,C.,
            Rodabough,R., Cancel-Tassin,G., Roupret,M., Comperat,E., Chen,C.,
            De Vivo,I., Giovannucci,E., Hunter,D.J., Kraft,P., Lindstrom,S.,
            Carta,A., Pavanello,S., Arici,C., Mastrangelo,G., Kamat,A.M.,
            Lerner,S.P., Barton Grossman,H., Lin,J., Gu,J., Pu,X.,
            Hutchinson,A., Burdette,L., Wheeler,W., Kogevinas,M., Tardon,A.,
            Serra,C., Carrato,A., Garcia-Closas,R., Lloreta,J., Schwenn,M.,
            Karagas,M.R., Johnson,A., Schned,A., Armenti,K.R., Hosain,G.M.,
            Andriole,G. Jr., Grubb,R. 3rd, Black,A., Ryan Diver,W.,
            Gapstur,S.M., Weinstein,S.J., Virtamo,J., Haiman,C.A., Landi,M.T.,
            Caporaso,N., Fraumeni,J.F. Jr., Vineis,P., Wu,X., Silverman,D.T.,
            Chanock,S. and Rothman,N.
  TITLE     Genome-wide association study identifies multiple loci associated
            with bladder cancer risk
  JOURNAL   Hum Mol Genet 23 (5), 1387-1398 (2014)
   PUBMED   24163127
REFERENCE   5  (bases 1 to 2383)
  AUTHORS   Pooley,K.A., Bojesen,S.E., Weischer,M., Nielsen,S.F., Thompson,D.,
            Amin Al Olama,A., Michailidou,K., Tyrer,J.P., Benlloch,S.,
            Brown,J., Audley,T., Luben,R., Khaw,K.T., Neal,D.E., Hamdy,F.C.,
            Donovan,J.L., Kote-Jarai,Z., Baynes,C., Shah,M., Bolla,M.K.,
            Wang,Q., Dennis,J., Dicks,E., Yang,R., Rudolph,A., Schildkraut,J.,
            Chang-Claude,J., Burwinkel,B., Chenevix-Trench,G., Pharoah,P.D.,
            Berchuck,A., Eeles,R.A., Easton,D.F., Dunning,A.M. and
            Nordestgaard,B.G.
  TITLE     A genome-wide association scan (GWAS) for mean telomere length
            within the COGS project: identified loci show little association
            with hormone-related cancer risk
  JOURNAL   Hum Mol Genet 22 (24), 5056-5064 (2013)
   PUBMED   23900074
REFERENCE   6  (bases 1 to 2383)
  AUTHORS   Fingerlin,T.E., Murphy,E., Zhang,W., Peljto,A.L., Brown,K.K.,
            Steele,M.P., Loyd,J.E., Cosgrove,G.P., Lynch,D., Groshong,S.,
            Collard,H.R., Wolters,P.J., Bradford,W.Z., Kossen,K., Seiwert,S.D.,
            du Bois,R.M., Garcia,C.K., Devine,M.S., Gudmundsson,G.,
            Isaksson,H.J., Kaminski,N., Zhang,Y., Gibson,K.F., Lancaster,L.H.,
            Cogan,J.D., Mason,W.R., Maher,T.M., Molyneaux,P.L., Wells,A.U.,
            Moffatt,M.F., Selman,M., Pardo,A., Kim,D.S., Crapo,J.D., Make,B.J.,
            Regan,E.A., Walek,D.S., Daniel,J.J., Kamatani,Y., Zelenika,D.,
            Smith,K., McKean,D., Pedersen,B.S., Talbert,J., Kidd,R.N.,
            Markin,C.R., Beckman,K.B., Lathrop,M., Schwarz,M.I. and
            Schwartz,D.A.
  TITLE     Genome-wide association study identifies multiple susceptibility
            loci for pulmonary fibrosis
  JOURNAL   Nat Genet 45 (6), 613-620 (2013)
   PUBMED   23583980
  REMARK    Erratum:[Nat Genet. 2013 Nov;45(11):1409]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC078795.19, DB500348.1, AK293661.1 and BC032841.2.
