LOCUS       NM_030891               5845 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens leucine rich repeat containing 3 (LRRC3), mRNA.
ACCESSION   NM_030891
VERSION     NM_030891.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5845)
  AUTHORS   Warnatz,H.J., Querfurth,R., Guerasimova,A., Cheng,X., Haas,S.A.,
            Hufton,A.L., Manke,T., Vanhecke,D., Nietfeld,W., Vingron,M.,
            Janitz,M., Lehrach,H. and Yaspo,M.L.
  TITLE     Functional analysis and identification of cis-regulatory elements
            of human chromosome 21 gene promoters
  JOURNAL   Nucleic Acids Res 38 (18), 6112-6123 (2010)
   PUBMED   20494980
  REMARK    GeneRIF: The C21orf30 distal promoter contains an activating
            cis-regulatory element that is responsive to serum depletion
            according to promoter reporter assays in HEK 293 cells.
REFERENCE   2  (bases 1 to 5845)
  AUTHORS   Wu,C., Ma,M.H., Brown,K.R., Geisler,M., Li,L., Tzeng,E., Jia,C.Y.,
            Jurisica,I. and Li,S.S.
  TITLE     Systematic identification of SH3 domain-mediated human
            protein-protein interactions by peptide array target screening
  JOURNAL   Proteomics 7 (11), 1775-1785 (2007)
   PUBMED   17474147
REFERENCE   3  (bases 1 to 5845)
  AUTHORS   Hu,Y.H., Warnatz,H.J., Vanhecke,D., Wagner,F., Fiebitz,A.,
            Thamm,S., Kahlem,P., Lehrach,H., Yaspo,M.L. and Janitz,M.
  TITLE     Cell array-based intracellular localization screening reveals novel
            functional features of human chromosome 21 proteins
  JOURNAL   BMC Genomics 7, 155 (2006)
   PUBMED   16780588
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5845)
  AUTHORS   Reymond,A., Camargo,A.A., Deutsch,S., Stevenson,B.J.,
            Parmigiani,R.B., Ucla,C., Bettoni,F., Rossier,C., Lyle,R.,
            Guipponi,M., de Souza,S., Iseli,C., Jongeneel,C.V., Bucher,P.,
            Simpson,A.J. and Antonarakis,S.E.
  TITLE     Nineteen additional unpredicted transcripts from human chromosome
            21
  JOURNAL   Genomics 79 (6), 824-832 (2002)
   PUBMED   12036297
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC064321.1, AK127604.1, AP001065.1 and AL117578.1.
            
            On Nov 23, 2018 this sequence version replaced NM_030891.5.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC064321.1, AY358120.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000291592.6/ ENSP00000291592.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1897              BC064321.1         25-1921
            1898-2355           AK127604.1         1539-1996
            2356-2402           BC064321.1         2380-2426
            2403-2403           AP001065.1         64479-64479
            2404-2505           BC064321.1         2428-2529
            2506-5377           AP001065.1         64582-67453
            5378-5845           AL117578.1         1799-2266
FEATURES             Location/Qualifiers
     source          1..5845
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.3"
     gene            1..5845
                     /gene="LRRC3"
                     /gene_synonym="C21orf102; C21orf30; LRRC3DN"
                     /note="leucine rich repeat containing 3"
