LOCUS       NM_144598               5852 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens leucine rich repeat containing 28 (LRRC28), transcript
            variant 1, mRNA.
ACCESSION   NM_144598
VERSION     NM_144598.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5852)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
REFERENCE   2  (bases 1 to 5852)
  AUTHORS   Kimura,K., Wakamatsu,A., Suzuki,Y., Ota,T., Nishikawa,T.,
            Yamashita,R., Yamamoto,J., Sekine,M., Tsuritani,K., Wakaguri,H.,
            Ishii,S., Sugiyama,T., Saito,K., Isono,Y., Irie,R., Kushida,N.,
            Yoneyama,T., Otsuka,R., Kanda,K., Yokoi,T., Kondo,H., Wagatsuma,M.,
            Murakawa,K., Ishida,S., Ishibashi,T., Takahashi-Fujii,A.,
            Tanase,T., Nagai,K., Kikuchi,H., Nakai,K., Isogai,T. and Sugano,S.
  TITLE     Diversification of transcriptional modulation: large-scale
            identification and characterization of putative alternative
            promoters of human genes
  JOURNAL   Genome Res 16 (1), 55-65 (2006)
   PUBMED   16344560
REFERENCE   3  (bases 1 to 5852)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
REFERENCE   4  (bases 1 to 5852)
  AUTHORS   Bonaldo,M.F., Lennon,G. and Soares,M.B.
  TITLE     Normalization and subtraction: two approaches to facilitate gene
            discovery
  JOURNAL   Genome Res 6 (9), 791-806 (1996)
   PUBMED   8889548
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC047306.1 and AC037479.9.
            
            On Nov 23, 2018 this sequence version replaced NM_144598.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.61706.1,
                                           SRR1660805.140750.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000301981.8/ ENSP00000304923.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1416              BC047306.1         35-1450
            1417-5852           AC037479.9         168398-172833
FEATURES             Location/Qualifiers
     source          1..5852
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q26.3"
     gene            1..5852
                     /gene="LRRC28"
                     /note="leucine rich repeat containing 28"
                     /db_xref="GeneID:123355"
                     /db_xref="HGNC:HGNC:28355"
     exon            1..61
                     /gene="LRRC28"
                     /inference="alignment:Splign:2.1.0"
     exon            62..289
                     /gene="LRRC28"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..1225
                     /gene="LRRC28"
                     /note="isoform 1 is encoded by transcript variant 1;
                     leucine-rich repeat-containing protein 28"
                     /codon_start=1
                     /product="leucine-rich repeat-containing protein 28
                     isoform 1"
                     /protein_id="NP_653199.2"
                     /db_xref="CCDS:CCDS10380.1"
                     /db_xref="GeneID:123355"
                     /db_xref="HGNC:HGNC:28355"
                     /translation="MASELCKTISVARLEKHKNLFLNYRNLHHFPLELLKDEGLQYLE
                     RLYMKRNSLTSLPENLAQKLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDNALEI
                     VCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRLLTLPERLHMCLSLQ
                     YLTVDRNRLWYVPRHLCQLPSLNELSMAGNRLAFLPLDLGRSRELQYVYVDNNIHLKG
                     LPSYLYNKVIGCSGCGAPIQVSEVKLLSFSSGQRTVFLPAEVKAIGTEHDHVLPLQEL
                     AMRGLYHTYHSLLKDLNFLSPISLPRSLLELLHCPLGHCHRCSEPMFTIVYPKLFPLR
                     ETPMAGLHQWKTTVSFVAYCCSTQCLQTFDLLS"
     exon            290..330
                     /gene="LRRC28"
                     /inference="alignment:Splign:2.1.0"
     exon            331..368
                     /gene="LRRC28"
                     /inference="alignment:Splign:2.1.0"
     exon            369..506
                     /gene="LRRC28"
                     /inference="alignment:Splign:2.1.0"
     exon            507..713
                     /gene="LRRC28"
                     /inference="alignment:Splign:2.1.0"
     exon            714..816
                     /gene="LRRC28"
                     /inference="alignment:Splign:2.1.0"
     exon            817..992
                     /gene="LRRC28"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1152
                     /gene="LRRC28"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..5852
                     /gene="LRRC28"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1395..1400
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRC28"
                     /note="hexamer: AATATA"
     polyA_site      1419
                     /gene="LRRC28"
                     /note="major polyA site"
     regulatory      3722..3727
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LRRC28"
                     /note="hexamer: TATAAA"
     polyA_site      3745
                     /gene="LRRC28"
     polyA_site      5852
                     /gene="LRRC28"
ORIGIN      
        1 gtcccccgct tggcttccag cgccgcttgc gctccggagc gctggctctg ctggcgctga
       61 gaaatggacc aattttgaca agatatagtg ctgcagcgtg cctgatggga tatattcagt
      121 catggcgtcc gaactttgta agacgatctc tgtggcaagg ctagaaaagc acaagaattt
      181 gttcttaaat tataggaatc tgcaccattt tccattggag ttactgaaag atgagggact
      241 gcagtacttg gagagactct atatgaaaag gaactccctg acatccttgc cagaaaacct
      301 tgctcagaag cttccaaacc ttgtggaact atacctgcac tcaaataaca tagttgtggt
      361 tccggaagcc attgggtctc ttgtaaaact ccaatgtctg gatcttagtg acaatgcctt
      421 agaaattgtt tgcccagaaa ttggtcgtct gagagcttta cgtcatcttc gattagctaa
      481 taaccaactg caattcctac ctccagaggt tggcgatttg aaggagctgc agacactaga
      541 catttctacc aatcgtttgc taactttacc cgagaggctt cacatgtgcc tttctctgca
      601 gtacctcact gtggaccgaa atcgtctatg gtatgtgccg cgccatctct gccagctgcc
      661 cagcctcaat gagctctcca tggctggaaa ccgtcttgca tttttgccac ttgatttagg
      721 tcgatctcga gaactacagt atgtatacgt ggataacaac attcacctga aaggcttgcc
      781 atcttatctg tacaataaag tcatcgggtg cagtggctgt ggtgctccca ttcaagtttc
      841 cgaggtgaag ctgctttcct tttcatcagg gcagcgaacc gttttcctcc cagctgaggt
      901 gaaggccata gggacggagc atgatcacgt cctccctctg caggaattgg ctatgagagg
