LOCUS       NM_001128922            4207 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens leucine rich repeat containing 32 (LRRC32), transcript
            variant 2, mRNA.
ACCESSION   NM_001128922
VERSION     NM_001128922.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4207)
  AUTHORS   Ma,J., Chen,Y., Li,T., Cao,Y., Hu,B., Liu,Y., Zhang,Y., Li,X.,
            Liu,J., Zhang,W., Niu,H., Gao,J., Zhang,Z., Yue,K., Wang,J.,
            Bao,G., Wang,C., Wang,P.G., Zou,T. and Xie,S.
  TITLE     Suppression of lysosome metabolism-meditated GARP/TGF-beta1
            complexes specifically depletes regulatory T cells to inhibit
            breast cancer metastasis
  JOURNAL   Oncogene 43 (25), 1930-1940 (2024)
   PUBMED   38698265
  REMARK    GeneRIF: Suppression of lysosome metabolism-meditated
            GARP/TGF-beta1 complexes specifically depletes regulatory T cells
            to inhibit breast cancer metastasis.
REFERENCE   2  (bases 1 to 4207)
  AUTHORS   Zhang,X., Sharma,P., Maschmeyer,P., Hu,Y., Lou,M., Kim,J.,
            Fujii,H., Unutmaz,D., Schwabe,R.F. and Winau,F.
  TITLE     GARP on hepatic stellate cells is essential for the development of
            liver fibrosis
  JOURNAL   J Hepatol 79 (5), 1214-1225 (2023)
   PUBMED   37348791
  REMARK    GeneRIF: GARP on hepatic stellate cells is essential for the
            development of liver fibrosis.
REFERENCE   3  (bases 1 to 4207)
  AUTHORS   Cai,H., Liu,Y., Dong,X., Jiang,F., Li,H., Ouyang,S., Yin,W., He,T.,
            Zeng,Q. and Yang,H.
  TITLE     Analysis of LAP+ and GARP+ Treg subsets in peripheral blood of
            patients with neuromyelitis optica spectrum disorders
  JOURNAL   Neurol Sci 44 (5), 1739-1747 (2023)
   PUBMED   36683084
  REMARK    GeneRIF: Analysis of LAP[+] and GARP[+] Treg subsets in peripheral
            blood of patients with neuromyelitis optica spectrum disorders.
REFERENCE   4  (bases 1 to 4207)
  AUTHORS   Lahimchi,M.R., Eslami,M. and Yousefi,B.
  TITLE     New insight into GARP striking role in cancer progression:
            application for cancer therapy
  JOURNAL   Med Oncol 40 (1), 33 (2022)
   PUBMED   36460874
  REMARK    GeneRIF: New insight into GARP striking role in cancer progression:
            application for cancer therapy.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4207)
  AUTHORS   Jiang,S., Zhang,Y., Zhang,X., Lu,B., Sun,P., Wu,Q., Ding,X. and
            Huang,J.
  TITLE     GARP Correlates With Tumor-Infiltrating T-Cells and Predicts the
            Outcome of Gastric Cancer
  JOURNAL   Front Immunol 12, 660397 (2021)
   PUBMED   34421887
  REMARK    GeneRIF: GARP Correlates With Tumor-Infiltrating T-Cells and
            Predicts the Outcome of Gastric Cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4207)
  AUTHORS   Macaulay,I.C., Tijssen,M.R., Thijssen-Timmer,D.C., Gusnanto,A.,
            Steward,M., Burns,P., Langford,C.F., Ellis,P.D., Dudbridge,F.,
            Zwaginga,J.J., Watkins,N.A., van der Schoot,C.E. and Ouwehand,W.H.
  TITLE     Comparative gene expression profiling of in vitro differentiated
            megakaryocytes and erythroblasts identifies novel activatory and
            inhibitory platelet membrane proteins
  JOURNAL   Blood 109 (8), 3260-3269 (2007)
   PUBMED   17192395
REFERENCE   7  (bases 1 to 4207)
  AUTHORS   Maire,G., Forus,A., Foa,C., Bjerkehagen,B., Mainguene,C.,
            Kresse,S.H., Myklebost,O. and Pedeutour,F.
