LOCUS       NM_024727               2597 bp    mRNA    linear   PRI 20-AUG-2024
DEFINITION  Homo sapiens leucine rich repeat containing 31 (LRRC31), transcript
            variant 1, mRNA.
ACCESSION   NM_024727 XM_001133921 XM_001133922 XM_001133923
VERSION     NM_024727.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2597)
  AUTHORS   D'Mello,R.J., Caldwell,J.M., Azouz,N.P., Wen,T., Sherrill,J.D.,
            Hogan,S.P. and Rothenberg,M.E.
  TITLE     LRRC31 is induced by IL-13 and regulates kallikrein expression and
            barrier function in the esophageal epithelium
  JOURNAL   Mucosal Immunol 9 (3), 744-756 (2016)
   PUBMED   26462420
  REMARK    GeneRIF: this report shows that leucine-rich repeat-containing
            protein 31 (LRRC31) regulates esophageal epithelial barrier
            function
REFERENCE   2  (bases 1 to 2597)
  AUTHORS   Walsh,K.M., Codd,V., Smirnov,I.V., Rice,T., Decker,P.A.,
            Hansen,H.M., Kollmeyer,T., Kosel,M.L., Molinaro,A.M., McCoy,L.S.,
            Bracci,P.M., Cabriga,B.S., Pekmezci,M., Zheng,S., Wiemels,J.L.,
            Pico,A.R., Tihan,T., Berger,M.S., Chang,S.M., Prados,M.D.,
            Lachance,D.H., O'Neill,B.P., Sicotte,H., Eckel-Passow,J.E., van der
            Harst,P., Wiencke,J.K., Samani,N.J., Jenkins,R.B. and Wrensch,M.R.
  CONSRTM   ENGAGE Consortium Telomere Group
  TITLE     Variants near TERT and TERC influencing telomere length are
            associated with high-grade glioma risk
  JOURNAL   Nat Genet 46 (7), 731-735 (2014)
   PUBMED   24908248
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA425899.1, BC117401.1, AK026912.1 and AC078795.19.
            
            On May 17, 2019 this sequence version replaced NM_024727.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: GQ891402.1, EU668335.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000316428.10/ ENSP00000325978.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-570               DA425899.1         1-570
            571-1798            BC117401.1         469-1696
            1799-2528           AK026912.1         1628-2357
            2529-2597           AC078795.19        61312-61380
FEATURES             Location/Qualifiers
     source          1..2597
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q26.2"
     gene            1..2597
                     /gene="LRRC31"
                     /gene_synonym="HEL-S-293"
                     /note="leucine rich repeat containing 31"
                     /db_xref="GeneID:79782"
                     /db_xref="HGNC:HGNC:26261"
                     /db_xref="MIM:620925"
     exon            1..303
                     /gene="LRRC31"
                     /gene_synonym="HEL-S-293"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..1787
                     /gene="LRRC31"
                     /gene_synonym="HEL-S-293"
                     /note="isoform 1 is encoded by transcript variant 1;
                     leucine-rich repeat-containing protein 31; epididymis
                     secretory protein Li 293; epididymis secretory sperm
                     binding protein"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 31
                     isoform 1"
                     /protein_id="NP_079003.2"
                     /db_xref="CCDS:CCDS43167.1"
                     /db_xref="GeneID:79782"
                     /db_xref="HGNC:HGNC:26261"
                     /db_xref="MIM:620925"
                     /translation="MSQTRKKTSSEGETKPQTSTVNKFLRGSNAESRKEDNDLKTSDS
                     QPSDWIQKTATSETAKPLSSEMEWRSSMEKNEHFLQKLGKKAVNKCLDLNNCGLTTAD
                     MKEMVALLPFLPDLEELDISWNGFVGGTLLSITQQMHLVSKLKILRLGSCRLTTDDVQ
                     ALGEAFEMIPELEELNLSWNSKVGGNLPLILQKFQKGSKIQMIELVDCSLTSEDGTFL
                     GQLLPMLQSLEVLDLSINRDIVGSLNSIAQGLKSTSNLKVLKLHSCGLSQKSVKILDA
                     AFRYLGELRKLDLSCNKDLGGGFEDSPAQLVMLKHLQVLDLHQCSLTADDVMSLTQVI
                     PLLSNLQELDLSANKKMGSSSENLLSRLRFLPALKSLVINNCALESETFTALAEASVH
                     LSALEVFNLSWNKCVGGNLKLLLETLKLSMSLQVLRLSSCSLVTEDVALLASVIQTGH
                     LAKLQKLDLSYNDSICDAGWTMFCQNVRFLKELIELDISLRPSNFRDCGQWFRHLLYA
                     VTKLPQITEIGMKRWILPASQEEELECFDQDKKRSIHFDHGGFQ"
     exon            304..447
                     /gene="LRRC31"
                     /gene_synonym="HEL-S-293"
                     /inference="alignment:Splign:2.1.0"