                     /db_xref="GeneID:81543"
                     /db_xref="HGNC:HGNC:14965"
                     /db_xref="MIM:617620"
     exon            1..146
                     /gene="LRRC3"
                     /gene_synonym="C21orf102; C21orf30; LRRC3DN"
                     /inference="alignment:Splign:2.1.0"
     exon            147..5845
                     /gene="LRRC3"
                     /gene_synonym="C21orf102; C21orf30; LRRC3DN"
                     /inference="alignment:Splign:2.1.0"
     CDS             294..1067
                     /gene="LRRC3"
                     /gene_synonym="C21orf102; C21orf30; LRRC3DN"
                     /note="leucine-rich repeat-containing protein 3;
                     intronless long ORF, AL117578; LRRC3 downstream neighbor
                     (non-protein coding)"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 3
                     precursor"
                     /protein_id="NP_112153.1"
                     /db_xref="CCDS:CCDS13711.1"
                     /db_xref="GeneID:81543"
                     /db_xref="HGNC:HGNC:14965"
                     /db_xref="MIM:617620"
                     /translation="MGTVRPPRPSLLLVSTRESCLFLLFCLHLGAACPQPCRCPDHAG
                     AVAVFCSLRGLQEVPEDIPANTVLLKLDANKISHLPDGAFQHLHRLRELDLSHNAIEA
                     IGSATFAGLAGGLRLLDLSYNRIQRIPKDALGKLSAKIRLSHNPLHCECALQEALWEL
                     KLDPDSVDEIACHTSVQEEFVGKPLVQALDAGASLCSVPHRTTDVAMLVTMFGWFAMV
                     IAYVVYYVRHNQEDARRHLEYLKSLPSAPASKDPIGPGP"
     polyA_site      2505
                     /gene="LRRC3"
                     /gene_synonym="C21orf102; C21orf30; LRRC3DN"
                     /note="major polyA site"
     regulatory      5821..5826
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRC3"
                     /gene_synonym="C21orf102; C21orf30; LRRC3DN"
                     /note="hexamer: AGTAAA"
     polyA_site      5845
                     /gene="LRRC3"
                     /gene_synonym="C21orf102; C21orf30; LRRC3DN"
                     /note="major polyA site"
ORIGIN      
        1 ggagtcgcgg cctccccagc tagtggtcgc gggcgcggtc gcaggggcag cggggtggcc
       61 gccgcgccag gcgtggagct gggtctggcg ggctccgaga ggcccgggag cggcgcgcag
      121 agcagcctcc ggccgccgcc gcgcagagct gccagagtgg actgcactgc ttctcccagc
      181 ggggcaggat ggcggtttca tgtctggttg gataaggcct tgcctgcgga aaccagctcc
      241 atccccaggc cctagcagag gctcgcgtgt ccccgtcccc aggtcaggtc aggatgggca
      301 ccgtgcgccc acctcgcccc tcgctcctgc tggtctccac ccgggagtct tgtctcttcc
      361 tcctcttctg cctgcacctg ggcgccgcct gcccacagcc ctgccggtgc cctgaccacg
      421 caggggctgt ggctgtcttc tgcagcttgc ggggccttca ggaggtcccc gaggacatcc
      481 cggccaacac cgtgctcctg aagctcgatg ccaacaagat ctcccacctc ccggacgggg
      541 ccttccagca cctgcaccgg ctcagggagc tggatctgtc tcacaacgcc atcgaggcca
      601 tcggctccgc caccttcgcg ggcctggccg ggggcctgcg gctgctggac ctgtcttaca
      661 accgcatcca gaggatcccc aaggacgccc tgggcaaact cagcgccaag atacgcctgt
      721 cccacaaccc cctgcactgc gagtgcgccc tgcaggaggc cctgtgggag ctgaagctgg
      781 accccgactc tgtggacgag atcgcctgcc acacctcagt gcaggaggag tttgtgggga