            
            On May 15, 2019 this sequence version replaced NM_001172779.1.
            
            Transcript Variant: This variant (2) uses an alternate 3' splice
            pattern with additional 3' coding exons, compared to variant 1. The
            resulting isoform (2) has a longer and distinct C-terminus,
            compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.212215.1,
                                           SRR3476690.1177324.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000446859.7/ ENSP00000414635.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-118               AC078795.19        87648-87765
            119-240             DB500348.1         1-122
            241-600             AK293661.1         1-360
            601-601             BC032841.2         222-222
            602-1958            AK293661.1         362-1718
            1959-2383           AC078795.19        107125-107549
FEATURES             Location/Qualifiers
     source          1..2383
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q26.2"
     gene            1..2383
                     /gene="LRRC34"
                     /note="leucine rich repeat containing 34"
                     /db_xref="GeneID:151827"
                     /db_xref="HGNC:HGNC:28408"
                     /db_xref="MIM:619037"
     exon            1..495
                     /gene="LRRC34"
                     /inference="alignment:Splign:2.1.0"
     CDS             357..1751
                     /gene="LRRC34"
                     /note="isoform 2 is encoded by transcript variant 2;
                     leucine-rich repeat-containing protein 34"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 34
                     isoform 2"
                     /protein_id="NP_001166250.1"
                     /db_xref="CCDS:CCDS54672.1"
                     /db_xref="GeneID:151827"
                     /db_xref="HGNC:HGNC:28408"
                     /db_xref="MIM:619037"
                     /translation="MAAQPPRPVGERSMGSSREAARAPARSPAWASTQASTPGAALAV
                     QRESPESGLQKHYSNLCMEKSQKINPFILHILQEVDEEIKKGLAAGITLNIAGNNRLV
                     PVERVTGEDFWILSKILKNCLYINGLDVGYNLLCDVGAYYAAKLLQKQLNLIYLNLMF
                     NDIGPEGGELIAKVLHKNRTLKYLRMTGNKIENKGGMFFAAMLQINSSLEKLDLGDCD
                     LGMQSVIAFATVLTQNQAIKAINLNRPILYSEQEESTVHVGRMLKENHCLVALHMCKH
                     DIKNSGIQQLCDALYLNSSLRYLDVSCNKITHDGMVYLADVLKSNTTLEVIDLSFNRI
                     ENAGANYLSETLTSHNRSLKALSVVSNNIEGEGLVALSQSMKTNLTFSHIYIWGNKFD
                     EATCIAYSDLIQMGCLKPDNTDVEPFVVDGRVYLAEVSNGLKKHYYWTSTYGESYDHS
                     SNAGFALVPVGQQP"
     exon            496..613
                     /gene="LRRC34"
                     /inference="alignment:Splign:2.1.0"
     exon            614..735
                     /gene="LRRC34"
                     /inference="alignment:Splign:2.1.0"
     exon            736..800
                     /gene="LRRC34"
                     /inference="alignment:Splign:2.1.0"
     exon            801..884
                     /gene="LRRC34"
                     /inference="alignment:Splign:2.1.0"
     exon            885..1013
                     /gene="LRRC34"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1109
                     /gene="LRRC34"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1264
                     /gene="LRRC34"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1420
                     /gene="LRRC34"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1547