      961 gctgtatcat acctaccaca gcttgctgaa agatttgaac tttctgtctc caatctcatt
     1021 acccagaagt ctcctagagc tgctgcactg ccctctgggg cactgtcatc ggtgtagtga
     1081 gcctatgttt accatcgtct accccaagct ctttcccttg agagagacgc caatggcagg
     1141 gctgcaccag tggaagacaa ctgttagttt tgtggcttac tgctgctcca cccagtgtct
     1201 gcagactttt gacctgctga gttgataaac actcaagaac ctcaggagcg ctgccagctt
     1261 gacactgggg aatccagcca gtccagcaca ctcttccatc ctgtcctgtc caatgcgggg
     1321 gcactgcaga actctctaga aatgtcatga ttgagcttca gagctaaaat gccttcaccc
     1381 ttcccccaag ttggaatata tcctccccca aattaaggac ccatttgtct tctgtgtttt
     1441 tcctttttat gtgagtgtgt cttttacaga aaccatttag attgatgggc ctccccaaat
     1501 ctaatttaaa gcaagtttcc ggtccttgga gaacagtgac ttgatcatct agccagattc
     1561 ccttttgaac acacatacct tcagtgatgc ttcctctcct ctcccctccc ttgctttccc
     1621 cagagagtta tttccctgag accatgttct ccacagtgtc tccagtggaa acttgtcagt
     1681 ttttgaggag tttcagcaaa ccccgtggcc tcaatggtct tgagtagcag ggtggggcgc
     1741 ctgagttggc agcaaagtga ggctcccatg gaggctcagt gagggtccca gagcacacac
     1801 cctctggaaa gttccagcct tgtttatacg ttctacagtg tagcaacaga cttttgtgag
     1861 ggattttaaa aacaaaaatg tagattgtaa tgaaatacac ttcctgtttt ttaaaagtgt
     1921 ttgcagaaaa atgatttttg aagtttttaa atttcctgat aagatttttt ttatatgaga
     1981 agaatttgag gaatatttga agctttacaa gatctgattt ttttctttct caatataaag
     2041 tttccataca atgagaaagg gggagaaaac acacattgaa ataagacctc cgtgttcttt
     2101 tttgatgggt ttatgattca gtttatactg actttgaaat atttttgtca catgtgaaag
     2161 gcttcagcta cttccactac tggttttttt ttgttgttgt tgagacggag tctcgctctg
     2221 tcgcccaggc tggagtgcag tggcgggatc tcggctcact gcaagctccg cctcccgggt
     2281 tcacgccatt ctcctgcctc agcctcccaa gtagctggga ccacaggcgc ccgccaccac
     2341 gcccggctaa ttttttgtat ttttagtaga gacggggttt caccgtgtta gccgggatgg
     2401 tctcgatctc ctgacctcgt gatccgcacg cctcggcctc ccaaagtgct gggattacag
     2461 gcgtgagcca ccgcgcccgg cccactactg gtttttaaca ggatgattca aagtacagcc
     2521 cgtgcacatt tacttcgtca cctggtgcac cacactgtct tcatgttggc cctcgtttct
     2581 tgtatactta gcttactgcc cagatgcaac tgagaaaata caggaaaagc aggtccaaat
     2641 tcagccttcg acttctgcaa aagtccataa acagaaagtc tgtgagcctc caccctgcca
     2701 gaaagaactc ttcatgaaga agtcacgtat ttgctcttcc tttcaaagga tggcatttta
     2761 atgttgcttt gctgccagat gttcatctgc ttgctgtgaa gtgattcttt ttttaaaatg
     2821 ttttttaatg atgtaagttt tctaaaaggc agggctgaat ggagaaccaa gaatttgctt
     2881 ggtagaaaaa ttattttttt ttaatttcag acttatcaaa aatttggttg agggaatttt
     2941 tattagctgc cctgacttta taatgctacg ctcttaacag tgccaaaaat cctacatagt
     3001 tactgacaaa tgtgtgatct ttttacagtc acaacacctg ctgcccggaa agcacaccgt
     3061 ccacgtagaa tggagaaggc agaaagttac cgtgtgttcc cactgtatct gcactgttct
     3121 tacttcctct tgtccctttt catatcttgg tctattcagc cttaacattt caaaggctta
     3181 tagtaaaata ggaactgaag atctgtatca aaatgtaaca ctttcatcct ttggaataat
     3241 tgaagtttaa cataacctct acatgtatat aagttagctg gtgaaaatgt ggcatgaaac
     3301 ttcacaattg tgcttcaggc ctaagtgact gctacctatg atttaagtga cagtaaatgt
     3361 cttgctacat ttttctattt catcctctac aatcatatgt catggaatgg agctatgaaa