  TITLE     11q13 alterations in two cases of hibernoma: large heterozygous
            deletions and rearrangement breakpoints near GARP in 11q13.5
  JOURNAL   Genes Chromosomes Cancer 37 (4), 389-395 (2003)
   PUBMED   12800150
REFERENCE   8  (bases 1 to 4207)
  AUTHORS   Roubin,R., Pizette,S., Ollendorff,V., Planche,J., Birnbaum,D. and
            Delapeyriere,O.
  TITLE     Structure and developmental expression of mouse Garp, a gene
            encoding a new leucine-rich repeat-containing protein
  JOURNAL   Int J Dev Biol 40 (3), 545-555 (1996)
   PUBMED   8840187
REFERENCE   9  (bases 1 to 4207)
  AUTHORS   Ollendorff,V., Noguchi,T., deLapeyriere,O. and Birnbaum,D.
  TITLE     The GARP gene encodes a new member of the family of leucine-rich
            repeat-containing proteins
  JOURNAL   Cell Growth Differ 5 (2), 213-219 (1994)
   PUBMED   8180135
REFERENCE   10 (bases 1 to 4207)
  AUTHORS   Ollendorff,V., Szepetowski,P., Mattei,M.G., Gaudray,P. and
            Birnbaum,D.
  TITLE     New gene in the homologous human 11q13-q14 and mouse 7F chromosomal
            regions
  JOURNAL   Mamm Genome 2 (3), 195-200 (1992)
   PUBMED   1543912
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC070079.1, BI010671.1,
            BC052210.1, DA591993.1 and AP001189.5.
            
            On Nov 23, 2018 this sequence version replaced NM_001128922.1.
            
            Summary: This gene encodes a type I membrane protein which contains
            20 leucine-rich repeats. Alterations in the chromosomal region
            11q13-11q14 are involved in several pathologies. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1-4 all encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC070079.1, SRR1660809.91003.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2153307, SAMEA2162946
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000260061.9/ ENSP00000260061.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-356               BC070079.1         1-356
            357-370             BI010671.1         86-99
            371-1985            BC070079.1         371-1985
            1986-2357           BC052210.1         1983-2354
            2358-2658           DA591993.1         255-555
            2659-4142           AP001189.5         101937-103420       c
            4143-4207           BC052210.1         4139-4203
FEATURES             Location/Qualifiers
     source          1..4207
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.5"
     gene            1..4207
                     /gene="LRRC32"
                     /gene_synonym="CPPRDD; D11S833E; GARP"
                     /note="leucine rich repeat containing 32"
                     /db_xref="GeneID:2615"
                     /db_xref="HGNC:HGNC:4161"
                     /db_xref="MIM:137207"
     exon            1..134
                     /gene="LRRC32"
                     /gene_synonym="CPPRDD; D11S833E; GARP"
                     /inference="alignment:Splign:2.1.0"
     exon            135..222
                     /gene="LRRC32"
                     /gene_synonym="CPPRDD; D11S833E; GARP"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..2127
                     /gene="LRRC32"
                     /gene_synonym="CPPRDD; D11S833E; GARP"
                     /note="isoform a precursor is encoded by transcript
                     variant 2; garpin; glycoprotein A repetitions predominant;
                     leucine-rich repeat-containing protein 32; transforming
                     growth factor beta activator LRRC32"
                     /codon_start=1