                     /gene="LRRC34"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..2383
                     /gene="LRRC34"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1881..1886
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRC34"
                     /note="hexamer: ATTAAA"
     polyA_site      1913
                     /gene="LRRC34"
                     /note="major polyA site"
     regulatory      2356..2361
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRC34"
                     /note="hexamer: TATAAA"
     polyA_site      2383
                     /gene="LRRC34"
ORIGIN      
        1 gcctttatca tgtgctgatg ctactctgct tcttcgctgg cccggcaggc cggtgcacac
       61 tttgtaggag cgggctttgt cataatcttc tttgtagccc cagccctagc tcagcagcgg
      121 agcccctcaa acctcgggaa ctcctccctg caaaggagcc aggacgccct ccctcaggct
      181 gcctttaacc agggcagggt gacaaaggac ctccacagag taggcggtca ctgccttagc
      241 agtgaggcct cagggcccgg gcaggcacag ccagcgggac tcgaagcagg ctggcgccga
      301 ggctcgtgta gccgcctcac agctgcaggc ggactgtaag tgcgcgcgcg gtcgccatgg
      361 cagcgcagcc gccgcggcca gtgggtgaga ggagcatggg gagctcccgg gaggccgccc
      421 gtgcgccggc caggtccccg gcttgggcct ccactcaggc cagtactccg ggcgcggccc
      481 tggcggtcca gcgcgaatct ccagaatctg gtctccagaa acattattct aatctgtgta
      541 tggaaaaatc ccagaaaatt aatcctttta tattgcatat actccaagaa gtggatgaag
      601 aaattaaaaa ggggctagca gcaggaatca cattaaacat tgctggtaac aatcgcttag
      661 tgccagtaga aagagttaca ggtgaagatt tttggattct ttccaaaatt ttaaagaatt
      721 gtctgtatat taatggtttg gatgttggat ataaccttct atgtgatgtt ggtgcatact
      781 atgctgcgaa actgcttcag aaacaactta atctcattta cttaaacctc atgtttaatg
      841 atattgggcc cgaaggtgga gaattgattg ctaaagtgct acataagaat cggactctga
      901 aatacctaag aatgactgga aacaaaattg aaaataaagg tggaatgttt tttgctgcaa
      961 tgctgcaaat taattcatca ttagagaaat tagatctggg tgactgtgat ctgggaatgc
     1021 aaagtgtgat agcatttgct acagtactaa ctcaaaacca agcaattaag gcaataaacc
     1081 taaaccgacc tatactgtac agtgaacagg aagagtctac agtccatgta ggccgcatgt
     1141 tgaaagaaaa tcactgtctt gttgcactac acatgtgtaa gcatgatata aaaaacagtg
     1201 gtatacaaca gttatgtgat gcactgtatc tgaacagtag cctgcgctac cttgatgtca
     1261 gctgcaacaa aataactcat gatggaatgg tgtatttggc tgatgtactg aaaagcaaca
     1321 ctaccctgga agtaatagat ctttccttta acagaataga aaatgcaggc gcaaactatc
     1381 tcagtgaaac tcttacttca cacaacagga gtcttaaagc gttgtcagta gtcagcaaca
     1441 acatagaggg agaaggactt gttgcacttt cacaatcaat gaaaacaaat ctcactttct
     1501 ctcatatcta catttgggga aacaaatttg atgaggctac gtgtatagca tattcagact
     1561 taattcaaat gggttgtcta aaaccagaca atacagatgt ggagccattt gtggtagatg
     1621 gacgtgtata tcttgcagaa gtctccaatg gccttaaaaa gcattattat tggacatcaa
     1681 cttatggaga atcttatgac cactcatcta atgcaggttt tgctcttgtt ccagtaggtc
     1741 aacagccatg aaaaagtagc tgtaaaataa ttttcataca cttgtcttat tgtttcacag
     1801 agattaatat tctatagcct attttctttt ataaattaaa acaagttact tttttcaaat
     1861 gtgtaaaaga taatgactgt attaaacttt gtataactgt ctattgtgaa aaactgagta
     1921 gggtaatttt ttaaaagaaa ttttacaata tagagactaa aattctaacc ctggagaaag
     1981 agaccaagga actagactaa atttcttttt ataatgaaaa tataaccaag tagtgaaata
     2041 gcgtacaagt aaaggtcatt gtaggtatct aactgaaagt tattaagtag tattaataaa
     2101 aaggtttgtg gtagaaaatt accagtgact ttcaaagggt ttcaaagttc agaagttgaa
     2161 aaagtattct acctatccta tttacgtgtt acagacaggt gttactaaca atttcataaa
     2221 tacaggcaaa tatatataaa catatacata cccctttccc aacaagccag tgctgccagc
     2281 tctcccactc tcctctcata accactatcc tgacttctaa ccccacagag tagttttgcc
     2341 tgttcttgac ctttatataa atggaagcat acagtataca ctc
//