     exon            448..615
                     /gene="LRRC31"
                     /gene_synonym="HEL-S-293"
                     /inference="alignment:Splign:2.1.0"
     exon            616..783
                     /gene="LRRC31"
                     /gene_synonym="HEL-S-293"
                     /inference="alignment:Splign:2.1.0"
     exon            784..951
                     /gene="LRRC31"
                     /gene_synonym="HEL-S-293"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1119
                     /gene="LRRC31"
                     /gene_synonym="HEL-S-293"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1287
                     /gene="LRRC31"
                     /gene_synonym="HEL-S-293"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1455
                     /gene="LRRC31"
                     /gene_synonym="HEL-S-293"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..2597
                     /gene="LRRC31"
                     /gene_synonym="HEL-S-293"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcatgtag gggaggatat tttgattgaa cacaggcttg acagaatctt cttttcttct
       61 tagaaatcct agaaaacaga aagcaacagg aagatgtctt attgggaact acccccatca
      121 acttcaccat gagtcaaaca aggaagaaaa cttcctcaga aggagaaact aagccccaga
      181 cttcaactgt caacaaattt ctcaggggct ccaatgctga aagcagaaaa gaggacaatg
      241 accttaaaac aagtgattcc caacccagcg actggataca gaagacagcc acctcagaga
      301 ctgctaagcc tctcagttca gaaatggaat ggagatccag tatggagaaa aatgagcatt
      361 tcctgcagaa gctgggcaaa aaggctgtca acaagtgtct agatttgaat aactgtggat
      421 taacaacagc ggacatgaaa gaaatggttg ccttgctgcc ttttctccca gacttggaag
      481 aactggatat ctcctggaat ggttttgtag gtggaaccct cctttccatc actcagcaaa
      541 tgcatctggt cagcaagtta aaaatcttga ggctgggtag ctgcagactc accactgacg
      601 atgttcaagc actgggagaa gcatttgaga tgattcctga acttgaagag ctaaatttgt
      661 cttggaacag taaagtggga ggaaatttgc ctctgatcct tcagaagttc caaaaaggga
      721 gcaagataca aatgattgag cttgtggatt gctccctcac gtcagaagat gggacatttc
      781 tgggtcaact gctacctatg ctgcaaagtc tcgaagtact tgatctttcc attaacagag
      841 acattgttgg cagtctgaac agtattgctc agggattaaa aagcacctca aatctgaaag
      901 tactgaagtt acattcatgt ggattatcac aaaagagtgt caaaatattg gatgctgctt
      961 ttaggtattt gggtgagctg aggaaattag atctttcctg caataaggat ctaggtggag
     1021 gttttgaaga ctcgccggct cagttggtca tgctaaagca tctacaagtc ctagatcttc
     1081 accagtgctc actaacagca gatgacgtga tgtcactgac ccaggtcatt cctttacttt
     1141 caaatcttca agaattggat ttatcagcca acaaaaagat gggcagttct tctgaaaact
     1201 tactcagcag gctccgattt ttaccagcat tgaagtcatt agttatcaac aactgtgctt
     1261 tggagagtga gacttttaca gctcttgctg aagcctctgt tcacctctct gctctggaag
     1321 tattcaacct ttcttggaac aagtgtgttg gtggcaactt gaagctgctt ctggaaacac
     1381 taaagctttc catgtctctt caagtgctga ggctgagcag ctgttccctg gtgacagagg
     1441 atgtggctct cctggcatcg gtcatacaga cgggtcatct ggccaaactg caaaagctgg
     1501 acctgagcta caatgacagc atctgtgatg cggggtggac catgttctgc caaaacgtgc
     1561 ggttcctcaa agagctaatc gagctggata ttagccttcg accatcaaat tttcgagatt
     1621 gtggacaatg gtttagacac ttgttatatg ctgtgaccaa gcttcctcag atcactgaga
     1681 taggaatgaa aagatggatt ctcccagctt cacaggagga agaactagaa tgctttgacc
     1741 aagataaaaa aagaagcatt cactttgacc atggtgggtt tcagtaaact gatttcccat
     1801 gtcctactaa gctacaaacc attctccaaa ggaaaagaac atgaacgaat tccagagtca
     1861 tgaactgaat ttcaacttct gggccattta atgggactta tattacaaga gctttgtaaa
     1921 tatatatata tattacatat atatatgtaa tatacatata tacacatata tataatatac
     1981 atatataata cacatatata tgtaaatata tatataatat ctaatatgag catgccatta
     2041 ttctctgtct atgaaacaaa aatggcattt ttcaatggat ttgttttgga tatataatta
     2101 gttcatttgc tgtttagaag ccttgccaaa agtgtttaga ttttggtact gcaactgctt
     2161 tcctcttgcc cagaaatgtt ttgcctcttc ttttcctaca agttaaatgt tctaaatata
     2221 aaggggtatg tgtgtgtgtg tgtaattcta atgtgaaagg cactagctgt ctaatagttt
     2281 catgtatcat tactattact atatgtatct taatgtagtc tatgtaggtt tttatcagaa
     2341 agtgtacctt tctatggttt attattttat attctggtgc cttttatctc agatataaac
     2401 catgaacagt aatgatagtc actgacatat aaatcttagt aaaaagtgat taaaaatcta
     2461 aaactcagta tgaaaaacat atcttgttag aataaattaa aaccttttat tgtttaaaaa
     2521 attgttaaca tattgcctcc aggcatttct ttgaaatgga atttgcttca taaaactaat
     2581 ttaattcgtt aatgaca
//