                     /product="transforming growth factor beta activator LRRC32
                     isoform a precursor"
                     /protein_id="NP_001122394.1"
                     /db_xref="CCDS:CCDS8245.1"
                     /db_xref="GeneID:2615"
                     /db_xref="HGNC:HGNC:4161"
                     /db_xref="MIM:137207"
                     /translation="MRPQILLLLALLTLGLAAQHQDKVPCKMVDKKVSCQVLGLLQVP
                     SVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHL
                     SLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAENS
                     LTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCISDFSLQ
                     QLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKLLHFPDLAALPRLIYLNLSNNL
                     IRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNASGRPLSQLLNLDLSYNEIELIPDSF
                     LEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNALETLELGARALGSLRTLL
                     LQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCVAFSGITSLRSLSL
                     VDNEIELLRAGAFLHTPLTELDLSSNPGLEVATGALGGLEASLEVLALQGNGLMVLQV
                     DLPCFICLKRLNLAENRLSHLPAWTQAVSLEVLDLRNNSFSLLPGSAMGGLETSLRRL
                     YLQGNPLSCCGNGWLAAQLHQGRVDVDATQDLICRFSSQEEVSLSHVRPEDCEKGGLK
                     NINLIIILTFILVSAILLTTLAACCCVRRQKFNQQYKA"
     exon            223..4207
                     /gene="LRRC32"
                     /gene_synonym="CPPRDD; D11S833E; GARP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4183..4188
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRC32"
                     /gene_synonym="CPPRDD; D11S833E; GARP"
                     /note="hexamer: ATTAAA"
     polyA_site      4207
                     /gene="LRRC32"
                     /gene_synonym="CPPRDD; D11S833E; GARP"
                     /note="major polyA site"
ORIGIN      
        1 ggtggggcag ctgagcggcc tgctcctcct cgggccgtga ccccggggtc tggcgcgggg
       61 tgggacccgg gggcgggttt gcgcaaaatg tgccgagact gcccgggaga ggagctgcgg
      121 ccgcgctgag ccagagccat gagaccccag atcctgctgc tcctggccct gctgacccta
      181 ggcctggctg cacaacacca agacaaagtg ccctgtaaga tggtggacaa gaaggtctcg
      241 tgccaggttc tgggcctgct ccaggtcccc tcggtgctcc cgccagacac tgagaccctt
      301 gatctatctg ggaaccagct gcggagtatc ctggcctcac ccctgggctt ctacacagca
      361 cttcgtcacc tggacctgag caccaatgag atcagcttcc tccagccagg agccttccag
      421 gccctgaccc acctggagca cctcagcctg gctcacaacc ggctggcgat ggccactgcg
      481 ctgagtgctg gtggcctggg ccccctgcca cgcgtgacct ccctggacct gtctgggaac
      541 agcctgtaca gcggcctgct ggagcggctg ctgggggagg cacccagcct gcataccctc
      601 tcactggcgg agaacagtct gactcgcctc acccgccaca ccttccggga catgcctgcg
      661 ctggagcagc ttgacctgca tagcaacgtg ctgatggaca tcgaggatgg cgccttcgag
      721 ggtctgcccc gcctgaccca tctcaacctc tccaggaatt ccctcacctg catctccgac
      781 ttcagcctcc agcagctgcg ggtgctagac ctgagctgca acagcatcga ggcctttcag
      841 acggcctccc agccccaggc tgagttccag ctcacctggc ttgacctgcg ggagaacaaa
      901 ctgctccatt tccccgacct ggccgcgctc ccgagactca tctacctgaa cttgtccaac
      961 aacctcatcc ggctccccac agggccaccc caggacagca agggcatcca cgcaccttcc
     1021 gagggctggt cagccctgcc cctctcagcc cccagcggga atgccagcgg ccgccccctt
     1081 tcccagctct tgaatctgga tttgagctac aatgagattg agctcatccc cgacagcttt
     1141 cttgagcacc tgacctccct gtgcttcctg aacctcagca gaaactgctt gcggaccttt
     1201 gaggcccggc gcttaggctc cctgccctgc ctgatgctcc ttgacttaag ccacaatgcc
     1261 ctggagacac tggaactggg cgccagagcc ctggggtctc tgcggacgct gctcctacag
     1321 ggcaatgccc tgcgggacct gcccccatac acctttgcca atctggccag cctgcagcgg