     3421 tgtgctaact tggtattcag gattctcatt gtgataaggt gatacattag ttttaccttg
     3481 tttgaaattt tacaaaaatg cttacaatcc aggcattctt tctctaccta ttatgaacta
     3541 cggtgtgtta aacaacagca gtgggctggg cagacaacct ttgggcagtc tcaaccttaa
     3601 tccttgggta cagcacctga acttaattga tgagaagtgg aacttaagtg gtttccctgg
     3661 tgctgttcat tatggaaatt ttatgctgga tttatcgatg tcattcttaa tcttttgata
     3721 ctataaagga gtcttaccaa ctggagaaaa tttgcctaca tgctatatat ttgaattgtg
     3781 tccaaagctt tgcagaaaag caaatctgaa gttattatat atgttgtttt cttgagcaac
     3841 agttacacta ggtagaaaag tattcacaca ataatagtaa tgcaaaaaaa gtgagctact
     3901 tggaaagtat catctctgtt caggtaagtt tacttcagtg aactcttgtg tggttagcga
     3961 taagttttaa agtccaggat agcctcatga gcataggcct tcctatgaag tagtgcaaag
     4021 ggggccgatt ttagtggatt accctatcag tgttcttcag tatgtccaat tgttatcata
     4081 ccaaaaacct taattacata acattgtgtg gatgaaatgc tgcatcttca gttaatacat
     4141 gttttgagca cattcttaaa atacataata attaaatgat ccctattcaa aagaaccctg
     4201 gcttgggtgg aggatccact ctggctaacg gataagagtg atgaacttct ttgttacctg
     4261 acccttctct tctggaaaag tgaggtgtac attaaacatc ttttggtcac cgtgcctcac
     4321 taagaccttt cacattccag cttgtccgac tagtgtaatg tacctctcac ttctgtttta
     4381 cgttgagcat tacgaattaa aatctttaca gtctaggggg aaaaaaaggc ttcaatacca
     4441 gttggcttat gaggctctgc atataatttt ctctaaaata tgtaactatt ttgtagtctg
     4501 tggggacttt caaagccaat ttttaaaatt agtagtagta aaggtttttc cctttcctga
     4561 atgaaaaatc agaaattcta atctttgcta taaagtactt aaacacaata cattgcctca
     4621 gcataaataa aaacattttt attaagatga tttatgaaca tggatttcta actggaccaa
     4681 cactaatgtt gcaacctgat aaaatttgag atgtaaattc atttcacaga ctcataaaca
     4741 cactctcttt aagactcttc tttaaatgga tccttacatt accctgcctg ttttattatg
     4801 ccttcatttt tgtggttttc attcactcct gcttgcttct attgaggttc tcctacattt
     4861 cccagaaact cagtgaatat cttgcctttt cttcaaacaa agggggtttt tataaagttt
     4921 gtatttttga aactagctct atgtctatct aaaaatcaag tctcggcagt ggctcatgcc
     4981 tataatccca gcactttggg aggccgagga gggcagatca tctgaggtca ggagtttgag
     5041 accagcctgg ccagcatggt gaaaccccat ctctactaaa aatacaaaaa attagccagg
     5101 cgtggtggcg cgcacctgca gtcccagcta ctcgggaggc tgaggcagga gaattgcttg
     5161 aacccggcag gaagaggttg cattgagctg agatcacgcc attacactcc agcctgggca
     5221 acagagcgag actccgtctc aaaaaaaaat cattcaagtt tcactgtgcc tacagtgagg
     5281 agctacctcc ttgtgtcatc agctaataga tctgaaagtg atgccggtgt ctctaggaaa
     5341 ggaattgatc atagccaagt gactgacatt ctctcggtca ggaaaagagc ttgcttcaca
     5401 gcctttgaag tatgactgta tgtgtggtcc ccttgtactt tggagacaga aggtactggc
     5461 agcgagtgtg gtggatgggc agaaggtgta gcattcggag attatttctg tatgtaatta
     5521 agagactttc aagggttagc cagacttttt tccactcaag tgtggattat ctttgctacc
     5581 tgtgttaaag aatatcaggt tttgtttctt attgtgattt ttgagtctaa atgatccaag
     5641 atttttaaaa tagatacata atgaaatcca ggcctctgaa aaattatggc aacattcatt
     5701 tggagtgtgg ctaaaaactc atactttatc caatttggtt gcctctctca gttactgcag
     5761 tttatagaat aattgagctt gaaccatgtg aatgctcaga atgtcaatgg tggagtattt
     5821 attcaagaga aatggctgaa tctcgatacg aa
//