      841 agcctctggt tcaggctctg gatgcgggtg ccagcctctg cagcgtcccc cacaggacca
      901 cagacgtggc catgctggtc accatgttcg gctggttcgc catggtgatc gcctacgtcg
      961 tgtactatgt gcgccacaac caggaggatg cccggaggca cctggagtac ctgaagtctc
     1021 tgcccagcgc ccccgcctcc aaggacccca tcggcccggg gccctagcgc ctgttccggc
     1081 agacccccgc cggtggctgc tgtcactttt gtagtaggtg gtgactgatg ctgcttttgc
     1141 tcttccctga ggcaggtgtc acagccatgt gtgctcccca ctgttgcact caggcacagc
     1201 agcacctcca ggctgggtgg ttttgccaca catccgtgtg acggatgagg aacctgaagc
     1261 ttagaggaac ggaatgactg cccgtgacga taccatcagg aaattatccc agtggaactt
     1321 caacccgggc tgtccatcgt gacattccgc ctccttccac catgccagcc tctcccacac
     1381 ggggccctgc aggctgtgga tatgcactca gaggactaag ggggtgctct gcaagcgaga
     1441 gggttcacca gagggagctt gggtgcaggt tcacccgctg aaggcgctga taagtcctgt
     1501 gctgaggagc tgacttgccc ttgtttactt acaaagtgca ttgtaggtaa acatgagcct
     1561 tgttccagtg ttcgaagtac attggaacgt aagccctgtt tccagagcaa agtaacagag
     1621 accaggtttt tctagagagc taagtgggat gtgtagctca aacaaactgt cctacccttt
     1681 tttattctca aatgtttgtt ttgagtaacc gtagtgccaa aatttcagtt cagtaatggg
     1741 gtgaacaata tggagagaga cctgggaaaa gtccagggta gcttgcccag gggaagacag
     1801 cagccacata cctgggggcc cgcctgcttc ctgcccctct gggtgtgcct gatgcgggag
     1861 gccctgcccc agggcgatct cagctcactg caacctttgc ctcccaggct caatcacttc
     1921 tgctgcctca gcctccctag tagctggaat tacaggcatg agccaccacg cctggctaat
     1981 ttttgtattt ttagtagaga ccgggtttca ccatgttggc caggctggtc tcgaactgtt
     2041 ggcctcaagt gatccgcccg cctcagcctc ccaaagtgct gggattacag gcgtcagcca
     2101 ccgcgcccgg ccctgtgcct tgctttttct actcactaag atataaaaca gctctttttc
     2161 caaggcccgg agtactgggg attgatgttt caaggccaat caatgggatg cttcgttttc
     2221 tccagcaaca ggaactctct cttttcacct ttgctgccag gaatctcaga gataatttag
     2281 tgctcaattt actaacctta cttcacattc aggttagatg ttacctccac ctatatgata
     2341 gtaattccta attttatttt ttattgtcct ttttatgagt gtttatattt taaagtactt
     2401 tgagtatttt tggggggggt gtaaatgagt gatcagtgta cattgtgtgt ggactgaagt
     2461 gtaggtatgt agagatgctt cgccaaacag atgcttaaaa atgaatggaa gttgagggtg
     2521 gtttctcttt ggaaagtatc aggtgacttg gaaggtgaga gcctgtccag ggtgtgtgca
     2581 ctggttctga ggtaccccgt gtgtgcagtg tgagtcacgg gggtgtctgt gttgtgaggt
     2641 gcttggtagg ctttgctctg cccacagtgc agacgcgggg tgggtgaggg gccaggccca
     2701 gtgtatgagt ggaggcagcc ccaggctccg cctgcttccc tcacgccacg ctgcctgagt
     2761 gtcgccatgc tcggaggaca gagacctcca cggaaactgg cagcgccact cacccttcca
     2821 gtgagagcta gaaccaagtg ccagcccccg ggggtgcacc cgtgctggtg tggggccacg
     2881 tggtccttgt ggtccaggca gggccagcat gtggcggggt gtccagctcc actgtttgga
     2941 ggaagtgggc gctgacacag cagagtgccc tgggcccgtg gggatttcct tccagaggac
     3001 acgtggctga aagcatagga taaggatgta taggtgaatg actggtgcca tccctggctg
     3061 tctgatagat gcaggtaggg caggtgaact gttgctggcc tggccagcag gcctagggtc
     3121 acatggtgat tggcgtcctc ctgccacccc ttctccatgc cagggtgcct gtggtgggtt
     3181 tgcccagcac gcatgacccc aggtcccaag gagagtgtga actgaggcct gggtggtgaa
     3241 ggcagggcct ctcctcagcc ctgtgtcctg tgggtgccag ccagtcccat ctcgcatttt
     3301 ggggtgccct ttccctgctg ccaggggact cttcatttgt ccttacccta gaatcagccc