     1381 ctcaacctgc aggggaaccg agtcagcccc tgtggggggc cagatgagcc tggcccctcc
     1441 ggctgtgtgg ccttctccgg catcacctcc ctccgcagcc tgagcctggt ggataatgag
     1501 atagagctgc tcagggcagg ggccttcctc cacaccccac tgactgagct ggacctttct
     1561 tccaatcctg ggctggaggt ggccacgggg gccttgggag gcctggaggc ctccttggag
     1621 gtcctggcac tgcagggcaa cgggctgatg gtcctgcagg tggacctgcc ctgcttcatc
     1681 tgcctcaagc ggctcaatct tgccgagaac cgcctgagcc accttcccgc ctggacacag
     1741 gctgtgtcac tggaggtgct ggacctgcga aacaacagct tcagcctcct gccaggcagt
     1801 gccatgggtg gcctggagac cagcctccgg cgcctctacc tgcaggggaa tccactcagc
     1861 tgctgcggca atggctggct ggcagcccag ctgcaccagg gccgtgtgga cgtggacgcc
     1921 acccaggacc tgatctgccg cttcagctcc caggaggagg tgtccctgag ccacgtgcgt
     1981 cccgaggact gtgagaaggg gggactgaag aacatcaacc tcatcatcat cctcaccttc
     2041 atactggtct ctgccatcct cctcaccacg ctggccgcct gctgctgcgt ccgccggcag
     2101 aagtttaacc aacagtataa agcctaaaga agccgggaga cactctaggt cagtggggga
     2161 gcctgaggta cagagaagag tgaggactga ctcaaggtca cacagtgatc cgggatccca
     2221 gaactctggt ctccaaatta cagcccagga cacctttctc tgccgcctgc tgcatcagtg
     2281 ggtgaccccc ttcccgggct gcactttggg tccagctgtg gaagccagaa gttgggcggt
     2341 ttcagggaca gccgagaata atgttgacct gtcagatcaa caaatcttca ctgagcatgt
     2401 attttgtgcc acaccctgct ctgggcactg ggaatgctgg gaaatgagat acattcccgc
     2461 cctcaagaat ctcccagtct ggtaggagag agtgctgcag agccacgtgg ccgccacgca
     2521 gtgtgcttag ggcctgaggt gtgaaagccc agggctccag agctcggcag gccccgctgg
     2581 tttggtgcgg tgagtcctgc cccggctgtg ccagggtgag ggagggccaa gcccaggagg
     2641 atttgtctga gacatttcca agcagactgt ttgtcacgtc ttctgagaat gactttcagt
     2701 ctctctgaaa atgaaaagct taggaccaga agagagaatt ggagctgtac gagtgtgtct
     2761 cggatctggt gttgttaggt gggccacggc ggctccagca gggtctggtt aaggggtcca
     2821 gcccagcact ggaccattcc gtctcctgct ctggacttgc cctctccctt cctggcactc
     2881 tcatgttgca taccctgacc ccagtgctgc tctaagcacc gtccctgccc agccccactt
     2941 ctccatcgca gccccacctt ggctgctgag ccaggagcta aaaccttaga tatctggttc
     3001 tgttttgcac ccagcttggc agatgtggat ttgaatccaa gccttgtgtc tgcccctatg
     3061 tgacagctct atattttatc cccgttttat aaaagaggaa actgaagttc tgaaaatctc
     3121 cttccagggc cccagctaac taatgccata ggtgagattc aaaccttcat ccttctgtct
     3181 ccagggcctg atctttacca ctgcaggggc tgcaggccgt taagtggaca ggaagtggcc
     3241 ccacatagcc cgagcagggt ctggaagcat cctgtgctgt gcacacctgc tctctcctct
     3301 ctcccaggca ggcagctgca ggcgctctcc tccttctctg cctgtttccc tcctcccttc
     3361 ctttccaccc tggtgtgggt tctcctgttc tctctgtgct cttgcattct ctcattccct
     3421 tttcctctat tgagcagagc ctggagtttg agactatgga atccaacctc cccattgcac
     3481 agatggggaa actgaggctt aggaagagaa tgaaacttgt ggagagctta tacagagcct
     3541 ctgggggaaa aaagagccct tatttgtggg gtgagattgg gggttggacc agagtgatgt
     3601 cctctctcag ctatcacatc acaagataat gctggctcca aacttccttt ctgtgcctca
     3661 tcatgcaagg atcttttttc cctcttacaa aaacaggtaa aaagcctcac ccagatgacc
     3721 cccatccctc ataccatgga gtcatgagct gtctgggaag aatggacgtg ctgggaccaa
     3781 ctcaagacct tgttttgctg tcttcatcat cttacctgtg cttggcccac agtctggctc
     3841 atgatgtggg ctcagtaatg tgcgagaaag tgaaaatgcc actctctcca ccccatttta
     3901 cagaggagaa caccaaggcc cagaggaagt taagggagag tcaatgggca gagccagggc
     3961 taggccctgg tggtgtgtgg agcacccagg cagacccagt cctggttggg atcacaccca
     4021 cgggtgctac tgcacgtaac actcctcctt aggcctggag gccaaggtgt gggtccccac
     4081 gcctgatctt tgaaaacact acacagggct gctgtcactt cccagggccc aggcctcagc
     4141 ccaggcctcg ggaccaactc tttgtataac ctacctgaat gtattaaaaa ctaattttgg
     4201 agaagca
//