     3361 agacactgga catcacccag acgtggccct tcaggaggtg cacagggcag gggcaggccc
     3421 gtccctccct gccccaattt gctgggctgc ctcagcccag ggtctggcct tctccttggt
     3481 gaaggtctgc tgggcccctg tccacctcct gctgggagga ggagatgggg agaggaccag
     3541 gaggacaccg gaggccctgt cccctgcact gtgagctcag tcaggtccat gagctgccca
     3601 ccgtcctggc cttactgtgc cccctgcccc accaacatag gtgaaagcac ctcccctcta
     3661 aggaagacca tagagacccc aacactgtgg gaccccaaag ctccttcatg ctcactggag
     3721 ctcccaccgt gggtgcttgc aagtcctcag cgctcccggg gtacagccct ccccttcctg
     3781 ccctctaatg tcctcccctc ccttgccctt ccctccactt cctttctctg ccgtcccctc
     3841 ctctcccatc ttgtgacctc tttactggcg gggcctggag cccatgatgg acacttgcgg
     3901 aaggaggggt ggcggagcac ccctgagatg acatcgctgc ctgccccaga gcaccccgcc
     3961 tctccctgtg actcagttct ttgcagccca gatgtgagca tgtgcaccct gggacctgct
     4021 gcccgttggg atgcccaggc caaatcagcc cctctgcctc catgctgcac tgattgcaag
     4081 agtttcccac atctgcagag gccgtgggct cagccccaca ccagccaggc caccagtgtt
     4141 gatagcggtg aggcggggac aaagggaatg tctcagttca cagtgtggac atggtggagg
     4201 tctcggcctt gcgagacaag gcagggggag gggataggaa attgggggta ttctgtgact
     4261 cctgggccac cggggagcca gaatcttcca gccagactgg atgggcaggg cttagcttcc
     4321 tgatgccgcc cattcaccac tttcaccccg ggaacctacc tgggcatcat gggaggcaga
     4381 gcctgaaccc caacccaacc ctaactctaa tgctaacccc taaaccatcc cccaccctaa
     4441 cccaatcctc gccctaaccc taatgctaac ccctgacccg acccaatcct aaccctgatg
     4501 ctaacccctg actcaactct caccctaacc ctgatgctaa cccctgaccc aatcctcacc
     4561 ctaaccctga tactaaccct taacctaacc caacccagcc ctaactccaa ctctaaagct
     4621 aactcctaac cctaggagag gagcccaggc cgggccctct ccctgctggt ttcctgttgg
     4681 gctttggagc cccagatgcc tgcccagagg cttccttgtg cggggtgggg tccagcagtg
     4741 ggggatgggc ccagagctgg tatagccacc agcagagcca tcctgatcca caggaccatc
     4801 cctggtgggg tggggccccc tggggcagga aggccactga ggccagggag actcccaggc
     4861 ccactcacgg cgcaggcccc acaggagctg gctggaggct atgggtgcgg ggcgtgggcc
     4921 tgccgggggt tgcgtgacag gcagtgggga gtgggttgtg ctggcagctg tgggtgagtg
     4981 aggaggctcc tctcatgaag ggccctgggg aagtggaatc tggccctgag agacccccgg
     5041 cctcctctgc aggggctgct ggcaggaggg gaaccgggga ccacctcccg ccacagagcc
     5101 tggggccccc agccttgcct acagggaggg tagatgagag tgtaaactgc atatgaggtt
     5161 gggctaaacc tggacatgtg tttcataacc aaagcagcca ggaatctccg gctctgccca
     5221 gtgatcatct gggcaggaca tggggacgag tgtccaggct gaagtcaggg cccggccagc
     5281 agagggccat tttgtattga gctccacagc tggtcacatt ctgtggaatg tgcagacgtg
     5341 cacggcccat cagacagggt ctggagtggg gctgccgtct tgggcagctc ctcccgggtg
     5401 tctgcaaaat gcagaggtca ccagagccaa ggcagcaagg caaggagccc ggcttctaag
     5461 gaactctgag caggtgtggt ccatggctgg gaggcagctg gccccacagc acatagcacg
     5521 gagggcggcg cggagtcctg gacgctcttg gcaggtcccc tcatggagga tgtgggggat
     5581 tggcttaggc ctggtctggc tggccttcct ggaccgcagt ggccaggagc tgaaaaccgt
     5641 gaccccagtc tccctgcagc tgttcttgat gggatttctg ttcgccagtc agatgcattt
     5701 gcacaggact tggatcctga actgtgtaac ctggagaggc aggtgtgagc gggccatgct
     5761 gctggcccag cctgtgccgg tgtctgtttc tgttgtctct cggcccttct gtgagccctc
     5821 agtaaagctc ttcgtgcttc agtca
//
